CA2821080C - Universal anti-tag chimeric antigen receptor-expressing t cells and methods of treating cancer - Google Patents

Universal anti-tag chimeric antigen receptor-expressing t cells and methods of treating cancer Download PDF

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Publication number
CA2821080C
CA2821080C CA2821080A CA2821080A CA2821080C CA 2821080 C CA2821080 C CA 2821080C CA 2821080 A CA2821080 A CA 2821080A CA 2821080 A CA2821080 A CA 2821080A CA 2821080 C CA2821080 C CA 2821080C
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cells
car
cancer
expressing
tagged proteins
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French (fr)
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CA2821080A1 (en
Inventor
Eduardo Davila
Koji Tamada
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University of Maryland Baltimore
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University of Maryland Baltimore
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Priority to CA3102782A priority Critical patent/CA3102782A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K47/6859—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from liver or pancreas cancer cell
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    • C07K—PEPTIDES
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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CA2821080A 2010-12-14 2011-12-14 Universal anti-tag chimeric antigen receptor-expressing t cells and methods of treating cancer Active CA2821080C (en)

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CA3102782A CA3102782A1 (en) 2010-12-14 2011-12-14 Universal anti-tag chimeric antigen receptor-expressing t cells and methods of treating cancer

Applications Claiming Priority (3)

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US42268110P 2010-12-14 2010-12-14
US61/422,681 2010-12-14
PCT/US2011/064808 WO2012082841A2 (en) 2010-12-14 2011-12-14 Universal anti-tag chimeric antigen receptor-expressing t cells and methods of treating cancer

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CA2821080A1 CA2821080A1 (en) 2012-06-21
CA2821080C true CA2821080C (en) 2021-02-02

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