DK137751B - Analogifremgangsmåde til fremstilling af alfa,alfa-diphenyl-alfa-(1-isopropyl-3-pyrrolidinyl)acetamid. - Google Patents
Analogifremgangsmåde til fremstilling af alfa,alfa-diphenyl-alfa-(1-isopropyl-3-pyrrolidinyl)acetamid.Info
- Publication number
- DK137751B DK137751B DK589175AA DK589175A DK137751B DK 137751 B DK137751 B DK 137751B DK 589175A A DK589175A A DK 589175AA DK 589175 A DK589175 A DK 589175A DK 137751 B DK137751 B DK 137751B
- Authority
- DK
- Denmark
- Prior art keywords
- alpha
- pyrrolidinyl
- acetamide
- diphenyl
- isopropyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/536,708 US4002766A (en) | 1974-12-26 | 1974-12-26 | Antiarrhythmia methods |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK589175A DK589175A (da) | 1976-06-27 |
| DK137751B true DK137751B (da) | 1978-05-01 |
| DK137751C DK137751C (da) | 1978-10-09 |
Family
ID=24139598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK589175AA DK137751B (da) | 1974-12-26 | 1975-12-23 | Analogifremgangsmåde til fremstilling af alfa,alfa-diphenyl-alfa-(1-isopropyl-3-pyrrolidinyl)acetamid. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4002766A (da) |
| JP (1) | JPS5191255A (da) |
| AU (1) | AU498763B2 (da) |
| BE (1) | BE836974A (da) |
| CA (1) | CA1055396A (da) |
| CH (1) | CH619932A5 (da) |
| DE (1) | DE2558501A1 (da) |
| DK (1) | DK137751B (da) |
| ES (1) | ES443846A1 (da) |
| FI (1) | FI753607A (da) |
| FR (1) | FR2295745A1 (da) |
| GB (1) | GB1535770A (da) |
| IE (1) | IE43901B1 (da) |
| NL (1) | NL185620C (da) |
| NO (1) | NO754377L (da) |
| PH (1) | PH13483A (da) |
| SE (1) | SE428126B (da) |
| ZA (1) | ZA757974B (da) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4133881A (en) * | 1977-04-27 | 1979-01-09 | A. H. Robins Company, Incorporated | Azetidinyl acetonitrile and acetamide antiarrhythmia compositions and methods |
| US4242261A (en) * | 1979-07-19 | 1980-12-30 | A. H. Robins Company, Inc. | Production of methylene-cycloamines |
| US4260606A (en) * | 1979-07-19 | 1981-04-07 | A. H. Robins Company, Inc. | 3-Methyleneazetidine derivatives |
| US4594343A (en) * | 1984-10-19 | 1986-06-10 | Shanklin Jr James R | 1-[(aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl]-α,α-diarylpyrrolidine, piperidine and homopiperidineacetamides and acetonitriles |
| US4812451A (en) * | 1984-10-19 | 1989-03-14 | A. H. Robins Company, Incorporated | 1-(aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl)-α,.alpha. |
| US4810703A (en) * | 1984-10-19 | 1989-03-07 | A. H. Robins Company, Incorporated | 1-((aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl)-alpha, alpha-diarylpyrrolidine, piperidine and homopiperidineacetamides and acetonitriles |
| IL76583A (en) * | 1984-10-19 | 1988-08-31 | Robins Co Inc A H | 1-(aminoalkyl)-alpha'alpha-diaryl pyrrolidinyl,piperidino and homopiperidino acetamides and acetonitriles and pharmaceutical compositions containing them |
| US4812452A (en) * | 1984-10-19 | 1989-03-14 | A. H. Robins Company, Incorporated | 1-((aminoalkyl and aminoalkylamino) carbonyl and thiocarbonyl)-α,α-diarylpyrrolidine, piperidine and homopiperidineacetamides and acetonitriles |
| GB8825505D0 (en) * | 1988-11-01 | 1988-12-07 | Pfizer Ltd | Therapeutic agents |
| US5932594A (en) * | 1988-11-01 | 1999-08-03 | Pfizer, Inc. | Muscarinic receptor antagonists |
| GB8906166D0 (en) * | 1989-03-17 | 1989-05-04 | Pfizer Ltd | Therapeutic agents |
| US5233053A (en) * | 1989-03-17 | 1993-08-03 | Pfizer Inc. | Pyrrolidine derivatives |
