SE428126B - Forfarande att framstella terapeutiskt aktiva 3-pyrrolidinyl-alfa,alfa-difenylacetamider och 3-pyrrolidinyl-alfa,alfa-difenylmetaner - Google Patents

Forfarande att framstella terapeutiskt aktiva 3-pyrrolidinyl-alfa,alfa-difenylacetamider och 3-pyrrolidinyl-alfa,alfa-difenylmetaner

Info

Publication number
SE428126B
SE428126B SE7514375A SE7514375A SE428126B SE 428126 B SE428126 B SE 428126B SE 7514375 A SE7514375 A SE 7514375A SE 7514375 A SE7514375 A SE 7514375A SE 428126 B SE428126 B SE 428126B
Authority
SE
Sweden
Prior art keywords
alfa
pyrrolidinyl
methetanes
difenyl
acetamides
Prior art date
Application number
SE7514375A
Other languages
English (en)
Other versions
SE7514375L (sv
Inventor
Jr W J Welstead
Original Assignee
Robins Co Inc A H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robins Co Inc A H filed Critical Robins Co Inc A H
Publication of SE7514375L publication Critical patent/SE7514375L/sv
Publication of SE428126B publication Critical patent/SE428126B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
SE7514375A 1974-12-26 1975-12-18 Forfarande att framstella terapeutiskt aktiva 3-pyrrolidinyl-alfa,alfa-difenylacetamider och 3-pyrrolidinyl-alfa,alfa-difenylmetaner SE428126B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/536,708 US4002766A (en) 1974-12-26 1974-12-26 Antiarrhythmia methods

Publications (2)

Publication Number Publication Date
SE7514375L SE7514375L (sv) 1976-06-28
SE428126B true SE428126B (sv) 1983-06-06

Family

ID=24139598

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7514375A SE428126B (sv) 1974-12-26 1975-12-18 Forfarande att framstella terapeutiskt aktiva 3-pyrrolidinyl-alfa,alfa-difenylacetamider och 3-pyrrolidinyl-alfa,alfa-difenylmetaner

Country Status (18)

