IL36801A - Novel phenylhydrazones of 1-benzoylhexahydro-4h-azepin-4-one and process for their preparation - Google Patents

Novel phenylhydrazones of 1-benzoylhexahydro-4h-azepin-4-one and process for their preparation

Info

Publication number
IL36801A
IL36801A IL3680167A IL3680167A IL36801A IL 36801 A IL36801 A IL 36801A IL 3680167 A IL3680167 A IL 3680167A IL 3680167 A IL3680167 A IL 3680167A IL 36801 A IL36801 A IL 36801A
Authority
IL
Israel
Prior art keywords
compound
hydrogen
novel
preparation
benzoylhexahydro
Prior art date
Application number
IL3680167A
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of IL36801A publication Critical patent/IL36801A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/08—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)

Description

Novel zones of and Process for their Preparation The present invention relates to novel compounds the general formula and to process preparing The hovel compounds of the general formula II valuable intermediates in organic and especially i the preparation of i hexahydroazeplho indoles described and claimed in the copendin patent application from which present application has been divided out The process of preparing the novel compounds of formula II can be represented by the followin wherein R and are selected from the group consisting of alkoxy and containing from 1 to 3 carbon and with the proviso that at least one of the two ortho positions the hydrazino in I is an to the phenyl group The alkyl group as used in the above from 1 to 3 carbon comprises the members and the alkoxy group comprises pro and The halogen atoms herein intend as substltutents of the phenyl group are chlorine and According to the present invention there provided a process which comprises heating a phenylhydrazine of the formula I with to obtain the phenylhydrazone of of formula II starting compounds for this invention are known The is prepared as shown in the In carryin ou the process of the present the selected phenylhydrazine formula 1 is refluxed with in a solvent such as toluene or the In the preferred embodiment of this inventionm an acid catalyst such as acetic acid a quantity of about to calculated on the amount of is added to obtain insufficientOCRQuality

Claims (1)

1. WHAT IS CLAIMED IS A compound of the formula wherein and wherein R and are selected from the grou cons sting of alkoxy and containing from 3 carbon and halo wit the proviso that at least one positions of s hydro compound according Claim 1 wherein R and and the compound the phenyihydrazone of A compound according to Claim wherein R is hydrogen and is so that the compound is the of i A compound according to Claim wherein R is hydrogen and is so that the compound the henylhydrazo e of A compound according to Claim wherein R is hydrogen and is so that the compound is of A compound according to Claim wherein is hydrogen and so that the compound is the of A compound according to Claim wherein R is hydrogen and is so that the compound the A compound according to Claim wherein R is hydrogen and is so that the compound is the of A proceao production o of 1 as claimed in Claim insufficientOCRQuality
IL3680167A 1966-05-10 1967-04-11 Novel phenylhydrazones of 1-benzoylhexahydro-4h-azepin-4-one and process for their preparation IL36801A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54888066A 1966-05-10 1966-05-10

Publications (1)

Publication Number Publication Date
IL36801A true IL36801A (en) 1971-11-29

Family

ID=24190763

Family Applications (2)

Application Number Title Priority Date Filing Date
IL3680167A IL36801A (en) 1966-05-10 1967-04-11 Novel phenylhydrazones of 1-benzoylhexahydro-4h-azepin-4-one and process for their preparation
IL2777667A IL27776A (en) 1966-05-10 1967-04-11 1,2,3,4,5,6-hexahydroazepino(4,5-b)-indoles and process for their preparation

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL2777667A IL27776A (en) 1966-05-10 1967-04-11 1,2,3,4,5,6-hexahydroazepino(4,5-b)-indoles and process for their preparation

Country Status (9)

