CA2966634C - Engineered gamma delta t-cells - Google Patents

Engineered gamma delta t-cells Download PDF

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Publication number
CA2966634C
CA2966634C CA2966634A CA2966634A CA2966634C CA 2966634 C CA2966634 C CA 2966634C CA 2966634 A CA2966634 A CA 2966634A CA 2966634 A CA2966634 A CA 2966634A CA 2966634 C CA2966634 C CA 2966634C
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cells
cell
engineered
antigen
tumor
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French (fr)
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CA2966634A1 (en
Inventor
Aya Jakobovits
Orit Foord
Andy An-Deh Lin
Marianne Theresa Santaguida
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Adicet Therapeutics Inc
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Adicet Therapeutics Inc
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • C07K—PEPTIDES
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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CA2966634A 2014-11-17 2015-11-17 Engineered gamma delta t-cells Active CA2966634C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462080500P 2014-11-17 2014-11-17
US62/080,500 2014-11-17
PCT/US2015/061189 WO2016081518A2 (en) 2014-11-17 2015-11-17 Engineered gamma delta t-cells

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CA2966634A1 CA2966634A1 (en) 2016-05-26
CA2966634C true CA2966634C (en) 2024-04-23

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CA2966634A Active CA2966634C (en) 2014-11-17 2015-11-17 Engineered gamma delta t-cells

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US (2) US11135245B2 (cg-RX-API-DMAC7.html)
EP (2) EP3220926B1 (cg-RX-API-DMAC7.html)
JP (2) JP7146397B2 (cg-RX-API-DMAC7.html)
KR (1) KR102660362B1 (cg-RX-API-DMAC7.html)
CN (2) CN117143814A (cg-RX-API-DMAC7.html)
AU (2) AU2015350103A1 (cg-RX-API-DMAC7.html)
CA (1) CA2966634C (cg-RX-API-DMAC7.html)
DK (1) DK3220926T3 (cg-RX-API-DMAC7.html)
ES (1) ES3023783T3 (cg-RX-API-DMAC7.html)
IL (2) IL297773B2 (cg-RX-API-DMAC7.html)
MX (1) MX2017006408A (cg-RX-API-DMAC7.html)
RU (1) RU2756247C2 (cg-RX-API-DMAC7.html)
WO (1) WO2016081518A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA201703505B (cg-RX-API-DMAC7.html)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1814580T3 (en) 2004-11-24 2016-12-12 Hutchinson Fred Cancer Res Methods of using il-21 for adoptive immunotherapy and identification of tumor antigens
GB201506423D0 (en) 2015-04-15 2015-05-27 Tc Biopharm Ltd Gamma delta T cells and uses thereof
MX2017006408A (es) 2014-11-17 2018-03-23 Adicet Bio Inc Linfocitos t gamma delta modificados geneticamente.
CN114504645A (zh) 2015-01-27 2022-05-17 拉法医疗公众有限公司 靶向cd1d的单域抗体
GB201507368D0 (en) 2015-04-30 2015-06-17 Ucl Business Plc Cell
KR102663157B1 (ko) 2015-06-09 2024-05-13 감마델타 테라퓨틱스 엘티디 Ｔｃｒ감마 델타 양성 ｔ 세포의 생산 방법
KR20180086183A (ko) 2015-09-03 2018-07-30 더 유에이비 리서치 파운데이션 유전자 조작 약물 내성 t 세포 및 이것의 사용 방법
WO2017197347A1 (en) 2016-05-12 2017-11-16 Adicet Bio, Inc. METHODS FOR SELECTIVE EXPANSION OF γδ T-CELL POPULATIONS AND COMPOSITIONS THEREOF
US10456423B2 (en) 2016-06-13 2019-10-29 SMART SURGICAL, Inc. Compositions for biological systems and methods for preparing and using the same
US10426796B2 (en) * 2016-06-13 2019-10-01 SMART SURGICAL, Inc. Compositions for biological systems and methods for preparing and using the same
