GR35044B - METHOD OF PREPARATION OF ORGANIC COMPOUNDS. - Google Patents

METHOD OF PREPARATION OF ORGANIC COMPOUNDS.

Info

Publication number
GR35044B
GR35044B GR670135044A GR670135044A GR35044B GR 35044 B GR35044 B GR 35044B GR 670135044 A GR670135044 A GR 670135044A GR 670135044 A GR670135044 A GR 670135044A GR 35044 B GR35044 B GR 35044B
Authority
GR
Greece
Prior art keywords
formula
preparation
organic compounds
azepine
benzoyl
Prior art date
Application number
GR670135044A
Other languages
Greek (el)
Original Assignee
The Upjohn Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Upjohn Company filed Critical The Upjohn Company
Publication of GR35044B publication Critical patent/GR35044B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/08—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

ία μέθοδος δια την παραγωγήν μιας ενώσεως του τύπου [*] εις τον οποίον το Ο είναι φαινύλιον και ειςτο οποίον τα R και R1 εκλέγονται από την ομάδα την αποτελουμένην από υδρογόνον αλκοξύ, και αλκύλιονπεριέχον από 1-3 άτομα άνθρακος, περιλαμβανόμενα και αλογόνον, η οποία περιλαμβάνει: την θέρμανσιν μιας φαινυλυδραζίνης του τύπου Ι: [*] εις τον οποίον τα R και R1 έχουν σημασίαν, την ανωτέρω, με το 1-βενζοϋλ-εξαϋδρο-4Η-αζεπίνη-4-εν δια την λήψιν της αντιστοίχου φαινυλυδραζόνης του 1-βενζοϋλεξαϋδρο-4Η-αζεπίνη-4- εν του τύπου ΙΙ: [*] εις τον οποίοντα R, R1 και Ο έχουν την αυτήν σημασίαν όπως ανωτέρω και θέρμανσιν της ενώσεως ταύτης μεεμυρμηκικόνοξύ δια την λήψιν του αντιστοίχου 3-βενζοϋλο-1,2,3,4,5,6-εξαϋδροαζεπινο [4,5-b] ινδολίου τουτύπου ΙΙΙ ανωτέρω. A method for producing a compound of formula [*] wherein C is phenyl and in which R and R1 are selected from the group consisting of hydrogen alkoxy, and alkyl containing from 1-3 carbon atoms, including halogen, which comprises: heating a phenylhydrazine of formula I: [*] wherein R and R1 are important, above, with 1-benzoyl-hexahydro-4H-azepine-4-en to obtain the corresponding phenylhydrazone of 1-benzoylexa-hydrochloride-4H-azepine-4-en of formula II: [*] wherein R, R1 and C have the same significance as above and heating of this compound with formic acid to obtain the corresponding 3-benzoyl-1,2,3,4,5,6-hexahydroazepine [4,5-b] indole of type III above.

GR670135044A 1966-05-10 1967-04-10 METHOD OF PREPARATION OF ORGANIC COMPOUNDS. GR35044B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54888066A 1966-05-10 1966-05-10

Publications (1)

Publication Number Publication Date
GR35044B true GR35044B (en) 1968-07-31

Family

ID=24190763

Family Applications (1)

Application Number Title Priority Date Filing Date
GR670135044A GR35044B (en) 1966-05-10 1967-04-10 METHOD OF PREPARATION OF ORGANIC COMPOUNDS.

Country Status (9)

