CA2854246A1 - Full length antibody display system for eukaryotic cells and its use - Google Patents

Full length antibody display system for eukaryotic cells and its use Download PDF

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Publication number
CA2854246A1
CA2854246A1 CA2854246A CA2854246A CA2854246A1 CA 2854246 A1 CA2854246 A1 CA 2854246A1 CA 2854246 A CA2854246 A CA 2854246A CA 2854246 A CA2854246 A CA 2854246A CA 2854246 A1 CA2854246 A1 CA 2854246A1
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Canada
Prior art keywords
cells
cell
population
antibody
heavy chain
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Abandoned
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CA2854246A
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English (en)
French (fr)
Inventor
Peter Michael HUELSMANN
Hendrik Knoetgen
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Filing date
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Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CA2854246A1 publication Critical patent/CA2854246A1/en
Abandoned legal-status Critical Current

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA2854246A 2011-12-22 2012-12-19 Full length antibody display system for eukaryotic cells and its use Abandoned CA2854246A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP11195375 2011-12-22
EP11195375.8 2011-12-22
EP12179029 2012-08-02
EP12179029.9 2012-08-02
PCT/EP2012/076163 WO2013092720A1 (en) 2011-12-22 2012-12-19 Full length antibody display system for eukaryotic cells and its use

Publications (1)

Publication Number Publication Date
CA2854246A1 true CA2854246A1 (en) 2013-06-27

Family

ID=47458959

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2854246A Abandoned CA2854246A1 (en) 2011-12-22 2012-12-19 Full length antibody display system for eukaryotic cells and its use

Country Status (12)

Country Link
US (1) US20150038354A1 (cg-RX-API-DMAC7.html)
EP (1) EP2794662A1 (cg-RX-API-DMAC7.html)
JP (1) JP2015503907A (cg-RX-API-DMAC7.html)
KR (1) KR20140107295A (cg-RX-API-DMAC7.html)
CN (1) CN104011080B (cg-RX-API-DMAC7.html)
BR (1) BR112014013035A2 (cg-RX-API-DMAC7.html)
CA (1) CA2854246A1 (cg-RX-API-DMAC7.html)
HK (1) HK1200849A1 (cg-RX-API-DMAC7.html)
MX (1) MX2014007262A (cg-RX-API-DMAC7.html)
RU (1) RU2625033C2 (cg-RX-API-DMAC7.html)
SG (1) SG11201403445YA (cg-RX-API-DMAC7.html)
WO (1) WO2013092720A1 (cg-RX-API-DMAC7.html)

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CN119654417A (zh) 2022-06-10 2025-03-18 富士胶片戴奥辛思生物技术英国有限公司 细胞的制备方法、异源多聚体蛋白质的制造方法、双特异性抗体的制造方法、载体组、哺乳动物细胞、cho细胞和细胞池的制备方法
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BR112014013035A2 (pt) 2018-10-09
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US20150038354A1 (en) 2015-02-05
RU2014129736A (ru) 2016-02-20
WO2013092720A1 (en) 2013-06-27
CN104011080B (zh) 2017-10-20
HK1200849A1 (en) 2015-08-14
JP2015503907A (ja) 2015-02-05
MX2014007262A (es) 2014-08-01
KR20140107295A (ko) 2014-09-04
CN104011080A (zh) 2014-08-27

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