CA3032429A1 (en) 2016-08-03 2018-02-08 Washington University Gene editing of car-t cells for the treatment of t cell malignancies with chimeric antigen receptors
KR102032354B1 (ko) * 2016-11-11 2019-10-16 가톨릭대학교 산학협력단 신규한 배양보조세포 및 이를 이용한 감마 델타 ｔ 세포의 증식 방법
CA3044593A1 (en) 2016-11-22 2018-05-31 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
WO2018119298A1 (en) * 2016-12-21 2018-06-28 TCR2 Therapeutics Inc. Engineered t cells for the treatment of cancer
MY200528A (en) * 2017-02-08 2023-12-30 Agency Science Tech & Res Gamma delta t cells and a method of augmenting the tumoricidal activity of the same
WO2018170335A1 (en) 2017-03-15 2018-09-20 Orca Biosystems Inc. Compositions and methods for hematopoietic stem cell transplants
GB201707048D0 (en) 2017-05-03 2017-06-14 King S College London Expansion of gamma delta cells, compositions, and methods of use thereof
US12384830B2 (en) * 2017-06-02 2025-08-12 Regents Of The University Of Minnesota Compositions and methods for improving immunotherapy
WO2018236986A1 (en) * 2017-06-20 2018-12-27 The Trustees Of Columbia University In The City Of New York Engineered t-cell receptors and methods of their use
MA49512A (fr) 2017-06-28 2020-05-06 Regeneron Pharma Protéines de liaison à l'antigène anti-papillomavirus humain et leurs méthodés d'utilisation
WO2019053272A1 (en) * 2017-09-15 2019-03-21 King's College London COMPOSITIONS AND METHODS FOR IMPROVING T GAMMA DELTA LYMPHOCYTES IN INTESTINE
TWI687227B (zh) * 2017-10-03 2020-03-11 生倍科技股份有限公司 用於t細胞免疫療法之組合及其用途
CN109777778B (zh) * 2017-11-14 2023-07-18 中国科学院广州生物医药与健康研究院 一种基因改造的γδT细胞
JP2021502816A (ja) * 2017-11-15 2021-02-04 アディセット バイオ， インコーポレイテッド δ３γδＴ細胞集団の選択的増殖方法及びその組成物
DE102017127984B4 (de) 2017-11-27 2019-12-05 Immatics US, Inc. Verfahren für die Vermehrung und Aktivierung von γδ-T-Zellen
CN108129566B (zh) * 2017-12-31 2021-05-11 中国科学院武汉病毒研究所 靶向间皮素的c-型单域抗体及其制备方法与应用
WO2019143961A2 (en) * 2018-01-19 2019-07-25 The Trustees Of The University Of Pennsylvania Compositions and methods for targeting gamma delta t cells with chimeric antigen receptors
WO2019178463A1 (en) * 2018-03-16 2019-09-19 H. Lee Moffitt Cancer Center And Research Institute Inc. Chimeric antigen receptors with mutated cd28 phosphorylation sites
GB201804701D0 (en) 2018-03-23 2018-05-09 Gammadelta Therapeutics Ltd Lymphocytes expressing heterologous targeting constructs
WO2019216338A1 (ja) * 2018-05-08 2019-11-14 国立大学法人大阪大学 ホモ接合型細胞の作製方法
CN110577932A (zh) * 2018-06-07 2019-12-17 亘喜生物科技（上海）有限公司 一种脐带血来源的嵌合抗原受体t细胞
BR112021000914A2 (pt) * 2018-07-18 2021-04-13 Amgen Inc. Receptores quiméricos para steap1 e seus métodos de uso
SG11202101038SA (en) * 2018-08-01 2021-02-25 Imcheck Therapeutics Sas Anti-btn3a antibodies and their use in treating cancer or infectious disorders
CN108949685B (zh) * 2018-08-02 2022-03-29 吉林大学第一医院 一种体外诱导扩增高杀伤活性γδT细胞的方法
US20210177903A1 (en) * 2018-08-07 2021-06-17 H. Lee Moffitt Cancer Center And Research Institute, Inc. Car t-cells for the treatment of bone metastatic cancer
US12156888B2 (en) 2018-08-07 2024-12-03 H. Lee Moffitt Cancer Center And Research Institute, Inc. CAR T-cells for the treatment of bone metastatic cancer
WO2020029171A1 (zh) * 2018-08-09 2020-02-13 深圳华大生命科学研究院 无内源hla基因背景的抗原递呈细胞系的构建方法、抗原递呈细胞系及其用途
WO2020032179A1 (ja) * 2018-08-10 2020-02-13 国立大学法人京都大学 Ｃｄ３陽性細胞の製造方法
