CA3138529C - Materials and methods for producing blood products - Google Patents

Materials and methods for producing blood products

Info

Publication number
CA3138529C
CA3138529C CA3138529A CA3138529A CA3138529C CA 3138529 C CA3138529 C CA 3138529C CA 3138529 A CA3138529 A CA 3138529A CA 3138529 A CA3138529 A CA 3138529A CA 3138529 C CA3138529 C CA 3138529C
Authority
CA
Canada
Prior art keywords
processes
materials
blood products
production
aqueous medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3138529A
Other languages
English (en)
French (fr)
Other versions
CA3138529A1 (en
Inventor
Joshua Donald Montgomery
Braden Carl Ishler
Stephen Edward Amos
Keith Andrew Moskowitz
Amber Nicole Lee
Rafael Jorda
Glen Michael Fitzpatrick
Michael Alexander Mathews
Original Assignee
Cellphire Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellphire Inc filed Critical Cellphire Inc
Publication of CA3138529A1 publication Critical patent/CA3138529A1/en
Application granted granted Critical
Publication of CA3138529C publication Critical patent/CA3138529C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/19—Platelets; Megacaryocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0281—Apparatus for treatment of blood or blood constituents prior to transfusion, e.g. washing, filtering or thawing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3413—Diafiltration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3496—Plasmapheresis; Leucopheresis; Lymphopheresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/38—Removing constituents from donor blood and storing or returning remainder to body, e.g. for transfusion
    • A61M1/382—Optimisation of blood component yield
    • A61M1/385—Optimisation of blood component yield taking into account of the patient characteristics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0644—Platelets; Megakaryocytes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/12—Addition of chemical agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/10—Cross-flow filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/16—Diafiltration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2531/00—Microcarriers

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Vascular Medicine (AREA)
  • Water Supply & Treatment (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Anesthesiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Developmental Biology & Embryology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • External Artificial Organs (AREA)
  • Medicinal Preparation (AREA)
CA3138529A 2019-05-03 2020-05-01 Materials and methods for producing blood products Active CA3138529C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962843061P 2019-05-03 2019-05-03
US62/843,061 2019-05-03
US201962936122P 2019-11-15 2019-11-15
US62/936,122 2019-11-15
PCT/US2020/031172 WO2020227149A1 (en) 2019-05-03 2020-05-01 Materials and methods for producing blood products

Publications (2)

Publication Number Publication Date
CA3138529A1 CA3138529A1 (en) 2020-11-12
CA3138529C true CA3138529C (en) 2025-10-07

Family

ID=73017071

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3138529A Active CA3138529C (en) 2019-05-03 2020-05-01 Materials and methods for producing blood products

Country Status (11)

Country Link
US (4) US11529587B2 (he)
EP (1) EP3962499A4 (he)
JP (2) JP7640531B2 (he)
KR (1) KR20220016092A (he)
CN (1) CN114072159A (he)
AU (2) AU2020267368B2 (he)
BR (1) BR112021021984A2 (he)
CA (1) CA3138529C (he)
IL (2) IL322149A (he)
SG (1) SG11202112054WA (he)
WO (1) WO2020227149A1 (he)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020112963A1 (en) 2018-11-30 2020-06-04 Cellphire, Inc. Platelets as delivery agents
US20200224164A1 (en) 2018-11-30 2020-07-16 Cellphire, Inc. Platelets as delivery agents
IL322149A (he) 2019-05-03 2025-09-01 Cellphire Inc חומרים ושיטות לייצור מוצרי דם
WO2021011857A1 (en) * 2019-07-17 2021-01-21 Cellphire, Inc. Use of platelets in treating infections
WO2023220739A1 (en) * 2022-05-12 2023-11-16 Cellphire, Inc. Platelet derivative compositions for use in subjects afflicted with hermansky pudlak syndrome or bernard soulier syndrome
WO2023081804A1 (en) * 2021-11-04 2023-05-11 Cellphire, Inc. Platelet derivative compositions, and methods of making and using such compositions
IL290586B1 (he) 2019-08-16 2025-08-01 Cellphire Inc טרומבוזומים כחומר הפיכה נוגד טסיות דם
WO2022178177A1 (en) * 2021-02-17 2022-08-25 Cellphire, Inc. Freeze-dried platelet derivative compositions for treating antiplatelet-induced coagulopathy
CA3170196A1 (en) 2020-02-04 2021-08-12 Cellphire, Inc. Anti-fibrinolytic loaded platelets
US20220273724A1 (en) 2021-02-17 2022-09-01 Cellphire Inc. Freeze-dried platelet derivative compositions for treating antiplatelet induced coagulopathy
WO2022178191A1 (en) * 2021-02-17 2022-08-25 Cellphire, Inc. Freeze-dried platelet derivative compositions for treating anticoagulant-induced coagulopathy
US20240164367A1 (en) * 2021-04-20 2024-05-23 Retham Technologies, Llc Methods for maintaining long-term platelet viability and activatability
CN115462369B (zh) * 2022-09-29 2023-09-22 安徽省立医院(中国科学技术大学附属第一医院) 一种玻璃化冷冻外泌体保存方法
CN121013903A (zh) * 2023-03-08 2025-11-25 艾慕优股份有限公司 用于全血保存的组合物和方法
WO2024192173A1 (en) 2023-03-14 2024-09-19 Cellphire, Inc. Hla-characterized platelet derivative compositions, and methods of making, selecting and using such compositions
WO2024229305A1 (en) 2023-05-03 2024-11-07 Cellphire, Inc. Platelet derivative compositions for use in controlling bleeding in a subject
WO2024233577A1 (en) 2023-05-11 2024-11-14 Vetstem, Inc. Platelet-rich plasma compositions, preparation, and uses thereof

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