CA3294778A1 - Angiotensinogen (agt) irna compositions and methods of use thereof - Google Patents

Angiotensinogen (agt) irna compositions and methods of use thereof

Info

Publication number
CA3294778A1
CA3294778A1 CA3294778A CA3294778A CA3294778A1 CA 3294778 A1 CA3294778 A1 CA 3294778A1 CA 3294778 A CA3294778 A CA 3294778A CA 3294778 A CA3294778 A CA 3294778A CA 3294778 A1 CA3294778 A1 CA 3294778A1
Authority
CA
Canada
Prior art keywords
angiotensinogen
agt
methods
irna compositions
irna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3294778A
Other languages
English (en)
Inventor
Donald Foster
Gregory Hinkle
K. Schlegel Mark
Original Assignee
Alnylam Pharmaceuticals Inc
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=66770566&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA3294778(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of CA3294778A1 publication Critical patent/CA3294778A1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/312—Phosphonates
    • C12N2310/3125—Methylphosphonates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/322—2'-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/343—Spatial arrangement of the modifications having patterns, e.g. ==--==--==--
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
CA3294778A 2018-05-14 2019-05-14 Angiotensinogen (agt) irna compositions and methods of use thereof Pending CA3294778A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862671094P 2018-05-14 2018-05-14
US62/671,094 2018-05-14
US201862727141P 2018-09-05 2018-09-05
US62/727,141 2018-09-05
US201962816996P 2019-03-12 2019-03-12
US62/816,996 2019-03-12
CA3100003A CA3100003C (en) 2018-05-14 2019-05-14 Angiotensinogen (agt) irna compositions and methods of use thereof

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA3100003A Division CA3100003C (en) 2018-05-14 2019-05-14 Angiotensinogen (agt) irna compositions and methods of use thereof

Publications (1)

Publication Number Publication Date
CA3294778A1 true CA3294778A1 (en) 2026-03-02

Family

ID=66770566

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3294778A Pending CA3294778A1 (en) 2018-05-14 2019-05-14 Angiotensinogen (agt) irna compositions and methods of use thereof
CA3100003A Active CA3100003C (en) 2018-05-14 2019-05-14 Angiotensinogen (agt) irna compositions and methods of use thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3100003A Active CA3100003C (en) 2018-05-14 2019-05-14 Angiotensinogen (agt) irna compositions and methods of use thereof

Country Status (30)

Country Link
US (3) US11015201B2 (enExample)
EP (2) EP3794122B1 (enExample)
JP (3) JP7346460B2 (enExample)
KR (2) KR20250171473A (enExample)
CN (4) CN112313335B (enExample)
AU (2) AU2019269418B2 (enExample)
BR (1) BR112020022943A2 (enExample)
CA (2) CA3294778A1 (enExample)
CL (3) CL2020002865A1 (enExample)
CO (1) CO2020015314A2 (enExample)
DK (1) DK3794122T5 (enExample)
ES (1) ES2967713T3 (enExample)
FI (1) FI3794122T3 (enExample)
HR (1) HRP20231412T1 (enExample)
HU (1) HUE064073T2 (enExample)
IL (2) IL292877B2 (enExample)
LT (1) LT3794122T (enExample)
MX (2) MX421205B (enExample)
MY (1) MY198716A (enExample)
PE (1) PE20210114A1 (enExample)
PH (1) PH12020551904A1 (enExample)
PL (1) PL3794122T3 (enExample)
PT (1) PT3794122T (enExample)
RS (1) RS64812B1 (enExample)
SG (1) SG11202011144QA (enExample)
SI (1) SI3794122T1 (enExample)
SM (1) SMT202300388T1 (enExample)
TW (1) TWI851574B (enExample)
WO (1) WO2019222166A1 (enExample)
ZA (1) ZA202108348B (enExample)

