ZA757974B - Antiarrhythmia compositions and methods - Google Patents

Antiarrhythmia compositions and methods

Info

Publication number
ZA757974B
ZA757974B ZA00757974A ZA757974A ZA757974B ZA 757974 B ZA757974 B ZA 757974B ZA 00757974 A ZA00757974 A ZA 00757974A ZA 757974 A ZA757974 A ZA 757974A ZA 757974 B ZA757974 B ZA 757974B
Authority
ZA
South Africa
Prior art keywords
antiarrhythmia
compositions
methods
antiarrhythmia compositions
Prior art date
Application number
ZA00757974A
Other languages
English (en)
Inventor
Jr W Welstead
Original Assignee
Robins Co Inc A H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robins Co Inc A H filed Critical Robins Co Inc A H
Publication of ZA757974B publication Critical patent/ZA757974B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
ZA00757974A 1974-12-26 1975-12-23 Antiarrhythmia compositions and methods ZA757974B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/536,708 US4002766A (en) 1974-12-26 1974-12-26 Antiarrhythmia methods

Publications (1)

Publication Number Publication Date
ZA757974B true ZA757974B (en) 1976-12-29

Family

ID=24139598

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA00757974A ZA757974B (en) 1974-12-26 1975-12-23 Antiarrhythmia compositions and methods

Country Status (18)

