CA3206549A1 - Methods of making modified tumor infiltrating lymphocytes and their use in adoptive cell therapy - Google Patents

Methods of making modified tumor infiltrating lymphocytes and their use in adoptive cell therapy Download PDF

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Publication number
CA3206549A1
CA3206549A1 CA3206549A CA3206549A CA3206549A1 CA 3206549 A1 CA3206549 A1 CA 3206549A1 CA 3206549 A CA3206549 A CA 3206549A CA 3206549 A CA3206549 A CA 3206549A CA 3206549 A1 CA3206549 A1 CA 3206549A1
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Prior art keywords
tils
population
expansion
days
seq
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CA3206549A
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English (en)
French (fr)
Inventor
Frederick G. Vogt
Maria Fardis
Yongliang Zhang
Cecile Chartier-Courtaud
Rafael CUBAS
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Iovance Biotherapeutics Inc
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Iovance Biotherapeutics Inc
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Publication of CA3206549A1 publication Critical patent/CA3206549A1/en
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
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    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • C07K—PEPTIDES
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    • C07—ORGANIC CHEMISTRY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
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    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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CA3206549A 2021-01-29 2022-01-28 Methods of making modified tumor infiltrating lymphocytes and their use in adoptive cell therapy Pending CA3206549A1 (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US202163143736P 2021-01-29 2021-01-29
US63/143,736 2021-01-29
US202163146486P 2021-02-05 2021-02-05
US63/146,486 2021-02-05
US202163224360P 2021-07-21 2021-07-21
US63/224,360 2021-07-21
US202163277571P 2021-11-09 2021-11-09
US63/277,571 2021-11-09
US202163285956P 2021-12-03 2021-12-03
US63/285,956 2021-12-03
PCT/US2022/014425 WO2022165260A1 (en) 2021-01-29 2022-01-28 Methods of making modified tumor infiltrating lymphocytes and their use in adoptive cell therapy

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CA3206549A1 true CA3206549A1 (en) 2022-08-04

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US20240307437A1 (en) 2024-09-19
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