BR112014000908A2 - composto, composição farmacêutica e respectivos usos e métodos para tratar hipogonadismo secundário ou distúrbio associado ao mesmo, infertilidade em mulher, diabetes do tipo 2 em humano do sexo masculino, câncer da mama em mulher e câncer do endomètrio, do ovàrio ou uterino em mulher, para prevenir a transição da síndrome metabólica para diabetes do tipo 2 em humano do sexo masculino e câncer da mama em mulher e para reduzir níveis de glicose no sangue em jejum de humano do sexo masculino - Google Patents
composto, composição farmacêutica e respectivos usos e métodos para tratar hipogonadismo secundário ou distúrbio associado ao mesmo, infertilidade em mulher, diabetes do tipo 2 em humano do sexo masculino, câncer da mama em mulher e câncer do endomètrio, do ovàrio ou uterino em mulher, para prevenir a transição da síndrome metabólica para diabetes do tipo 2 em humano do sexo masculino e câncer da mama em mulher e para reduzir níveis de glicose no sangue em jejum de humano do sexo masculinoInfo
- Publication number
- BR112014000908A2 BR112014000908A2 BR112014000908A BR112014000908A BR112014000908A2 BR 112014000908 A2 BR112014000908 A2 BR 112014000908A2 BR 112014000908 A BR112014000908 A BR 112014000908A BR 112014000908 A BR112014000908 A BR 112014000908A BR 112014000908 A2 BR112014000908 A2 BR 112014000908A2
- Authority
- BR
- Brazil
- Prior art keywords
- women
- diabetes
- type
- breast cancer
- male
- Prior art date
Links
- 206010006187 Breast cancer Diseases 0.000 title 2
- 208000026310 Breast neoplasm Diseases 0.000 title 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 title 2
- 206010014733 Endometrial cancer Diseases 0.000 title 1
- 206010014759 Endometrial neoplasm Diseases 0.000 title 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title 1
- 241000282412 Homo Species 0.000 title 1
- 208000001145 Metabolic Syndrome Diseases 0.000 title 1
- 206010033128 Ovarian cancer Diseases 0.000 title 1
- 206010061535 Ovarian neoplasm Diseases 0.000 title 1
- 206010059594 Secondary hypogonadism Diseases 0.000 title 1
- 208000002495 Uterine Neoplasms Diseases 0.000 title 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 title 1
- 239000008280 blood Substances 0.000 title 1
- 210000004369 blood Anatomy 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 208000035475 disorder Diseases 0.000 title 1
- 230000002357 endometrial effect Effects 0.000 title 1
- 239000008103 glucose Substances 0.000 title 1
- 201000003368 hypogonadotropic hypogonadism Diseases 0.000 title 1
- 208000000509 infertility Diseases 0.000 title 1
- 230000036512 infertility Effects 0.000 title 1
- 231100000535 infertility Toxicity 0.000 title 1
- 230000002611 ovarian Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000007704 transition Effects 0.000 title 1
- 206010046766 uterine cancer Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
- C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Gynecology & Obstetrics (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Pregnancy & Childbirth (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161515278P | 2011-08-04 | 2011-08-04 | |
| PCT/US2012/049451 WO2013020017A1 (en) | 2011-08-04 | 2012-08-03 | Trans-clomiphene metabolites and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112014000908A2 true BR112014000908A2 (pt) | 2017-02-21 |
Family
ID=46724628
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014000908A BR112014000908A2 (pt) | 2011-08-04 | 2012-08-03 | composto, composição farmacêutica e respectivos usos e métodos para tratar hipogonadismo secundário ou distúrbio associado ao mesmo, infertilidade em mulher, diabetes do tipo 2 em humano do sexo masculino, câncer da mama em mulher e câncer do endomètrio, do ovàrio ou uterino em mulher, para prevenir a transição da síndrome metabólica para diabetes do tipo 2 em humano do sexo masculino e câncer da mama em mulher e para reduzir níveis de glicose no sangue em jejum de humano do sexo masculino |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9981906B2 (https=) |
| EP (2) | EP3351527A1 (https=) |
| JP (2) | JP6433785B2 (https=) |
| KR (1) | KR20140054110A (https=) |
| CN (1) | CN103702975B (https=) |
| AU (2) | AU2012289964B2 (https=) |
| BR (1) | BR112014000908A2 (https=) |
| CA (1) | CA2841572C (https=) |
| CL (1) | CL2014000268A1 (https=) |
| CO (1) | CO6862154A2 (https=) |
| CR (1) | CR20140124A (https=) |
| EA (1) | EA201490416A1 (https=) |
| IL (1) | IL230287B (https=) |
| MX (1) | MX355316B (https=) |
| MY (2) | MY170718A (https=) |
| NI (1) | NI201400008A (https=) |
| PH (1) | PH12014500144A1 (https=) |
| SG (1) | SG10201606425WA (https=) |