| US6693202B1 (en) * | 1999-02-16 | 2004-02-17 | Theravance, Inc. | Muscarinic receptor antagonists |
| TWI295669B (en) * | 2002-10-30 | 2008-04-11 | Theravance Inc | Substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds |
| EP1615881A2 (en) * | 2003-04-01 | 2006-01-18 | Theravance, Inc. | Diarylmethyl and related compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
| TW200510298A (en) * | 2003-06-13 | 2005-03-16 | Theravance Inc | Substituted pyrrolidine and related compounds |
| WO2005007645A1 (en) * | 2003-07-11 | 2005-01-27 | Theravance, Inc. | Substituted 4-amino-1-benzylpiperidine compounds |
| WO2005087763A1 (en) * | 2004-03-11 | 2005-09-22 | Theravance, Inc. | Diphenylmethyl compounds useful as muscarinic receptor antagonists |
| JP2007528414A (ja) * | 2004-03-11 | 2007-10-11 | セラヴァンス， インコーポレーテッド | ムスカリンレセプターアンタゴニストとしての有用なジフェニルメチル化合物 |
| TW200540154A (en) * | 2004-06-10 | 2005-12-16 | Theravance Inc | Crystalline form of a substituted pyrrolidine compound |
| US7442806B2 (en) * | 2005-12-27 | 2008-10-28 | Teva Pharmaceutical Industries Ltd. | Processes for preparing darifenacin hydrobromide |
| KR101495708B1 (ko) * | 2007-02-23 | 2015-02-25 | 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 | 무스카린 수용체 안타고니스트로 유용한 4차 암모늄 디페닐메틸 화합물 |
| WO2008133900A1 (en) | 2007-04-24 | 2008-11-06 | Theravance, Inc. | Quaternary ammonium compounds useful as muscarinic receptor antagonists |
| WO2012166909A1 (en) * | 2011-06-03 | 2012-12-06 | Galleon Pharmaceuticals, Inc. | Compositions and methods for treating breathing control disorders or diseases |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3192210A (en) * | 1961-12-04 | 1965-06-29 | Robins Co Inc A H | 4-(omega-substituted alkyl)-3, 3-disubstituted-1-substituted-2-pyrrolidinones and 4-(omega-substituted alkyl)-3, 3-disubstituted-1-substituted-2-thionpyrrolidinones |
| US3466321A (en) * | 1965-05-17 | 1969-09-09 | Ucb Sa | Derivatives of phenyl-acetic acid |
| US3878217A (en) * | 1972-01-28 | 1975-04-15 | Richardson Merrell Inc | Alpha-aryl-4-substituted piperidinoalkanol derivatives |
-
1974
- 1974-12-26 US US05/536,708 patent/US4002766A/en not_active Expired - Lifetime
-
1975
- 1975-12-15 AU AU87549/75A patent/AU498763B2/en not_active Expired
- 1975-12-18 SE SE7514375A patent/SE428126B/xx not_active IP Right Cessation
- 1975-12-19 FI FI753607A patent/FI753607A/fi not_active Application Discontinuation
- 1975-12-22 BE BE163037A patent/BE836974A/xx not_active IP Right Cessation
- 1975-12-22 CH CH1660475A patent/CH619932A5/fr not_active IP Right Cessation
- 1975-12-23 FR FR7539571A patent/FR2295745A1/fr active Granted
- 1975-12-23 CA CA242,431A patent/CA1055396A/en not_active Expired
- 1975-12-23 IE IE2823/75A patent/IE43901B1/en unknown
- 1975-12-23 GB GB52610/75A patent/GB1535770A/en not_active Expired
- 1975-12-23 NO NO754377A patent/NO754377L/no unknown
- 1975-12-23 ZA ZA00757974A patent/ZA757974B/xx unknown
- 1975-12-23 DK DK589175AA patent/DK137751B/da not_active IP Right Cessation
- 1975-12-24 NL NLAANVRAGE7515071,A patent/NL185620C/xx not_active IP Right Cessation
- 1975-12-24 PH PH17925A patent/PH13483A/en unknown
- 1975-12-24 DE DE19752558501 patent/DE2558501A1/de active Granted
- 1975-12-24 ES ES443846A patent/ES443846A1/es not_active Expired
- 1975-12-26 JP JP50159798A patent/JPS5191255A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| DK589175A (da) | 1976-06-27 |
| SE7514375L (sv) | 1976-06-28 |