CN113307872B (zh) * 2018-08-11 2022-12-06 广东天科雅生物医药科技有限公司 一种工程化核酸、t细胞及其应用和产生方法
CN109161533B (zh) * 2018-08-28 2020-07-24 深圳市菲鹏生物制药股份有限公司 无血清培养组合物及其应用
CA3113409A1 (en) 2018-09-19 2020-03-26 Lava Therapeutics B.V. Dual acting cd1d immunoglobulin
AU2019354395A1 (en) * 2018-10-01 2021-05-06 Adicet Therapeutics, Inc. Compositions and methods regarding engineered and non-engineered γδ -T cells for treatment of solid tumors
EA202190926A1 (ru) 2018-10-01 2021-06-25 Эдисет Био, Инк. Композиции и способы в отношении сконструированных и несконструированных t-клеток для лечения гематологических опухолей
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
JP7569313B2 (ja) 2018-10-23 2024-10-17 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Ｎｙ－ｅｓｏ－１ ｔ細胞受容体およびそれらの使用の方法
GB201818243D0 (en) 2018-11-08 2018-12-26 Gammadelta Therapeutics Ltd Methods for isolating and expanding cells
JP2022510387A (ja) * 2018-12-03 2022-01-26 アディセット バイオ， インコーポレイテッド ガンマデルタｔ細胞集団の選択的生体内増殖方法及びその組成物
CN111544585B (zh) * 2019-02-11 2024-12-27 北京卡替医疗技术有限公司 一种可助推免疫细胞在体内扩增的佐剂
JP6884450B2 (ja) * 2019-02-14 2021-06-09 学校法人獨協学園獨協医科大学 Ｔ細胞ワクチン
AU2020226401A1 (en) * 2019-02-18 2021-10-14 Memorial Sloan-Kettering Cancer Center Combinations of multiple chimeric antigen receptors for immunotherapy
EP3927353A4 (en) * 2019-02-24 2022-11-23 Gamida-Cell Ltd. METHOD OF ECOTAXY AND RETENTION OF GAMMADELTA T LYMPHOCYTES, OPTIONALLY WITH NATURAL KILLER CELLS, ALLOWING THE GENERATION OF CELLULAR COMPOSITIONS FOR USE IN THERAPY
CA3128971A1 (en) * 2019-03-08 2020-09-17 Klinikum Der Universitat Munchen Ccr8 expressing lymphocytes for targeted tumor therapy
CN109758590B (zh) * 2019-03-28 2022-02-11 广东工业大学 一种用于筛选人前列腺癌肿瘤抗原表位肽的方法
MX2021012004A (es) * 2019-03-30 2021-11-04 Biontech Us Inc Composiciones y metodos para preparar composiciones de celulas t y usos de las mismas.
US12404331B2 (en) 2019-04-19 2025-09-02 Tcrcure Biopharma Corp. Anti-PD-1 antibodies and uses thereof
WO2020219843A1 (en) * 2019-04-26 2020-10-29 The University Of North Carolina At Chapel Hill Chimeric antigen receptor constructs and their use in car-t cells
KR20220017892A (ko) * 2019-05-08 2022-02-14 얀센 바이오테크 인코포레이티드 T세포 매개 면역의 조절을 위한 물질 및 방법
KR20220073729A (ko) * 2019-07-17 2022-06-03 케이스 웨스턴 리저브 유니버시티 Hiv 감염 치료용 장기 생존 t 세포
WO2021016652A1 (en) * 2019-07-29 2021-02-04 The University Of Melbourne METHODS AND COMPOSITIONS FOR MONITORING, TREATING AND PREVENTING CMV INFECTION OR GRAFT REJECTION USING γδ T-CELLS
WO2021032960A1 (en) * 2019-08-16 2021-02-25 GammaDelta Therapeutics Limited Novel anti-tcr delta variable 1 antibodies
WO2021073290A1 (en) * 2019-10-17 2021-04-22 The University Of Hong Kong Methods to prepare v-t cells derived exosomes for treatment of epstein-barr virus-associated cancers
US20210130461A1 (en) 2019-10-31 2021-05-06 Morphosys Ag Anti-tumor combination therapy comprising anti-cd19 antibody and gamma delta t-cells
IL293459A (en) * 2019-12-03 2022-07-01 Adicet Bio Inc Methods for expanding γδ t-cell populations with multivalent agents and compositions thereof
AU2021211485A1 (en) 2020-01-24 2022-09-15 Regeneron Pharmaceuticals, Inc. Preferentially expressed antigen in melanoma (PRAME) T cell receptors and methods of use thereof
KR20220150918A (ko) * 2020-03-03 2022-11-11 얀센 바이오테크 인코포레이티드 γδ T 세포 및 이의 용도
CA3158133A1 (en) 2020-04-28 2021-11-04 Lyell Immunopharma, Inc. Methods for culturing cells
