ZA816927B - 5-substituted 9-cyanomethylene-dithieno(3,4-b:4',3'-e)-azepines,their preparation,and therapeutic agents which contain these compounds - Google Patents

5-substituted 9-cyanomethylene-dithieno(3,4-b:4',3'-e)-azepines,their preparation,and therapeutic agents which contain these compounds

Info

Publication number
ZA816927B
ZA816927B ZA816927A ZA816927A ZA816927B ZA 816927 B ZA816927 B ZA 816927B ZA 816927 A ZA816927 A ZA 816927A ZA 816927 A ZA816927 A ZA 816927A ZA 816927 B ZA816927 B ZA 816927B
Authority
ZA
South Africa
Prior art keywords
carbon atoms
substituted
nitrogen
oxygen
membered
Prior art date
Application number
ZA816927A
Inventor
Gerd Steiner
Hans Juergen Teschendorf
Horst Kreiskott
Hans Peter Hofmann
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of ZA816927B publication Critical patent/ZA816927B/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1. Claims for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE A 5-substituted 9-cyanomethylene-dithieno-[3,4-b:4',3'-e]azepine of the general formula I see diagramm : EP0050212,P13,F1 where R**1 and R**2 are hydrogen or halogen, especially chlorine or bromine, and A is -NR**3 R**4 , where R**3 and R**4 , together with the nitrogen atom linking them, are a 5-membered to 7-membered saturated ring, which may contain nitrogen or oxygen as a further hetero-atom, an additional nitrogen present being unsubstituted or substituted by alkyl of 1 to 3 carbon atoms, hydroxyalkyl of 2 or 3 carbon atoms, alkoxyalkyl, where alkyl and alkoxy are of 1 to 3 carbon atoms, cycloalkyl or cycloalkylmethyl, where cycloalkyl is of 3 to 7 carbon atoms or alkynyl of 2 to 5 carbon atoms, and may additionally be substituted by oxygen in the form of an N-oxide, or A is -NHR**5 , where R**5 is aminoalkyl of 2 to 7 carbon atoms, the amine nitrogen being unsubstituted or substituted by lower alkyl of 1 to 5 carbon atoms or being a constituent of a 5-membered to 7-membered saturated ring, which may contain nitrogen or oxygen as a further hetero-atom, a nitrogen present being substituted by lower alkyl of 1 to 3 carbon atoms or hydroxyalkyl of 2 or 3 carbon atoms, and its physiologically tolerated acid addition salts. 1. Claims for the Contracting State : AT A process for the preparation of a 5-substituted 9-cyanomethylene-dithieno-[3,4-b:4'.3'-e]azepine of the general formula I see diagramm : EP0050212,P14,F1 where R**1 and R**2 are hydrogen or halogen, especially chlorine or bromine, and A is -NR**3 R**4 , where R**3 and R**4 , together with the nitrogen atom linking them, are a 5-membered to 7-membered saturated ring, which may contain nitrogen or oxygen as a further hetero-atom, an additional nitrogen present being unsubstituted or substituted by alkyl of 1 to 3 carbon atoms, hydroxyalkyl of 2 or 3 carbon atoms, alkoxyalkyl, where alkyl and alkoxy are of 1 to 3 carbon atoms, cycloalkyl or cycloalkylmethyl, where cycloalkyl is of 3 to 7 carbon atoms or alkynyl of 2 to 5 carbon atoms, and may additionally be substituted by oxygen in the form of an N-oxide, or A is -NHR**5 , where R**5 is aminoalkyl of 2 to 7 carbon atoms, the amine nitrogen being unsubstituted or substituted by lower alkyl of 1 to 5 carbon atoms or being a constituent of a 5-membered to 7-membered saturated ring, which may contain nitrogen or oxygen as a further hetero-atom, a nitrogen present being substituted by lower alkyl of 1 to 3 carbon atoms or hydroxyalkyl of 2 or 3 carbon atoms, and its physiologically tolerated acid addition salts, wherein a compound of the formula II see diagramm : EP0050212,P14,F2 where R**1 and R**2 have the meanings given in the case of formula I and Z is a nucleofugic leaving group, is reacted with a nucleophile AH, where A has the meanings given in the case of formula I, and, if desired, the resulting compound is converted into the N-oxide and/or into the acid addition salt of a physiologically tolerated acid.
ZA816927A 1980-10-08 1981-10-07 5-substituted 9-cyanomethylene-dithieno(3,4-b:4',3'-e)-azepines,their preparation,and therapeutic agents which contain these compounds ZA816927B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803037971 DE3037971A1 (en) 1980-10-08 1980-10-08 5-SUBSTITUTED 9-CYANMETHYLENE DITHIENO (3,4-B: 4 '3'-E) -AZEPINE

