FR2434166A2 - PROCESS FOR THE PREPARATION OF VINCADIFFORMIN AND SIMILAR DERIVATIVES - Google Patents

PROCESS FOR THE PREPARATION OF VINCADIFFORMIN AND SIMILAR DERIVATIVES

Info

Publication number
FR2434166A2
FR2434166A2 FR7921371A FR7921371A FR2434166A2 FR 2434166 A2 FR2434166 A2 FR 2434166A2 FR 7921371 A FR7921371 A FR 7921371A FR 7921371 A FR7921371 A FR 7921371A FR 2434166 A2 FR2434166 A2 FR 2434166A2
Authority
FR
France
Prior art keywords
vincadifformin
preparation
similar derivatives
derivatives
similar
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7921371A
Other languages
French (fr)
Other versions
FR2434166B2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Omnium Chimique SA
Original Assignee
Omnium Chimique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/936,454 external-priority patent/US4267330A/en
Priority claimed from US06/034,792 external-priority patent/US4283536A/en
Application filed by Omnium Chimique SA filed Critical Omnium Chimique SA
Publication of FR2434166A2 publication Critical patent/FR2434166A2/en
Application granted granted Critical
Publication of FR2434166B2 publication Critical patent/FR2434166B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C391/00—Compounds containing selenium
    • C07C391/02—Compounds containing selenium having selenium atoms bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/313—Compounds having groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/515—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an acetalised, ketalised hemi-acetalised, or hemi-ketalised hydroxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/02—Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen
    • C07C47/14—Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/02—Synthesis of the oxirane ring
    • C07D301/03—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds
    • C07D301/14—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds with organic peracids, or salts, anhydrides or esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/32—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by aldehydo- or ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D303/40—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by ester radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Procédé de synthèse de vincadifformine et autres dérivés polycycliques similaires, de même que de nouveaux dérivés de 1,2,3,4,5,6-hexahydroazépinoØ4,5-bõindole utilisables comme produits intermédiaires. Les composés synthétisés ont pour formule générale :Process for the synthesis of vincadifformin and other similar polycyclic derivatives, as well as new derivatives of 1,2,3,4,5,6-hexahydroazépinoØ4,5-bõindole which can be used as intermediates. The compounds synthesized have the general formula:

FR7921371A 1978-08-24 1979-08-24 PROCESS FOR THE PREPARATION OF VINCADIFFORMIN AND SIMILAR DERIVATIVES Granted FR2434166A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/936,454 US4267330A (en) 1978-08-24 1978-08-24 Process for the synthesis of vincadifformine and related derivatives
US06/034,792 US4283536A (en) 1977-12-29 1979-04-30 Preparation of vincadifformine and related derivatives

Publications (2)

Publication Number Publication Date
FR2434166A2 true FR2434166A2 (en) 1980-03-21
FR2434166B2 FR2434166B2 (en) 1983-11-10

Family

ID=26711371

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7921371A Granted FR2434166A2 (en) 1978-08-24 1979-08-24 PROCESS FOR THE PREPARATION OF VINCADIFFORMIN AND SIMILAR DERIVATIVES
FR8005741A Granted FR2445332A2 (en) 1978-08-24 1980-03-14 1,2,3,4,5,6-HEXAHYDROAZEPINO- (4,5-B) -INDOLE DERIVATIVES AND THEIR PREPARATION PROCESS

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR8005741A Granted FR2445332A2 (en) 1978-08-24 1980-03-14 1,2,3,4,5,6-HEXAHYDROAZEPINO- (4,5-B) -INDOLE DERIVATIVES AND THEIR PREPARATION PROCESS

Country Status (3)

Country Link
DE (1) DE2934342A1 (en)
FR (2) FR2434166A2 (en)
GB (1) GB2029828B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0219654A2 (en) * 1985-10-24 1987-04-29 Degussa Aktiengesellschaft Process for the preparation of 4-chlorbutanals

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4307617C2 (en) * 1993-03-08 1997-03-27 Mannesmann Ag Method for measuring the radial profile and / or the absolute diameter of rotationally symmetrical bodies

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1524830A (en) * 1966-05-31 1968-05-10 Geigy Ag J R New indole derivatives and their preparation
FR2413391A1 (en) * 1977-12-29 1979-07-27 Omnium Chimique Sa PROCESS FOR THE PREPARATION OF VINCADIFFORMIN

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH445508A (en) * 1964-12-03 1967-10-31 Geigy Ag J R Process for the production of new indole derivatives
GR35044B (en) * 1966-05-10 1968-07-31 The Upjohn Company METHOD OF PREPARATION OF ORGANIC COMPOUNDS.
DE2758896A1 (en) * 1977-12-30 1979-07-05 Martin E Kuehne Alkaloid vincadifformine prodn. - in 7 steps from tetra:hydro-beta-carboline

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1524830A (en) * 1966-05-31 1968-05-10 Geigy Ag J R New indole derivatives and their preparation
FR2413391A1 (en) * 1977-12-29 1979-07-27 Omnium Chimique Sa PROCESS FOR THE PREPARATION OF VINCADIFFORMIN

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
EXBK/78 *
EXBK/79 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0219654A2 (en) * 1985-10-24 1987-04-29 Degussa Aktiengesellschaft Process for the preparation of 4-chlorbutanals
EP0219654A3 (en) * 1985-10-24 1988-01-13 Degussa Aktiengesellschaft Process for the preparation of 4-chlorbutanals

Also Published As

Publication number Publication date
FR2445332A2 (en) 1980-07-25
DE2934342A1 (en) 1980-03-13
GB2029828B (en) 1983-04-27
DE2934342C2 (en) 1993-02-11
FR2445332B2 (en) 1983-06-17
GB2029828A (en) 1980-03-26
FR2434166B2 (en) 1983-11-10

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