BE833787A - Procede de preparation de nouveaux amides d'acide 2,3-dihydro-1-benzothiepin-4-carboxylique - Google Patents

Procede de preparation de nouveaux amides d'acide 2,3-dihydro-1-benzothiepin-4-carboxylique

Info

Publication number
BE833787A
BE833787A BE160345A BE160345A BE833787A BE 833787 A BE833787 A BE 833787A BE 160345 A BE160345 A BE 160345A BE 160345 A BE160345 A BE 160345A BE 833787 A BE833787 A BE 833787A
Authority
BE
Belgium
Prior art keywords
benzothiepin
dihydro
preparation
carboxylic acid
new amides
Prior art date
Application number
BE160345A
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of BE833787A publication Critical patent/BE833787A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BE160345A 1974-09-26 1975-09-25 Procede de preparation de nouveaux amides d'acide 2,3-dihydro-1-benzothiepin-4-carboxylique BE833787A (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US50952474A 1974-09-26 1974-09-26
US58514775A 1975-06-09 1975-06-09
US74320876A 1976-11-18 1976-11-18
US05/854,176 US4185109A (en) 1974-09-26 1977-11-23 1-Benzothiepin-4-carboxamides

Publications (1)

Publication Number Publication Date
BE833787A true BE833787A (fr) 1976-03-25

Family

ID=27504481

Family Applications (1)

Application Number Title Priority Date Filing Date
BE160345A BE833787A (fr) 1974-09-26 1975-09-25 Procede de preparation de nouveaux amides d'acide 2,3-dihydro-1-benzothiepin-4-carboxylique

Country Status (10)

Country Link
US (1) US4185109A (fr)
AT (1) AT346338B (fr)
AU (1) AU496764B2 (fr)
BE (1) BE833787A (fr)
CA (1) CA1066279A (fr)
CH (3) CH617433A5 (fr)
DE (1) DE2542329C2 (fr)
FR (1) FR2285872A1 (fr)
NL (1) NL7511316A (fr)
SE (1) SE420725B (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4242266A (en) * 1974-09-26 1980-12-30 Ciba-Geigy Corporation 1-Benzothiepin-4-carboxylic acid derivatives
US4277484A (en) * 1978-09-20 1981-07-07 Ciba-Geigy Corporation 1-Benzothiepin-4-carboxamides
US4582850A (en) * 1985-02-28 1986-04-15 Ciba-Geigy Corporation Topical and systemic treatment of psoriasis using 7-chloro-N-(3,4-dichlorophenyl)-2,3-dihydro-5-hydroxy-1-benzothiepin-4-carboxamide 1,1-dioxide and pharmaceutically acceptable salts thereof
US4803197A (en) * 1987-01-12 1989-02-07 Ciba-Geigy Corporation 2,1-benzothiazepine-2,2-dioxide-5-carboxylic acid derivatives
US6262277B1 (en) * 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
US6221897B1 (en) * 1998-06-10 2001-04-24 Aventis Pharma Deutschland Gmbh Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use
AU3103800A (en) 1998-12-23 2000-07-31 G.D. Searle Llc Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acidderivatives for cardiovascular indications
ES2189529T3 (es) * 1998-12-23 2003-07-01 Searle Llc Combinaciones de inhiidores para el transporte de acidos biliares en el ileon y agentes complejantes para indicaciones cardiovasculares.
JP2002533411A (ja) * 1998-12-23 2002-10-08 ジー．ディー．サール エルエルシー 心臓血管に適用するための組み合わせ
DK1140186T3 (da) * 1998-12-23 2003-09-29 Searle Llc Kombinationer af cholesterylestertransferproteinhæmmere og derivater af fibrinsyre til hjertekar indikationer
WO2000038723A1 (fr) 1998-12-23 2000-07-06 G.D. Searle Llc Combinaisons d'inhibiteurs de la proteine de transfert de l'ester de cholesteryle et d'agents sequestrants de l'acide biliaire, utilisees dans le cadre de toubles cardio-vasculaires
US6462091B1 (en) 1998-12-23 2002-10-08 G.D. Searle & Co. Combinations of cholesteryl ester transfer protein inhibitors and HMG coA reductase inhibitors for cardiovascular indications
MXPA01006471A (es) 1998-12-23 2004-03-10 Searle Llc Combinaciones de inhibidores de transporte de acido biliar ileal e inhibidores de proteina de transferencia de ester colesterilio cpara indicaciones cardiovasculares.
BR9916565A (pt) 1998-12-23 2002-01-29 Searle Llc Combinações de inibidores do transporte ácido da bile ileal e derivados do ácido fìbrico para indicações cardiovasculares
US20020061888A1 (en) * 2000-03-10 2002-05-23 Keller Bradley T. Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders
JP2003528830A (ja) 2000-03-10 2003-09-30 ファルマシア・コーポレーション テトラヒドロベンゾチエピン類の製造方法
US20040077625A1 (en) * 2001-07-25 2004-04-22 Tremont Samuel J. Novel 1,4-benzothiazepine and 1,5-benzothiazepine compounds as inhibitors of apical sodium codependent bile acid transport abd taurocholate uptake
MXPA04003524A (es) * 2001-11-02 2004-07-23 Searle Llc Compuestos de benzotiepina monofluorados y difluorados novedosos como inhibidores de transporte de acido biliar co-dependiente de sodio apical (asbt) y captacion de taurocolato.
CA2471639A1 (fr) 2002-01-17 2003-07-31 Pharmacia Corporation Nouveaux composes d'alkyl/aryl hydroxy ou cetothiepine servant d'inhibiteurs du transport des acides biliaires de type ileal et de l'absorption de taurocholate
CA2853285C (fr) 2011-10-28 2020-05-05 Lumena Pharmaceuticals, Inc. Inhibiteurs du recyclage de l'acide biliaire pour traitement de maladies cholestatiques hepatiques pediatriques

