CA2889699C - Glucopyranosyl derivatives and their uses in medicine - Google Patents
Glucopyranosyl derivatives and their uses in medicine Download PDFInfo
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- CA2889699C CA2889699C CA2889699A CA2889699A CA2889699C CA 2889699 C CA2889699 C CA 2889699C CA 2889699 A CA2889699 A CA 2889699A CA 2889699 A CA2889699 A CA 2889699A CA 2889699 C CA2889699 C CA 2889699C
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- 125000005640 glucopyranosyl group Chemical group 0.000 title abstract description 6
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- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 28
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- 150000001875 compounds Chemical class 0.000 claims description 414
- -1 hydroxy, cyano, amino Chemical group 0.000 claims description 369
- 229920006395 saturated elastomer Polymers 0.000 claims description 174
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 171
- 125000000217 alkyl group Chemical group 0.000 claims description 73
- 125000001424 substituent group Chemical group 0.000 claims description 42
- 125000000623 heterocyclic group Chemical group 0.000 claims description 33
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 29
- 125000003118 aryl group Chemical group 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 27
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- 125000003282 alkyl amino group Chemical group 0.000 claims description 26
- 125000004432 carbon atom Chemical group C* 0.000 claims description 26
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- 125000003342 alkenyl group Chemical group 0.000 claims description 23
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- 125000004217 4-methoxybenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])* 0.000 claims description 5
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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| CN201310450401.2 | 2013-09-27 | ||
| CN201310450401 | 2013-09-27 | ||
| PCT/CN2014/087587 WO2015043511A1 (en) | 2013-09-27 | 2014-09-26 | Glucopyranosyl derivatives and their uses in medicine |
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| WO2016173425A1 (en) * | 2015-04-30 | 2016-11-03 | Sunshine Lake Pharma Co., Ltd. | A glucopyranosyl derivative and preparation method and uses thereof |
| CN106674294B (zh) * | 2015-11-06 | 2020-07-07 | 广东东阳光药业有限公司 | 吡喃葡萄糖基衍生物的结晶形式 |
| CA3005920C (en) * | 2015-11-27 | 2023-08-22 | Sunshine Lake Pharma Co., Ltd. | A complex of a glucopyranosyl derivative and preparation method and use thereof |
| CN105646604A (zh) * | 2016-03-01 | 2016-06-08 | 孙霖 | 埃格列净晶型b及制备方法 |
| CN105646603A (zh) * | 2016-03-01 | 2016-06-08 | 孙霖 | 埃格列净晶型a及制备方法 |
| ES2926790T3 (es) * | 2016-05-04 | 2022-10-28 | Youngene Therapeutics Co Ltd | Solvato de dietilamina del inhibidor del transportador de sodio-glucosa, y método de preparación y aplicación del mismo |
| CN107778336B (zh) * | 2016-08-24 | 2022-09-27 | 宜昌东阳光长江药业股份有限公司 | 吡喃葡萄糖基衍生物的结晶形式 |
| CN106674245B (zh) * | 2017-01-10 | 2019-07-26 | 北京中海康医药科技发展有限公司 | 吡喃葡萄糖基衍生物的制备及医药上的应用 |
| JP2019001746A (ja) * | 2017-06-15 | 2019-01-10 | 株式会社クラレ | ジオールの製造方法 |
| CN107986972A (zh) * | 2017-11-10 | 2018-05-04 | 潍坊润安化学科技有限公司 | 一种3-(4-硝基苯氧基)丙酸制备方法 |
| AU2021305132A1 (en) * | 2020-07-08 | 2023-02-09 | Sunshine Lake Pharma Co., Ltd. | Method for preparing glucopyranosyl derivatives and intermediates thereof |
| WO2022161377A1 (en) * | 2021-01-27 | 2022-08-04 | Sunshine Lake Pharma Co., Ltd. | A phamaceutical composition comprising a glucopyranosyl derivative |
| WO2022204907A1 (en) * | 2021-03-30 | 2022-10-06 | Sunshine Lake Pharma Co., Ltd. | Method for preparing cocrystal of l-pyroglutamic acid and glucopyranosyl derivative |
| CN114835563B (zh) * | 2022-05-23 | 2024-04-26 | 浙江中欣氟材股份有限公司 | 一种4,4`-二氟二苯甲酮的合成方法 |
| CN117430571B (zh) * | 2022-07-15 | 2025-08-29 | 宜昌东阳光长江药业股份有限公司 | 一种制备吡喃葡萄糖基衍生物的关键中间体及其制备方法 |
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| PH12000002657B1 (en) | 1999-10-12 | 2006-02-21 | Bristol Myers Squibb Co | C-aryl glucoside SGLT2 inhibitors |
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| EP1724278B1 (en) * | 2004-03-04 | 2014-05-07 | Kissei Pharmaceutical Co., Ltd. | Nitrogenous fused-ring derivatives, medicinal compositions containing the derivatives, and use thereof as drugs |
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| WO2006018150A1 (de) | 2004-08-11 | 2006-02-23 | Boehringer Ingelheim International Gmbh | D-xylopyranosyl-phenyl-substituierte cyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
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| WO2013178064A1 (zh) | 2012-05-29 | 2013-12-05 | 广东东阳光药业有限公司 | 吡喃葡萄糖基衍生物、其制备方法及其在医药上的应用 |
| CN103570657A (zh) | 2012-07-19 | 2014-02-12 | 天津药物研究院 | 一类含偕二甲基的苯基c-葡萄糖苷衍生物、其制备方法和用途 |
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| WO2014164286A1 (en) | 2013-03-11 | 2014-10-09 | Janssen Pharmaceutica Nv | Dual sglt1/sglt2 inhibitors |
| CN104059042B (zh) | 2013-03-22 | 2017-02-08 | 正大天晴药业集团股份有限公司 | C-三芳基葡萄糖苷类sglt-2抑制剂 |
| CN104619713B (zh) | 2013-05-24 | 2017-06-16 | 四川海思科制药有限公司 | 氧杂双环衍生物、制备方法及其应用 |
| WO2014206349A1 (zh) | 2013-06-28 | 2014-12-31 | 四川海思科制药有限公司 | 氧杂-硫杂-双环[3.2.1]辛烷衍生物、制备方法及其用途 |
| WO2015027963A1 (zh) | 2013-09-02 | 2015-03-05 | 四川海思科制药有限公司 | 芳环类衍生物、其药物组合物及其应用 |
| CN107311992B (zh) | 2013-09-09 | 2020-08-18 | 上海研健新药研发有限公司 | C-芳基葡糖苷衍生物、其制备方法及其在医药上的应用 |
| CN104017031A (zh) * | 2014-06-21 | 2014-09-03 | 李友香 | 降血糖药物和组合物 |
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| EP2895490B1 (en) | 2016-10-19 |
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| US9394329B2 (en) | 2016-07-19 |
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| CN104513283A (zh) | 2015-04-15 |
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| AU2014327928A1 (en) | 2015-05-14 |
| JP6450769B2 (ja) | 2019-01-09 |
| US20150266916A1 (en) | 2015-09-24 |
| EP2895490A4 (en) | 2015-10-28 |
| EP2895490A1 (en) | 2015-07-22 |
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