CH613454A5 - Process for the preparation of new benzodiazepine derivatives - Google Patents
Process for the preparation of new benzodiazepine derivativesInfo
- Publication number
- CH613454A5 CH613454A5 CH1517275A CH1517275A CH613454A5 CH 613454 A5 CH613454 A5 CH 613454A5 CH 1517275 A CH1517275 A CH 1517275A CH 1517275 A CH1517275 A CH 1517275A CH 613454 A5 CH613454 A5 CH 613454A5
- Authority
- CH
- Switzerland
- Prior art keywords
- preparation
- benzodiazepine derivatives
- formula
- image
- new benzodiazepine
- Prior art date
Links
- 229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 title 1
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 title 1
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- YEBHOSNNUQLOLY-UHFFFAOYSA-N 9h-thieno[2,3-i][1,5]benzodiazepine Chemical class N1=CC=CN=C2C3=CCSC3=CC=C21 YEBHOSNNUQLOLY-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB51240/74A GB1533235A (en) | 1974-11-26 | 1974-11-26 | Benzodiazepine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH613454A5 true CH613454A5 (en) | 1979-09-28 |
Family
ID=10459213
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH604478A CH613455A5 (en) | 1974-11-26 | 1975-11-24 | Process for the preparation of new benzodiazepine derivatives |
| CH1517275A CH613454A5 (en) | 1974-11-26 | 1975-11-24 | Process for the preparation of new benzodiazepine derivatives |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH604478A CH613455A5 (en) | 1974-11-26 | 1975-11-24 | Process for the preparation of new benzodiazepine derivatives |
Country Status (30)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL62792A (en) * | 1980-05-07 | 1985-02-28 | Byk Gulden Lomberg Chem Fab | Acylated dihydrothienodiazepinone compounds,process for their preparation,and medicaments containing them |
| GB8819059D0 (en) * | 1988-08-11 | 1988-09-14 | Lilly Industries Ltd | Benzodiazepine compounds & their use as pharmaceuticals |
| GB9009229D0 (en) * | 1990-04-25 | 1990-06-20 | Lilly Industries Ltd | Pharmaceutical compounds |
| TW268005B (enrdf_load_html_response) * | 1992-05-29 | 1996-01-11 | Lilly Industries Ltd | |
| US6043358A (en) | 1995-11-01 | 2000-03-28 | Merck & Co., Inc. | Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases |
| CA2234641A1 (en) * | 1995-11-01 | 1997-05-09 | Merck & Co., Inc. | Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases |
| CA2302409A1 (en) | 1997-09-02 | 1999-03-11 | Hiroshi Yasumatsu | Condensed thiophene compounds and pharmaceutical use thereof |
| RU2185383C1 (ru) * | 2001-05-22 | 2002-07-20 | Институт молекулярной генетики РАН | ВЫСОКОМЕЧЕННЫЙ ТРИТИЕМ 2-МЕТИЛ-4-(4-МЕТИЛ-1-ПИПЕРАЗИНИЛ)-10Н-ТИЕНО[2,3-b][1,5]БЕНЗОДИАЗЕПИН |
| PL199016B1 (pl) * | 2002-06-20 | 2008-08-29 | Adamed Sp Z Oo | Sposób wytwarzania olanzapiny |
| SI21270A (sl) | 2002-07-15 | 2004-02-29 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Kristalne oblike olanzapina in postopki za njihovo pripravo |
| DE10301923B3 (de) * | 2003-01-17 | 2004-09-16 | Krka Tovarna Zdravil, D.D. | Verfahren und Zwischenprodukte zur Herstellung von Olanzapin |
