JP6715265B2 - 膜内外ｐＨ勾配ベシクルを調製する方法 - Google Patents

膜内外ｐＨ勾配ベシクルを調製する方法 Download PDF

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Publication number
JP6715265B2
JP6715265B2 JP2017557435A JP2017557435A JP6715265B2 JP 6715265 B2 JP6715265 B2 JP 6715265B2 JP 2017557435 A JP2017557435 A JP 2017557435A JP 2017557435 A JP2017557435 A JP 2017557435A JP 6715265 B2 JP6715265 B2 JP 6715265B2
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mosm
vesicles
buffer
alkaline
gradient
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JP2018519370A (ja
JP2018519370A5 (enExample
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ルロワ・ジャン−クリストフ
フォルスター・ヴィンセント
アゴストーニ，ヴァレンティナ
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Versantis AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1273—Polymersomes; Liposomes with polymerisable or polymerised bilayer-forming substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2017557435A 2015-05-04 2016-05-03 膜内外ｐＨ勾配ベシクルを調製する方法 Active JP6715265B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15166247.5 2015-05-04
EP15166247 2015-05-04
PCT/EP2016/059912 WO2016177741A1 (en) 2015-05-04 2016-05-03 Method for preparing transmembrane ph-gradient vesicles

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JP2018519370A JP2018519370A (ja) 2018-07-19
JP2018519370A5 JP2018519370A5 (enExample) 2019-01-17
JP6715265B2 true JP6715265B2 (ja) 2020-07-01

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US (2) US11376218B2 (enExample)
EP (1) EP3291797B1 (enExample)
JP (1) JP6715265B2 (enExample)
CN (1) CN107750156B (enExample)
AU (1) AU2016256979B2 (enExample)
CA (1) CA2987844A1 (enExample)
DK (1) DK3291797T3 (enExample)
ES (1) ES2826896T3 (enExample)
MX (1) MX381655B (enExample)
PT (1) PT3291797T (enExample)
RU (1) RU2717824C2 (enExample)
WO (1) WO2016177741A1 (enExample)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107750156B (zh) * 2015-05-04 2020-08-21 沃桑缇斯股份公司 用于制备跨膜pH梯度囊泡的方法
WO2022106425A1 (en) 2020-11-17 2022-05-27 Genfit Methods of treatment of liver failure
AU2023381087A1 (en) 2022-11-16 2025-05-08 Genfit Use of transmembrane ph gradient liposomes for treating hyperammonemic crisis associated with inborn errors of metabolism

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Publication number Publication date
JP2018519370A (ja) 2018-07-19
US20180104189A1 (en) 2018-04-19
HK1250663A1 (en) 2019-01-11
CN107750156B (zh) 2020-08-21
CN107750156A (zh) 2018-03-02
MX381655B (es) 2025-03-13
DK3291797T3 (da) 2020-09-21
RU2017141919A3 (enExample) 2019-09-20
RU2717824C2 (ru) 2020-03-26
EP3291797A1 (en) 2018-03-14
RU2017141919A (ru) 2019-06-04
EP3291797B1 (en) 2020-09-02
ES2826896T3 (es) 2021-05-19
BR112017023578A2 (pt) 2018-09-04
MX2017014130A (es) 2018-07-06
PT3291797T (pt) 2020-10-19
AU2016256979A1 (en) 2017-12-07
WO2016177741A1 (en) 2016-11-10
AU2016256979B2 (en) 2021-01-28
US12427112B2 (en) 2025-09-30
US20220287971A1 (en) 2022-09-15
US11376218B2 (en) 2022-07-05
CA2987844A1 (en) 2016-11-10

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