Country Link
BE (1) BE698268A (en)
CH (1) CH506543A (en)
DE (1) DE1695943A1 (en)
ES (1) ES340258A1 (en)
FR (1) FR6699M (en)
GB (2) GB1180615A (en)
GR (1) GR35044B (en)
IL (2) IL27776A (en)
NL (1) NL6706513A (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2434166A2 (en) * 1978-08-24 1980-03-21 Omnium Chimique Sa PROCESS FOR THE PREPARATION OF VINCADIFFORMIN AND SIMILAR DERIVATIVES
FR2663935A1 (en) * 1990-06-27 1992-01-03 Adir NOVEL 1,2,3,4,5,6-HEXAHYDROAZEPINO [4,5-B] INDOLES AND 1,2,3,4-TETRAHYDROBETHACARBOLINES, PROCESSES FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
MY122278A (en) 1999-07-19 2006-04-29 Upjohn Co 1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position
US7030109B2 (en) 1999-07-19 2006-04-18 Pharmacia & Upjohn Company 1,2,3,4,5,6-Hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position
AU2001269781A1 (en) * 2000-07-06 2002-01-21 Pharmacia And Upjohn Company Substituted 2,3,7,8,9,10,11,12-octahydroazepino(4,5-b)pyrano(3,2-e) indoles
AR035493A1 (en) 2000-09-20 2004-06-02 Upjohn Co DERIVATIVES OF AZEPINO (4,5B) INDOLINA SUBSTITUTED, PHARMACEUTICAL COMPOSITION AND THE USE OF SUCH DERIVATIVES TO PREPARE A MEDICINAL PRODUCT
TWI329111B (en) 2002-05-24 2010-08-21 X Ceptor Therapeutics Inc Azepinoindole and pyridoindole derivatives as pharmaceutical agents
US7595311B2 (en) * 2002-05-24 2009-09-29 Exelixis, Inc. Azepinoindole derivatives as pharmaceutical agents
BRPI0412262A (en) * 2003-07-23 2006-09-19 X Ceptor Therapeutics Inc azepine derivatives as pharmaceutical agents
WO2023092045A1 (en) 2021-11-17 2023-05-25 Terran Biosciences, Inc. Salt and solid forms of tabernanthalog

Also Published As

Publication number Publication date
FR6699M (en) 1969-02-10
ES340258A1 (en) 1968-06-01
IL27776A (en) 1971-11-29
GB1180615A (en) 1970-02-04
GB1180616A (en) 1970-02-04
CH506543A (en) 1971-04-30
NL6706513A (en) 1967-11-13
IL36801A (en) 1971-11-29
DE1695943A1 (en) 1971-05-13
BE698268A (en) 1967-11-10

Similar Documents

Publication Publication Date Title
ES370394A1 (en) 11-substituted 5 11-dihydro-6h-pyrido(2 3-b)(1 4)benzodiazepin-6-ones
GR35044B (en) METHOD OF PREPARATION OF ORGANIC COMPOUNDS.
ES381894A1 (en) O-acyl-lysergols and process for preparing them
ES411187A1 (en) Heterocyclic ethers of piperazine n alkanols
ES320296A1 (en) Procedure for the preparation of new derivatives of indol. (Machine-translation by Google Translate, not legally binding)
ES396453A1 (en) 2-amino-4,5,7,8-tetrahydro-6h-thiazolo or oxazolo(5,4-d)azepines and salts
ES332806A1 (en) A method of preparing acetals. (Machine-translation by Google Translate, not legally binding)
ES401198A1 (en) Substituted phenylalkanol derivatives
ES396134A1 (en) 1,1,1-trichloro-2-amido-2-amino-ethanes
ES341174A1 (en) 1,2,3,4,5,6-hexahydro-azepino(4,5-b) indole derivatives
ES320729A1 (en) Procedure for the synthesis of new derivatives of antranilic acid. (Machine-translation by Google Translate, not legally binding)
ES398804A1 (en) Carboxylic acyl derivatives of digoxin
GR33446B (en) METHOD OF MANUFACTURING NEW PRODUCERS OF PYRIDAZONE.
GB1436820A (en) Ergoline derivatives
ES274910A1 (en) Iminodibenzyl derivatives
ES364723A1 (en) Procedure for the preparation of new derivatives of paminoalquil-bencensulfonamida. (Machine-translation by Google Translate, not legally binding)
ES364726A1 (en) Procedure for the preparation of new derivatives of paminoalquil-bencensulfonamida. (Machine-translation by Google Translate, not legally binding)
ES310461A1 (en) Procedure for obtaining heterociclic compounds with grupo azo. (Machine-translation by Google Translate, not legally binding)
GB1378403A (en) Process for the preparation of 3-2h-isoquinolones
ES369805A1 (en) Procedure for the preparation of new indolinas basically replaced. (Machine-translation by Google Translate, not legally binding)
ES383347A1 (en) Procedure for the preparation of new derivatives of the p-aminoalquil-bencensulfonamida. (Machine-translation by Google Translate, not legally binding)
ES373928A1 (en) Procedure for the preparation of new derivatives of azepine. (Machine-translation by Google Translate, not legally binding)
GB1489979A (en) Triazolo benzo-diazepines and triazolo benzodiazocines
ES432289A1 (en) Heterocyclic compounds
ES426874A1 (en) Procedure for the obtaining of new diazepine derivatives. (Machine-translation by Google Translate, not legally binding)