CA2841572C - Trans-clomiphene metabolites and uses thereof - Google Patents
Trans-clomiphene metabolites and uses thereof Download PDFInfo
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- CA2841572C CA2841572C CA2841572A CA2841572A CA2841572C CA 2841572 C CA2841572 C CA 2841572C CA 2841572 A CA2841572 A CA 2841572A CA 2841572 A CA2841572 A CA 2841572A CA 2841572 C CA2841572 C CA 2841572C
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- trans
- clomiphene
- metabolite
- hydroxylation
- pharmaceutically acceptable
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
- C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
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- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
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- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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| PCT/US2012/049451 WO2013020017A1 (en) | 2011-08-04 | 2012-08-03 | Trans-clomiphene metabolites and uses thereof |
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| US20120284764A1 (en) * | 2011-05-05 | 2012-11-08 | Keith Ball | Method and system for requesting services by a media device |
| UA113291C2 (xx) | 2011-08-04 | 2017-01-10 | Метаболіти транскломіфену і їх застосування | |
| SG11201407397WA (en) | 2012-05-31 | 2014-12-30 | Repros Therapeutics Inc | Formulations and methods for vaginal delivery of antiprogestins |
| ES2688821T3 (es) | 2012-11-02 | 2018-11-07 | Repros Therapeutics Inc. | Métodos y composiciones para tratar afecciones dependientes de la progesterona |
| WO2014070523A1 (en) * | 2012-11-02 | 2014-05-08 | Repros Therapeutics Inc. | Trans-clomiphene for use in cancer therapy |
| WO2017123577A1 (en) * | 2016-01-12 | 2017-07-20 | Repros Therapeutics Inc. | Trans-clomiphene and progesterone receptor antagonist combination therapy for treating hormone-dependent conditions |
| CN108883083A (zh) * | 2016-02-25 | 2018-11-23 | 艾森潘帕克制药股份有限公司 | 两种氯米芬异构体的口服剂型及使用其治疗继发性腺功能减退症的方法 |
| WO2017182097A1 (en) | 2016-04-22 | 2017-10-26 | F.I.S. - Fabbrica Italiana Sintetici S.P.A. | Process for the preparation of enclomiphene citrate having needle shaped crystal habit. |
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| CN103702975A (zh) | 2014-04-02 |
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| US9981906B2 (en) | 2018-05-29 |
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| AU2012289964A1 (en) | 2014-01-30 |
| UA113291C2 (xx) | 2017-01-10 |
| KR20140054110A (ko) | 2014-05-08 |
| PH12014500144A1 (en) | 2014-02-24 |
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| HK1196349A1 (zh) | 2014-12-12 |
| JP2014529584A (ja) | 2014-11-13 |
| SG10201606425WA (en) | 2016-09-29 |
| JP2019023210A (ja) | 2019-02-14 |
| IL230287B (en) | 2019-07-31 |
| NZ621892A (en) | 2016-03-31 |
| EP3351527A1 (en) | 2018-07-25 |
| BR112014000908A2 (pt) | 2017-02-21 |
| CO6862154A2 (es) | 2014-02-10 |
| CA2841572A1 (en) | 2013-02-07 |
| AU2012289964B2 (en) | 2017-03-23 |
| MX355316B (es) | 2018-04-16 |
| CN103702975B (zh) | 2016-03-16 |
| WO2013020017A1 (en) | 2013-02-07 |
| JP6433785B2 (ja) | 2018-12-05 |
| MY191802A (en) | 2022-07-15 |
| ZA201400406B (en) | 2014-11-26 |
| MX2014000825A (es) | 2014-02-27 |
| AU2017204171A1 (en) | 2017-07-13 |
| IL230287A0 (en) | 2014-03-06 |
| CR20140124A (es) | 2014-05-13 |
| MY170718A (en) | 2019-08-27 |
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