RU2717824C2 - СПОСОБ ПОЛУЧЕНИЯ ВЕЗИКУЛ С ТРАНСМЕМБРАННЫМ ГРАДИЕНТОМ pH - Google Patents

СПОСОБ ПОЛУЧЕНИЯ ВЕЗИКУЛ С ТРАНСМЕМБРАННЫМ ГРАДИЕНТОМ pH Download PDF

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RU2717824C2
RU2717824C2 RU2017141919A RU2017141919A RU2717824C2 RU 2717824 C2 RU2717824 C2 RU 2717824C2 RU 2017141919 A RU2017141919 A RU 2017141919A RU 2017141919 A RU2017141919 A RU 2017141919A RU 2717824 C2 RU2717824 C2 RU 2717824C2
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RU2017141919A3 (enExample
RU2017141919A (ru
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Жан-Кристоф ЛЕРУ
Винсент Форстер
Валентина АГОСТОНИ
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Ферзантис Аг
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1273—Polymersomes; Liposomes with polymerisable or polymerised bilayer-forming substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU2017141919A 2015-05-04 2016-05-03 СПОСОБ ПОЛУЧЕНИЯ ВЕЗИКУЛ С ТРАНСМЕМБРАННЫМ ГРАДИЕНТОМ pH RU2717824C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15166247.5 2015-05-04
EP15166247 2015-05-04
PCT/EP2016/059912 WO2016177741A1 (en) 2015-05-04 2016-05-03 Method for preparing transmembrane ph-gradient vesicles

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RU2017141919A RU2017141919A (ru) 2019-06-04
RU2017141919A3 RU2017141919A3 (enExample) 2019-09-20
RU2717824C2 true RU2717824C2 (ru) 2020-03-26

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US (2) US11376218B2 (enExample)
EP (1) EP3291797B1 (enExample)
JP (1) JP6715265B2 (enExample)
CN (1) CN107750156B (enExample)
AU (1) AU2016256979B2 (enExample)
CA (1) CA2987844A1 (enExample)
DK (1) DK3291797T3 (enExample)
ES (1) ES2826896T3 (enExample)
MX (1) MX381655B (enExample)
PT (1) PT3291797T (enExample)
RU (1) RU2717824C2 (enExample)
WO (1) WO2016177741A1 (enExample)

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Publication number Priority date Publication date Assignee Title
CN107750156B (zh) * 2015-05-04 2020-08-21 沃桑缇斯股份公司 用于制备跨膜pH梯度囊泡的方法
WO2022106425A1 (en) 2020-11-17 2022-05-27 Genfit Methods of treatment of liver failure
AU2023381087A1 (en) 2022-11-16 2025-05-08 Genfit Use of transmembrane ph gradient liposomes for treating hyperammonemic crisis associated with inborn errors of metabolism

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JP2018519370A (ja) 2018-07-19
US20180104189A1 (en) 2018-04-19
HK1250663A1 (en) 2019-01-11
CN107750156B (zh) 2020-08-21
CN107750156A (zh) 2018-03-02
MX381655B (es) 2025-03-13
DK3291797T3 (da) 2020-09-21
JP6715265B2 (ja) 2020-07-01
RU2017141919A3 (enExample) 2019-09-20
EP3291797A1 (en) 2018-03-14
RU2017141919A (ru) 2019-06-04
EP3291797B1 (en) 2020-09-02
ES2826896T3 (es) 2021-05-19
BR112017023578A2 (pt) 2018-09-04
MX2017014130A (es) 2018-07-06
PT3291797T (pt) 2020-10-19
AU2016256979A1 (en) 2017-12-07
WO2016177741A1 (en) 2016-11-10
AU2016256979B2 (en) 2021-01-28
US12427112B2 (en) 2025-09-30
US20220287971A1 (en) 2022-09-15
US11376218B2 (en) 2022-07-05
CA2987844A1 (en) 2016-11-10

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