CN115996733A (zh) * 2020-06-22 2023-04-21 南京传奇生物科技有限公司 用于免疫疗法的基因工程化γδT细胞
CA3188601A1 (en) 2020-07-08 2022-01-13 LAVA Therapeutics N.V. Antibodies that bind psma and gamma-delta t cell receptors
CN116024176A (zh) * 2020-07-14 2023-04-28 广州泛恩生物科技有限公司 基于tnfrsf18阳性t细胞的用于杀伤肿瘤的tcr-t细胞及其制备方法和应用
CN117295505A (zh) * 2021-02-08 2023-12-26 加利福尼亚大学董事会 嗜乳脂蛋白亚家族3成员a1（btn3a1，cd277）的调节
GB202105113D0 (en) * 2021-04-09 2021-05-26 Gammadelta Therapeutics Ltd Novel method
EP4419118A4 (en) * 2021-10-20 2025-04-30 University of Pittsburgh - Of the Commonwealth System of Higher Education Methods and materials for expanding tumor infiltrating gamma-delta t cells
WO2023092119A2 (en) 2021-11-22 2023-05-25 Ludwig Institute For Cancer Research Ltd Methods for predicting responsiveness to a cancer therapy
JP2024542815A (ja) * 2021-12-05 2024-11-15 アディセット セラピューティクス， インク． Ｂ細胞悪性腫瘍の治療
KR20230105166A (ko) 2022-01-03 2023-07-11 주식회사 이뮤노맥스 감마-델타 t 세포의 증식 배양 방법
CN114149978B (zh) * 2022-02-09 2022-04-26 深圳博雅感知药业有限公司 制备car-t细胞的方法
AU2023220748A1 (en) 2022-02-16 2024-07-25 Priothera Sas Methods of treatment with car cells in combination with s1p receptor modulators
GB202204926D0 (en) 2022-04-04 2022-05-18 Gammadelta Therapeutics Ltd Method for expanding gammadelta T cells
WO2023242434A1 (en) * 2022-06-17 2023-12-21 Gadeta B.V. Modified immune cells
CN115624618A (zh) * 2022-09-16 2023-01-20 深圳善乐生物科技有限公司 一种HPV多肽抗原负载γδT细胞在HPV阳性宫颈癌免疫治疗中的应用
AU2023372375A1 (en) 2022-10-31 2025-04-24 Regeneron Pharmaceuticals, Inc. Methods of treating cancer with a combination of adoptive cell therapy and a targeted immunocytokine
WO2024211478A1 (en) 2023-04-07 2024-10-10 Regeneron Pharmaceuticals, Inc. Methods of treating cancer with a lymphotoxin beta receptor agonist
WO2024243511A1 (en) 2023-05-25 2024-11-28 Regeneron Pharmaceuticals, Inc. T cell receptors that bind presented hpv16-, mart1-, cmv-, ebv-, or influenza- peptides
US12221483B1 (en) * 2024-01-30 2025-02-11 China Medical University Hospital Fusion protein and nucleic acid encoding sequence thereof, and uses of the same
WO2025165915A1 (en) * 2024-01-31 2025-08-07 Adicet Therapeutics, Inc. Compositions and methods for enhancing engineered t cell therapies
WO2025229538A1 (en) * 2024-05-01 2025-11-06 Janssen Biotech, Inc. Materials, methods, and systems for cellular expansion of gamma delta t-cells

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260223A (en) 1986-07-03 1993-11-09 President & Fellows Of Harvard College Methods for detection of human gamma, γ T cell receptor
US5185250A (en) * 1986-07-03 1993-02-09 T Cell Sciences, Inc. Human γ, δT cell antigen receptor polypeptides and nucleic acids
CA2133411A1 (en) 1992-04-03 1993-10-14 Alexander T. YOUNG Gene therapy using targeted viral vectors
CA2110946A1 (en) * 1992-12-09 1994-06-10 Elazar Rabbani Induction of immunocompatibility by nucleic acid
EP1189635A4 (en) 1999-06-17 2003-04-23 Univ Vermont AUTOLOGOUS ADOPTIVE IMMUNOTHERAPY WITH T-CELLS OR B-CELLS B WHICH HAVE BEEN SENSITIZED TO ANTIGENS-SPECIFIC
AU7729000A (en) 1999-09-30 2001-04-30 National Jewish Medical And Research Center Modulation of gammadelta t cells to regulate airway hyperresponsiveness
US6737398B1 (en) 1999-09-30 2004-05-18 National Jewish Medical And Research Center Modulation of γδ T cells to regulate airway hyperresponsiveness