Country Link
US (1) US4002766A (sv)
JP (1) JPS5191255A (sv)
AU (1) AU498763B2 (sv)
BE (1) BE836974A (sv)
CA (1) CA1055396A (sv)
CH (1) CH619932A5 (sv)
DE (1) DE2558501A1 (sv)
DK (1) DK137751B (sv)
ES (1) ES443846A1 (sv)
FI (1) FI753607A (sv)
FR (1) FR2295745A1 (sv)
GB (1) GB1535770A (sv)
IE (1) IE43901B1 (sv)
NL (1) NL185620C (sv)
NO (1) NO754377L (sv)
PH (1) PH13483A (sv)
SE (1) SE428126B (sv)
ZA (1) ZA757974B (sv)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4133881A (en) * 1977-04-27 1979-01-09 A. H. Robins Company, Incorporated Azetidinyl acetonitrile and acetamide antiarrhythmia compositions and methods
US4242261A (en) * 1979-07-19 1980-12-30 A. H. Robins Company, Inc. Production of methylene-cycloamines
US4260606A (en) * 1979-07-19 1981-04-07 A. H. Robins Company, Inc. 3-Methyleneazetidine derivatives
US4812452A (en) * 1984-10-19 1989-03-14 A. H. Robins Company, Incorporated 1-((aminoalkyl and aminoalkylamino) carbonyl and thiocarbonyl)-α,α-diarylpyrrolidine, piperidine and homopiperidineacetamides and acetonitriles
US4810703A (en) * 1984-10-19 1989-03-07 A. H. Robins Company, Incorporated 1-((aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl)-alpha, alpha-diarylpyrrolidine, piperidine and homopiperidineacetamides and acetonitriles
IL76583A (en) * 1984-10-19 1988-08-31 Robins Co Inc A H 1-(aminoalkyl)-alpha'alpha-diaryl pyrrolidinyl,piperidino and homopiperidino acetamides and acetonitriles and pharmaceutical compositions containing them
US4812451A (en) * 1984-10-19 1989-03-14 A. H. Robins Company, Incorporated 1-(aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl)-α,.alpha.
US4594343A (en) * 1984-10-19 1986-06-10 Shanklin Jr James R 1-[(aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl]-α,α-diarylpyrrolidine, piperidine and homopiperidineacetamides and acetonitriles
US5932594A (en) * 1988-11-01 1999-08-03 Pfizer, Inc. Muscarinic receptor antagonists
GB8825505D0 (en) * 1988-11-01 1988-12-07 Pfizer Ltd Therapeutic agents
US5233053A (en) * 1989-03-17 1993-08-03 Pfizer Inc. Pyrrolidine derivatives
GB8906166D0 (en) * 1989-03-17 1989-05-04 Pfizer Ltd Therapeutic agents
US6693202B1 (en) 1999-02-16 2004-02-17 Theravance, Inc. Muscarinic receptor antagonists
TW200800953A (en) * 2002-10-30 2008-01-01 Theravance Inc Intermediates for preparing substituted 4-amino-1-(pyridylmethyl) piperidine
US7317102B2 (en) * 2003-04-01 2008-01-08 Theravance, Inc. Diarylmethyl and related compounds
TW200510298A (en) * 2003-06-13 2005-03-16 Theravance Inc Substituted pyrrolidine and related compounds
EP1644356A1 (en) * 2003-07-11 2006-04-12 Theravance, Inc. Substituted 4-amino-1-benzylpiperidine compounds
EP1723142A1 (en) * 2004-03-11 2006-11-22 Theravance, Inc. Diphenylmethyl compounds useful as muscarinic receptor antagonists
JP2007528414A (ja) * 2004-03-11 2007-10-11 セラヴァンス， インコーポレーテッド ムスカリンレセプターアンタゴニストとしての有用なジフェニルメチル化合物
TW200540154A (en) * 2004-06-10 2005-12-16 Theravance Inc Crystalline form of a substituted pyrrolidine compound
WO2007076157A2 (en) * 2005-12-27 2007-07-05 Teva Pharmaceuticals Industries Ltd. Processes for preparing darifenacin hydrobromide
MX2009008527A (es) * 2007-02-23 2009-08-27 Theravance Inc Compuestos de amonio cuaternario y difenilmetilo utiles como antagonistas del receptor muscarinico.
US8202891B2 (en) * 2007-04-24 2012-06-19 Theravance, Inc. Quaternary ammonium compounds useful as muscarinic receptor antagonists
WO2012166909A1 (en) * 2011-06-03 2012-12-06 Galleon Pharmaceuticals, Inc. Compositions and methods for treating breathing control disorders or diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3192210A (en) * 1961-12-04 1965-06-29 Robins Co Inc A H 4-(omega-substituted alkyl)-3, 3-disubstituted-1-substituted-2-pyrrolidinones and 4-(omega-substituted alkyl)-3, 3-disubstituted-1-substituted-2-thionpyrrolidinones
US3466321A (en) * 1965-05-17 1969-09-09 Ucb Sa Derivatives of phenyl-acetic acid
US3878217A (en) * 1972-01-28 1975-04-15 Richardson Merrell Inc Alpha-aryl-4-substituted piperidinoalkanol derivatives

Also Published As

Publication number Publication date
DK137751B (da) 1978-05-01
ES443846A1 (es) 1977-07-16
FI753607A (sv) 1976-06-27
CA1055396A (en) 1979-05-29
NL185620B (nl) 1990-01-02
ZA757974B (en) 1976-12-29
US4002766A (en) 1977-01-11
BE836974A (fr) 1976-04-16
FR2295745B1 (sv) 1980-06-27
SE7514375L (sv) 1976-06-28
DE2558501A1 (de) 1976-07-08
IE43901L (en) 1976-06-26
FR2295745A1 (fr) 1976-07-23
NL185620C (nl) 1990-06-01
NL7515071A (nl) 1976-06-29
AU8754975A (en) 1977-06-23
PH13483A (en) 1980-05-21
AU498763B2 (en) 1979-03-22
JPS5191255A (en) 1976-08-10
IE43901B1 (en) 1981-07-01
CH619932A5 (sv) 1980-10-31
JPS612658B2 (sv) 1986-01-27
GB1535770A (en) 1978-12-13
DE2558501C2 (sv) 1987-07-16
DK137751C (sv) 1978-10-09
NO754377L (sv) 1976-06-29
DK589175A (sv) 1976-06-27

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