Country Link
BE (1) BE698268A (en)
CH (1) CH506543A (en)
DE (1) DE1695943A1 (en)
ES (1) ES340258A1 (en)
FR (1) FR6699M (en)
GB (2) GB1180616A (en)
GR (1) GR35044B (en)
IL (2) IL36801A (en)
NL (1) NL6706513A (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2434166A2 (en) * 1978-08-24 1980-03-21 Omnium Chimique Sa PROCESS FOR THE PREPARATION OF VINCADIFFORMIN AND SIMILAR DERIVATIVES
FR2663935A1 (en) * 1990-06-27 1992-01-03 Adir NOVEL 1,2,3,4,5,6-HEXAHYDROAZEPINO [4,5-B] INDOLES AND 1,2,3,4-TETRAHYDROBETHACARBOLINES, PROCESSES FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
MY122278A (en) 1999-07-19 2006-04-29 Upjohn Co 1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position
US7030109B2 (en) 1999-07-19 2006-04-18 Pharmacia & Upjohn Company 1,2,3,4,5,6-Hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position
WO2002004456A1 (en) * 2000-07-06 2002-01-17 Pharmacia & Upjohn Company SUBSTITUTED 2,3,7,8,9,10,11,12-OCTAHYDROAZEPINO[4,5-b]PYRANO[3,2-e]INDOLES
PE20020510A1 (en) 2000-09-20 2002-06-12 Upjohn Co DERIVATIVES OF AZEPYL [4,5b] INDOLINE SUBSTITUTE AS LIGANDS OF SEROTONIN (5-HT) RECEPTORS
US7595311B2 (en) 2002-05-24 2009-09-29 Exelixis, Inc. Azepinoindole derivatives as pharmaceutical agents
TWI329111B (en) * 2002-05-24 2010-08-21 X Ceptor Therapeutics Inc Azepinoindole and pyridoindole derivatives as pharmaceutical agents
AU2004259009A1 (en) 2003-07-23 2005-02-03 Exelixis, Inc. Azepine derivatives as pharmaceutical agents
WO2023092045A1 (en) 2021-11-17 2023-05-25 Terran Biosciences, Inc. Salt and solid forms of tabernanthalog

Also Published As

Publication number Publication date
IL27776A (en) 1971-11-29
ES340258A1 (en) 1968-06-01
GR35044B (en) 1968-07-31
DE1695943A1 (en) 1971-05-13
GB1180615A (en) 1970-02-04
FR6699M (en) 1969-02-10
BE698268A (en) 1967-11-10
GB1180616A (en) 1970-02-04
CH506543A (en) 1971-04-30
NL6706513A (en) 1967-11-13

Similar Documents

Publication Publication Date Title
IL36801A (en) Novel phenylhydrazones of 1-benzoylhexahydro-4h-azepin-4-one and process for their preparation
Ykman et al. Reactions of carbonyl azides with α-keto phosphorus ylides: Synthesis of N-2 acyl and N-2 carbethoxy-1, 2, 3-triazoles
GB939675A (en) New dyes and the production thereof
JPH01160957A (en) Bis(indoryl)ethylene
Buzykin et al. Reaction of azines with 5-pyrazolones
Mao et al. Syntheses of dihydropyrenes with functionality in the cavity of the. pi.-electron cloud
ES403209A1 (en) Novel acetophenone oxime derivatives
Shvo et al. Stereoselectivity in the formation of heterocyclic amine oxides
Tsunashima et al. The chemistry of carbazole. VI. On the formation of N‐ethylcarbazoles in the cadogan reaction
Akiba et al. Wittig-horner reaction of a phosphonate of reissert analogue a new method for introduction of alkyl groups into isoquinoline
Carroll et al. Benzylation and Benzoylation of Methyl Phenacyl Sulfone
ES406031A1 (en) Indol-2-ylphenylacetic acids and esters
US3349091A (en) 1-aminoalkyl-5-[(halo/alkoxy) phenyl]-2-pyrrolepropionic acids
IE42933B1 (en) Glyoxylic acid derivatives
GB1431248A (en) Production of 1,1,3,3-substituted hydroxy indanes
US3956311A (en) Process for the preparation of 3-anilino-pyrazolones-(5)
Ballester et al. Unsaturated carboxylic acid dienolates. Michael addition to enones through tandem 1, 2-addition-oxy-cope rearrangement.
US3598844A (en) Azidocinnamic aldehydes
Padwa et al. Reaction of hydrazonyl chlorides and carboalkoxymethylene triphenylphosphoranes to give 5‐alkoxy substituted pyrazoles
US3274246A (en) Phosphorinanone-phenylhydrazones
GB1346126A (en) Process for the manufacture of 1,1-dianthraquinonyls
IL39209A (en) 3,5-dihydrophenazine derivatives
US2478661A (en) Oxazolone derivative and process for preparing same
US2770653A (en) Diaralkylalkylenediamine preparation
GB1346378A (en) 2-stilbenyl-4-styryl-v-triazoles their use for the optical brightening of organic materials and processes for their manufacture