Publications (1)

Publication Number Publication Date
ZA816927B true ZA816927B (en) 1982-10-27

Family

ID=6113891

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA816927A ZA816927B (en) 1980-10-08 1981-10-07 5-substituted 9-cyanomethylene-dithieno(3,4-b:4',3'-e)-azepines,their preparation,and therapeutic agents which contain these compounds

Country Status (8)

Country Link
EP (1) EP0050212B1 (en)
JP (1) JPS5788179A (en)
AT (1) ATE5820T1 (en)
CA (1) CA1170258A (en)
DE (2) DE3037971A1 (en)
DK (1) DK152289C (en)
IE (1) IE51635B1 (en)
ZA (1) ZA816927B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3309719A1 (en) * 1983-03-18 1984-09-20 Basf Ag, 6700 Ludwigshafen 2,3,5,6-TETRA-SUBSTITUTED P-BENZOQUINONES, THEIR PRODUCTION AND USE
DE3524743A1 (en) * 1985-07-11 1987-01-15 Basf Ag METHOD FOR PRODUCING 4,5-DIHYDRO-DITHIENO- (3,4-B: 4 ', 3'-E) -AZEPINE-5,9-DION
DE3524744A1 (en) * 1985-07-11 1987-01-15 Basf Ag 4-SUBSTITUTED 10-CYANMETHYLENE THIENO (4,3-E) -BENZO-AZEPINE
DE3717069A1 (en) * 1987-05-21 1988-12-08 Basf Ag 5-SUBSTITUTED 10-CYANMETHYLENE THIENO (3,4-B) -BENZO-AZEPINE
DE3717068A1 (en) * 1987-05-21 1988-12-08 Basf Ag 4-SUBSTITUTED 10-CYANMETHYLENE PYRROLO (4,3-E) -BENZO-AZEPINE
RU2464023C2 (en) * 2008-05-16 2012-10-20 АКСИС, Инс Therapeutic agent for treating fibromyalgia

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH560220A5 (en) * 1971-11-26 1975-03-27 Wander Ag Dr A 4-(1-piperazinyl)-10h-thieno (3,2-c) (1) benzaepines - - antipsychotics, sedatives, hypnotics or muscle relaxants
DE2918778A1 (en) * 1979-05-10 1980-11-20 Basf Ag 6-SUBSTITUTED 11-ALKYLENE MORPHANTRIDINE

Also Published As

Publication number Publication date
IE51635B1 (en) 1987-01-21
DE3161895D1 (en) 1984-02-16
EP0050212B1 (en) 1984-01-11
DK152289C (en) 1988-07-11
ATE5820T1 (en) 1984-01-15
EP0050212A1 (en) 1982-04-28
CA1170258A (en) 1984-07-03
DE3037971A1 (en) 1982-05-13
IE812330L (en) 1982-04-08
JPH0243754B2 (en) 1990-10-01
DK152289B (en) 1988-02-15
DK443881A (en) 1982-04-09
JPS5788179A (en) 1982-06-01

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