IE43694L - Thieno-4,1-oxazepinones - Google Patents

Thieno-4,1-oxazepinones

Info

Publication number
IE43694L
IE43694L IE761583A IE158376A IE43694L IE 43694 L IE43694 L IE 43694L IE 761583 A IE761583 A IE 761583A IE 158376 A IE158376 A IE 158376A IE 43694 L IE43694 L IE 43694L
Authority
IE
Ireland
Prior art keywords
formula vii
resulting
reacted
compounds
ammonia
Prior art date
Application number
IE761583A
Other versions
IE43694B1 (en
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19752531677 external-priority patent/DE2531677A1/en
Priority claimed from DE19752531679 external-priority patent/DE2531679A1/en
Priority claimed from DE2531678A external-priority patent/DE2531678C3/en
Priority claimed from DE2533924A external-priority patent/DE2533924C3/en
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Publication of IE43694L publication Critical patent/IE43694L/en
Publication of IE43694B1 publication Critical patent/IE43694B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

6-Aryl-4H-s-triazolo[3,4-c]thieno[2,3-e]-1,4-diazepines of the formula VII are prepared from compounds of the formula V. This entails using a strong hydrohalic acid to split open the bond on the oxygen atom of the oxepine ring. The resulting hydrohalide is extracted with a solvent which is immiscible with water, and the residue is reacted with a phosphorous or sulphur halide. The resulting dihalo compound is reacted with ammonia or a substance which provides ammonia, and the resulting product is dehydrogenated. The substituents in the formula VII and V have the meaning stated in Claim 1. The compounds of the formula VII and their acid addition salts have proved to have anxiolytic, antispasmodic and muscle-relaxant activity. In addition, they display a potent anticonvulsant action and extremely low toxicity. They furthermore increase the feed intake of mammals. <IMAGE> [FR2318165A1]
IE1583/76A 1975-07-16 1976-07-16 Thieno-4,1-oxazepinones IE43694B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19752531677 DE2531677A1 (en) 1975-07-16 1975-07-16 Aryl- triazolo-thieno-diazephines - anticonvulsants anxiolytics and antiaagression prepn. from substd. thienyl acetamides
DE19752531679 DE2531679A1 (en) 1975-07-16 1975-07-16 Aryl- triazolo-thieno-diazephines - anticonvulsants anxiolytics and antiaagression prepn. from substd. thienyl acetamides
DE2531678A DE2531678C3 (en) 1975-07-16 1975-07-16 Thieno [2,3e] triazole [3,4c] 5,6-dihydro-1,4-diazepines and processes for their preparation
DE2533924A DE2533924C3 (en) 1975-07-30 1975-07-30 Process for the preparation of 6-aryl-4H-striazolo [3,4-c] thieno [2,3-e] 1,4-diazepines

Publications (2)

Publication Number Publication Date
IE43694L true IE43694L (en) 1977-01-16
IE43694B1 IE43694B1 (en) 1981-05-06

Family

ID=27432000

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1583/76A IE43694B1 (en) 1975-07-16 1976-07-16 Thieno-4,1-oxazepinones

Country Status (17)

Country Link
AU (1) AU506140B2 (en)
BG (1) BG25227A3 (en)
CA (1) CA1077475A (en)
CH (2) CH627181A5 (en)
DD (1) DD126744A5 (en)
ES (1) ES449849A1 (en)
FR (1) FR2318165A1 (en)
GR (1) GR60819B (en)
HU (1) HU172620B (en)
IE (1) IE43694B1 (en)
IL (1) IL50032A (en)
LU (1) LU75384A1 (en)
MX (1) MX4246E (en)
NL (1) NL186008C (en)
PT (1) PT65374B (en)
RO (1) RO76083A (en)
YU (1) YU40458B (en)

Also Published As

Publication number Publication date
FR2318165A1 (en) 1977-02-11
LU75384A1 (en) 1977-07-27
IL50032A (en) 1981-03-31
PT65374B (en) 1978-06-08
YU40458B (en) 1986-02-28
NL186008C (en) 1990-09-03
HU172620B (en) 1978-11-28
PT65374A (en) 1976-08-01
RO76083A (en) 1981-06-22
GR60819B (en) 1978-08-30
IE43694B1 (en) 1981-05-06
CH630630A5 (en) 1982-06-30
IL50032A0 (en) 1976-09-30
BG25227A3 (en) 1978-08-10
CA1077475A (en) 1980-05-13
FR2318165B1 (en) 1980-02-01
YU175376A (en) 1982-06-30
DD126744A5 (en) 1977-08-10
ES449849A1 (en) 1977-08-16
NL7607871A (en) 1977-01-18
AU506140B2 (en) 1979-12-13
MX4246E (en) 1982-03-02
AU1591376A (en) 1978-01-19
CH627181A5 (en) 1981-12-31
NL186008B (en) 1990-04-02

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