CA2890427C - Antibodies to s. aureus surface determinants - Google Patents

Antibodies to s. aureus surface determinants Download PDF

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Publication number
CA2890427C
CA2890427C CA2890427A CA2890427A CA2890427C CA 2890427 C CA2890427 C CA 2890427C CA 2890427 A CA2890427 A CA 2890427A CA 2890427 A CA2890427 A CA 2890427A CA 2890427 C CA2890427 C CA 2890427C
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Prior art keywords
amino acid
seq
acid sequence
cdr2
cdr3
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CA2890427A
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English (en)
French (fr)
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CA2890427A1 (en
Inventor
Bret SELLMAN
Christine TKACZYK
Partha S. Chowdhury
Lei Hua
Peter Pavlik
Rebecca BUONPANE
Chew-Shun Chang
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MedImmune LLC
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MedImmune LLC
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Publication of CA2890427A1 publication Critical patent/CA2890427A1/en
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1271Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/40Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911Bacteria
    • G01N33/56938Staphylococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507Comprising a combination of two or more separate antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567Framework region [FR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA2890427A 2012-11-06 2013-11-06 Antibodies to s. aureus surface determinants Active CA2890427C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261723137P 2012-11-06 2012-11-06
US61/723,137 2012-11-06
US201361782405P 2013-03-14 2013-03-14
US61/782,405 2013-03-14
PCT/US2013/068624 WO2014074540A2 (en) 2012-11-06 2013-11-06 Antibodies to s. aureus surface determinants

Publications (2)

Publication Number Publication Date
CA2890427A1 CA2890427A1 (en) 2014-05-15
CA2890427C true CA2890427C (en) 2022-05-31

Family

ID=50685304

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2890427A Active CA2890427C (en) 2012-11-06 2013-11-06 Antibodies to s. aureus surface determinants

Country Status (16)

Country Link
US (3) US9879070B2 (OSRAM)
EP (2) EP3640338A1 (OSRAM)
JP (2) JP6694269B2 (OSRAM)
KR (1) KR102288394B1 (OSRAM)
CN (2) CN104968797B (OSRAM)
AU (2) AU2013341361A1 (OSRAM)
BR (1) BR112015010125A2 (OSRAM)
CA (1) CA2890427C (OSRAM)
DK (1) DK2917360T3 (OSRAM)
ES (1) ES2776179T3 (OSRAM)
HU (1) HUE049012T2 (OSRAM)
MX (2) MX375324B (OSRAM)
PL (1) PL2917360T3 (OSRAM)
RU (1) RU2698131C2 (OSRAM)
SG (2) SG11201503232TA (OSRAM)
WO (1) WO2014074540A2 (OSRAM)

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Also Published As

Publication number Publication date
CN104968797A (zh) 2015-10-07
CN104968797B (zh) 2018-11-30
HUE049012T2 (hu) 2020-09-28
WO2014074540A3 (en) 2014-07-10
CN109553681A (zh) 2019-04-02
EP2917360B1 (en) 2020-01-08
ES2776179T3 (es) 2020-07-29
WO2014074540A2 (en) 2014-05-15
EP2917360A4 (en) 2017-01-25
HK1215054A1 (en) 2016-08-12
KR20150094621A (ko) 2015-08-19
DK2917360T3 (da) 2020-03-30
EP2917360A2 (en) 2015-09-16
RU2698131C2 (ru) 2019-08-22
JP2019089801A (ja) 2019-06-13
US10730934B2 (en) 2020-08-04
JP6694269B2 (ja) 2020-05-13
MX375324B (es) 2025-03-06
RU2019122610A (ru) 2020-02-18
BR112015010125A2 (pt) 2017-08-22
AU2018241107B2 (en) 2020-09-17
CA2890427A1 (en) 2014-05-15
MX2015005477A (es) 2015-11-30
US20150291685A1 (en) 2015-10-15
MX2022008079A (es) 2022-07-11
KR102288394B1 (ko) 2021-08-09
SG10201703678TA (en) 2017-06-29
US20190016787A1 (en) 2019-01-17
EP3640338A1 (en) 2020-04-22
US9879070B2 (en) 2018-01-30
PL2917360T3 (pl) 2020-06-29
SG11201503232TA (en) 2015-05-28
RU2015121624A (ru) 2016-12-27
AU2018241107A1 (en) 2018-10-25
AU2013341361A1 (en) 2015-06-04
JP2016507470A (ja) 2016-03-10
US11447543B2 (en) 2022-09-20
US20200407429A1 (en) 2020-12-31
HK1215452A1 (zh) 2016-08-26

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