CH506543A - Verfahren zur Herstellung von neuen 1,2,3,4,5,6-Hexahydroazepino (4,5-b)indolen - Google Patents

Verfahren zur Herstellung von neuen 1,2,3,4,5,6-Hexahydroazepino (4,5-b)indolen

Info

Publication number
CH506543A
CH506543A CH637567A CH637567A CH506543A CH 506543 A CH506543 A CH 506543A CH 637567 A CH637567 A CH 637567A CH 637567 A CH637567 A CH 637567A CH 506543 A CH506543 A CH 506543A
Authority
CH
Switzerland
Prior art keywords
hhai
formula
benzyl
hydrochloride
mixture
Prior art date
Application number
CH637567A
Other languages
German (de)
English (en)
Inventor
Boling Jr Hester Jackson
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of CH506543A publication Critical patent/CH506543A/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/08—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)
CH637567A 1966-05-10 1967-05-05 Verfahren zur Herstellung von neuen 1,2,3,4,5,6-Hexahydroazepino (4,5-b)indolen CH506543A (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54888066A 1966-05-10 1966-05-10

Publications (1)

Publication Number Publication Date
CH506543A true CH506543A (de) 1971-04-30

Family

ID=24190763

Family Applications (1)

Application Number Title Priority Date Filing Date
CH637567A CH506543A (de) 1966-05-10 1967-05-05 Verfahren zur Herstellung von neuen 1,2,3,4,5,6-Hexahydroazepino (4,5-b)indolen

Country Status (9)

Country Link
BE (1) BE698268A (es)
CH (1) CH506543A (es)
DE (1) DE1695943A1 (es)
ES (1) ES340258A1 (es)
FR (1) FR6699M (es)
GB (2) GB1180615A (es)
GR (1) GR35044B (es)
IL (2) IL36801A (es)
NL (1) NL6706513A (es)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003099821A1 (en) * 2002-05-24 2003-12-04 X-Ceptor Therapeutics, Inc. Azepinoindole and pyridoindole derivatives as pharmaceutical agents
WO2005056554A2 (en) * 2003-12-02 2005-06-23 Exelixis, Inc. Azepinoindole derivatives as pharmaceutical agents
EP1648408A1 (en) * 2003-07-23 2006-04-26 X-Ceptor Therapeutics, Inc. Azepine derivatives as pharmaceutical agents

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2434166A2 (fr) * 1978-08-24 1980-03-21 Omnium Chimique Sa Procede de preparation de vincadifformine et derives similaires
FR2663935A1 (fr) * 1990-06-27 1992-01-03 Adir Nouveaux 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles et 1,2,3,4-tetrahydrobethacarbolines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
MY122278A (en) * 1999-07-19 2006-04-29 Upjohn Co 1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position
US7030109B2 (en) 1999-07-19 2006-04-18 Pharmacia & Upjohn Company 1,2,3,4,5,6-Hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position
WO2002004456A1 (en) * 2000-07-06 2002-01-17 Pharmacia & Upjohn Company SUBSTITUTED 2,3,7,8,9,10,11,12-OCTAHYDROAZEPINO[4,5-b]PYRANO[3,2-e]INDOLES
US6583135B2 (en) * 2000-09-20 2003-06-24 Pharmacia & Upjohn Company Substituted azepino[4,5b]indole derivatives
WO2023092045A1 (en) 2021-11-17 2023-05-25 Terran Biosciences, Inc. Salt and solid forms of tabernanthalog

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003099821A1 (en) * 2002-05-24 2003-12-04 X-Ceptor Therapeutics, Inc. Azepinoindole and pyridoindole derivatives as pharmaceutical agents
US7485634B2 (en) 2002-05-24 2009-02-03 Exelixis, Inc. Azepinoindole and pyridoindole derivatives as pharmaceutical agents
US7595311B2 (en) 2002-05-24 2009-09-29 Exelixis, Inc. Azepinoindole derivatives as pharmaceutical agents
EP1648408A1 (en) * 2003-07-23 2006-04-26 X-Ceptor Therapeutics, Inc. Azepine derivatives as pharmaceutical agents
EP1648408A4 (en) * 2003-07-23 2006-11-29 Exelixis Inc AZEPINE DERIVATIVES AS PHARMACEUTICAL AGENTS
US8466143B2 (en) 2003-07-23 2013-06-18 Exelixis, Inc. Azepine derivatives as pharmaceutical agents
WO2005056554A2 (en) * 2003-12-02 2005-06-23 Exelixis, Inc. Azepinoindole derivatives as pharmaceutical agents
WO2005056554A3 (en) * 2003-12-02 2005-08-18 X Ceptor Therapeutics Inc Azepinoindole derivatives as pharmaceutical agents

Also Published As

Publication number Publication date
ES340258A1 (es) 1968-06-01
DE1695943A1 (de) 1971-05-13
GB1180616A (en) 1970-02-04
IL36801A (en) 1971-11-29
FR6699M (es) 1969-02-10
GR35044B (el) 1968-07-31
NL6706513A (es) 1967-11-13
IL27776A (en) 1971-11-29
BE698268A (es) 1967-11-10
GB1180615A (en) 1970-02-04

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Legal Events

Date Code Title Description
PL Patent ceased