CH617691A5 - - Google Patents
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- Publication number
- CH617691A5 CH617691A5 CH1267878A CH1267878A CH617691A5 CH 617691 A5 CH617691 A5 CH 617691A5 CH 1267878 A CH1267878 A CH 1267878A CH 1267878 A CH1267878 A CH 1267878A CH 617691 A5 CH617691 A5 CH 617691A5
- Authority
- CH
- Switzerland
- Prior art keywords
- group
- formula
- nitro
- lower alkyl
- compound
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 claims description 24
- 125000000217 alkyl group Chemical group 0.000 claims description 13
- -1 nitro, amino, carboxyl Chemical group 0.000 claims description 13
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 7
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 229910052717 sulfur Inorganic materials 0.000 claims description 6
- 239000011593 sulfur Substances 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 4
- 229910052736 halogen Inorganic materials 0.000 claims description 4
- 150000002367 halogens Chemical class 0.000 claims description 4
- 229910052760 oxygen Inorganic materials 0.000 claims description 4
- 239000001301 oxygen Chemical group 0.000 claims description 4
- 125000003342 alkenyl group Chemical group 0.000 claims description 3
- 125000002947 alkylene group Chemical group 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims description 2
- 125000003545 alkoxy group Chemical group 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 239000001257 hydrogen Substances 0.000 claims description 2
- 150000002431 hydrogen Chemical class 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 125000001841 imino group Chemical group [H]N=* 0.000 claims description 2
- 150000003254 radicals Chemical class 0.000 claims description 2
- 150000002391 heterocyclic compounds Chemical class 0.000 claims 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 6
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 6
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 241000204031 Mycoplasma Species 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- 241000700159 Rattus Species 0.000 description 3
- 241001502500 Trichomonadida Species 0.000 description 3
- 238000009835 boiling Methods 0.000 description 3
- 230000007717 exclusion Effects 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 239000011541 reaction mixture Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- RVRFUCQSUAQDHE-UHFFFAOYSA-N 4-chloro-2-(1-methyl-5-nitroimidazol-2-yl)quinazoline Chemical compound CN1C([N+]([O-])=O)=CN=C1C1=NC(Cl)=C(C=CC=C2)C2=N1 RVRFUCQSUAQDHE-UHFFFAOYSA-N 0.000 description 2
- 208000004881 Amebiasis Diseases 0.000 description 2
- 206010001980 Amoebiasis Diseases 0.000 description 2
- 241000699800 Cricetinae Species 0.000 description 2
- 241000224421 Heterolobosea Species 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 208000005448 Trichomonas Infections Diseases 0.000 description 2
- 206010044620 Trichomoniasis Diseases 0.000 description 2
- 210000003001 amoeba Anatomy 0.000 description 2
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical compound NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 239000003610 charcoal Substances 0.000 description 2
- 239000007795 chemical reaction product Substances 0.000 description 2
- 230000000973 chemotherapeutic effect Effects 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 2
- 235000019341 magnesium sulphate Nutrition 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 2
- UHZYTMXLRWXGPK-UHFFFAOYSA-N phosphorus pentachloride Chemical compound ClP(Cl)(Cl)(Cl)Cl UHZYTMXLRWXGPK-UHFFFAOYSA-N 0.000 description 2
