HRP20141147T1 - Antibakterijska kombinacijska terapija za lijeäśenje gram pozitivnih bakterijskih zaraza - Google Patents
Antibakterijska kombinacijska terapija za lijeäśenje gram pozitivnih bakterijskih zaraza Download PDFInfo
- Publication number
- HRP20141147T1 HRP20141147T1 HRP20141147AT HRP20141147T HRP20141147T1 HR P20141147 T1 HRP20141147 T1 HR P20141147T1 HR P20141147A T HRP20141147A T HR P20141147AT HR P20141147 T HRP20141147 T HR P20141147T HR P20141147 T1 HRP20141147 T1 HR P20141147T1
- Authority
- HR
- Croatia
- Prior art keywords
- preparation
- treatment
- use according
- gram
- combination therapy
- Prior art date
Links
- 230000000844 anti-bacterial effect Effects 0.000 title 1
- 238000002648 combination therapy Methods 0.000 title 1
- 208000027136 gram-positive bacterial infections Diseases 0.000 title 1
- 241000192125 Firmicutes Species 0.000 claims 3
- 241001112696 Clostridia Species 0.000 claims 2
- BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 241000193163 Clostridioides difficile Species 0.000 claims 1
- 241000193403 Clostridium Species 0.000 claims 1
- NVNLLIYOARQCIX-MSHCCFNRSA-N Nisin Chemical compound N1C(=O)[C@@H](CC(C)C)NC(=O)C(=C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@@H](NC(=O)C(=C/C)/NC(=O)[C@H](N)[C@H](C)CC)CSC[C@@H]1C(=O)N[C@@H]1C(=O)N2CCC[C@@H]2C(=O)NCC(=O)N[C@@H](C(=O)N[C@H](CCCCN)C(=O)N[C@@H]2C(NCC(=O)N[C@H](C)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCSC)C(=O)NCC(=O)N[C@H](CS[C@@H]2C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H](CCSC)C(=O)N[C@H](CCCCN)C(=O)N[C@@H]2C(N[C@H](C)C(=O)N[C@@H]3C(=O)N[C@@H](C(N[C@H](CC=4NC=NC=4)C(=O)N[C@H](CS[C@@H]3C)C(=O)N[C@H](CO)C(=O)N[C@H]([C@H](C)CC)C(=O)N[C@H](CC=3NC=NC=3)C(=O)N[C@H](C(C)C)C(=O)NC(=C)C(=O)N[C@H](CCCCN)C(O)=O)=O)CS[C@@H]2C)=O)=O)CS[C@@H]1C NVNLLIYOARQCIX-MSHCCFNRSA-N 0.000 claims 1
- 108010053775 Nisin Proteins 0.000 claims 1
- 241000295644 Staphylococcaceae Species 0.000 claims 1
- 206010041925 Staphylococcal infections Diseases 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 208000015688 methicillin-resistant staphylococcus aureus infectious disease Diseases 0.000 claims 1
- 229960002509 miconazole Drugs 0.000 claims 1
- 239000004309 nisin Substances 0.000 claims 1
- 235000010297 nisin Nutrition 0.000 claims 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N nitrate group Chemical group [N+](=O)([O-])[O-] NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (6)
1. Pripravak koji sadrži mikonazol, i njegove farmaceutski prihvatljive soli, te nizin, i njegove farmaceutski prihvatljive soli, za uporabu u liječenju zaraze pripisane ili uzrokovane gram-pozitivnim bakterijama.
2. Pripravak za uporabu prema zahtjevu 1 pri čemu je mikonazol sol nitratna sol.
3. Pripravak za uporabu prema zahtjevu 1 pri čemu su gram-pozitivne bakterije izabrane iz skupine koja se sastoji od Staphylococci, Enterococci i Clostridia.
4. Pripravak za uporabu prema zahtjevu 3 pri čemu su teško lječive gram-pozitivne bakterije izabrane iz skupine koja se sastoji od MRSA, MRSE, VISA, VRSA, VRE i Clostridia.
5. Pripravak za uporabu prema zahtjevima 3 ili 4 pri čemu Gram pozitivni organizam otporan na više lijekova Clostridium sorte je C. difficile.
