ES340258A1 - Procedimiento para la produccion de 1,2,3,4,5,6-hexahidroa-zepino (4,5-b) indoles y derivados. - Google Patents

Procedimiento para la produccion de 1,2,3,4,5,6-hexahidroa-zepino (4,5-b) indoles y derivados.

Info

Publication number
ES340258A1
ES340258A1 ES340258A ES340258A ES340258A1 ES 340258 A1 ES340258 A1 ES 340258A1 ES 340258 A ES340258 A ES 340258A ES 340258 A ES340258 A ES 340258A ES 340258 A1 ES340258 A1 ES 340258A1
Authority
ES
Spain
Prior art keywords
alkyl
pharmaceutically acceptable
acid addition
addition salts
active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES340258A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of ES340258A1 publication Critical patent/ES340258A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/08—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
ES340258A 1966-05-10 1967-05-08 Procedimiento para la produccion de 1,2,3,4,5,6-hexahidroa-zepino (4,5-b) indoles y derivados. Expired ES340258A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54888066A 1966-05-10 1966-05-10

Publications (1)

Publication Number Publication Date
ES340258A1 true ES340258A1 (es) 1968-06-01

Family

ID=24190763

Family Applications (1)

Application Number Title Priority Date Filing Date
ES340258A Expired ES340258A1 (es) 1966-05-10 1967-05-08 Procedimiento para la produccion de 1,2,3,4,5,6-hexahidroa-zepino (4,5-b) indoles y derivados.

Country Status (9)

Country Link
BE (1) BE698268A (es)
CH (1) CH506543A (es)
DE (1) DE1695943A1 (es)
ES (1) ES340258A1 (es)
FR (1) FR6699M (es)
GB (2) GB1180616A (es)
GR (1) GR35044B (es)
IL (2) IL27776A (es)
NL (1) NL6706513A (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2934342A1 (de) * 1978-08-24 1980-03-13 Martin E Kuehne Verfahren zur herstellung von +vincadifformin und verwandter derivate sowie zwischenverbindungen
FR2663935A1 (fr) * 1990-06-27 1992-01-03 Adir Nouveaux 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles et 1,2,3,4-tetrahydrobethacarbolines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
MY122278A (en) * 1999-07-19 2006-04-29 Upjohn Co 1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position
US7030109B2 (en) 1999-07-19 2006-04-18 Pharmacia & Upjohn Company 1,2,3,4,5,6-Hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position
AU2001269781A1 (en) * 2000-07-06 2002-01-21 Pharmacia And Upjohn Company Substituted 2,3,7,8,9,10,11,12-octahydroazepino(4,5-b)pyrano(3,2-e) indoles
EP1319005A2 (en) * 2000-09-20 2003-06-18 PHARMACIA & UPJOHN COMPANY Substituted azepino[4,5-b]indoline derivatives
TWI329111B (en) 2002-05-24 2010-08-21 X Ceptor Therapeutics Inc Azepinoindole and pyridoindole derivatives as pharmaceutical agents
US7595311B2 (en) 2002-05-24 2009-09-29 Exelixis, Inc. Azepinoindole derivatives as pharmaceutical agents
US8466143B2 (en) 2003-07-23 2013-06-18 Exelixis, Inc. Azepine derivatives as pharmaceutical agents
US20230257385A1 (en) 2021-11-17 2023-08-17 Terran Biosciences Inc. Salt and solid forms of tabernanthalog

Also Published As

Publication number Publication date
GB1180615A (en) 1970-02-04
CH506543A (de) 1971-04-30
GB1180616A (en) 1970-02-04
IL36801A (en) 1971-11-29
FR6699M (es) 1969-02-10
DE1695943A1 (de) 1971-05-13
GR35044B (el) 1968-07-31
IL27776A (en) 1971-11-29
BE698268A (es) 1967-11-10
NL6706513A (es) 1967-11-13

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