CA2907726A1 - Combination of catalytic mtorc1/2 inhibitors and selective inhibitors of aurora a kinase - Google Patents
Combination of catalytic mtorc1/2 inhibitors and selective inhibitors of aurora a kinaseInfo
- Publication number
- CA2907726A1 CA2907726A1 CA2907726A CA2907726A CA2907726A1 CA 2907726 A1 CA2907726 A1 CA 2907726A1 CA 2907726 A CA2907726 A CA 2907726A CA 2907726 A CA2907726 A CA 2907726A CA 2907726 A1 CA2907726 A1 CA 2907726A1
- Authority
- CA
- Canada
- Prior art keywords
- aryl
- another embodiment
- heteroaryl
- chloro
- pyrimido
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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| ITUA20164278A1 (it) * | 2016-06-10 | 2017-12-10 | International Soc For Drug Development S R L | COMPOSTI 2-OXO-1,2-DIIDROPIRIDIN-3-CARBOSSAMMIDE E LORO USO COME INIBITORI DUALI DI PDK1/AurA |
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| WO2020146779A1 (en) * | 2019-01-11 | 2020-07-16 | The Regents Of The University Of California | mTORC1 INHIBITORS FOR ACTIVATING AUTOPHAGY |
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| US4099012A (en) | 1975-08-28 | 1978-07-04 | Ciba-Geigy Corporation | 2-pyrazolyl-benzophenones |
| NL8000715A (nl) | 1979-02-07 | 1980-08-11 | Hoffmann La Roche | Pyrimido-2-benzazepinen, werkwijzen ter bereiding ervan, alsmede farmaceutische preparaten, die deze pyrimido-2- benzazepinen bevatten. |
| US4481142A (en) | 1979-02-07 | 1984-11-06 | Hoffmann-La Roche Inc. | Pyrimido-2-benzazepines |
| US4469633A (en) | 1980-05-16 | 1984-09-04 | Hoffmann-La Roche Inc. | N-oxides of 5-oxo-1-phenyl-2-benzazepines |
| EP0273697A3 (en) | 1986-12-30 | 1989-11-29 | Merck & Co. Inc. | 2-benzazepines with 5- and 6- membered heterocyclic rings |
| US5166151A (en) | 1988-03-25 | 1992-11-24 | Merck & Co., Inc. | 2-Benzazepines with 5- and 6-membered heterocyclic rings, compositions and medical methods of use thereof |
| US5721356A (en) | 1989-09-15 | 1998-02-24 | Gensia, Inc. | Orally active adenosine kinase inhibitors |
| US5210082A (en) | 1991-05-16 | 1993-05-11 | Merck & Co., Inc. | 2-benzazepines with 5- and 6-membered heterocyclic rings to treat pain and anxiety disorders |
| IL108523A0 (en) | 1993-02-03 | 1994-05-30 | Gensia Inc | Pharmaceutical compositions containing adenosine kinase inhibitors for preventing or treating conditions involving inflammatory responses and pain |
| US5747487A (en) | 1993-07-29 | 1998-05-05 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
| PT819129E (pt) | 1995-04-03 | 2001-01-31 | Novartis Ag | Derivados pirazole e processos para a sua preparacao |
| US5593997A (en) | 1995-05-23 | 1997-01-14 | Pfizer Inc. | 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors |
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| GB9521987D0 (en) | 1995-10-26 | 1996-01-03 | Ludwig Inst Cancer Res | Phosphoinositide 3-kinase modulators |
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- 2014-03-21 US US14/777,888 patent/US9724354B2/en active Active
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- 2014-03-21 CN CN201480025923.0A patent/CN105209042B/zh not_active Expired - Fee Related
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|---|---|
| JP6360881B2 (ja) | 2018-07-18 |
| EP2976086A4 (en) | 2016-11-16 |
| US9724354B2 (en) | 2017-08-08 |
| US20160271140A1 (en) | 2016-09-22 |
| JP2016514727A (ja) | 2016-05-23 |
| CN105209042B (zh) | 2019-03-08 |
| HK1220901A1 (zh) | 2017-05-19 |
| WO2014153509A1 (en) | 2014-09-25 |
| EP2976086A1 (en) | 2016-01-27 |
| US20180117060A1 (en) | 2018-05-03 |
| CN105209042A (zh) | 2015-12-30 |
| EP2976086B1 (en) | 2020-10-14 |
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