CH617433A5 - - Google Patents

Download PDF

Info

Publication number
CH617433A5
CH617433A5 CH1240875A CH1240875A CH617433A5 CH 617433 A5 CH617433 A5 CH 617433A5 CH 1240875 A CH1240875 A CH 1240875A CH 1240875 A CH1240875 A CH 1240875A CH 617433 A5 CH617433 A5 CH 617433A5
Authority
CH
Switzerland
Prior art keywords
amino
mono
phenylene
lower alkyl
radical
Prior art date
Application number
CH1240875A
Other languages
German (de)
English (en)
Inventor
Melvin Harris Rosen
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of CH617433A5 publication Critical patent/CH617433A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CH1240875A 1974-09-26 1975-09-24 CH617433A5 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US50952474A 1974-09-26 1974-09-26
US58514775A 1975-06-09 1975-06-09
US74320876A 1976-11-18 1976-11-18
US05/854,176 US4185109A (en) 1974-09-26 1977-11-23 1-Benzothiepin-4-carboxamides

Publications (1)

Publication Number Publication Date
CH617433A5 true CH617433A5 (es) 1980-05-30

Family

ID=27504481

Family Applications (3)

Application Number Title Priority Date Filing Date
CH1240875A CH617433A5 (es) 1974-09-26 1975-09-24
CH919179A CH623581A5 (es) 1974-09-26 1979-10-11
CH919079A CH623580A5 (es) 1974-09-26 1979-10-11

Family Applications After (2)

Application Number Title Priority Date Filing Date
CH919179A CH623581A5 (es) 1974-09-26 1979-10-11
CH919079A CH623580A5 (es) 1974-09-26 1979-10-11

Country Status (10)

Country Link
US (1) US4185109A (es)
AT (1) AT346338B (es)
AU (1) AU496764B2 (es)
BE (1) BE833787A (es)
CA (1) CA1066279A (es)
CH (3) CH617433A5 (es)
DE (1) DE2542329C2 (es)
FR (1) FR2285872A1 (es)
NL (1) NL7511316A (es)
SE (1) SE420725B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4242266A (en) * 1974-09-26 1980-12-30 Ciba-Geigy Corporation 1-Benzothiepin-4-carboxylic acid derivatives
US4277484A (en) * 1978-09-20 1981-07-07 Ciba-Geigy Corporation 1-Benzothiepin-4-carboxamides
US4582850A (en) * 1985-02-28 1986-04-15 Ciba-Geigy Corporation Topical and systemic treatment of psoriasis using 7-chloro-N-(3,4-dichlorophenyl)-2,3-dihydro-5-hydroxy-1-benzothiepin-4-carboxamide 1,1-dioxide and pharmaceutically acceptable salts thereof
US4803197A (en) * 1987-01-12 1989-02-07 Ciba-Geigy Corporation 2,1-benzothiazepine-2,2-dioxide-5-carboxylic acid derivatives
US6262277B1 (en) * 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
US6221897B1 (en) * 1998-06-10 2001-04-24 Aventis Pharma Deutschland Gmbh Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use
BR9916484A (pt) * 1998-12-23 2002-01-22 Searle Llc Combinações de inibidores do transporte de ácido biliar ileal e de agentes sequestrantes de ácido biliar em indicações cardiovasculares
WO2000038723A1 (en) 1998-12-23 2000-07-06 G.D. Searle Llc Combinations of cholesteryl ester transfer protein inhibitors and bile acid sequestering agents for cardiovascular indications
EP1140187B1 (en) * 1998-12-23 2003-09-03 G.D. Searle LLC. Combinations of an ibat inhibitor and a mtp inhibitor for cardiovascular indications
EA200100707A1 (ru) 1998-12-23 2001-12-24 Джи.Ди.Сирл Ллс Сочетания ингибиторов транспорта желчных кислот в подвздошной кишке и производных фибриновой кислоты для сердечно-сосудистых показаний
EP1340509A1 (en) 1998-12-23 2003-09-03 G.D. Searle LLC. Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications
CN1342089A (zh) 1998-12-23 2002-03-27 G.D.瑟尔有限公司 适用于心血管疾病的回肠胆汁酸转运抑制剂和胆固醇酯转移蛋白抑制剂的组合
DE69908643T2 (de) * 1998-12-23 2004-05-13 G.D. Searle Llc, Chicago Kombinationen von cholesteryl ester transfer protein inhibitoren und nicotinsäure derivaten für kardiovaskuläre indikationen
WO2000038722A1 (en) 1998-12-23 2000-07-06 G.D. Searle & Co. COMBINATIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS AND HMG CoA REDUCTASE INHIBITORS FOR CARDIOVASCULAR INDICATIONS
AU2001247331A1 (en) * 2000-03-10 2001-09-24 Pharmacia Corporation Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders
US6794544B2 (en) 2000-03-10 2004-09-21 Pharmacia Corporation Method for the preparation of tetrahydrobenzothiepines
US20040077625A1 (en) * 2001-07-25 2004-04-22 Tremont Samuel J. Novel 1,4-benzothiazepine and 1,5-benzothiazepine compounds as inhibitors of apical sodium codependent bile acid transport abd taurocholate uptake
JP2005518347A (ja) * 2001-11-02 2005-06-23 ジー．ディー． サール エルエルシー 頂端ナトリウム共依存性胆汁酸輸送（ａｓｂｔ）およびタウロコール酸塩取り込みの阻害剤としての新規一および二フッ化ベンゾチエピン化合物
CA2471639A1 (en) 2002-01-17 2003-07-31 Pharmacia Corporation Novel alkyl/aryl hydroxy or keto thiepines.
EA201891154A1 (ru) 2011-10-28 2019-02-28 ЛУМЕНА ФАРМАСЬЮТИКАЛС ЭлЭлСи Ингибиторы рециклинга желчных кислот при лечении холестатических заболеваний печени у детей

