CA3223483A1 - Novel polymer-coated crosslinked alginate gel fiber - Google Patents

Novel polymer-coated crosslinked alginate gel fiber Download PDF

Info

Publication number
CA3223483A1
CA3223483A1 CA3223483A CA3223483A CA3223483A1 CA 3223483 A1 CA3223483 A1 CA 3223483A1 CA 3223483 A CA3223483 A CA 3223483A CA 3223483 A CA3223483 A CA 3223483A CA 3223483 A1 CA3223483 A1 CA 3223483A1
Authority
CA
Canada
Prior art keywords
cell
formula
approximately
alginic acid
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3223483A
Other languages
English (en)
French (fr)
Inventor
Shoji Furusako
Tsutomu Satoh
Tomohiro NARUMI
Shingo Sato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mochida Pharmaceutical Co Ltd
Original Assignee
Mochida Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP2021/048567 external-priority patent/WO2022145420A1/ja
Application filed by Mochida Pharmaceutical Co Ltd filed Critical Mochida Pharmaceutical Co Ltd
Publication of CA3223483A1 publication Critical patent/CA3223483A1/en
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/04Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/04Alginic acid; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/20Material Coatings
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/10Hollow fibers or tubes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M3/00Tissue, human, animal or plant cell, or virus culture apparatus
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/10Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0676Pancreatic cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0681Cells of the genital tract; Non-germinal cells from gonads
    • C12N5/0682Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2511/00Cells for large scale production
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/30Synthetic polymers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/50Proteins
    • C12N2533/54Collagen; Gelatin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/70Polysaccharides
    • C12N2533/74Alginate
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/70Polysaccharides
    • C12N2533/78Cellulose
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2537/00Supports and/or coatings for cell culture characterised by physical or chemical treatment
    • C12N2537/10Cross-linking
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068General culture methods using substrates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Sustainable Development (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Reproductive Health (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Materials For Medical Uses (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
CA3223483A 2021-06-23 2022-06-22 Novel polymer-coated crosslinked alginate gel fiber Pending CA3223483A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2021-104094 2021-06-23
JP2021104094 2021-06-23
JPPCT/JP2021/048567 2021-12-27
PCT/JP2021/048567 WO2022145420A1 (ja) 2020-12-28 2021-12-27 新規な多層ポリマーコーティング架橋アルギン酸ゲルファイバ
PCT/JP2022/024935 WO2022270549A1 (ja) 2021-06-23 2022-06-22 新規なポリマーコーティング架橋アルギン酸ゲルファイバ

Publications (1)

Publication Number Publication Date
CA3223483A1 true CA3223483A1 (en) 2022-12-29

Family

ID=84545455

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3223483A Pending CA3223483A1 (en) 2021-06-23 2022-06-22 Novel polymer-coated crosslinked alginate gel fiber

Country Status (8)

Country Link
US (1) US12312574B2 (https=)
EP (1) EP4361249A4 (https=)
JP (3) JPWO2022270549A1 (https=)
KR (1) KR20240024839A (https=)
CN (2) CN116710110A (https=)
AU (1) AU2022298245A1 (https=)
CA (1) CA3223483A1 (https=)
WO (1) WO2022270549A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019240219A1 (ja) * 2018-06-14 2019-12-19 持田製薬株式会社 新規な架橋アルギン酸
CN113181217A (zh) * 2021-04-28 2021-07-30 吉林大学 一种细胞支架、其搭载胰岛细胞复合物、制备方法、应用
CN117631135B (zh) 2024-01-25 2024-04-09 四川大学 一种双功能柔性水凝胶光纤及其制备方法和应用

