MX2015005477A - Anticuerpos contra determinantes de la superficie de s. aureus. - Google Patents

Anticuerpos contra determinantes de la superficie de s. aureus.

Info

Publication number
MX2015005477A
MX2015005477A MX2015005477A MX2015005477A MX2015005477A MX 2015005477 A MX2015005477 A MX 2015005477A MX 2015005477 A MX2015005477 A MX 2015005477A MX 2015005477 A MX2015005477 A MX 2015005477A MX 2015005477 A MX2015005477 A MX 2015005477A
Authority
MX
Mexico
Prior art keywords
antibodies
aureus
binding fragments
chain variable
variable region
Prior art date
Application number
MX2015005477A
Other languages
English (en)
Inventor
Bret Sellman
Lei Huang
Partha S Chowdhury
Christine Tkaczyk
Peter Pavlik
Rebecca Buonpane
Chew-Shun Chang
Original Assignee
Medimmune Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune Llc filed Critical Medimmune Llc
Publication of MX2015005477A publication Critical patent/MX2015005477A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/56938—Staphylococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Se describen anticuerpos y fragmentos de unión al antígeno de estos dirigidos contra determinantes antigénicos de la superficie Staphylococcus aureus (S. aureus) y toxinas secretadas. También se proporcionan métodos para detectar, diagnosticar y tratar S. aureus empleando los anticuerpos y fragmentos de unión al antígeno de estos.
MX2015005477A 2012-11-06 2013-11-06 Anticuerpos contra determinantes de la superficie de s. aureus. MX2015005477A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261723137P 2012-11-06 2012-11-06
US201361782405P 2013-03-14 2013-03-14
PCT/US2013/068624 WO2014074540A2 (en) 2012-11-06 2013-11-06 Antibodies to s. aureus surface determinants

Publications (1)

Publication Number Publication Date
MX2015005477A true MX2015005477A (es) 2015-11-30

Family

ID=50685304

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015005477A MX2015005477A (es) 2012-11-06 2013-11-06 Anticuerpos contra determinantes de la superficie de s. aureus.
MX2022008079A MX2022008079A (es) 2012-11-06 2015-04-29 Anticuerpos contra determinantes de la superficie de s. aureus.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2022008079A MX2022008079A (es) 2012-11-06 2015-04-29 Anticuerpos contra determinantes de la superficie de s. aureus.

Country Status (17)

Country Link
US (3) US9879070B2 (es)
EP (2) EP2917360B1 (es)
JP (2) JP6694269B2 (es)
KR (1) KR102288394B1 (es)
CN (2) CN104968797B (es)
AU (2) AU2013341361A1 (es)
BR (1) BR112015010125A2 (es)
CA (1) CA2890427C (es)
DK (1) DK2917360T3 (es)
ES (1) ES2776179T3 (es)
HK (2) HK1215054A1 (es)
HU (1) HUE049012T2 (es)
MX (2) MX2015005477A (es)
PL (1) PL2917360T3 (es)
RU (1) RU2698131C2 (es)
SG (2) SG10201703678TA (es)
WO (1) WO2014074540A2 (es)

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Also Published As

Publication number Publication date
AU2013341361A1 (en) 2015-06-04
US9879070B2 (en) 2018-01-30
WO2014074540A3 (en) 2014-07-10
US20200407429A1 (en) 2020-12-31
SG11201503232TA (en) 2015-05-28
US20150291685A1 (en) 2015-10-15
EP2917360A4 (en) 2017-01-25
BR112015010125A2 (pt) 2017-08-22
RU2019122610A (ru) 2020-02-18
HK1215054A1 (zh) 2016-08-12
US10730934B2 (en) 2020-08-04
DK2917360T3 (da) 2020-03-30
EP2917360A2 (en) 2015-09-16
JP6694269B2 (ja) 2020-05-13
US20190016787A1 (en) 2019-01-17
PL2917360T3 (pl) 2020-06-29
CN104968797A (zh) 2015-10-07
CN104968797B (zh) 2018-11-30
MX2022008079A (es) 2022-07-11
AU2018241107B2 (en) 2020-09-17
WO2014074540A2 (en) 2014-05-15
KR20150094621A (ko) 2015-08-19
KR102288394B1 (ko) 2021-08-09
EP2917360B1 (en) 2020-01-08
RU2698131C2 (ru) 2019-08-22
CA2890427A1 (en) 2014-05-15
RU2015121624A (ru) 2016-12-27
EP3640338A1 (en) 2020-04-22
HK1215452A1 (zh) 2016-08-26
CN109553681A (zh) 2019-04-02
US11447543B2 (en) 2022-09-20
AU2018241107A1 (en) 2018-10-25
HUE049012T2 (hu) 2020-09-28
ES2776179T3 (es) 2020-07-29
JP2016507470A (ja) 2016-03-10
SG10201703678TA (en) 2017-06-29
CA2890427C (en) 2022-05-31
JP2019089801A (ja) 2019-06-13

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