| AR047460A1 (es) * | 2004-01-27 | 2006-01-18 | Synthon Bv | Proceso para la fabricacion de acetato de 2-metil-4-(4-metil-1-piperazinil)-10h-tieno[2,3-b][1,5]benzodiazepina (acetato de olanzapina) |
| AR048272A1 (es) | 2004-03-18 | 2006-04-12 | Lek Pharmaceuticals | Sintesis de 2 metil - 4- (4- metil -1- piperazinil) - 10 h- tieno ( 2,3-b) (1,5) benzodiazepina y sus sales, metodos para su preparacion, composiciones farmaceuticas que la contienen y su uso en la fabricacion de medicamentos para el tratamiento de enfermedades mentales. |
| BRPI0512742A (pt) * | 2004-06-30 | 2008-04-15 | Athersys Inc | composto, composição farmacêutica, e, método de tratamento de uma doença, distúrbio e/ou condição em um paciente em que modulação de uma função 5-ht2c é desejada |
| EP2292624A1 (en) | 2009-07-20 | 2011-03-09 | LEK Pharmaceuticals d.d. | Process for the purification of olanzapine |
-
1974
- 1974-11-25 SU SU742191705A patent/SU629879A3/ru active
- 1974-11-26 GB GB51240/74A patent/GB1533235A/en not_active Expired
-
1975
- 1975-11-20 CA CA240,082A patent/CA1075687A/en not_active Expired
- 1975-11-20 DK DK524175A patent/DK146887C/da active
- 1975-11-20 IL IL48502A patent/IL48502A/xx unknown
- 1975-11-21 PH PH17788A patent/PH11669A/en unknown
- 1975-11-21 AU AU86858/75A patent/AU506340B2/en not_active Expired
- 1975-11-22 DE DE2552403A patent/DE2552403C2/de not_active Expired
- 1975-11-24 CH CH604478A patent/CH613455A5/xx not_active IP Right Cessation
- 1975-11-24 NZ NZ179335A patent/NZ179335A/xx unknown
- 1975-11-24 CH CH1517275A patent/CH613454A5/xx not_active IP Right Cessation
- 1975-11-24 ZA ZA757344A patent/ZA757344B/xx unknown
- 1975-11-24 SE SE7513185A patent/SE421209B/xx not_active IP Right Cessation
- 1975-11-25 AR AR261340A patent/AR221203A1/es active
- 1975-11-25 IE IE2565/75A patent/IE42564B1/en unknown
- 1975-11-25 BE BE6045266A patent/BE835932A/xx not_active IP Right Cessation
- 1975-11-25 RO RO7584018A patent/RO69912A/ro unknown
- 1975-11-25 DD DD189666A patent/DD123343A5/xx unknown
- 1975-11-25 YU YU02983/75A patent/YU298375A/xx unknown
- 1975-11-25 JP JP50141080A patent/JPS6044314B2/ja not_active Expired
- 1975-11-25 FR FR7535900A patent/FR2292479A1/fr active Granted
- 1975-11-26 PL PL1975184991A patent/PL100135B1/pl unknown
- 1975-11-26 BG BG031601A patent/BG29573A3/xx unknown
- 1975-11-26 NL NLAANVRAGE7513833,A patent/NL186088C/xx not_active IP Right Cessation
- 1975-11-26 CS CS757991A patent/CS236753B2/cs unknown
- 1975-11-26 HU HU75LI00000284A patent/HU172493B/hu unknown
- 1975-11-26 AT AT898275A patent/AT351547B/de not_active IP Right Cessation
- 1975-11-26 ES ES443011A patent/ES443011A1/es not_active Expired
-
1976
- 1976-10-07 SU SU762406250A patent/SU626702A3/ru active
-
1977
- 1977-02-22 PH PH19480A patent/PH24534A/en unknown
-
1978
- 1978-11-27 SE SE7812194A patent/SE429045B/sv not_active IP Right Cessation
-
1981
- 1981-09-24 KE KE3163A patent/KE3163A/xx unknown
- 1981-11-26 HK HK586/81A patent/HK58681A/xx unknown
-
1982
- 1982-12-30 MY MY149/82A patent/MY8200149A/xx unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased |