PT3291797T - Método para preparar vesículas de gradiente de ph transmembranar - Google Patents

Método para preparar vesículas de gradiente de ph transmembranar

Info

Publication number
PT3291797T
PT3291797T PT167245976T PT16724597T PT3291797T PT 3291797 T PT3291797 T PT 3291797T PT 167245976 T PT167245976 T PT 167245976T PT 16724597 T PT16724597 T PT 16724597T PT 3291797 T PT3291797 T PT 3291797T
Authority
PT
Portugal
Prior art keywords
transmembrane
preparing
gradient vesicles
vesicles
gradient
Prior art date
Application number
PT167245976T
Other languages
English (en)
Portuguese (pt)
Original Assignee
Versantis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Versantis AG filed Critical Versantis AG
Publication of PT3291797T publication Critical patent/PT3291797T/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1273—Polymersomes; Liposomes with polymerisable or polymerised bilayer-forming substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PT167245976T 2015-05-04 2016-05-03 Método para preparar vesículas de gradiente de ph transmembranar PT3291797T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15166247 2015-05-04

Publications (1)

Publication Number Publication Date
PT3291797T true PT3291797T (pt) 2020-10-19

Family

ID=53052718

Family Applications (1)

Application Number Title Priority Date Filing Date
PT167245976T PT3291797T (pt) 2015-05-04 2016-05-03 Método para preparar vesículas de gradiente de ph transmembranar

Country Status (12)

Country Link
US (2) US11376218B2 (enExample)
EP (1) EP3291797B1 (enExample)
JP (1) JP6715265B2 (enExample)
CN (1) CN107750156B (enExample)
AU (1) AU2016256979B2 (enExample)
CA (1) CA2987844A1 (enExample)
DK (1) DK3291797T3 (enExample)
ES (1) ES2826896T3 (enExample)
MX (1) MX381655B (enExample)
PT (1) PT3291797T (enExample)
RU (1) RU2717824C2 (enExample)
WO (1) WO2016177741A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107750156B (zh) * 2015-05-04 2020-08-21 沃桑缇斯股份公司 用于制备跨膜pH梯度囊泡的方法
WO2022106425A1 (en) 2020-11-17 2022-05-27 Genfit Methods of treatment of liver failure
AU2023381087A1 (en) 2022-11-16 2025-05-08 Genfit Use of transmembrane ph gradient liposomes for treating hyperammonemic crisis associated with inborn errors of metabolism

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5297024A (en) 1976-02-09 1977-08-15 Nissan Motor Co Ltd Air fuel ratio controller
FR2521565B1 (fr) 1982-02-17 1985-07-05 Dior Sa Parfums Christian Melange pulverulent de constituants lipidiques et de constituants hydrophobes, procede pour le preparer, phases lamellaires lipidiques hydratees et procede de fabrication, compositions pharmaceutiques ou cosmetiques comportant des phases lamellaires lipidiques hydratees
FR2553002B1 (fr) 1983-10-06 1992-03-27 Centre Nat Rech Scient Procede perfectionne d'obtention de liposomes unilamellaires de diametres eleves, leur application pharmacologique pour l'encapsulage d'un principe actif en vue de son administration extemporanee et dispositif correspondant
US4532089A (en) 1984-01-14 1985-07-30 Northwestern University Method of preparing giant size liposomes
US5077056A (en) 1984-08-08 1991-12-31 The Liposome Company, Inc. Encapsulation of antineoplastic agents in liposomes
US5230899A (en) * 1985-08-07 1993-07-27 Smithkline Beecham Corporation Methods and compositions for making liposomes
US5622713A (en) 1985-09-17 1997-04-22 The Regents Of The University Of California Method of detoxifying animal suffering from overdose
EP0253308B1 (en) 1986-07-15 1990-10-24 FIN-OMET S.r.l. A method for producing dispensable towels as well as towels thus produced and their relating container
EP0285638A4 (en) 1986-09-18 1989-06-14 Liposome Technology Inc METHOD FOR PRODUCING A HIGH DENSITY LIPOSOME.
JPS63211222A (ja) 1987-02-27 1988-09-02 Terumo Corp リポソ−ムの製法
CA1330199C (en) 1987-12-22 1994-06-14 Thomas D. Madden Spontaneous vesiculation of multilamellar liposomes
US5807572A (en) 1988-02-18 1998-09-15 Depotech Corporation Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride
ATE77051T1 (de) 1988-03-04 1992-06-15 Takeda Chemical Industries Ltd Liposom-zusammensetzung.
WO1990003808A1 (en) 1988-10-07 1990-04-19 The Liposome Company, Inc. Heat treating liposomes
US5049392A (en) 1989-01-18 1991-09-17 The Liposome Company, Inc. Osmotically dependent vesicles
US5185154A (en) 1989-02-02 1993-02-09 Liposome Technology, Inc. Method for instant preparation of a drug containing large unilamellar vesicles
DE3913875C1 (enExample) 1989-04-27 1990-08-09 Heraeus Quarzschmelze Gmbh, 6450 Hanau, De
JPH04505616A (ja) 1989-05-15 1992-10-01 ザ　リポソーム　カンパニー，インコーポレイテッド プロトン勾配によるリポソームへの薬剤の蓄積
AU638271B2 (en) 1989-06-22 1993-06-24 Nexstar Pharmaceuticals, Inc. Encapsulation process
US5039305A (en) 1989-12-18 1991-08-13 Ford Motor Company Multiple ratio compact transaxle assembly for automotive vehicles
US5773024A (en) 1989-12-22 1998-06-30 Imarx Pharmaceutical Corp. Container with multi-phase composition for use in diagnostic and therapeutic applications
JP3228957B2 (ja) 1990-06-14 2001-11-12 キヤノン株式会社 巨大リポソームの製造方法及び巨大リポソーム形成用キット
IS1685B (is) 1990-12-11 1998-02-24 Bracco International B.V. Aðferð við að búa til fitukúlur (liposomes) sem eru gæddar auknum hæfileika til að draga í sig og halda í sér aðskotaefnum
US5327038A (en) 1991-05-09 1994-07-05 Rockwell International Corporation Walking expansion actuator
CA2093381A1 (en) 1992-04-07 1993-10-08 Hideyuki Sawahara Liposome formulation and process for production thereof
JPH06710A (ja) 1992-06-17 1994-01-11 Toshimasu Eguchi 工作機械及びその加工方法
JPH069710A (ja) 1992-06-25 1994-01-18 Canon Inc 巨大リポソームの調製方法、ｌｂ膜製造装置及び該装置を用いたｌｂ膜の製造方法
US5766627A (en) 1993-11-16 1998-06-16 Depotech Multivescular liposomes with controlled release of encapsulated biologically active substances
EP0825852B1 (en) 1995-04-18 2004-07-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Liposome drug-loading method and composition
US5686309A (en) * 1996-01-19 1997-11-11 Coulter International Corp. Method and apparatus for determination of hemoglobin content of individual red blood cells
GB9605915D0 (en) 1996-03-21 1996-05-22 Univ Bruxelles Liposome encapsulated amphiphilic drug compositions
US20020136762A1 (en) 1998-01-14 2002-09-26 See Jackie R. Method for inducing a systemic immune response to an antigen
US6106858A (en) 1997-09-08 2000-08-22 Skyepharma, Inc. Modulation of drug loading in multivescular liposomes
US6306432B1 (en) 1997-09-08 2001-10-23 Chiron Corporation High and low load formulations of IGF-I in multivesicular liposomes
ES2373861T3 (es) 1997-09-18 2012-02-09 Pacira Pharmaceuticals, Inc. Composiciones anestésicas liposomiales de liberación sostenida.
IN190388B (enExample) 1997-10-01 2003-07-26 Biomira Usa Inc
US7419683B2 (en) * 1997-10-31 2008-09-02 United States Of America As Represented By The Secretary Of The Army Method of inhibiting side effects of pharmaceutical compositions containing amphiphilic vehicles or drug carrier molecules
ATE554748T1 (de) 1997-11-14 2012-05-15 Pacira Pharmaceuticals Inc Herstellung von multivesikulären liposomen
US20050031679A1 (en) 1998-03-27 2005-02-10 Clemens Unger Method for producing liposomal formulations of active ingredients
CA2340118C (en) 1998-08-12 2009-01-13 Yissum Research Development Company Of The Hebrew University Of Jerusalem Liposomal bupivacaine compositions prepared using an ammonium sulfate gradient
NZ516648A (en) 1999-07-16 2004-01-30 Alza Corp A liposome composition having resistance to freeze/thaw damage
ATE341331T1 (de) 2000-06-14 2006-10-15 William Leslie Porter Lipide zur änderung des abwehrsystems
AR031744A1 (es) 2001-11-08 2003-10-01 Paoli Tomas De Proliposomas en polvo, un procedimiento para la elaboracion de dichas proliposomas en polvo, procedimiento para la preparacion de una composicion farmaceutica empleando proliposomas en polvo y aparato para ser empleado en el procedimiento de elaboracion de dichas proliposomas en polvo
EP1448165B1 (en) * 2001-11-13 2007-09-19 Celator Pharmaceuticals, Inc. Lipid carrier compositions and methods for improved drug retention
WO2003075889A1 (en) 2002-03-05 2003-09-18 Transave, Inc. An inhalation system for prevention and treatment of intracellular infections
GB0312309D0 (en) * 2003-05-29 2003-07-02 Gaslini Children S Hospital G Targeted liposome
RU2369384C2 (ru) * 2003-11-20 2009-10-10 ЙЭм БАЙОСАЙЕНСИЗ ИНК. Стабильные липосомальные композиции
EP1547580A1 (en) 2003-12-23 2005-06-29 MediGene Oncology GmbH Loading of a camptothecin drug into colloidal nanoparticles
AU2005235455B2 (en) 2004-04-22 2011-01-20 Jazz Pharmaceuticals Therapeutics, Inc. Liposomal formulations of anthracycline agents and cytidine analogs
JP5176320B2 (ja) * 2004-08-11 2013-04-03 コニカミノルタエムジー株式会社 リポソーム含有製剤の製造方法
TW200618820A (en) * 2004-11-05 2006-06-16 Alza Corp Liposome formulations of boronic acid compounds
US20060239925A1 (en) * 2005-04-21 2006-10-26 Konica Minolta Medical & Graphic, Inc. Method of manufacturing pharmaceutical preparation containing liposomes
ES2275443B1 (es) 2005-11-30 2008-06-01 Italfarmaco, S.A. Procedimiento de preparacion de liposomas.
ES2708851T3 (es) 2006-10-06 2019-04-11 Bionet Pharma Gmbh Un implante del núcleo pulposo espinal
US8071127B2 (en) * 2006-10-24 2011-12-06 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
JP5080779B2 (ja) * 2006-10-25 2012-11-21 テルモ株式会社 リポソーム製剤の製造方法
JP2008136967A (ja) 2006-12-04 2008-06-19 Shinshu Univ リポソームおよびその製造方法
US20090017108A1 (en) 2007-07-11 2009-01-15 Alexander Yuzhakov Liposome compositions for treatment of hepatitis C
CA2697044A1 (en) * 2007-08-21 2009-02-26 Alza Corporation Liposome formulations of boronic acid compounds
US20110105995A1 (en) 2008-01-16 2011-05-05 Zhu Ting F Uniform-sized, multi-drug carrying, and photosensitive liposomes for advanced drug delivery
EP2253308A1 (en) 2009-05-22 2010-11-24 Ludwig-Maximilians-Universität München Pharmaceutical composition comprising microbubbles for targeted tumor therapy
US20100305500A1 (en) 2009-05-29 2010-12-02 Pacira Pharmaceuticals, Inc. Hyaluronidase as an adjuvant for increasing the injection volume and dispersion of large diameter synthetic membrane vesicles containing a therapeutic agent
JP5771366B2 (ja) 2009-09-02 2015-08-26 株式会社バイオメッドコア リポソーム製造装置及び方法
WO2011038073A1 (en) 2009-09-23 2011-03-31 Formatech, Inc. Methods for the preparation of liposomes comprising docetaxel
DK177529B1 (en) * 2009-10-23 2013-09-08 Bio Bedst Aps Liposomes with improved storage stability
EP3175844A1 (en) 2010-04-09 2017-06-07 Pacira Pharmaceuticals, Inc. Large diameter synthetic membrane vesicles
EP2394640A1 (en) 2010-05-21 2011-12-14 MediGene AG Improved liposomal formulations of lipophilic compounds
EP2433619A1 (en) 2010-09-24 2012-03-28 Intsel Chimos Novel antitumoral agent and its therapeutic uses
US9226984B2 (en) 2010-12-14 2016-01-05 Technical University of Denmark and Rigshospitalet Entrapment of radionuclides in nanoparticle compositions
PT2661308T (pt) * 2011-01-05 2019-07-31 Prenatal Int Gmbh Composição aquosa hipotónica com teor de cloreto reduzido com ou sem fosfolípido
JP2012158576A (ja) 2011-02-03 2012-08-23 Yuki Goto 高圧力を利用したリポソームの粒子径制御方法
US8871811B2 (en) 2011-02-07 2014-10-28 Professional Compounding Centers of America, Ltd Permeation enhancers for topical formulations
JP2014101273A (ja) 2011-02-28 2014-06-05 Tokyo Medical And Dental Univ 脂質構造体の製造方法
CA2864469C (en) * 2012-02-17 2020-07-07 Celsion Corporation Thermosensitive nanoparticle formulations and method of making the same
CN102626390B (zh) 2012-04-19 2013-05-29 海南灵康制药有限公司 一种天麻素多相脂质体注射液
CN102716089B (zh) 2012-06-29 2013-12-11 海南灵康制药有限公司 一种盐酸吉西他滨脂质体注射剂
GB201212896D0 (en) 2012-07-20 2012-09-05 European Molecular Biology Lab Embl Giant array liposome for high-throughput lipid-protein interaction screening
EP2695606A1 (en) 2012-08-09 2014-02-12 ETH Zürich Liposome composition for peritoneal dialysis
RU2516893C1 (ru) * 2012-12-14 2014-05-20 Общество с ограниченной ответственностью "Уральский центр биофармацевтических технологий" Липосомальная композиция и способ ее получения
US20140205543A1 (en) 2013-01-24 2014-07-24 Memorial Sloan-Kettering Cancer Center Method for diagnosing or treating tumors using sphingomyelin containing liposomes
CN103182333B (zh) 2013-03-01 2015-07-29 重庆大学 一种脂质体制备和收集装置及方法
CN107750156B (zh) * 2015-05-04 2020-08-21 沃桑缇斯股份公司 用于制备跨膜pH梯度囊泡的方法

Also Published As

Publication number Publication date
JP2018519370A (ja) 2018-07-19
US20180104189A1 (en) 2018-04-19
HK1250663A1 (en) 2019-01-11
CN107750156B (zh) 2020-08-21
CN107750156A (zh) 2018-03-02
MX381655B (es) 2025-03-13
DK3291797T3 (da) 2020-09-21
JP6715265B2 (ja) 2020-07-01
RU2017141919A3 (enExample) 2019-09-20
RU2717824C2 (ru) 2020-03-26
EP3291797A1 (en) 2018-03-14
RU2017141919A (ru) 2019-06-04
EP3291797B1 (en) 2020-09-02
ES2826896T3 (es) 2021-05-19
BR112017023578A2 (pt) 2018-09-04
MX2017014130A (es) 2018-07-06
AU2016256979A1 (en) 2017-12-07
WO2016177741A1 (en) 2016-11-10
AU2016256979B2 (en) 2021-01-28
US12427112B2 (en) 2025-09-30
US20220287971A1 (en) 2022-09-15
US11376218B2 (en) 2022-07-05
CA2987844A1 (en) 2016-11-10

Similar Documents

Publication Publication Date Title
IL261845B (en) A method for preparing glucagon-like peptides
EP3321272A4 (en) Method for preparing l-bpa
EP3176129A4 (en) Method for producing difluorophosphate
IL259085A (en) A method for preparing membranes
ZA201702942B (en) Method for preparing diol
EP3287439A4 (en) Method for preparing taurine
GB201515082D0 (en) Apparatus & method
EP3150711A4 (en) Method for preparing l-ergothioneine
PT3196196T (pt) Método para a preparação de calcobutrol
IL266044B (en) Method for the production of 3-alkylsulfanyl-2-chloro-n-(1-alkyl-h1-tetrazol-5-yl)-4-trifluoromethyl-benzamides
IL250682A0 (en) A method for the preparation of 2'-o-fucosyl lactose
EP3257855A4 (en) Method for preparing ibrutinib
GB201401308D0 (en) Process for preparing membranes
GB201509794D0 (en) Method for preparing an assymetric membrane
EP3241837A4 (en) Method for preparing sofosbuvir crystal form-6
GB201401310D0 (en) Process for preparing membranes
EP3246343A4 (en) Method for preparing polyolefin
GB201905146D0 (en) Method for preparing aronatic hydrocarbons
GB201516031D0 (en) Apparatus & method
PL3138556T3 (pl) Sposób wytwarzania liposomu
IL258148B (en) Methods for producing flumetamol
ZA201903463B (en) Method for preparing hexadecahydropyrene
GB201714060D0 (en) Method for preparing itraconazole preparation
PT3291797T (pt) Método para preparar vesículas de gradiente de ph transmembranar
IL271512B (en) A method for the preparation of modified 4-aminoindan derivatives