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4352883A (en) 1979-03-28 1982-10-05 Damon Corporation Encapsulation of biological material
US4391909A (en) * 1979-03-28 1983-07-05 Damon Corporation Microcapsules containing viable tissue cells
JPS60160885A (ja) * 1984-01-30 1985-08-22 Asama Kasei Kk 固定化した微生物、植物細胞および/または酵素
US5589591A (en) 1986-07-03 1996-12-31 Advanced Magnetics, Inc. Endotoxin-free polysaccharides
WO1993013136A1 (en) 1991-12-20 1993-07-08 Howmedica Inc. Ultra-pure polysaccharide materials for medical use
JP2678431B2 (ja) * 1994-05-06 1997-11-17 ナショナル・サイエンス・カウンシル 細胞培養用の液体コアマイクロカプセルの製造方法及び液体コアマイクロカプセル
JPH08269102A (ja) 1995-03-30 1996-10-15 Shiseido Co Ltd エンドトキシンフリーのβ1,3−グルカン及びその製造法並びに医療用ゲル素材
JPH09324001A (ja) 1996-04-02 1997-12-16 Kyowa Hakko Kogyo Co Ltd ヒアルロン酸ナトリウムの精製法
US6281341B1 (en) 1997-04-30 2001-08-28 Biomm, Inc. & University Of Miami Hetero-polysaccharide conjugate and methods of making and using the same
AU780366B2 (en) 2000-01-20 2005-03-17 Diatranz Otsuka Limited Preparation and xenotransplantation of porcine islets
JP2005036036A (ja) 2003-07-16 2005-02-10 Tanabe Seiyaku Co Ltd エンドトキシン除去方法
WO2005095626A1 (ja) * 2004-03-31 2005-10-13 Nippon Soda Co., Ltd. 固定化生体触媒およびそれを用いた有機酸塩の製造方法
JP4986273B2 (ja) 2005-09-15 2012-07-25 持田製薬株式会社 アルギン酸を含む創傷被覆材
US8815283B2 (en) 2009-06-02 2014-08-26 Mcmaster University Immuno-compatible hydrogel system
JP4901931B2 (ja) 2009-09-18 2012-03-21 大阪瓦斯株式会社 コンロ
EP2489779B1 (en) 2009-10-14 2019-01-09 The University of Tokyo Coated micro gel fibers
EP2680862B1 (en) * 2011-03-04 2016-07-20 Wake Forest University Health Sciences Encapsulated cells for hormone replacement therapy
JP6074765B2 (ja) 2013-01-18 2017-02-08 国立大学法人 東京大学 移植用神経束及びその製造方法
CN103981147B (zh) * 2013-02-08 2017-11-10 中国科学院上海生命科学研究院 一种新的制备肝实质细胞的方法
WO2014171842A1 (en) 2013-04-19 2014-10-23 Living Cell Technologies New Zealand Limited Biocompatible encapsulation system
JP6332782B2 (ja) 2013-06-07 2018-05-30 国立大学法人 鹿児島大学 細胞凝集塊作製法
CN105078923A (zh) 2014-05-07 2015-11-25 中国科学院大连化学物理研究所 Peg原位共价接枝的海藻酸盐微胶囊及其制备和应用
WO2015178427A1 (ja) 2014-05-20 2015-11-26 国立大学法人 東京大学 中空マイクロファイバ
JP6439918B2 (ja) 2014-10-17 2018-12-19 国立大学法人 東京大学 3次元細胞構造体の製造方法
EP3380655A4 (en) 2015-11-25 2019-04-10 NUtech Ventures Large scale cell manufacture system
US11655343B2 (en) * 2016-03-24 2023-05-23 Takeda Pharmaceutical Company Limited Alginate hydrogel compositions
SG11201811763SA (en) * 2016-07-18 2019-02-27 Eth Zuerich B-cell-mimetic cells
KR20190118181A (ko) 2017-02-16 2019-10-17 아지노모토 가부시키가이샤 폴리머 비드
JP7090868B2 (ja) 2017-10-19 2022-06-27 国立大学法人 東京大学 接着剤及びその使用
JP7034467B2 (ja) 2017-10-20 2022-03-14 国立大学法人 東京大学 細胞の三次元培養方法、細胞構造体、細胞構造体の製造方法、細胞の運搬方法及び細胞の保存方法
US20200392439A1 (en) 2017-12-23 2020-12-17 The University Of Tokyo Array and use thereof
JP7346380B2 (ja) 2018-02-28 2023-09-19 持田製薬株式会社 新規光架橋性アルギン酸誘導体
WO2019240219A1 (ja) * 2018-06-14 2019-12-19 持田製薬株式会社 新規な架橋アルギン酸
JP7388722B2 (ja) 2018-08-10 2023-11-29 国立大学法人 東京大学 アルギン酸中空マイクロファイバ
CN114302749A (zh) * 2019-06-28 2022-04-08 持田制药株式会社 使用了化学交联海藻酸的移植用器件
JP6601931B1 (ja) 2019-07-17 2019-11-06 株式会社セルファイバ 細胞ファイバ製造システム、細胞ファイバ製造方法及びプログラム
CN114929754A (zh) 2019-12-18 2022-08-19 持田制药株式会社 新型交联海藻酸
JP2023015413A (ja) 2019-12-18 2023-02-01 持田製薬株式会社 化学架橋アルギン酸ゲルファイバ
JPWO2022145419A1 (https=) * 2020-12-28 2022-07-07
US20240132854A1 (en) * 2020-12-28 2024-04-25 Mochida Pharmaceutical Co., Ltd. Novel multilayer polymer-coated crosslinked alginate gel fiber
JP7789382B2 (ja) 2023-05-03 2025-12-22 Sk8Insoll株式会社 インソール提示システムおよびインソール提示方法