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3287368A (en) * 1965-06-08 1966-11-22 Mcneilab Inc Dihydrobenzothiepin-5(2h)-one oximes
US3287370A (en) * 1965-06-08 1966-11-22 Mcneilab Inc Tetrahydrobenzothiepins
US3389144A (en) * 1965-06-08 1968-06-18 Mcneilab Inc 5-pyridyl-2, 3, 4, 5-tetrahydrobenzothiepin-5-ols
US3444176A (en) * 1967-04-28 1969-05-13 Mcneilab Inc Certain 4-diloweralkylamino-lower alkyl - 5 - pyridyl (or phenyl)-2,3-dihydro - 1 - benzothiepins and derivatives thereof
US3505355A (en) * 1968-08-12 1970-04-07 Mcneilab Inc Certain dihydrobenzo-thiepin-5(2h)-ones
DE2264938A1 (de) * 1971-07-15 1975-06-12 Warner Lambert Co 3-arylaminocarbonyl-4-hydroxy-benzo eckige klammer auf b eckige klammer zu thiacyclohex(3)en-1,1-dioxide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US3769292A (en) * 1972-04-28 1973-10-30 Warner Lambert Co N-(pyridyl)2h 1-benzothiopyran-3-carboxamide-4-hydroxy 1,1-dioxides
US3828055A (en) * 1972-04-28 1974-08-06 Warner Lambert Co Heterocyclic amides of 4-hydroxy-2h-1-benzothiopyran-3-carboxylic acid 1,1-dioxide
US3826791A (en) * 1972-04-28 1974-07-30 Warner Lambert Co Heterocyclic amides of 4-hydroxy-2h-1-benzothiopyran-3-carboxylic acid 1,1-dioxide and process for their production
US3962261A (en) * 1974-02-04 1976-06-08 Warner-Lambert Company 2,3,4,5-tetra hydro-5-oxo-1-benzothiepi n-4-carboxamide 1,1-dioxides

Also Published As

Publication number Publication date
SE7510196L (sv) 1976-03-29
DE2542329C2 (de) 1984-05-24
NL7511316A (nl) 1976-03-30
AT346338B (de) 1978-11-10
FR2285872A1 (fr) 1976-04-23
CH623580A5 (es) 1981-06-15
AU496764B2 (en) 1978-10-26
BE833787A (fr) 1976-03-25
SE420725B (sv) 1981-10-26
DE2542329A1 (de) 1976-04-15
CA1066279A (en) 1979-11-13
ATA734175A (de) 1978-03-15
CH623581A5 (es) 1981-06-15
AU8514875A (en) 1977-03-31
FR2285872B1 (es) 1978-11-10
US4185109A (en) 1980-01-22

Similar Documents

Publication Publication Date Title
CH617433A5 (es)
EP0658559A1 (de) Thienothiazinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als 5-dipoxygenase und Cyclooxygenaseinhibitoren
CH624395A5 (es)
EP0263352A1 (de) Neue Imidazo-benzoxazinone, ihre Herstellung und diese Verbindungen enthaltende Arzneimittel
DE3533331A1 (de) Pyridothiazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3442860A1 (de) 5-alkyl-1-phenyl-2-piperazinoalkylpyrazolin-3- on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
EP0093252A2 (de) Thiomethylpyridin-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
EP0576906A1 (de) Neue Thienothiazinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Antiinflammatorium und Analgeticum
DE2832358C2 (es)
DE2514334A1 (de) Neue pyridinderivate, verfahren zu deren herstellung und ihre verwendung in pharmazeutischen zusammensetzungen
EP0110298B1 (de) Acridanon-Derivate
CH617188A5 (es)
EP0211157A1 (de) Isoxazolderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutischen Präparate
AT346347B (de) Verfahren zur herstellung von neuen 2,3- dihydro-1-benzo-thiepin-4-carbonsaeureamiden und ihren salzen mit basen
EP0160173A1 (de) Benzothiazolderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltendes Arzneimittel
CH639656A5 (de) Stickstoffhaltige heterocyclische verbindungen und verfahren zu deren herstellung.
CH634315A5 (de) Verfahren zur herstellung von substituierten 2-vinylchromonen.
DE2356005A1 (de) Neue 7-amino-imidazo eckige klammer auf 1,2-a eckige klammer zu pyrimidine, diese enthaltende arzneimittel sowie verfahren zu deren herstellung
DD153549A5 (de) Verfahren zur herstellung von pyridinderivaten
DE4425647A1 (de) Heterocyclyl-1-phenyl substituierte Chinoloncarbonsäuren
DD236929A5 (de) Verfahren zur herstellung von benzazolderivaten
AT400568B (de) Neue n-heterocyclische thienothiazincarboxamide, verfahren zu ihrer herstellung und ihre verwendung
DE2237502A1 (de) Neue heterocyclische verbindungen und verfahren zu deren herstellung
AT400437B (de) Neue n-heterocyclische thienothiazincarboxamide, verfahren zu ihrer herstellung und ihre verwendung
DE2255562C3 (de) I -Aminoalkyl-piperidin-4-spiro-2'-thiazolidin-4'-on-derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneipräparate

Legal Events

Date Code Title Description
PL Patent ceased