CA2996989C - Bi-heteroaryl substituted 1,4-benzodiazepines and uses thereof for the treatment of cancer - Google Patents

Bi-heteroaryl substituted 1,4-benzodiazepines and uses thereof for the treatment of cancer Download PDF

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Publication number
CA2996989C
CA2996989C CA2996989A CA2996989A CA2996989C CA 2996989 C CA2996989 C CA 2996989C CA 2996989 A CA2996989 A CA 2996989A CA 2996989 A CA2996989 A CA 2996989A CA 2996989 C CA2996989 C CA 2996989C
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compound
formula
cancer
compounds
treatment
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English (en)
French (fr)
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CA2996989A1 (en
Inventor
Patrick Rene Angibaud
Diego Fernando Domenico BROGGINI
Filip Albert C Cuyckens
Steven Anna HOSTYN
Russell Mark JONES
Olivier Alexis Georges Querolle
Wim Vermeulen
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Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA2996989A 2015-09-23 2016-09-22 Bi-heteroaryl substituted 1,4-benzodiazepines and uses thereof for the treatment of cancer Active CA2996989C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15186478.2 2015-09-23
EP15186478 2015-09-23
PCT/EP2016/072501 WO2017050865A1 (en) 2015-09-23 2016-09-22 Bi-heteroaryl substituted 1,4-benzodiazepines and uses thereof for the treatment of cancer

Publications (2)

Publication Number Publication Date
CA2996989A1 CA2996989A1 (en) 2017-03-30
CA2996989C true CA2996989C (en) 2023-10-03

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA2996989A Active CA2996989C (en) 2015-09-23 2016-09-22 Bi-heteroaryl substituted 1,4-benzodiazepines and uses thereof for the treatment of cancer

Country Status (17)

Country Link
US (2) US11542247B2 (https=)
EP (1) EP3353164B1 (https=)
JP (1) JP6896711B2 (https=)
KR (1) KR102691777B1 (https=)
CN (1) CN108137546B (https=)
AU (1) AU2016328693B2 (https=)
BR (1) BR112018005625B1 (https=)
CA (1) CA2996989C (https=)
DK (1) DK3353164T3 (https=)
ES (1) ES2904513T3 (https=)
HR (1) HRP20220012T1 (https=)
HU (1) HUE057090T2 (https=)
LT (1) LT3353164T (https=)
MX (1) MX378230B (https=)
RU (1) RU2747644C2 (https=)
SI (1) SI3353164T1 (https=)
WO (1) WO2017050865A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11155555B2 (en) * 2015-09-23 2021-10-26 Janssen Pharmaceutica Nv Compounds
JP2023520916A (ja) * 2020-04-08 2023-05-22 リミックス セラピューティクス インコーポレイテッド スプライシングを調整するための化合物及び方法

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