CA2987844A1 - Method for preparing transmembrane ph-gradient vesicles - Google Patents

Method for preparing transmembrane ph-gradient vesicles

Info

Publication number
CA2987844A1
CA2987844A1 CA2987844A CA2987844A CA2987844A1 CA 2987844 A1 CA2987844 A1 CA 2987844A1 CA 2987844 A CA2987844 A CA 2987844A CA 2987844 A CA2987844 A CA 2987844A CA 2987844 A1 CA2987844 A1 CA 2987844A1
Authority
CA
Canada
Prior art keywords
vesicles
mosm
buffer
osmolarity
basic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA2987844A
Other languages
English (en)
French (fr)
Inventor
Jean-Christophe Leroux
Vincent Forster
Valentina AGOSTONI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Versantis AG
Original Assignee
Versantis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Versantis AG filed Critical Versantis AG
Publication of CA2987844A1 publication Critical patent/CA2987844A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1273—Polymersomes; Liposomes with polymerisable or polymerised bilayer-forming substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA2987844A 2015-05-04 2016-05-03 Method for preparing transmembrane ph-gradient vesicles Pending CA2987844A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15166247.5 2015-05-04
EP15166247 2015-05-04
PCT/EP2016/059912 WO2016177741A1 (en) 2015-05-04 2016-05-03 Method for preparing transmembrane ph-gradient vesicles

Publications (1)

Publication Number Publication Date
CA2987844A1 true CA2987844A1 (en) 2016-11-10

Family

ID=53052718

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2987844A Pending CA2987844A1 (en) 2015-05-04 2016-05-03 Method for preparing transmembrane ph-gradient vesicles

Country Status (12)

Country Link
US (2) US11376218B2 (enExample)
EP (1) EP3291797B1 (enExample)
JP (1) JP6715265B2 (enExample)
CN (1) CN107750156B (enExample)
AU (1) AU2016256979B2 (enExample)
CA (1) CA2987844A1 (enExample)
DK (1) DK3291797T3 (enExample)
ES (1) ES2826896T3 (enExample)
MX (1) MX381655B (enExample)
PT (1) PT3291797T (enExample)
RU (1) RU2717824C2 (enExample)
WO (1) WO2016177741A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107750156B (zh) * 2015-05-04 2020-08-21 沃桑缇斯股份公司 用于制备跨膜pH梯度囊泡的方法
WO2022106425A1 (en) 2020-11-17 2022-05-27 Genfit Methods of treatment of liver failure
AU2023381087A1 (en) 2022-11-16 2025-05-08 Genfit Use of transmembrane ph gradient liposomes for treating hyperammonemic crisis associated with inborn errors of metabolism

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Also Published As

Publication number Publication date
JP2018519370A (ja) 2018-07-19
US20180104189A1 (en) 2018-04-19
HK1250663A1 (en) 2019-01-11
CN107750156B (zh) 2020-08-21
CN107750156A (zh) 2018-03-02
MX381655B (es) 2025-03-13
DK3291797T3 (da) 2020-09-21
JP6715265B2 (ja) 2020-07-01
RU2017141919A3 (enExample) 2019-09-20
RU2717824C2 (ru) 2020-03-26
EP3291797A1 (en) 2018-03-14
RU2017141919A (ru) 2019-06-04
EP3291797B1 (en) 2020-09-02
ES2826896T3 (es) 2021-05-19
BR112017023578A2 (pt) 2018-09-04
MX2017014130A (es) 2018-07-06
PT3291797T (pt) 2020-10-19
AU2016256979A1 (en) 2017-12-07
WO2016177741A1 (en) 2016-11-10
AU2016256979B2 (en) 2021-01-28
US12427112B2 (en) 2025-09-30
US20220287971A1 (en) 2022-09-15
US11376218B2 (en) 2022-07-05

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