CA3054605A1 - Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists - Google Patents

Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists Download PDF

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Publication number
CA3054605A1
CA3054605A1 CA3054605A CA3054605A CA3054605A1 CA 3054605 A1 CA3054605 A1 CA 3054605A1 CA 3054605 A CA3054605 A CA 3054605A CA 3054605 A CA3054605 A CA 3054605A CA 3054605 A1 CA3054605 A1 CA 3054605A1
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Canada
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CA3054605A
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English (en)
French (fr)
Inventor
John L. Magnani
John M. Peterson
Arun K. Sarkar
Yusufbhai U. VOHRA
Myung-Gi Baek
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Crescent Biopharma Inc
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Glycomimetics Inc
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Publication of CA3054605A1 publication Critical patent/CA3054605A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/207—Cyclohexane rings not substituted by nitrogen atoms, e.g. kasugamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
CA3054605A 2017-03-15 2018-03-12 Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists Pending CA3054605A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762471860P 2017-03-15 2017-03-15
US62/471,860 2017-03-15
PCT/US2018/021977 WO2018169853A1 (en) 2017-03-15 2018-03-12 Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists

Publications (1)

Publication Number Publication Date
CA3054605A1 true CA3054605A1 (en) 2018-09-20

Family

ID=61768538

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3054605A Pending CA3054605A1 (en) 2017-03-15 2018-03-12 Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists

Country Status (5)

Country Link
US (3) US11197877B2 (enExample)
EP (1) EP3596096A1 (enExample)
JP (2) JP7272956B2 (enExample)
CA (1) CA3054605A1 (enExample)
WO (1) WO2018169853A1 (enExample)

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* Cited by examiner, † Cited by third party
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JP7275131B2 (ja) 2017-11-30 2023-05-17 グリコミメティクス， インコーポレイテッド 骨髄浸潤リンパ球を動員する方法、およびその使用
AU2018395417B2 (en) 2017-12-29 2023-07-13 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
JP7225539B2 (ja) * 2018-01-31 2023-02-21 株式会社三洋物産 遊技機
JP7225540B2 (ja) * 2018-01-31 2023-02-21 株式会社三洋物産 遊技機
JP7225538B2 (ja) * 2018-01-31 2023-02-21 株式会社三洋物産 遊技機
WO2019173229A1 (en) 2018-03-05 2019-09-12 Glycomimetics, Inc. Methods for treating acute myeloid leukemia and related conditions
JP2020069140A (ja) * 2018-10-31 2020-05-07 株式会社三洋物産 遊技機
JP2020069143A (ja) * 2018-10-31 2020-05-07 株式会社三洋物産 遊技機
JP2020069137A (ja) * 2018-10-31 2020-05-07 株式会社三洋物産 遊技機
JP2020069141A (ja) * 2018-10-31 2020-05-07 株式会社三洋物産 遊技機
US11845771B2 (en) * 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
JP2020146312A (ja) * 2019-03-14 2020-09-17 株式会社三洋物産 遊技機
JP2020146311A (ja) * 2019-03-14 2020-09-17 株式会社三洋物産 遊技機
US20220220144A1 (en) * 2019-04-24 2022-07-14 Glycomimetics, Inc. Multimeric pan-selectin antagonists
EP3997247A1 (en) * 2019-07-12 2022-05-18 GlycoMimetics, Inc. Methods for use of gene expression as an indicator of e-selectin inhibitor efficacy and clinical outcome for multiple tumor types
CN116113637A (zh) * 2020-09-17 2023-05-12 糖模拟物有限公司 E-选择素靶向剂

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