CA3175110A1 - Human monoclonal antibodies to severe acute respiratory syndrome coronavirus 2 (sars-cov-2) - Google Patents

Human monoclonal antibodies to severe acute respiratory syndrome coronavirus 2 (sars-cov-2)

Info

Publication number
CA3175110A1
CA3175110A1 CA3175110A CA3175110A CA3175110A1 CA 3175110 A1 CA3175110 A1 CA 3175110A1 CA 3175110 A CA3175110 A CA 3175110A CA 3175110 A CA3175110 A CA 3175110A CA 3175110 A1 CA3175110 A1 CA 3175110A1
Authority
CA
Canada
Prior art keywords
antibody
seq
amino acid
acid sequence
antibody fragment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3175110A
Other languages
English (en)
French (fr)
Inventor
James E. Crowe, Jr.
Seth ZOST
Robert Carnahan
Pavlo Gilchuk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vanderbilt University
Original Assignee
Vanderbilt University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vanderbilt University filed Critical Vanderbilt University
Publication of CA3175110A1 publication Critical patent/CA3175110A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/102—Coronaviridae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/102—Coronaviridae (F)
    • C07K16/104—Severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/165—Coronaviridae, e.g. avian infectious bronchitis virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/10—Detection of antigens from microorganism in sample from host

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA3175110A 2020-03-26 2021-03-25 Human monoclonal antibodies to severe acute respiratory syndrome coronavirus 2 (sars-cov-2) Pending CA3175110A1 (en)

Applications Claiming Priority (25)

Application Number Priority Date Filing Date Title
US202063000299P 2020-03-26 2020-03-26
US63/000,299 2020-03-26
US202063002896P 2020-03-31 2020-03-31
US63/002,896 2020-03-31
US202063003716P 2020-04-01 2020-04-01
US63/003,716 2020-04-01
US202063023545P 2020-05-12 2020-05-12
US63/023,545 2020-05-12
US202063024248P 2020-05-13 2020-05-13
US202063024204P 2020-05-13 2020-05-13
US63/024,248 2020-05-13
US63/024,204 2020-05-13
US202063027173P 2020-05-19 2020-05-19
US63/027,173 2020-05-19
US202063037984P 2020-06-11 2020-06-11
US63/037,984 2020-06-11
US202063040246P 2020-06-17 2020-06-17
US202063040224P 2020-06-17 2020-06-17
US63/040,224 2020-06-17
US63/040,246 2020-06-17
US202163142196P 2021-01-27 2021-01-27
US63/142,196 2021-01-27
US202163161890P 2021-03-16 2021-03-16
US63/161,890 2021-03-16
PCT/US2021/024215 WO2021195418A1 (en) 2020-03-26 2021-03-25 Human monoclonal antibodies to severe acute respiratory syndrome coronavirus 2 (sars-cov-2)

Publications (1)

Publication Number Publication Date
CA3175110A1 true CA3175110A1 (en) 2021-09-30

Family

ID=75540042

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3175110A Pending CA3175110A1 (en) 2020-03-26 2021-03-25 Human monoclonal antibodies to severe acute respiratory syndrome coronavirus 2 (sars-cov-2)

Country Status (31)

Country Link
US (2) US11345741B2 (https=)
EP (2) EP4045533B1 (https=)
JP (1) JP7819926B2 (https=)
KR (1) KR20220158053A (https=)
CN (1) CN115768790A (https=)
AU (1) AU2021242306B2 (https=)
BR (1) BR112022018949A2 (https=)
CA (1) CA3175110A1 (https=)
CL (1) CL2022002594A1 (https=)
CO (1) CO2022014820A2 (https=)
CR (1) CR20220545A (https=)
DK (1) DK4045533T5 (https=)
DO (1) DOP2022000199A (https=)
EC (1) ECSP22083269A (https=)
ES (1) ES2973425T3 (https=)
FI (1) FI4045533T3 (https=)
HR (1) HRP20240182T1 (https=)
HU (1) HUE065039T2 (https=)
IL (1) IL296537A (https=)
LT (1) LT4045533T (https=)
MX (1) MX2022011892A (https=)
PE (1) PE20230415A1 (https=)
PH (1) PH12022552500A1 (https=)
PL (1) PL4045533T3 (https=)
PT (1) PT4045533T (https=)
RS (1) RS65199B1 (https=)
SI (1) SI4045533T1 (https=)
SM (1) SMT202400070T1 (https=)
TW (1) TWI896628B (https=)
UY (1) UY39135A (https=)
WO (1) WO2021195418A1 (https=)

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TW202342095A (zh) * 2021-11-05 2023-11-01 英商阿斯特捷利康英國股份有限公司 用於治療和預防ｃｏｖｉｄ—１９之組成物
WO2023108936A1 (zh) * 2021-12-14 2023-06-22 杭州安旭生物科技股份有限公司 一种可结合SARS-CoV-2病毒的中和抗体及其应用
TW202342510A (zh) 2022-02-18 2023-11-01 英商Ｒｑ生物科技有限公司 抗體
CA3256035A1 (en) 2022-04-14 2023-10-19 Invisishield Technologies Ltd. COMPOSITIONS FOR PREVENTING OR TREATMENT OF CORONAVIRUS INFECTIONS
WO2023201306A1 (en) 2022-04-14 2023-10-19 Invisishield Technologies Ltd. Compositions for preventing or treating influenza infections
JP2025514858A (ja) * 2022-04-29 2025-05-09 アストラゼネカ・ユーケイ・リミテッド ＳＡＲＳ－ＣｏＶ－２抗体、及びその使用方法
CN114870061B (zh) * 2022-05-31 2024-09-24 康码（上海）生物科技有限公司 一种基于病毒阻断剂的空气喷雾剂及其用途
WO2024019110A1 (ja) * 2022-07-20 2024-01-25 国立感染症研究所長が代表する日本国 ＳＡＲＳ－ＣｏＶ－２に対する抗体
CN115925934B (zh) * 2022-07-26 2025-11-07 北京昌平实验室 一种稳定性提高的人源化单克隆抗体及其应用
CN116284270A (zh) * 2022-12-29 2023-06-23 北京吉诺卫生物科技有限公司 新型三聚体重组蛋白疫苗
CN118240073B (zh) * 2024-04-19 2026-01-30 四川大学 一种对新型冠状病毒原始株和变异株S-RBD具有pH依赖结合特性的纳米抗体改造及其潜在应用

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