Country Link
US (1) US4002766A (ko)
JP (1) JPS5191255A (ko)
AU (1) AU498763B2 (ko)
BE (1) BE836974A (ko)
CA (1) CA1055396A (ko)
CH (1) CH619932A5 (ko)
DE (1) DE2558501A1 (ko)
DK (1) DK137751B (ko)
ES (1) ES443846A1 (ko)
FI (1) FI753607A (ko)
FR (1) FR2295745A1 (ko)
GB (1) GB1535770A (ko)
IE (1) IE43901B1 (ko)
NL (1) NL185620C (ko)
NO (1) NO754377L (ko)
PH (1) PH13483A (ko)
SE (1) SE428126B (ko)
ZA (1) ZA757974B (ko)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4133881A (en) * 1977-04-27 1979-01-09 A. H. Robins Company, Incorporated Azetidinyl acetonitrile and acetamide antiarrhythmia compositions and methods
US4242261A (en) * 1979-07-19 1980-12-30 A. H. Robins Company, Inc. Production of methylene-cycloamines
US4260606A (en) * 1979-07-19 1981-04-07 A. H. Robins Company, Inc. 3-Methyleneazetidine derivatives
US4812451A (en) * 1984-10-19 1989-03-14 A. H. Robins Company, Incorporated 1-(aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl)-α,.alpha.
US4812452A (en) * 1984-10-19 1989-03-14 A. H. Robins Company, Incorporated 1-((aminoalkyl and aminoalkylamino) carbonyl and thiocarbonyl)-α,α-diarylpyrrolidine, piperidine and homopiperidineacetamides and acetonitriles
US4594343A (en) * 1984-10-19 1986-06-10 Shanklin Jr James R 1-[(aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl]-α,α-diarylpyrrolidine, piperidine and homopiperidineacetamides and acetonitriles
US4810703A (en) * 1984-10-19 1989-03-07 A. H. Robins Company, Incorporated 1-((aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl)-alpha, alpha-diarylpyrrolidine, piperidine and homopiperidineacetamides and acetonitriles
IL76583A (en) * 1984-10-19 1988-08-31 Robins Co Inc A H 1-(aminoalkyl)-alpha'alpha-diaryl pyrrolidinyl,piperidino and homopiperidino acetamides and acetonitriles and pharmaceutical compositions containing them
GB8825505D0 (en) * 1988-11-01 1988-12-07 Pfizer Ltd Therapeutic agents
US5932594A (en) * 1988-11-01 1999-08-03 Pfizer, Inc. Muscarinic receptor antagonists
US5233053A (en) * 1989-03-17 1993-08-03 Pfizer Inc. Pyrrolidine derivatives
GB8906166D0 (en) * 1989-03-17 1989-05-04 Pfizer Ltd Therapeutic agents
US6693202B1 (en) * 1999-02-16 2004-02-17 Theravance, Inc. Muscarinic receptor antagonists
TW200800953A (en) * 2002-10-30 2008-01-01 Theravance Inc Intermediates for preparing substituted 4-amino-1-(pyridylmethyl) piperidine
JP4767842B2 (ja) * 2003-04-01 2011-09-07 セラヴァンス， インコーポレーテッド β２アドレナリン作用性レセプターアゴニスト活性およびムスカリン性レセプターアンタゴニスト活性を有するジアリールメチル化合物および関連化合物
TW200510298A (en) * 2003-06-13 2005-03-16 Theravance Inc Substituted pyrrolidine and related compounds
US7368463B2 (en) * 2003-07-11 2008-05-06 Theravance, Inc. Substituted 4-amino-1-benzylpiperidine compounds
JP2007528414A (ja) * 2004-03-11 2007-10-11 セラヴァンス， インコーポレーテッド ムスカリンレセプターアンタゴニストとしての有用なジフェニルメチル化合物
EP1723142A1 (en) * 2004-03-11 2006-11-22 Theravance, Inc. Diphenylmethyl compounds useful as muscarinic receptor antagonists
TW200540154A (en) * 2004-06-10 2005-12-16 Theravance Inc Crystalline form of a substituted pyrrolidine compound
WO2007076159A2 (en) * 2005-12-27 2007-07-05 Teva Pharmaceutical Industries Ltd. Pure darifenacin hydrobromide substantially free of oxidized darifenacin and salts thereof and processes for the preparation thereof
RU2452728C2 (ru) 2007-02-23 2012-06-10 Тереванс, Инк. Четвертичные аммониевые дифенилметилсоединения, применимые в качестве антагонистов мускариновых рецепторов
ES2425592T3 (es) 2007-04-24 2013-10-16 Theravance, Inc. Compuestos de amonio cuaternario de utilidad como antagonistas de los receptores muscarínicos
WO2012166909A1 (en) * 2011-06-03 2012-12-06 Galleon Pharmaceuticals, Inc. Compositions and methods for treating breathing control disorders or diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3192210A (en) * 1961-12-04 1965-06-29 Robins Co Inc A H 4-(omega-substituted alkyl)-3, 3-disubstituted-1-substituted-2-pyrrolidinones and 4-(omega-substituted alkyl)-3, 3-disubstituted-1-substituted-2-thionpyrrolidinones
US3466321A (en) * 1965-05-17 1969-09-09 Ucb Sa Derivatives of phenyl-acetic acid
US3878217A (en) * 1972-01-28 1975-04-15 Richardson Merrell Inc Alpha-aryl-4-substituted piperidinoalkanol derivatives

Also Published As

Publication number Publication date
US4002766A (en) 1977-01-11
SE7514375L (sv) 1976-06-28
FR2295745B1 (ko) 1980-06-27
ES443846A1 (es) 1977-07-16
FI753607A (ko) 1976-06-27
AU8754975A (en) 1977-06-23
NO754377L (ko) 1976-06-29
DK137751C (ko) 1978-10-09
FR2295745A1 (fr) 1976-07-23
CH619932A5 (ko) 1980-10-31
JPS612658B2 (ko) 1986-01-27
PH13483A (en) 1980-05-21
GB1535770A (en) 1978-12-13
IE43901L (en) 1976-06-26
AU498763B2 (en) 1979-03-22
DE2558501C2 (ko) 1987-07-16
NL185620B (nl) 1990-01-02
IE43901B1 (en) 1981-07-01
JPS5191255A (en) 1976-08-10
NL185620C (nl) 1990-06-01
DK137751B (da) 1978-05-01
SE428126B (sv) 1983-06-06
BE836974A (fr) 1976-04-16
DE2558501A1 (de) 1976-07-08
CA1055396A (en) 1979-05-29
DK589175A (ko) 1976-06-27
NL7515071A (nl) 1976-06-29

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