| UA (1) | UA113291C2 (https=) |
| WO (1) | WO2013020017A1 (https=) |
| ZA (1) | ZA201400406B (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120284764A1 (en) * | 2011-05-05 | 2012-11-08 | Keith Ball | Method and system for requesting services by a media device |
| UA113291C2 (xx) | 2011-08-04 | 2017-01-10 | Метаболіти транскломіфену і їх застосування | |
| CA2872644A1 (en) | 2012-05-31 | 2013-12-05 | Allergan Pharmaceuticals International Limited | Formulations and methods for vaginal delivery of antiprogestins |
| HK1216502A1 (zh) * | 2012-11-02 | 2016-11-18 | Repros Therapeutics Inc. | 用於癌症治療的反式-克羅米芬 |
| US9545411B2 (en) | 2012-11-02 | 2017-01-17 | Repros Therapeutics Inc. | Methods and compositions for treating progesterone-dependent conditions |
| WO2017123577A1 (en) * | 2016-01-12 | 2017-07-20 | Repros Therapeutics Inc. | Trans-clomiphene and progesterone receptor antagonist combination therapy for treating hormone-dependent conditions |
| RU2018133603A (ru) * | 2016-02-25 | 2020-03-25 | Эспен Парк Фармасьютикалз, Инк. | Пероральная дозированная форма двух изомеров кломифена и способ ее использования для лечения вторичного гипогонадизма и минимизации побочных эффектов лекарственного препарата у мужчин |
| EP3368506B1 (en) | 2016-04-22 | 2023-09-06 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Process for the preparation of enclomiphene citrate having needle shaped crystal habit. |
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-
2012
- 2012-03-08 UA UAA201402168A patent/UA113291C2/uk unknown
- 2012-08-03 US US14/236,868 patent/US9981906B2/en not_active Expired - Fee Related
- 2012-08-03 CN CN201280038230.6A patent/CN103702975B/zh not_active Expired - Fee Related
- 2012-08-03 MY MYPI2014000022A patent/MY170718A/en unknown
- 2012-08-03 AU AU2012289964A patent/AU2012289964B2/en not_active Ceased
- 2012-08-03 CA CA2841572A patent/CA2841572C/en not_active Expired - Fee Related
- 2012-08-03 EP EP18161551.9A patent/EP3351527A1/en not_active Withdrawn
- 2012-08-03 JP JP2014524097A patent/JP6433785B2/ja not_active Expired - Fee Related
- 2012-08-03 MX MX2014000825A patent/MX355316B/es active IP Right Grant
- 2012-08-03 WO PCT/US2012/049451 patent/WO2013020017A1/en not_active Ceased
- 2012-08-03 KR KR1020147004588A patent/KR20140054110A/ko not_active Ceased
- 2012-08-03 MY MYPI2017001676A patent/MY191802A/en unknown
- 2012-08-03 PH PH1/2014/500144A patent/PH12014500144A1/en unknown
- 2012-08-03 BR BR112014000908A patent/BR112014000908A2/pt active Search and Examination
- 2012-08-03 EA EA201490416A patent/EA201490416A1/ru unknown
- 2012-08-03 SG SG10201606425WA patent/SG10201606425WA/en unknown
- 2012-08-03 EP EP12750508.9A patent/EP2744777A1/en not_active Withdrawn
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2014
- 2014-01-02 IL IL230287A patent/IL230287B/en active IP Right Grant
- 2014-01-17 ZA ZA2014/00406A patent/ZA201400406B/en unknown
- 2014-01-24 CO CO14014339A patent/CO6862154A2/es unknown
- 2014-01-30 NI NI201400008A patent/NI201400008A/es unknown
- 2014-02-03 CL CL2014000268A patent/CL2014000268A1/es unknown
- 2014-03-13 CR CR20140124A patent/CR20140124A/es unknown
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2017
- 2017-06-20 AU AU2017204171A patent/AU2017204171A1/en not_active Abandoned
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2018
- 2018-10-01 JP JP2018186696A patent/JP2019023210A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| MY170718A (en) | 2019-08-27 |
| CN103702975A (zh) | 2014-04-02 |
| HK1196349A1 (zh) | 2014-12-12 |
| JP6433785B2 (ja) | 2018-12-05 |
| UA113291C2 (xx) | 2017-01-10 |
| EP3351527A1 (en) | 2018-07-25 |
| CN103702975B (zh) | 2016-03-16 |
| WO2013020017A1 (en) | 2013-02-07 |
| MX2014000825A (es) | 2014-02-27 |
| EP2744777A1 (en) | 2014-06-25 |
| ZA201400406B (en) | 2014-11-26 |
| SG10201606425WA (en) | 2016-09-29 |
| US9981906B2 (en) | 2018-05-29 |
| CA2841572A1 (en) | 2013-02-07 |
| MX355316B (es) | 2018-04-16 |
| CL2014000268A1 (es) | 2014-11-14 |
| PH12014500144A1 (en) | 2014-02-24 |
| CO6862154A2 (es) | 2014-02-10 |
| AU2017204171A1 (en) | 2017-07-13 |
| JP2014529584A (ja) | 2014-11-13 |
| AU2012289964A1 (en) | 2014-01-30 |
| KR20140054110A (ko) | 2014-05-08 |
| MY191802A (en) | 2022-07-15 |
| CR20140124A (es) | 2014-05-13 |
| IL230287B (en) | 2019-07-31 |
| AU2012289964B2 (en) | 2017-03-23 |
| NZ621892A (en) | 2016-03-31 |
| JP2019023210A (ja) | 2019-02-14 |
| CA2841572C (en) | 2020-10-13 |
| NI201400008A (es) | 2015-12-10 |
| EA201490416A1 (ru) | 2014-11-28 |
| US20140163114A1 (en) | 2014-06-12 |
| IL230287A0 (en) | 2014-03-06 |
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