Also Published As

Publication number Publication date
JPWO2022270549A1 (https=) 2022-12-29
JP7545000B2 (ja) 2024-09-03
US12312574B2 (en) 2025-05-27
JP7450793B2 (ja) 2024-03-15
JP2024063159A (ja) 2024-05-10
CN116710110A (zh) 2023-09-05
AU2022298245A1 (en) 2024-01-18
KR20240024839A (ko) 2024-02-26
EP4361249A4 (en) 2025-09-24
CN117529547A (zh) 2024-02-06
WO2022270549A1 (ja) 2022-12-29
US20240174959A1 (en) 2024-05-30
JP2024020393A (ja) 2024-02-14
EP4361249A1 (en) 2024-05-01

Similar Documents

Publication Publication Date Title
US12312574B2 (en) Polymer-coated crosslinked alginate gel fiber
JP7274547B2 (ja) 凝集方法
JP7534219B2 (ja) 移植可能な粒子及び関連方法
Abbadessa et al. A synthetic thermosensitive hydrogel for cartilage bioprinting and its biofunctionalization with polysaccharides
Dankers et al. A modular and supramolecular approach to bioactive scaffolds for tissue engineering
KR102597919B1 (ko) 지속적으로 수확하고 세포 출혈없는 강화된 관류에 의한 세포 배양 과정
EP2428235B1 (de) Verwendung von durch Polymerisation härtbaren Zusammensetzungen zur Herstellung biologisch abbaubarer, bioverträglicher, vernetzter Polymere
Wartenberg et al. Glycosaminoglycan-based cryogels as scaffolds for cell cultivation and tissue regeneration
IL281810B2 (en) Implantable devices for cell therapy and related methods
US20210340481A1 (en) Alginate hollow microfiber
CN1320162A (zh) 三维细胞培养物质及使用它培养细胞的方法
Trossmann et al. Recombinant spider silk bioinks for continuous protein release by encapsulated producer cells
KR20150054850A (ko) 단백질 산생 촉진제
US20240132854A1 (en) Novel multilayer polymer-coated crosslinked alginate gel fiber
Wei et al. Hydrogels to support transplantation of human embryonic stem cell-derived retinal pigment epithelial cells
Urosev et al. Injectable Poly (oligoethylene glycol methacrylate)-based hydrogels fabricated from highly branched precursor polymers: Controlling gel properties by precursor polymer morphology
JP2023015413A (ja) 化学架橋アルギン酸ゲルファイバ
Volkmer et al. 2-(dimethylamino) ethyl methacrylate/(2-hydroxyethyl) methacrylate/α-tricalcium phosphate cryogels for bone repair, preparation and evaluation of the biological response of human trabecular bone-derived cells and mesenchymal stem cells
KR20230123959A (ko) 화학 가교 알긴산을 사용한 이식용 디바이스
US20260008873A1 (en) Covalently photocrosslinked polysaccharides and methods of use thereof
WO2023079524A2 (en) Polymer-interaction molecule conjugates and methods of use
US20240342340A1 (en) Multilayer structure using chemically crosslinked alginic acid
KR20160113710A (ko) 관류 배지
Tariq et al. Novel Hydrophilic Oligomer-Crosslinked Gelatin-Based Hydrogels for Biomedical Applications
Fu et al. Development of ZmT-PEG hydrogels through Michael addition reaction and protein self-assembly for 3D cell culture

Legal Events

Date Code Title Description
MFA Maintenance fee for application paid

Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 3RD ANNIV.) - STANDARD

Year of fee payment: 3

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20250407

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20250407