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 description 2
- 150000003246 quinazolines Chemical class 0.000 description 2
- 238000013207 serial dilution Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 239000012730 sustained-release form Substances 0.000 description 2
- DVLXDTZDJJGUMH-UHFFFAOYSA-N 2-(5-nitro-1H-imidazol-2-yl)quinazoline Chemical class [N+](=O)([O-])C1=CN=C(N1)C1=NC2=CC=CC=C2C=N1 DVLXDTZDJJGUMH-UHFFFAOYSA-N 0.000 description 1
- KVLDTILNBYXMLB-UHFFFAOYSA-N 2-[[2-(1-methyl-5-nitroimidazol-2-yl)quinazolin-4-yl]amino]ethanol Chemical compound CN1C([N+]([O-])=O)=CN=C1C1=NC(NCCO)=C(C=CC=C2)C2=N1 KVLDTILNBYXMLB-UHFFFAOYSA-N 0.000 description 1
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 description 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
- CGKCVDOCGJPNOG-UHFFFAOYSA-N 4-[2-(1-methyl-5-nitroimidazol-2-yl)quinazolin-4-yl]morpholine Chemical compound CN1C([N+]([O-])=O)=CN=C1C1=NC(N2CCOCC2)=C(C=CC=C2)C2=N1 CGKCVDOCGJPNOG-UHFFFAOYSA-N 0.000 description 1
- GVRRXASZZAKBMN-UHFFFAOYSA-N 4-chloroquinazoline Chemical compound C1=CC=C2C(Cl)=NC=NC2=C1 GVRRXASZZAKBMN-UHFFFAOYSA-N 0.000 description 1
- 241000224489 Amoeba Species 0.000 description 1
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 206010036030 Polyarthritis Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 229940124323 amoebicide Drugs 0.000 description 1
- 230000000507 anthelmentic effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000002141 anti-parasite Effects 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000008280 chlorinated hydrocarbons Chemical class 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000002140 halogenating effect Effects 0.000 description 1
- 230000026030 halogenation Effects 0.000 description 1
- 238000005658 halogenation reaction Methods 0.000 description 1
- 150000007857 hydrazones Chemical class 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 231100000636 lethal dose Toxicity 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 description 1
- 208000030428 polyarticular arthritis Diseases 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH604175A CH612432A5 (en, 2012) | 1975-05-12 | 1975-05-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH617691A5 true CH617691A5 (en, 2012) | 1980-06-13 |
Family
ID=4303274
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH604175A CH612432A5 (en, 2012) | 1975-05-12 | 1975-05-12 | |
| CH1267878A CH617691A5 (en, 2012) | 1975-05-12 | 1978-12-13 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH604175A CH612432A5 (en, 2012) | 1975-05-12 | 1975-05-12 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4055642A (en, 2012) |
| JP (1) | JPS51138689A (en, 2012) |
| AT (1) | ATA342176A (en, 2012) |
| AU (1) | AU1389176A (en, 2012) |
| BE (1) | BE841669A (en, 2012) |
| CA (1) | CA1071626A (en, 2012) |
| CH (2) | CH612432A5 (en, 2012) |
| DE (1) | DE2619110A1 (en, 2012) |
| DK (1) | DK197476A (en, 2012) |
| ES (1) | ES447751A1 (en, 2012) |
| FI (1) | FI761232A7 (en, 2012) |
| FR (1) | FR2310756A1 (en, 2012) |
| GB (1) | GB1551117A (en, 2012) |
| IL (1) | IL49546A0 (en, 2012) |
| NL (1) | NL7604894A (en, 2012) |
| NO (1) | NO761537L (en, 2012) |
| PT (1) | PT65084B (en, 2012) |
| SE (1) | SE409455B (en, 2012) |
| ZA (1) | ZA762813B (en, 2012) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2826526A1 (de) * | 1977-06-17 | 1979-01-04 | Gist Brocades Nv | Kupferkomplexe von phenanthrolin-, isochinolin- und chinazolinderivaten, verfahren zu ihrer herstellung und ihre verwendung bei der bekaempfung von mykoplasmainfektionen |
