DK152289C - METHOD OF ANALOGUE FOR THE PREPARATION OF 5-SUBSTITUTED 9-CYANMETHYLENE-DITHIENO (3,4-B: 4`, 3`-E) AZEPINES OR ACID ADDITION SALTS THEREOF - Google Patents
METHOD OF ANALOGUE FOR THE PREPARATION OF 5-SUBSTITUTED 9-CYANMETHYLENE-DITHIENO (3,4-B: 4`, 3`-E) AZEPINES OR ACID ADDITION SALTS THEREOFInfo
- Publication number
- DK152289C DK152289C DK443881A DK443881A DK152289C DK 152289 C DK152289 C DK 152289C DK 443881 A DK443881 A DK 443881A DK 443881 A DK443881 A DK 443881A DK 152289 C DK152289 C DK 152289C
- Authority
- DK
- Denmark
- Prior art keywords
- carbon atoms
- substituted
- nitrogen
- oxygen
- membered
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
1. Claims for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE A 5-substituted 9-cyanomethylene-dithieno-[3,4-b:4',3'-e]azepine of the general formula I see diagramm : EP0050212,P13,F1 where R**1 and R**2 are hydrogen or halogen, especially chlorine or bromine, and A is -NR**3 R**4 , where R**3 and R**4 , together with the nitrogen atom linking them, are a 5-membered to 7-membered saturated ring, which may contain nitrogen or oxygen as a further hetero-atom, an additional nitrogen present being unsubstituted or substituted by alkyl of 1 to 3 carbon atoms, hydroxyalkyl of 2 or 3 carbon atoms, alkoxyalkyl, where alkyl and alkoxy are of 1 to 3 carbon atoms, cycloalkyl or cycloalkylmethyl, where cycloalkyl is of 3 to 7 carbon atoms or alkynyl of 2 to 5 carbon atoms, and may additionally be substituted by oxygen in the form of an N-oxide, or A is -NHR**5 , where R**5 is aminoalkyl of 2 to 7 carbon atoms, the amine nitrogen being unsubstituted or substituted by lower alkyl of 1 to 5 carbon atoms or being a constituent of a 5-membered to 7-membered saturated ring, which may contain nitrogen or oxygen as a further hetero-atom, a nitrogen present being substituted by lower alkyl of 1 to 3 carbon atoms or hydroxyalkyl of 2 or 3 carbon atoms, and its physiologically tolerated acid addition salts. 1. Claims for the Contracting State : AT A process for the preparation of a 5-substituted 9-cyanomethylene-dithieno-[3,4-b:4'.3'-e]azepine of the general formula I see diagramm : EP0050212,P14,F1 where R**1 and R**2 are hydrogen or halogen, especially chlorine or bromine, and A is -NR**3 R**4 , where R**3 and R**4 , together with the nitrogen atom linking them, are a 5-membered to 7-membered saturated ring, which may contain nitrogen or oxygen as a further hetero-atom, an additional nitrogen present being unsubstituted or substituted by alkyl of 1 to 3 carbon atoms, hydroxyalkyl of 2 or 3 carbon atoms, alkoxyalkyl, where alkyl and alkoxy are of 1 to 3 carbon atoms, cycloalkyl or cycloalkylmethyl, where cycloalkyl is of 3 to 7 carbon atoms or alkynyl of 2 to 5 carbon atoms, and may additionally be substituted by oxygen in the form of an N-oxide, or A is -NHR**5 , where R**5 is aminoalkyl of 2 to 7 carbon atoms, the amine nitrogen being unsubstituted or substituted by lower alkyl of 1 to 5 carbon atoms or being a constituent of a 5-membered to 7-membered saturated ring, which may contain nitrogen or oxygen as a further hetero-atom, a nitrogen present being substituted by lower alkyl of 1 to 3 carbon atoms or hydroxyalkyl of 2 or 3 carbon atoms, and its physiologically tolerated acid addition salts, wherein a compound of the formula II see diagramm : EP0050212,P14,F2 where R**1 and R**2 have the meanings given in the case of formula I and Z is a nucleofugic leaving group, is reacted with a nucleophile AH, where A has the meanings given in the case of formula I, and, if desired, the resulting compound is converted into the N-oxide and/or into the acid addition salt of a physiologically tolerated acid.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3037971 | 1980-10-08 | ||