6. Pripravak za uporabu prema zahtjevu 1 za oralnu administraciju.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0813211.0A GB0813211D0 (en) | 2008-07-18 | 2008-07-18 | Antibacterial combination therapy for the treatment of gram positive bacterial infections |
| EP09784726.3A EP2328573B1 (en) | 2008-07-18 | 2009-07-17 | Antibacterial combination therapy for the treatment of gram positive bacterial infections |
| PCT/GB2009/001772 WO2010007381A1 (en) | 2008-07-18 | 2009-07-17 | Antibacterial combination therapy for the treatment of gram positive bacterial infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20141147T1 true HRP20141147T1 (hr) | 2015-01-30 |
Family
ID=39737300
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20141147AT HRP20141147T1 (hr) | 2008-07-18 | 2014-11-25 | Antibakterijska kombinacijska terapija za lijeäśenje gram pozitivnih bakterijskih zaraza |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8614179B2 (hr) |
| EP (1) | EP2328573B1 (hr) |
| JP (1) | JP6023425B2 (hr) |
| CN (1) | CN102112125B (hr) |
| AU (1) | AU2009272485B2 (hr) |
| CA (1) | CA2730826A1 (hr) |
| CY (1) | CY1116056T1 (hr) |
| DK (1) | DK2328573T3 (hr) |
| ES (1) | ES2523968T3 (hr) |
| GB (1) | GB0813211D0 (hr) |
| HR (1) | HRP20141147T1 (hr) |
| PL (1) | PL2328573T3 (hr) |
| PT (1) | PT2328573E (hr) |
| WO (1) | WO2010007381A1 (hr) |
| ZA (1) | ZA201100705B (hr) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20090100357A (ko) * | 2006-11-16 | 2009-09-23 | 이-테라퓨틱스 리미티드 | 다중-약물 내성 세균 감염의 치료를 위한 이미다졸 |
| GB0714226D0 (en) * | 2007-07-20 | 2007-08-29 | Therapeutics Ltd E | anti-bacterial combination therapy |
| GB0813211D0 (en) | 2008-07-18 | 2008-08-27 | E Therapeutics Plc | Antibacterial combination therapy for the treatment of gram positive bacterial infections |
| BRPI0904249B1 (pt) * | 2009-08-28 | 2018-03-06 | Biolab Sanus Farmacêutica Ltda. | Compostos éteres aralquil benzílicos, processo de preparação dos mesmos, uso dos referidos compostos, composição farmacêutica |
| US8826904B2 (en) | 2011-07-12 | 2014-09-09 | Cardeas Pharma Corporation | Formulations of aminoglycoside and fosfomycin combinations and methods and systems for treatment of ventilator associated pneumonia (VAP) and ventilator associated tracheal (VAT) bronchitis |
| US10471083B2 (en) | 2011-07-12 | 2019-11-12 | Savara Inc. | Formulations of aminoglycoside and fosfomycin in combination for treatment of ventilator associated pneumonia (VAP) and ventilator associated tracheal (VAT) bronchitis |
| US20150238473A1 (en) | 2012-09-27 | 2015-08-27 | University Of Rochester | Methods and compositions for treating infection |
| US9662372B2 (en) | 2013-02-20 | 2017-05-30 | Biolog, Inc. | Compositions and methods to inactivate and/or reduce production of microbial toxins |
| GB201305277D0 (en) * | 2013-03-22 | 2013-05-01 | Helperby Therapeutics Ltd | Novel combination and use |
| RU2549447C1 (ru) * | 2014-03-14 | 2015-04-27 | Алексей Игоревич Панюков | Противовоспалительное антибактериальное ранозаживляющее средство |
| DE102014218913A1 (de) * | 2014-09-19 | 2016-03-24 | Heraeus Medical Gmbh | Verfahren zur Herstellung eines antibiotischen Polymehtylmethacrylat-Knochenzementpulvers und ein antibiotisches Polymethtylmethacrylat-Knochenzementpulver |
| CN109512999B (zh) * | 2016-03-04 | 2022-05-10 | 广州英赛特生物技术有限公司 | 含氧碳氢衍生物的脂肪醇作为多粘菌素的协同增效剂的应用 |
| US10526343B2 (en) | 2018-03-26 | 2020-01-07 | University Of Sharjah | Heterocyclic systems and pharmaceutical applications thereof |
| US10485790B1 (en) * | 2018-09-13 | 2019-11-26 | Syneurx International (Taiwan) Corp. | Salts of cycloserine compounds and applications thereof |
| WO2022257105A1 (en) * | 2021-06-11 | 2022-12-15 | The Hong Kong Polytechnic University | Methods for treating bacterial cell populations |
| US20230062900A1 (en) * | 2021-08-05 | 2023-03-02 | Jonathan SORRES | New antibacterial compound isolated from psiloxylon mauritianum and its derivatives |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3249109A (en) | 1963-11-01 | 1966-05-03 | Maeth Harry | Topical dressing |
