DK443881A - METHOD OF PREPARING 5-SUBSTITUTED 9-CYANMETHYLENDITHIENO (3,4-B.4! .3! -E) AZEPINES - Google Patents

METHOD OF PREPARING 5-SUBSTITUTED 9-CYANMETHYLENDITHIENO (3,4-B.4! .3! -E) AZEPINES

Info

Publication number
DK443881A
DK443881A DK443881A DK443881A DK443881A DK 443881 A DK443881 A DK 443881A DK 443881 A DK443881 A DK 443881A DK 443881 A DK443881 A DK 443881A DK 443881 A DK443881 A DK 443881A
Authority
DK
Denmark
Prior art keywords
carbon atoms
substituted
nitrogen
oxygen
membered
Prior art date
Application number
DK443881A
Other languages
Danish (da)
Other versions
DK152289B (en
DK152289C (en
Inventor
G Steiner
H J Teschendorf
H Kreiskott
H P Hofmann
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of DK443881A publication Critical patent/DK443881A/en
Publication of DK152289B publication Critical patent/DK152289B/en
Application granted granted Critical
Publication of DK152289C publication Critical patent/DK152289C/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

1. Claims for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE A 5-substituted 9-cyanomethylene-dithieno-[3,4-b:4',3'-e]azepine of the general formula I see diagramm : EP0050212,P13,F1 where R**1 and R**2 are hydrogen or halogen, especially chlorine or bromine, and A is -NR**3 R**4 , where R**3 and R**4 , together with the nitrogen atom linking them, are a 5-membered to 7-membered saturated ring, which may contain nitrogen or oxygen as a further hetero-atom, an additional nitrogen present being unsubstituted or substituted by alkyl of 1 to 3 carbon atoms, hydroxyalkyl of 2 or 3 carbon atoms, alkoxyalkyl, where alkyl and alkoxy are of 1 to 3 carbon atoms, cycloalkyl or cycloalkylmethyl, where cycloalkyl is of 3 to 7 carbon atoms or alkynyl of 2 to 5 carbon atoms, and may additionally be substituted by oxygen in the form of an N-oxide, or A is -NHR**5 , where R**5 is aminoalkyl of 2 to 7 carbon atoms, the amine nitrogen being unsubstituted or substituted by lower alkyl of 1 to 5 carbon atoms or being a constituent of a 5-membered to 7-membered saturated ring, which may contain nitrogen or oxygen as a further hetero-atom, a nitrogen present being substituted by lower alkyl of 1 to 3 carbon atoms or hydroxyalkyl of 2 or 3 carbon atoms, and its physiologically tolerated acid addition salts. 1. Claims for the Contracting State : AT A process for the preparation of a 5-substituted 9-cyanomethylene-dithieno-[3,4-b:4'.3'-e]azepine of the general formula I see diagramm : EP0050212,P14,F1 where R**1 and R**2 are hydrogen or halogen, especially chlorine or bromine, and A is -NR**3 R**4 , where R**3 and R**4 , together with the nitrogen atom linking them, are a 5-membered to 7-membered saturated ring, which may contain nitrogen or oxygen as a further hetero-atom, an additional nitrogen present being unsubstituted or substituted by alkyl of 1 to 3 carbon atoms, hydroxyalkyl of 2 or 3 carbon atoms, alkoxyalkyl, where alkyl and alkoxy are of 1 to 3 carbon atoms, cycloalkyl or cycloalkylmethyl, where cycloalkyl is of 3 to 7 carbon atoms or alkynyl of 2 to 5 carbon atoms, and may additionally be substituted by oxygen in the form of an N-oxide, or A is -NHR**5 , where R**5 is aminoalkyl of 2 to 7 carbon atoms, the amine nitrogen being unsubstituted or substituted by lower alkyl of 1 to 5 carbon atoms or being a constituent of a 5-membered to 7-membered saturated ring, which may contain nitrogen or oxygen as a further hetero-atom, a nitrogen present being substituted by lower alkyl of 1 to 3 carbon atoms or hydroxyalkyl of 2 or 3 carbon atoms, and its physiologically tolerated acid addition salts, wherein a compound of the formula II see diagramm : EP0050212,P14,F2 where R**1 and R**2 have the meanings given in the case of formula I and Z is a nucleofugic leaving group, is reacted with a nucleophile AH, where A has the meanings given in the case of formula I, and, if desired, the resulting compound is converted into the N-oxide and/or into the acid addition salt of a physiologically tolerated acid.
DK443881A 1980-10-08 1981-10-07 METHOD OF ANALOGUE FOR THE PREPARATION OF 5-SUBSTITUTED 9-CYANMETHYLENE-DITHIENO (3,4-B: 4`, 3`-E) AZEPINES OR ACID ADDITION SALTS THEREOF DK152289C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3037971 1980-10-08
DE19803037971 DE3037971A1 (en) 1980-10-08 1980-10-08 5-SUBSTITUTED 9-CYANMETHYLENE DITHIENO (3,4-B: 4 '3'-E) -AZEPINE

