CA3051051A1 - Method and device for processing tissues and cells - Google Patents

Method and device for processing tissues and cells Download PDF

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Publication number
CA3051051A1
CA3051051A1 CA3051051A CA3051051A CA3051051A1 CA 3051051 A1 CA3051051 A1 CA 3051051A1 CA 3051051 A CA3051051 A CA 3051051A CA 3051051 A CA3051051 A CA 3051051A CA 3051051 A1 CA3051051 A1 CA 3051051A1
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CA
Canada
Prior art keywords
sample
processing samples
support plate
microfluidic
microfluidic chip
Prior art date
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Pending
Application number
CA3051051A
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English (en)
French (fr)
Inventor
Ahmed ZOBI
Justin STOVNER
Hugo SALAS
David Duarte
Jered Haun
Alan WIDGEROW
Derek BANYARD
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University of California San Diego UCSD
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University of California San Diego UCSD
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Application filed by University of California San Diego UCSD filed Critical University of California San Diego UCSD
Publication of CA3051051A1 publication Critical patent/CA3051051A1/en
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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    • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B04B9/10—Control of the drive; Speed regulating
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    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
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    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883—Serpentine channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00158—Elements containing microarrays, i.e. "biochip"
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements
    • G01N2035/00495—Centrifuges
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0439—Rotary sample carriers, i.e. carousels
    • G01N2035/0446—Combinations of the above
    • G01N2035/0449—Combinations of the above using centrifugal transport of liquid

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Molecular Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Combined Means For Separation Of Solids (AREA)
  • Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
  • Filtration Of Liquid (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Centrifugal Separators (AREA)
CA3051051A 2016-06-08 2017-06-07 Method and device for processing tissues and cells Pending CA3051051A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662347290P 2016-06-08 2016-06-08
US62/347,290 2016-06-08
PCT/US2017/036429 WO2017214323A1 (en) 2016-06-08 2017-06-07 Method and device for processing tissues and cells

Publications (1)

Publication Number Publication Date
CA3051051A1 true CA3051051A1 (en) 2017-12-14

Family

ID=60578121

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3051051A Pending CA3051051A1 (en) 2016-06-08 2017-06-07 Method and device for processing tissues and cells

Country Status (9)

Country Link
US (3) US10589268B2 (enExample)
EP (1) EP3469374A4 (enExample)
JP (2) JP7072228B2 (enExample)
KR (4) KR102370343B1 (enExample)
CN (2) CN109564231B (enExample)
BR (1) BR112018075194B1 (enExample)
CA (1) CA3051051A1 (enExample)
IL (3) IL263422B (enExample)
WO (1) WO2017214323A1 (enExample)

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CN109174382A (zh) * 2018-09-19 2019-01-11 北京新星靓京广医疗美容医院有限公司 一种点对点定向脂肪移植的装置
WO2020100039A1 (en) * 2018-11-13 2020-05-22 National Research Council Of Canada World-to-chip automated interface for centrifugal microfluidic platforms

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WO2019232100A1 (en) 2018-05-30 2019-12-05 The Regents Of The University Of California Microfluidic filter device and method for dissociation of tissue and cell aggregates and enrichment of single cells
US11291997B2 (en) * 2018-08-02 2022-04-05 Colorado State University Research Foundation Rotary manifold for paper-based immunoassays
WO2020036869A1 (en) 2018-08-16 2020-02-20 Emd Millipore Corporation Closed bioprocessing device
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CN110302851A (zh) * 2019-04-24 2019-10-08 山东科技大学 基于微流体控制与贾敏效应观测的实验系统及其实验方法
US12453812B2 (en) 2019-06-24 2025-10-28 The Regents Of The University Of California Integrated system for mechanical processing of lipoaspirate
CN110243750B (zh) * 2019-06-28 2024-05-03 佛山科学技术学院 一种采样器及应用该采样器的流式细胞仪
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KR102081615B1 (ko) * 2019-10-07 2020-02-26 주식회사 미리메딕스 체외진단에 사용되는 비전기식 휴대용 시료 및 시약 혼합 장치
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CN111298854B (zh) * 2020-02-27 2021-08-06 西人马联合测控（泉州）科技有限公司 芯片的成型方法以及晶圆
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KR20230008875A (ko) * 2020-05-11 2023-01-16 신틀 헬스 테크놀로지스 인코포레이티드 조직 및 세포 처리 방법 및 장치
KR102424845B1 (ko) * 2020-07-30 2022-07-25 재단법인대구경북과학기술원 미세 유동 장치
CA3198587A1 (en) * 2020-10-12 2022-04-21 The Regents Of The University Of California Integrated microfluidic system for the processing of tissues into cellular suspensions
KR102561447B1 (ko) * 2020-12-23 2023-08-01 성균관대학교산학협력단 유체다이오드 및 유체이송장치
CN117157531A (zh) * 2020-12-31 2023-12-01 映泰健康医疗科技有限公司 活塞机构、流体控制机构及其应用
CN112791645B (zh) * 2021-01-26 2022-05-13 驻马店职业技术学院 流体驱动控制阀
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US20230330658A1 (en) * 2022-04-18 2023-10-19 Saudi Arabian Oil Company Calcite coated microfluidic cell and methods thereof
KR102711038B1 (ko) * 2022-05-06 2024-09-27 충남대학교산학협력단 미세유체 시스템
CN114949985B (zh) * 2022-06-30 2023-06-20 山东和光智慧能源科技有限公司 一种可快速拆装π型除污器
CN115322875B (zh) * 2022-08-12 2023-06-30 中科院南昌高新技术产业协同创新研究院 干细胞预处理装置和方法
WO2024085844A2 (en) * 2022-10-20 2024-04-25 Izmir Yuksek Teknoloji Enstitusu Rektorlugu Closed-channel microfluidic platform working with centrifugal principle
WO2024206527A2 (en) * 2023-03-28 2024-10-03 The Regents Of The University Of California Fluidic device for washing of lipoaspirate
WO2025105824A1 (ko) * 2023-11-14 2025-05-22 고려대학교 산학협력단 원심력을 이용한 디스크 기반 지질 나노입자 제조용 미세유체 플랫폼 및 이를 이용한 방법
CN118518454B (zh) * 2024-07-23 2024-09-13 天津医科大学第二医院 一种适用于质谱检测的样本预处理装置

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JP2022109993A (ja) 2022-07-28
JP7072228B2 (ja) 2022-05-20
JP2019526036A (ja) 2019-09-12

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