HRP20201127T1 - Antigeni stafilokokne koagulaze i metode primjene istih - Google Patents

Antigeni stafilokokne koagulaze i metode primjene istih Download PDF

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HRP20201127T1
HRP20201127T1 HRP20201127TT HRP20201127T HRP20201127T1 HR P20201127 T1 HRP20201127 T1 HR P20201127T1 HR P20201127T T HRP20201127T T HR P20201127TT HR P20201127 T HRP20201127 T HR P20201127T HR P20201127 T1 HRP20201127 T1 HR P20201127T1
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HRP20201127TT
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Molly MCADOW
Andrea DEDENT
Alice Cheng
Carla EMOLO
Dominique Missiakas
Olaf Schneewind
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University Of Chicago
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/085—Staphylococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
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  • Wood Science & Technology (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
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  • General Engineering & Computer Science (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)

Claims (13)

1. Imunogena kompozicija koja sadrži najmanje dvije različite domene 1-2 stafilokokne koagulaze, pri čemu svaka od najmanje dvije domene 1-2 je najmanje 80% identičan po sekvenci domeni 1-2 od SEQ ID NO: 33-41 i pri čemu je barem jedna od domene 1-2 sadržana u proteinu koagulaze dužine manje od pune kojem nedostaju svi od domene veznika (L domen), domene ponavljanja (R domena), ili domene vezivanja fibrinogena (Fgb domen).
2. Kompozicija prema patentnom zahtjevu 1, pri čemu proteinu koagulaze dužine manje od pune nedostaju svi segmenti domene veznika (L) ili ponavljanja (R).
3. Kompozicija prema patentnom zahtjevu 1, pri čemu proteinu koagulaze dužine manje od pune nedostaju svi segmenti domene veznika (L) ili vezivanja fibrinogena (Fgb).
4. Kompozicija prema bilo kojem od patentnih zahtjeva 1 do 3, pri čemu jedna od domena 1-2 je iz S. aureus Newman, 85/2082, MW2, MSSA476, N315, Mu50, MRSA252, Cowan I, WIS ili USA300 soja.
5. Kompozicija prema bilo kojem od patentnih zahtjeva 1 do 4. pri čemu jedna od domena 1-2 je Coa domena 1-2 najmanje 80% identična po sekvenci sa SEQ ID NO identificiranoj u SEQ ID NO: 33-37 i 41.
6. Kompozicija prema bilo kojem od patentnih zahtjeva 1 do 5, pri čemu jedna od domena 1 -2 je domena 1-2 von Willebrand-ovog faktor vezujućeg proteina (vWbp) najmanje 80% identičan po sekvenci sa SEQ ID NO identificiranoj u SEQ ID NO:38-40.
7. Efikasna količina kompozicije prema bilo kojem od patentnih zahtjeva I do 6 za primjenu u metodi liječenja ili prevencije stafilokokne infekcije kod subjekta.
8. Efikasna količina kompozicije prema bilo kojem od patentnih zahtjeva 1 do 6 za primjenu u metodi prema patentnom zahtjevu 7, pri čemu je subjekt liječen na osnovu testa koji ukazuje na stafilokoknu infekciju.
9. Efikasna količina kompozicije prema bilo kojem od patentnih zahtjeva 1 do 6 za primjenu u metodi prema patentnom zahtjevu 7 ili 8, pri čemu kompozicija ili polipeptid se administrira intravenski. intramuskularno, intravaskularno, intratrahealno, intratekalno, intraokularno. intraperitonealno. topikalno, oralno, putem injekcije, putem infuzije, ili putem bolusa.
10. Efikasna količina kompozicije prema bilo kojem od patentnih zahtjeva 1 do 6 za primjenu u metodi prema bilo kojem od patentnih zahtjeva 7 do 9, pri čemu spomenuta metoda dodatno sadrži administraciju jednog ili više antibiotika subjektu.
11. Efikasna količina kompozicije prema bilo kojem od patentnih zahtjeva 1 do 6 za primjenu u metodi prema bilo kojem od patentnih zahtjeva 7 do 10, pri čemu je subjekt imunodeficijentan, imunokompromitiran, hospitaliziran. podvrgnut invazivnoj medicinskoj proceduri, ima respiratornu infekciju, zaražen virusom gripe ili na respiratoru.
12. Efikasna količina kompozicije prema bilo kojem od patentnih zahtjeva 1 do 6 za primjenu u metodi prema bilo kojem od patentnih zahtjeva 7 do 11. pri čemu subjekt ima kožni apsces, čir. ili furunkul.
13. Imunogena kompozicija prema patentnom zahtjevu 1, koja sadrži najmanje šest različitih domena 1-2 stafilokoknih koagulaza pri čemu kompozicija sadrži barem stafilokokne Coa domene 1-2 iz sojeva MRSA252. MW2, N315 i USA300 i domene 1-2 von Willebrand-ovog faktor vezujućeg proteina (vWbp) iz 5. aureus N315 i USA300.
HRP20201127TT 2012-04-26 2020-07-17 Antigeni stafilokokne koagulaze i metode primjene istih HRP20201127T1 (hr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261638831P 2012-04-26 2012-04-26
US201261674619P 2012-07-23 2012-07-23
EP13781494.3A EP2844275B1 (en) 2012-04-26 2013-03-14 Staphylococcal coagulase antigens and methods of their use
PCT/US2013/031695 WO2013162746A1 (en) 2012-04-26 2013-03-14 Staphylococcal coagulase antigens and methods of their use

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HRP20201127T1 true HRP20201127T1 (hr) 2020-11-27

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US (3) US9968668B2 (hr)
EP (2) EP2844275B1 (hr)
JP (2) JP6670106B2 (hr)
CN (1) CN104768572B (hr)
AU (1) AU2013252883B2 (hr)
BR (1) BR112014026861A2 (hr)
CA (1) CA2910319C (hr)
DK (1) DK2844275T3 (hr)
ES (1) ES2806945T3 (hr)
HK (1) HK1207571A1 (hr)
HR (1) HRP20201127T1 (hr)
NZ (1) NZ702285A (hr)
PL (1) PL2844275T3 (hr)
WO (1) WO2013162746A1 (hr)

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US9181329B2 (en) * 2007-08-31 2015-11-10 The University Of Chicago Methods and compositions related to immunizing against Staphylococcal lung diseases and conditions
CA2910319C (en) * 2012-04-26 2022-06-14 University Of Chicago Staphylococcal coagulase antigens and methods of their use
WO2014074540A2 (en) * 2012-11-06 2014-05-15 Medimmune, Llc Antibodies to s. aureus surface determinants
EP3096788B1 (en) * 2014-01-24 2019-07-31 Church, William, R. Antibody specific to staphylococcus aureus, therapeutic method and detection method using same
EP3416979A4 (en) * 2016-02-12 2019-09-11 The University of Chicago COMPOSITIONS AND METHODS ASSOCIATED WITH ANTIBODIES THAT NEUTRALIZE COAGULASE ACTIVITY IN CASES OF GOLDEN STAPHYLOCOCCUS DISEASE
US10738338B2 (en) 2016-10-18 2020-08-11 The Research Foundation for the State University Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate

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