IL27776A - 1,2,3,4,5,6-hexahydroazepino(4,5-b)-indoles and process for their preparation - Google Patents

1,2,3,4,5,6-hexahydroazepino(4,5-b)-indoles and process for their preparation

Info

Publication number
IL27776A
IL27776A IL2777667A IL2777667A IL27776A IL 27776 A IL27776 A IL 27776A IL 2777667 A IL2777667 A IL 2777667A IL 2777667 A IL2777667 A IL 2777667A IL 27776 A IL27776 A IL 27776A
Authority
IL
Israel
Prior art keywords
compound
indole
hexahydroazepino
methyl
benzoyl
Prior art date
Application number
IL2777667A
Other languages
English (en)
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of IL27776A publication Critical patent/IL27776A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/08—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)
IL2777667A 1966-05-10 1967-04-11 1,2,3,4,5,6-hexahydroazepino(4,5-b)-indoles and process for their preparation IL27776A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54888066A 1966-05-10 1966-05-10

Publications (1)

Publication Number Publication Date
IL27776A true IL27776A (en) 1971-11-29

Family

ID=24190763

Family Applications (2)

Application Number Title Priority Date Filing Date
IL3680167A IL36801A (en) 1966-05-10 1967-04-11 Novel phenylhydrazones of 1-benzoylhexahydro-4h-azepin-4-one and process for their preparation
IL2777667A IL27776A (en) 1966-05-10 1967-04-11 1,2,3,4,5,6-hexahydroazepino(4,5-b)-indoles and process for their preparation

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL3680167A IL36801A (en) 1966-05-10 1967-04-11 Novel phenylhydrazones of 1-benzoylhexahydro-4h-azepin-4-one and process for their preparation

Country Status (9)

Country Link
BE (1) BE698268A (es)
CH (1) CH506543A (es)
DE (1) DE1695943A1 (es)
ES (1) ES340258A1 (es)
FR (1) FR6699M (es)
GB (2) GB1180615A (es)
GR (1) GR35044B (es)
IL (2) IL36801A (es)
NL (1) NL6706513A (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2434166A2 (fr) * 1978-08-24 1980-03-21 Omnium Chimique Sa Procede de preparation de vincadifformine et derives similaires
FR2663935A1 (fr) * 1990-06-27 1992-01-03 Adir Nouveaux 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles et 1,2,3,4-tetrahydrobethacarbolines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
MY122278A (en) * 1999-07-19 2006-04-29 Upjohn Co 1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position
US7030109B2 (en) 1999-07-19 2006-04-18 Pharmacia & Upjohn Company 1,2,3,4,5,6-Hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position
WO2002004456A1 (en) * 2000-07-06 2002-01-17 Pharmacia & Upjohn Company SUBSTITUTED 2,3,7,8,9,10,11,12-OCTAHYDROAZEPINO[4,5-b]PYRANO[3,2-e]INDOLES
US6583135B2 (en) * 2000-09-20 2003-06-24 Pharmacia & Upjohn Company Substituted azepino[4,5b]indole derivatives
US7595311B2 (en) 2002-05-24 2009-09-29 Exelixis, Inc. Azepinoindole derivatives as pharmaceutical agents
TWI329111B (en) 2002-05-24 2010-08-21 X Ceptor Therapeutics Inc Azepinoindole and pyridoindole derivatives as pharmaceutical agents
RU2006105646A (ru) 2003-07-23 2007-09-10 Экселиксис, Инк. (Us) Производные азепина в качестве фармацевтических агентов
WO2023092045A1 (en) 2021-11-17 2023-05-25 Terran Biosciences, Inc. Salt and solid forms of tabernanthalog

Also Published As

Publication number Publication date
ES340258A1 (es) 1968-06-01
DE1695943A1 (de) 1971-05-13
GB1180616A (en) 1970-02-04
IL36801A (en) 1971-11-29
FR6699M (es) 1969-02-10
GR35044B (el) 1968-07-31
NL6706513A (es) 1967-11-13
CH506543A (de) 1971-04-30
BE698268A (es) 1967-11-10
GB1180615A (en) 1970-02-04

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