Publications (3)

Publication Number Publication Date
DK443881A true DK443881A (en) 1982-04-09
DK152289B DK152289B (en) 1988-02-15
DK152289C DK152289C (en) 1988-07-11

Family

ID=6113891

Family Applications (1)

Application Number Title Priority Date Filing Date
DK443881A DK152289C (en) 1980-10-08 1981-10-07 METHOD OF ANALOGUE FOR THE PREPARATION OF 5-SUBSTITUTED 9-CYANMETHYLENE-DITHIENO (3,4-B: 4`, 3`-E) AZEPINES OR ACID ADDITION SALTS THEREOF

Country Status (8)

Country Link
EP (1) EP0050212B1 (en)
JP (1) JPS5788179A (en)
AT (1) ATE5820T1 (en)
CA (1) CA1170258A (en)
DE (2) DE3037971A1 (en)
DK (1) DK152289C (en)
IE (1) IE51635B1 (en)
ZA (1) ZA816927B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3309719A1 (en) * 1983-03-18 1984-09-20 Basf Ag, 6700 Ludwigshafen 2,3,5,6-TETRA-SUBSTITUTED P-BENZOQUINONES, THEIR PRODUCTION AND USE
DE3524744A1 (en) * 1985-07-11 1987-01-15 Basf Ag 4-SUBSTITUTED 10-CYANMETHYLENE THIENO (4,3-E) -BENZO-AZEPINE
DE3524743A1 (en) * 1985-07-11 1987-01-15 Basf Ag METHOD FOR PRODUCING 4,5-DIHYDRO-DITHIENO- (3,4-B: 4 ', 3'-E) -AZEPINE-5,9-DION
DE3717069A1 (en) * 1987-05-21 1988-12-08 Basf Ag 5-SUBSTITUTED 10-CYANMETHYLENE THIENO (3,4-B) -BENZO-AZEPINE
DE3717068A1 (en) * 1987-05-21 1988-12-08 Basf Ag 4-SUBSTITUTED 10-CYANMETHYLENE PYRROLO (4,3-E) -BENZO-AZEPINE
WO2009139470A1 (en) * 2008-05-16 2009-11-19 学校法人聖マリアンナ医科大学 Pharmaceutical composition for treatment of fibromyalgia

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH560220A5 (en) * 1971-11-26 1975-03-27 Wander Ag Dr A 4-(1-piperazinyl)-10h-thieno (3,2-c) (1) benzaepines - - antipsychotics, sedatives, hypnotics or muscle relaxants
DE2918778A1 (en) * 1979-05-10 1980-11-20 Basf Ag 6-SUBSTITUTED 11-ALKYLENE MORPHANTRIDINE

Also Published As

Publication number Publication date
DK152289B (en) 1988-02-15
IE812330L (en) 1982-04-08
DK152289C (en) 1988-07-11
DE3161895D1 (en) 1984-02-16
CA1170258A (en) 1984-07-03
JPH0243754B2 (en) 1990-10-01
EP0050212A1 (en) 1982-04-28
ZA816927B (en) 1982-10-27
ATE5820T1 (en) 1984-01-15
EP0050212B1 (en) 1984-01-11
IE51635B1 (en) 1987-01-21
DE3037971A1 (en) 1982-05-13
JPS5788179A (en) 1982-06-01

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