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SG11201609376SA (en) 2014-05-22 2016-12-29 Alnylam Pharmaceuticals Inc Angiotensinogen (agt) irna compositions and methods of use thereof
TWI851574B (zh) 2018-05-14 2024-08-11 美商阿尼拉製藥公司 血管收縮素原（ＡＧＴ）ｉＲＮＡ組成物及其使用方法
IL292865A (en) * 2019-11-13 2022-07-01 Alnylam Pharmaceuticals Inc Methods and preparations for the treatment of angiotensinogen-related disorder - (agt)
WO2021231552A1 (en) * 2020-05-12 2021-11-18 Duke University Compositions and methods for controlling blood pressure
EP4149618A4 (en) 2020-05-12 2024-07-03 Duke University COMPOSITIONS AND METHODS FOR CONTROLLING BLOOD PRESSURE
KR20230108728A (ko) 2020-11-18 2023-07-18 아이오니스 파마수티컬즈, 인코포레이티드 앤지오텐시노겐 발현을 조절하기 위한 화합물 및 방법
IL309296A (en) * 2021-06-30 2024-02-01 Alnylam Pharmaceuticals Inc Methods and compositions for the treatment of angiotensinogen-related disorder (AGT-)
CA3228255A1 (en) * 2021-08-04 2023-02-09 Alnylam Pharmaceuticals, Inc. Irna compositions and methods for silencing angiotensinogen (agt)
US20240401045A1 (en) 2021-10-01 2024-12-05 Adarx Pharmaceuticals, Inc. Angiotensinogen-modulating compositions and methods of use thereof
CN113862268B (zh) * 2021-10-20 2025-05-13 厦门甘宝利生物医药有限公司 Agt抑制剂及其用途
KR20240103025A9 (ko) * 2021-11-16 2025-12-10 상하이 아르고 바이오파마슈티칼 씨오., 엘티디. 안지오텐시노겐(agt) 단백질의 발현을 저해하는 조성물 및 방법
US20250197853A1 (en) * 2021-11-19 2025-06-19 Tuojie Biotech (Shanghai) Co., Ltd. Sirna targeting angiotensinogen and pharmaceutical use of sirna
CN118541487A (zh) * 2022-01-20 2024-08-23 上海拓界生物医药科技有限公司 一种dsRNA、其应用及制备方法
WO2023155909A1 (zh) * 2022-02-18 2023-08-24 南京明德新药研发有限公司 三氮唑核苷类似物及其作为嵌入基团的应用
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CN117264948B (zh) * 2022-06-14 2024-05-10 广州必贝特医药股份有限公司 抑制血管紧张素原基因表达的RNAi抑制剂及其应用
WO2024013334A1 (en) * 2022-07-15 2024-01-18 Silence Therapeutics Gmbh Nucleic acids for inhibiting expression of agt in a cell
WO2024031101A1 (en) * 2022-08-05 2024-02-08 Sanegene Bio Usa Inc. Double stranded rna targeting angiotensinogen (agt) and methods of use thereof
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CN118475697A (zh) * 2023-05-15 2024-08-09 苏州时安生物技术有限公司 一种用于调节血管紧张素原基因表达的双链rna、其缀合物、药物组合物及用途
JP2026520610A (ja) 2023-06-13 2026-06-23 アーナター セラピューティクス インコーポレイテッド アンジオテンシノーゲンのための高度ｒｎａ標的化技術（ａｒｎａｔａｒ）
EP4715053A1 (en) * 2023-06-16 2026-03-25 SynerK Inc. Nucleic acid targeting angiotensinogen and use thereof
KR20260018106A (ko) * 2023-07-06 2026-02-06 씨에스피씨 종콰이 팔마씨우티컬 테크놀로지 (스자좡) 컴퍼니 리미티드 AGT유전자 발현을 억제하는 RNAi제 및 이의 응용
WO2025007961A1 (zh) * 2023-07-06 2025-01-09 大睿生物 调控AGT表达的dsRNA分子
TW202509216A (zh) * 2023-07-14 2025-03-01 大陸商北京安龍生物醫藥有限公司 靶向血管收縮素原的寡核苷酸及其用途
JP2026526369A (ja) 2023-08-16 2026-08-07 チェンドゥ ゴーウェル バイオファーマシューティカル カンパニー，リミテッド ｓｉＲＮＡ、ｓｉＲＮＡコンジュゲート、医薬組成物及びその使用
WO2024227458A2 (zh) * 2023-08-22 2024-11-07 成都先衍生物技术有限公司 一种靶向AGT基因表达的siRNA及其缀合物和用途
CN121006363A (zh) * 2023-09-18 2025-11-25 广州必贝特医药股份有限公司 用于同时抑制两个靶基因表达的siRNA、药物及其应用
CN119876130A (zh) * 2023-10-23 2025-04-25 广东东阳光药业股份有限公司 一种新型的双链siRNA、其缀合物及其用途
IL328055A (en) * 2023-11-03 2026-06-01 Ionis Pharmaceuticals Inc Methods and compositions for reducing angiotensinogen
CN118995714B (zh) * 2024-09-26 2025-12-12 杭州天龙药业有限公司 靶向抑制AGT基因表达的siRNA及其在治疗高血压中的应用
CN120005876A (zh) * 2023-11-15 2025-05-16 纳肽得(青岛)生物医药有限公司 抑制血管紧张素原表达的siRNA及其用途
WO2025128614A1 (en) 2023-12-12 2025-06-19 Alnylam Pharmaceuticals, Inc. Methods and compositions for treating an angiotensinogen- (agt-) associated disorder
WO2025130862A1 (zh) * 2023-12-18 2025-06-26 广东东阳光药业股份有限公司 一种新型的双链siRNA、其缀合物及其用途
CN120350001A (zh) * 2024-01-22 2025-07-22 尧唐(上海)生物科技有限公司 靶向AGT基因的gRNA及其应用
WO2026026829A1 (zh) * 2024-07-31 2026-02-05 苏州吉玛基因股份有限公司 靶向血管紧张素原的双链rna分子、其修饰物和应用
CN121450643A (zh) * 2024-08-02 2026-02-03 广东东阳光药业股份有限公司 一种靶向AGT的双链siRNA、其缀合物及其用途
CN118685411B (zh) * 2024-08-27 2024-11-05 苏州炫景生物科技有限公司 抑制agt基因表达的双链寡核苷酸、其缀合物及用途
WO2026050125A1 (en) 2024-08-28 2026-03-05 Alnylam Pharmaceuticals, Inc. Methods and compositions for treating an angiotensinogen- (agt-) associated disorder
CN119040330B (zh) * 2024-11-01 2025-03-04 北京悦康科创医药科技股份有限公司 一种调控AGT基因表达的siRNA及其用途
WO2026108961A1 (zh) * 2024-11-22 2026-05-28 苏州瑞博生物技术股份有限公司 寡核苷酸、寡核苷酸缀合物及组合物和用途
CN119736294A (zh) * 2024-12-24 2025-04-01 瑞孚医药科技（广州）有限公司 一种含碳环核苷的siRNA缀合物及其药物组合物和用途

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