DE19803037971 DE3037971A1 (en) | 1980-10-08 | 1980-10-08 | 5-SUBSTITUTED 9-CYANMETHYLENE DITHIENO (3,4-B: 4 '3'-E) -AZEPINE |
Publications (3)
Publication Number | Publication Date |
---|---|
DK443881A DK443881A (en) | 1982-04-09 |
DK152289B DK152289B (en) | 1988-02-15 |
DK152289C true DK152289C (en) | 1988-07-11 |
Family
ID=6113891
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK443881A DK152289C (en) | 1980-10-08 | 1981-10-07 | METHOD OF ANALOGUE FOR THE PREPARATION OF 5-SUBSTITUTED 9-CYANMETHYLENE-DITHIENO (3,4-B: 4`, 3`-E) AZEPINES OR ACID ADDITION SALTS THEREOF |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0050212B1 (en) |
JP (1) | JPS5788179A (en) |
AT (1) | ATE5820T1 (en) |
CA (1) | CA1170258A (en) |
DE (2) | DE3037971A1 (en) |
DK (1) | DK152289C (en) |
IE (1) | IE51635B1 (en) |
ZA (1) | ZA816927B (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3309719A1 (en) * | 1983-03-18 | 1984-09-20 | Basf Ag, 6700 Ludwigshafen | 2,3,5,6-TETRA-SUBSTITUTED P-BENZOQUINONES, THEIR PRODUCTION AND USE |
DE3524743A1 (en) * | 1985-07-11 | 1987-01-15 | Basf Ag | METHOD FOR PRODUCING 4,5-DIHYDRO-DITHIENO- (3,4-B: 4 ', 3'-E) -AZEPINE-5,9-DION |
DE3524744A1 (en) * | 1985-07-11 | 1987-01-15 | Basf Ag | 4-SUBSTITUTED 10-CYANMETHYLENE THIENO (4,3-E) -BENZO-AZEPINE |
DE3717069A1 (en) * | 1987-05-21 | 1988-12-08 | Basf Ag | 5-SUBSTITUTED 10-CYANMETHYLENE THIENO (3,4-B) -BENZO-AZEPINE |
DE3717068A1 (en) * | 1987-05-21 | 1988-12-08 | Basf Ag | 4-SUBSTITUTED 10-CYANMETHYLENE PYRROLO (4,3-E) -BENZO-AZEPINE |
RU2464023C2 (en) * | 2008-05-16 | 2012-10-20 | АКСИС, Инс | Therapeutic agent for treating fibromyalgia |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH560220A5 (en) * | 1971-11-26 | 1975-03-27 | Wander Ag Dr A | 4-(1-piperazinyl)-10h-thieno (3,2-c) (1) benzaepines - - antipsychotics, sedatives, hypnotics or muscle relaxants |
DE2918778A1 (en) * | 1979-05-10 | 1980-11-20 | Basf Ag | 6-SUBSTITUTED 11-ALKYLENE MORPHANTRIDINE |
-
1980
- 1980-10-08 DE DE19803037971 patent/DE3037971A1/en not_active Withdrawn
-
1981
- 1981-09-17 DE DE8181107343T patent/DE3161895D1/en not_active Expired
- 1981-09-17 EP EP81107343A patent/EP0050212B1/en not_active Expired
- 1981-09-17 AT AT81107343T patent/ATE5820T1/en not_active IP Right Cessation
- 1981-10-01 JP JP56154922A patent/JPS5788179A/en active Granted
- 1981-10-06 IE IE2330/81A patent/IE51635B1/en unknown
- 1981-10-07 DK DK443881A patent/DK152289C/en active
- 1981-10-07 ZA ZA816927A patent/ZA816927B/en unknown
- 1981-10-07 CA CA000387495A patent/CA1170258A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
IE51635B1 (en) | 1987-01-21 |
DE3161895D1 (en) | 1984-02-16 |
EP0050212B1 (en) | 1984-01-11 |
ATE5820T1 (en) | 1984-01-15 |
EP0050212A1 (en) | 1982-04-28 |
CA1170258A (en) | 1984-07-03 |
DE3037971A1 (en) | 1982-05-13 |
IE812330L (en) | 1982-04-08 |
JPH0243754B2 (en) | 1990-10-01 |
DK152289B (en) | 1988-02-15 |
DK443881A (en) | 1982-04-09 |
ZA816927B (en) | 1982-10-27 |
JPS5788179A (en) | 1982-06-01 |
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