| GB8429739D0 (en) * | 1984-11-24 | 1985-01-03 | Fbc Ltd | Fungicides |
| JP2657760B2 (ja) * | 1992-07-15 | 1997-09-24 | 小野薬品工業株式会社 | ４−アミノキナゾリン誘導体およびそれを含有する医薬品 |
| AU5261001A (en) | 2000-04-27 | 2001-11-12 | Imperial Cancer Research Technology Ltd | Condensed heteroaryl derivatives |
| CL2004000409A1 (es) * | 2003-03-03 | 2005-01-07 | Vertex Pharma | Compuestos derivados de 2-(cilo sustituido)-1-(amino u oxi sustituido)-quinazolina, inhibidores de canales ionicos de sodio y calcio dependientes de voltaje; composicion farmaceutica; y uso del compuesto en el tratamiento de dolor agudo, cronico, neu |
| CA2528774A1 (en) * | 2003-06-20 | 2005-01-27 | Coley Pharmaceutical Gmbh | Small molecule toll-like receptor (tlr) antagonists |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3324122A (en) * | 1964-12-14 | 1967-06-06 | Norwich Pharma Co | Series of 4-substituted-2-(5-nitro-2-furyl) quinazolines |
| US3705898A (en) * | 1970-01-26 | 1972-12-12 | Morton Norwich Products Inc | Certain 4 - amino - 2-(5-nitro-2-thienyl) quinazolines and the intermediate 4 - chloro-(5 - nitro-2-thienyl)quinazolines therefor |
| BE795636A (fr) * | 1972-02-19 | 1973-08-20 | Schering Ag | Nitroimidazolylpyrimidines, et leur procede de preparation |
-
1975
- 1975-05-12 CH CH604175A patent/CH612432A5/xx not_active IP Right Cessation
-
1976
- 1976-05-03 FI FI761232A patent/FI761232A7/fi not_active Application Discontinuation
- 1976-05-03 DE DE19762619110 patent/DE2619110A1/de not_active Withdrawn
- 1976-05-03 DK DK197476A patent/DK197476A/da unknown
- 1976-05-04 NO NO761537A patent/NO761537L/no unknown
- 1976-05-05 SE SE7605158A patent/SE409455B/xx unknown
- 1976-05-05 US US05/683,291 patent/US4055642A/en not_active Expired - Lifetime
- 1976-05-07 GB GB18778/76A patent/GB1551117A/en not_active Expired
- 1976-05-07 NL NL7604894A patent/NL7604894A/xx unknown
- 1976-05-10 ES ES447751A patent/ES447751A1/es not_active Expired
- 1976-05-10 IL IL49546A patent/IL49546A0/xx unknown
- 1976-05-10 BE BE166912A patent/BE841669A/xx unknown
- 1976-05-10 CA CA252,103A patent/CA1071626A/en not_active Expired
- 1976-05-10 PT PT65084A patent/PT65084B/pt unknown
- 1976-05-11 AT AT342176A patent/ATA342176A/de not_active Application Discontinuation
- 1976-05-11 JP JP51053730A patent/JPS51138689A/ja active Pending
- 1976-05-12 AU AU13891/76A patent/AU1389176A/en not_active Expired
- 1976-05-12 FR FR7614235A patent/FR2310756A1/fr active Granted
- 1976-05-12 ZA ZA762813A patent/ZA762813B/xx unknown
-
1978
- 1978-12-13 CH CH1267878A patent/CH617691A5/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FR2310756A1 (fr) | 1976-12-10 |
| FR2310756B1 (en, 2012) | 1978-10-20 |
| ZA762813B (en) | 1977-12-28 |
| SE7605158L (sv) | 1976-11-13 |
| SE409455B (sv) | 1979-08-20 |
| ATA342176A (de) | 1980-08-15 |
| AU1389176A (en) | 1977-11-17 |
| US4055642A (en) | 1977-10-25 |
| BE841669A (fr) | 1976-11-10 |
| GB1551117A (en) | 1979-08-22 |
| FI761232A7 (en, 2012) | 1976-11-13 |
| NO761537L (en, 2012) | 1976-11-15 |
| DK197476A (da) | 1976-11-13 |
| CH612432A5 (en, 2012) | 1979-07-31 |
| CA1071626A (en) | 1980-02-12 |
| PT65084B (fr) | 1978-02-06 |
| ES447751A1 (es) | 1977-10-01 |
| NL7604894A (nl) | 1976-11-16 |
| DE2619110A1 (de) | 1976-11-25 |
| JPS51138689A (en) | 1976-11-30 |
| PT65084A (fr) | 1976-06-01 |
| IL49546A0 (en) | 1976-07-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased | ||
| PLX | Patent declared invalid from date of grant onwards |