CA2994829A1 - Bispecific car t-cells for solid tumor targeting - Google Patents

Bispecific car t-cells for solid tumor targeting Download PDF

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Publication number
CA2994829A1
CA2994829A1 CA2994829A CA2994829A CA2994829A1 CA 2994829 A1 CA2994829 A1 CA 2994829A1 CA 2994829 A CA2994829 A CA 2994829A CA 2994829 A CA2994829 A CA 2994829A CA 2994829 A1 CA2994829 A1 CA 2994829A1
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nucleic acid
cell
specific
alternatives
cells
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French (fr)
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Michael C. Jensen
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Seattle Childrens Hospital
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Seattle Childrens Hospital
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    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • AHUMAN NECESSITIES
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    • A61K40/00Cellular immunotherapy
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
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    • A61K40/31Chimeric antigen receptors [CAR]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
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    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
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    • A61K40/4203Receptors for growth factors
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    • AHUMAN NECESSITIES
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    • A61K40/00Cellular immunotherapy
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    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
    • A61K40/4202Receptors, cell surface antigens or cell surface determinants
    • A61K40/421Immunoglobulin superfamily
    • A61K40/4211CD19 or B4
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/70503Immunoglobulin superfamily
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    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K2319/00Fusion polypeptide
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    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16041Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Biotechnology (AREA)
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  • Developmental Biology & Embryology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA2994829A 2015-08-07 2016-08-03 Bispecific car t-cells for solid tumor targeting Pending CA2994829A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562202698P 2015-08-07 2015-08-07
US62/202,698 2015-08-07
PCT/US2016/045360 WO2017027291A1 (en) 2015-08-07 2016-08-03 Bispecific car t-cells for solid tumor targeting

Publications (1)

Publication Number Publication Date
CA2994829A1 true CA2994829A1 (en) 2017-02-16

Family

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CA2994829A Pending CA2994829A1 (en) 2015-08-07 2016-08-03 Bispecific car t-cells for solid tumor targeting

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US (3) US11458167B2 (cg-RX-API-DMAC7.html)
EP (1) EP3331920A4 (cg-RX-API-DMAC7.html)
JP (3) JP7162530B2 (cg-RX-API-DMAC7.html)
CN (1) CN108174604B (cg-RX-API-DMAC7.html)
AU (2) AU2016306209B2 (cg-RX-API-DMAC7.html)
CA (1) CA2994829A1 (cg-RX-API-DMAC7.html)
HK (1) HK1256087A1 (cg-RX-API-DMAC7.html)
MX (1) MX2018001568A (cg-RX-API-DMAC7.html)
WO (1) WO2017027291A1 (cg-RX-API-DMAC7.html)

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CN111315872A (zh) * 2017-06-30 2020-06-19 纪念斯隆-凯特林癌症中心 用于癌症的过继性细胞疗法的组合物和方法
WO2021019472A1 (en) * 2019-07-30 2021-02-04 University Health Network T cell receptors and methods of use thereof
EP3645019A4 (en) * 2017-06-30 2021-08-25 Memorial Sloan-Kettering Cancer Center COMPOSITIONS AND PROCEDURES FOR ADOPTIVE CELL THERAPY
US12241097B2 (en) 2017-06-30 2025-03-04 Memorial Sloan Kettering Cancer Center Compositions and methods for adoptive cell therapy for cancer

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RU2763795C2 (ru) 2014-04-23 2022-01-11 Джуно Терапьютикс, Инк. Способы выделения, культивирования и генетической инженерии популяций клеток иммунной системы для адоптивной терапии
EP4400516A1 (en) 2014-12-15 2024-07-17 The Regents of the University of California Bispecific or-gate chimeric antigen receptor responsive to cd19 and cd20
WO2017027291A1 (en) * 2015-08-07 2017-02-16 Seattle Children's Hospital (dba Seattle Children's Research Institute) Bispecific car t-cells for solid tumor targeting
EP3411393B1 (en) 2016-02-05 2021-04-07 City of Hope Administration of engineered t cells for treatment of cancers in the central nervous system
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