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3287370A (en) * 1965-06-08 1966-11-22 Mcneilab Inc Tetrahydrobenzothiepins
US3287368A (en) * 1965-06-08 1966-11-22 Mcneilab Inc Dihydrobenzothiepin-5(2h)-one oximes
US3389144A (en) * 1965-06-08 1968-06-18 Mcneilab Inc 5-pyridyl-2, 3, 4, 5-tetrahydrobenzothiepin-5-ols
US3444176A (en) * 1967-04-28 1969-05-13 Mcneilab Inc Certain 4-diloweralkylamino-lower alkyl - 5 - pyridyl (or phenyl)-2,3-dihydro - 1 - benzothiepins and derivatives thereof
US3505355A (en) * 1968-08-12 1970-04-07 Mcneilab Inc Certain dihydrobenzo-thiepin-5(2h)-ones
DE2264938A1 (de) * 1971-07-15 1975-06-12 Warner Lambert Co 3-arylaminocarbonyl-4-hydroxy-benzo eckige klammer auf b eckige klammer zu thiacyclohex(3)en-1,1-dioxide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US3826791A (en) * 1972-04-28 1974-07-30 Warner Lambert Co Heterocyclic amides of 4-hydroxy-2h-1-benzothiopyran-3-carboxylic acid 1,1-dioxide and process for their production
US3769292A (en) * 1972-04-28 1973-10-30 Warner Lambert Co N-(pyridyl)2h 1-benzothiopyran-3-carboxamide-4-hydroxy 1,1-dioxides
US3828055A (en) * 1972-04-28 1974-08-06 Warner Lambert Co Heterocyclic amides of 4-hydroxy-2h-1-benzothiopyran-3-carboxylic acid 1,1-dioxide
US3962261A (en) * 1974-02-04 1976-06-08 Warner-Lambert Company 2,3,4,5-tetra hydro-5-oxo-1-benzothiepi n-4-carboxamide 1,1-dioxides

Also Published As

Publication number Publication date
CA1066279A (fr) 1979-11-13
SE7510196L (sv) 1976-03-29
AT346338B (de) 1978-11-10
DE2542329C2 (de) 1984-05-24
US4185109A (en) 1980-01-22
FR2285872B1 (fr) 1978-11-10
AU496764B2 (en) 1978-10-26
FR2285872A1 (fr) 1976-04-23
DE2542329A1 (de) 1976-04-15
CH623581A5 (fr) 1981-06-15
ATA734175A (de) 1978-03-15
AU8514875A (en) 1977-03-31
CH623580A5 (fr) 1981-06-15
NL7511316A (nl) 1976-03-30
CH617433A5 (fr) 1980-05-30
SE420725B (sv) 1981-10-26

Similar Documents

Publication Publication Date Title
FR2285872A1 (fr) Procede de preparation de nouveaux amides d'acide 2,3-dihydro-1-benzothiepin-4-carboxylique
RO68925A (fr) Procede pour la preparation des derives d'acide phenoxyacetique
FR2296639A1 (fr) Procede de preparation de l'acide 7-d-(-)a-amino-a-(p-hydroxyphenylacetamido)-desacetoxycephalosporanique
FR2286817A1 (fr) Procede de preparation d'acide 5-fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)-indenyl-3-acetique
BE823901A (fr) Procede de preparation d'acide p-nitrobenzoique
FR2288742A1 (fr) Procede de preparation d'isochromannes
RO69916A (fr) Procede pour la preparation du nitryle d'acide 3,7-dimethylocte-2-en-oique
FR2288078A1 (fr) Procede de preparation de l'acide 3-hydroxy-2-naphtoique
RO63501A (fr) Procede pour la preparation d'acide 3-cetoglutarique
FR2281892A1 (fr) Procede de defluoration d'acide phosphorique
FR2316232A1 (fr) Procede de preparation d'acide 5-alcoyl-picolique
FR2295952A1 (fr) Procede de preparation d'acide 3,6-dichloropicolinique
FR2275441A1 (fr) Procede de preparation d'acetoxybutanal
BE815214A (fr) Procede de preparation d'acide 3-acetamido-5-amino-2
BE820267A (fr) Procede pour la preparation d'acide p. isobutyle-hydratropique
BE824582A (fr) Procede de preparation de l'acide 1h-tetrazole-1-acetique
BE817021A (fr) Procede de preparation d'acide phenyl-2 ethylenephosphonique
FR2300568A1 (fr) Procede de preparation de nouveaux derives de l'acide 5-carboxyalcoyle-2-iminobarbiturique
FR2295024A1 (fr) Procede de preparation d'a-oxothiodimethylamides
FR2273791A1 (fr) Procede de preparation d'acide hydroxy-2 naphtalene-carboxylique-3
BE825524R (fr) Procede de preparation de l'acide 3-hydroxy-2-naphtoique
RO64271A (fr) Procede pour la preparation des derives d'acide thiazolidin-4-one-2-acetique
FR2283119A1 (fr) Procede de preparation de l'acide tiglique
FR2312488A1 (fr) Procede de production d'acide trans-4-aminomethyl-cyclohexane-1-carboxylique
RO65698A2 (fr) Procede de preparation d'acide 5-ethyle-5-sec-butyle-2-thiobarbiturique

Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: CIBA-GEIGY A.G.

Effective date: 19880930