| IE43901L (en) | 1976-06-26 |
| NL185620C (nl) | 1990-06-01 |
| DE2558501A1 (de) | 1976-07-08 |
| CH619932A5 (da) | 1980-10-31 |
| ES443846A1 (es) | 1977-07-16 |
| FI753607A (da) | 1976-06-27 |
| GB1535770A (en) | 1978-12-13 |
| AU8754975A (en) | 1977-06-23 |
| PH13483A (en) | 1980-05-21 |
| BE836974A (fr) | 1976-04-16 |
| AU498763B2 (en) | 1979-03-22 |
| CA1055396A (en) | 1979-05-29 |
| SE428126B (sv) | 1983-06-06 |
| ZA757974B (en) | 1976-12-29 |
| NO754377L (da) | 1976-06-29 |
| JPS5191255A (en) | 1976-08-10 |
| FR2295745B1 (da) | 1980-06-27 |
| IE43901B1 (en) | 1981-07-01 |
| NL185620B (nl) | 1990-01-02 |
| FR2295745A1 (fr) | 1976-07-23 |
| US4002766A (en) | 1977-01-11 |
| NL7515071A (nl) | 1976-06-29 |
| DE2558501C2 (da) | 1987-07-16 |
| JPS612658B2 (da) | 1986-01-27 |
| DK137751C (da) | 1978-10-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK137751B (da) | Analogifremgangsmåde til fremstilling af alfa,alfa-diphenyl-alfa-(1-isopropyl-3-pyrrolidinyl)acetamid. | |
| DK138800B (da) | Analogifremgangsmåde til fremstilling af 4-aminoquinazolinderivater. | |
| DK136075B (da) | Analogifremgangsmåde til fremstilling af 11beta-hydroxy-16-methyl-3-oxo-17alfa-acyloxyandrosta-1,4,15-trien-17beta-carboxylater. | |
| DK135711B (da) | Analogifremgangsmåde til fremstilling af hidtil ukendte, hjerteaktive substituerede fenoxyisopropanolaminer. | |
| DK137835B (da) | Analogifremgangsmåde til fremstilling af thienothiazinderivater. | |
| DK179675A (da) | Fremgangsmade til fremstilling af 6-amino-5-r3-2,4-diaminopyrimidin-3-oxider | |
| DK129987B (da) | Analogifremgangsmåde til fremstilling af guanidiner. | |
| DK139846B (da) | Analogifremgangsmåde til fremstilling af 3-alkoxypyrazin-2-carboxamider. | |
| DK135796B (da) | Fremgangsmåde til fremstilling af alkyl-tert-alkylethere. | |
| DK390975A (da) | Fremgangsmade til fremstilling af omega-nor-cycloalkyl-13,14-dehydroprostaglandiner | |
| DK137449B (da) | Fremgangsmåde til fremstilling af N,N-diallyldichloracetamid. | |
| DK140557B (da) | Analogifremgangsmåde til fremstilling af sultiner af 17-hydroxy-3-oxo-17alfa-pregn-4-en-21-sulfinsyrer. | |
| DK136313B (da) | Analogifremgangsmåde til fremstilling af N-substituerede m-trifluormethylbenzylaminer. | |
| DK135284B (da) | Fremgangsmåde til fremstilling af 1,3-bis(halomethyl)phenobarbitaler. | |
| DK137646B (da) | Fremgangsmåde til fremstilling af 6-chlor-2-chlormethyl-4-phenylquinazolin-3-oxid. | |
| DK138694B (da) | Fremgangsmåde til fremstilling af phenylphosphonothiodichlorid. | |
| DK132221B (da) | Fremgangsmåde til fremstilling af 2,4-diamino-5-benzylpyrimider. | |
| DK138499B (da) | Fremgangsmåde til fremstilling af 11beta-hydroksy-18-alkyløstranforbindelser. | |
| DK130987B (da) | Analogifremgangsmåde til fremstilling af 15alfa,16alfa-methylen-4-androsten-3-oner. | |
| DK140313B (da) | Analogifremgangsmåde til fremstilling af 1-sulfonyl-5(6)-substitueret-benzimidazoler. | |
| DK505275A (da) | Fremgangsmade til fremstilling af 7,7-diphenylhexahydro-1,4-oxazepiner | |
| DK137088B (da) | Analogifremgangsmåde til fremstilling af 13-alkyl-D-homogonadien-3-oner. | |
| DK456475A (da) | Fremgangsmade til fremstilling af 13beta-alkyl-4-gonen-3,17-dioner | |
| DK138420B (da) | Analogifremgangsmåde til fremstilling af caroverin-fumarat. | |
| DK132661C (da) | Fremgangsmade til fremstilling af 17-acylestere af 17alfa,21-dihydroxysteroider af pregnanrekken |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed |