CA2978185A1 - Antibodies to icos - Google Patents

Antibodies to icos Download PDF

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Publication number
CA2978185A1
CA2978185A1 CA2978185A CA2978185A CA2978185A1 CA 2978185 A1 CA2978185 A1 CA 2978185A1 CA 2978185 A CA2978185 A CA 2978185A CA 2978185 A CA2978185 A CA 2978185A CA 2978185 A1 CA2978185 A1 CA 2978185A1
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CA
Canada
Prior art keywords
seq
amino acid
acid sequence
antibody
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA2978185A
Other languages
English (en)
French (fr)
Inventor
Stephen Sazinsky
Jennifer S. MICHAELSON
Sriram Sathyanarayanan
Kutlu Goksu ELPEK
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jounce Therapeutics Inc
Original Assignee
Jounce Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jounce Therapeutics Inc filed Critical Jounce Therapeutics Inc
Publication of CA2978185A1 publication Critical patent/CA2978185A1/en
Pending legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507Comprising a combination of two or more separate antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75Agonist effect on antigen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA2978185A 2015-03-23 2016-03-22 Antibodies to icos Pending CA2978185A1 (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201562137034P 2015-03-23 2015-03-23
US62/137,034 2015-03-23
US201562147484P 2015-04-14 2015-04-14
US62/147,484 2015-04-14
US201562156588P 2015-05-04 2015-05-04
US62/156,588 2015-05-04
US201562242489P 2015-10-16 2015-10-16
US62/242,489 2015-10-16
US201562255635P 2015-11-16 2015-11-16
US62/255,635 2015-11-16
PCT/US2016/023524 WO2016154177A2 (en) 2015-03-23 2016-03-22 Antibodies to icos

Publications (1)

Publication Number Publication Date
CA2978185A1 true CA2978185A1 (en) 2016-09-29

Family

ID=56978549

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2978185A Pending CA2978185A1 (en) 2015-03-23 2016-03-22 Antibodies to icos

Country Status (34)

Country Link
US (3) US10023635B2 (enExample)
EP (2) EP3273992B1 (enExample)
JP (2) JP6944924B2 (enExample)
KR (2) KR20230164243A (enExample)
CN (2) CN114907481A (enExample)
AU (2) AU2016235362B2 (enExample)
BR (1) BR112017020054A2 (enExample)
CA (1) CA2978185A1 (enExample)
CL (1) CL2017002401A1 (enExample)
CO (1) CO2017010618A2 (enExample)
CY (1) CY1123409T1 (enExample)
DK (1) DK3273992T3 (enExample)
EA (1) EA037621B1 (enExample)
EC (1) ECSP17070399A (enExample)
ES (1) ES2811345T3 (enExample)
HR (1) HRP20201090T1 (enExample)
HU (1) HUE049938T2 (enExample)
IL (2) IL254338B (enExample)
LT (1) LT3273992T (enExample)
MA (1) MA53297A (enExample)
MD (1) MD3273992T2 (enExample)
ME (1) ME03819B (enExample)
MX (2) MX386500B (enExample)
PH (2) PH12021552158A1 (enExample)
PL (1) PL3273992T3 (enExample)
PT (1) PT3273992T (enExample)
RS (1) RS60614B1 (enExample)
RU (1) RU2742241C2 (enExample)
SG (2) SG11201707769VA (enExample)
SI (1) SI3273992T1 (enExample)
SM (1) SMT202000444T1 (enExample)
TW (1) TWI719970B (enExample)
WO (1) WO2016154177A2 (enExample)
ZA (1) ZA201705920B (enExample)

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