JP4968498B2 (ja) 2002-01-23 2012-07-04 ユニバーシティ オブ ユタ リサーチ ファウンデーション ジンクフィンガーヌクレアーゼを用いる、標的化された染色体変異誘発
CN1306027C (zh) * 2002-12-12 2007-03-21 中国医学科学院基础医学研究所 一种体外扩增γδT淋巴细胞的方法
WO2004092741A2 (en) * 2003-04-14 2004-10-28 Montana State University Mapping discontinuous antibody or aptamer epitopes for protein structure determination and other applications
US7985739B2 (en) 2003-06-04 2011-07-26 The Board Of Trustees Of The Leland Stanford Junior University Enhanced sleeping beauty transposon system and methods for using the same
BRPI0511782B8 (pt) * 2004-06-03 2021-05-25 Novimmune Sa anticorpos anti-cd3, uso e método de produção dos mesmos, composição farmacêutica, molécula de ácido nucleico isolada e vetor
US7340913B2 (en) 2004-08-05 2008-03-11 Manitowoc Foodservice Companies, Inc. Ice machine and ice-making assembly including a water distributor
US20080026986A1 (en) * 2006-06-05 2008-01-31 Rong-Fu Wang Reversal of the suppressive function of specific t cells via toll-like receptor 8 signaling
CA2662701C (en) * 2006-09-08 2015-12-08 Abbott Laboratories Interleukin-13 binding proteins
JP2012501178A (ja) 2008-08-26 2012-01-19 マクロジェニクス，インコーポレーテッド Ｔ細胞受容体抗体およびその使用方法
MX336846B (es) 2010-01-22 2016-02-03 Sangamo Biosciences Inc Alteracion genomica dirigida.
US8945868B2 (en) * 2010-07-21 2015-02-03 Sangamo Biosciences, Inc. Methods and compositions for modification of a HLA locus
EP3323833B1 (en) 2011-04-01 2019-12-04 Memorial Sloan-Kettering Cancer Center T cell receptor-like bispecific antibodies specific for a wt1 peptide presented by hla-a2
US9499788B2 (en) 2011-05-19 2016-11-22 Instituto De Medicina Molecular Cell line of lymphocytes comprising gamma-delta T cells, composition and production method thereof
WO2013074916A1 (en) 2011-11-18 2013-05-23 Board Of Regents, The University Of Texas System Car+ t cells genetically modified to eliminate expression of t- cell receptor and/or hla
MX349096B (es) 2011-11-28 2017-07-11 Merck Patent Gmbh Anticuerpos anti-pd-l1 y sus usos.
CN103130894B (zh) * 2011-11-30 2017-04-12 中国医学科学院基础医学研究所 抗人γδTCR单克隆抗体的重组单链抗体G5‑4ScFv及其编码基因与应用
EP2684600A1 (en) 2012-07-10 2014-01-15 Laboratoires Meiners Sarl Core-shell capsules and methods for encapsulation of reactive ingredients by diffusional exchange through spherical capsule membranes
EP2916858A1 (en) 2012-11-08 2015-09-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for inducing il-2-free proliferation of gamma delta t cells
CN102994448A (zh) * 2012-12-13 2013-03-27 上海柯莱逊生物技术有限公司 一种体外扩增γδT细胞的方法
EP2961262B1 (en) 2013-03-01 2019-07-24 Regents of the University of Minnesota Talen-based gene correction
WO2015061694A2 (en) 2013-10-25 2015-04-30 Board Of Regents, The University Of Texas System Polyclonal gamma delta t cells for immunotherapy
JP6617138B2 (ja) * 2014-04-10 2019-12-11 ラヴァ・セラピューティクス・ベー・フェー ヒトＶγ９Ｖδ２ Ｔ細胞受容体と結合する免疫グロブリン
MX2017006408A (es) 2014-11-17 2018-03-23 Adicet Bio Inc Linfocitos t gamma delta modificados geneticamente.
AU2016274633B2 (en) 2015-06-09 2022-04-21 Gammadelta Therapeutics Ltd Methods for the production of TCR gamma delta+ T cells
MA42895A (fr) 2015-07-15 2018-05-23 Juno Therapeutics Inc Cellules modifiées pour thérapie cellulaire adoptive
EP3743081A4 (en) 2018-01-23 2021-12-01 New York University SPECIFIC ANTIBODIES OF THE DELTA 1 CHAIN OF THE T-LYMPHOCYTE RECEPTOR

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