| US3598122A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US4144317A (en) | 1975-05-30 | 1979-03-13 | Alza Corporation | Device consisting of copolymer having acetoxy groups for delivering drugs |
| US4262003A (en) | 1975-12-08 | 1981-04-14 | Alza Corporation | Method and therapeutic system for administering scopolamine transdermally |
| US4307717A (en) | 1977-11-07 | 1981-12-29 | Lectec Corporation | Sterile improved bandage containing a medicament |
| NZ210840A (en) | 1984-01-18 | 1987-05-29 | Johnson & Johnson Baby Prod | Composition comprising synergistic combination of miconazole nitrate and zinc oxide |
| US4725439A (en) | 1984-06-29 | 1988-02-16 | Alza Corporation | Transdermal drug delivery device |
| HU199682B (en) * | 1988-04-01 | 1990-03-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producin synergetic veterinary composition |
| GB9224598D0 (en) * | 1992-11-24 | 1993-01-13 | Smithkline Beecham Plc | Novel compositions |
| JP2875140B2 (ja) | 1993-08-16 | 1999-03-24 | 明治製菓株式会社 | 抗ｍｒｓａ組成物 |
| US6461607B1 (en) | 1998-08-24 | 2002-10-08 | Ganeden Biotech, Inc. | Probiotic, lactic acid-producing bacteria and uses thereof |
| FR2843302B1 (fr) | 2002-08-09 | 2004-10-22 | Centre Nat Rech Scient | Forme galenique pour la delivrance colique de principes actifs |
| EP1737378A2 (en) | 2004-04-02 | 2007-01-03 | Baylor College of Medicine | Novel modification of medical prostheses |
| KR20090100357A (ko) | 2006-11-16 | 2009-09-23 | 이-테라퓨틱스 리미티드 | 다중-약물 내성 세균 감염의 치료를 위한 이미다졸 |
| GB0714226D0 (en) | 2007-07-20 | 2007-08-29 | Therapeutics Ltd E | anti-bacterial combination therapy |
| US20100239682A1 (en) | 2007-09-17 | 2010-09-23 | Antoine Andremont | Colonic delivery of antimicrobial agents |
| GB0724996D0 (en) * | 2007-12-21 | 2008-01-30 | Therapeutics Ltd E | Antibacterial combination therapy for the treatment of gram positive bacterial infections |
| GB0813211D0 (en) | 2008-07-18 | 2008-08-27 | E Therapeutics Plc | Antibacterial combination therapy for the treatment of gram positive bacterial infections |
-
2008
- 2008-07-18 GB GBGB0813211.0A patent/GB0813211D0/en not_active Ceased
-
2009
- 2009-07-17 US US13/054,491 patent/US8614179B2/en not_active Expired - Fee Related
- 2009-07-17 DK DK09784726.3T patent/DK2328573T3/en active
- 2009-07-17 JP JP2011517993A patent/JP6023425B2/ja not_active Expired - Fee Related
- 2009-07-17 AU AU2009272485A patent/AU2009272485B2/en not_active Ceased
- 2009-07-17 PL PL09784726T patent/PL2328573T3/pl unknown
- 2009-07-17 EP EP09784726.3A patent/EP2328573B1/en not_active Not-in-force
- 2009-07-17 CA CA2730826A patent/CA2730826A1/en not_active Abandoned
- 2009-07-17 CN CN200980128141.9A patent/CN102112125B/zh not_active Expired - Fee Related
- 2009-07-17 WO PCT/GB2009/001772 patent/WO2010007381A1/en active Application Filing
- 2009-07-17 ES ES09784726.3T patent/ES2523968T3/es active Active
- 2009-07-17 PT PT97847263T patent/PT2328573E/pt unknown
-
2011
- 2011-01-27 ZA ZA2011/00705A patent/ZA201100705B/en unknown
-
2014
- 2014-11-17 CY CY20141100959T patent/CY1116056T1/el unknown
- 2014-11-25 HR HRP20141147AT patent/HRP20141147T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010007381A1 (en) | 2010-01-21 |
| EP2328573A1 (en) | 2011-06-08 |
| AU2009272485A1 (en) | 2010-01-21 |
| CN102112125A (zh) | 2011-06-29 |
| CY1116056T1 (el) | 2017-02-08 |
| ES2523968T3 (es) | 2014-12-03 |
| JP6023425B2 (ja) | 2016-11-09 |
| ZA201100705B (en) | 2012-04-25 |
| EP2328573B1 (en) | 2014-08-27 |
| CN102112125B (zh) | 2016-06-22 |
| CA2730826A1 (en) | 2010-01-21 |
| DK2328573T3 (en) | 2014-12-08 |
| JP2012503594A (ja) | 2012-02-09 |
| PL2328573T3 (pl) | 2015-02-27 |
| US20110257078A1 (en) | 2011-10-20 |
| AU2009272485B2 (en) | 2015-02-12 |
| PT2328573E (pt) | 2014-12-03 |
| GB0813211D0 (en) | 2008-08-27 |
| US8614179B2 (en) | 2013-12-24 |
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