CA2805765A1 - Modulation of dystrophia myotonica-protein kinase (dmpk) expression - Google Patents

Modulation of dystrophia myotonica-protein kinase (dmpk) expression Download PDF

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Publication number
CA2805765A1
CA2805765A1 CA2805765A CA2805765A CA2805765A1 CA 2805765 A1 CA2805765 A1 CA 2805765A1 CA 2805765 A CA2805765 A CA 2805765A CA 2805765 A CA2805765 A CA 2805765A CA 2805765 A1 CA2805765 A1 CA 2805765A1
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Prior art keywords
modified
compound
animal
oligonucleotide
seq
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CA2805765A
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English (en)
French (fr)
Inventor
C. Frank Bennett
Susan M. Freier
Robert A. Macleod
Sanjay K. Pandey
Charles A. Thornton
Thurman Wheeler
Seng H. Cheng
Andrew Leger
Bruce M. Wentworth
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Ionis Pharmaceuticals Inc
University of Rochester
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Individual
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Application filed by Individual filed Critical Individual
Publication of CA2805765A1 publication Critical patent/CA2805765A1/en
Pending legal-status Critical Current

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3525—MOE, methoxyethoxy

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CA2805765A 2010-07-19 2011-07-19 Modulation of dystrophia myotonica-protein kinase (dmpk) expression Pending CA2805765A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US36577510P 2010-07-19 2010-07-19
US36576210P 2010-07-19 2010-07-19
US61/365,762 2010-07-19
US61/365,775 2010-07-19
US201161478021P 2011-04-21 2011-04-21
US61/478,021 2011-04-21
PCT/US2011/044555 WO2012012443A2 (en) 2010-07-19 2011-07-19 Modulation of dystrophia myotonica-protein kinase (dmpk) expression

Publications (1)

Publication Number Publication Date
CA2805765A1 true CA2805765A1 (en) 2012-01-26

Family

ID=45497419

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2805791A Abandoned CA2805791A1 (en) 2010-07-19 2011-07-19 Modulation of nuclear-retained rna
CA2805765A Pending CA2805765A1 (en) 2010-07-19 2011-07-19 Modulation of dystrophia myotonica-protein kinase (dmpk) expression

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Application Number Title Priority Date Filing Date
CA2805791A Abandoned CA2805791A1 (en) 2010-07-19 2011-07-19 Modulation of nuclear-retained rna

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US (7) US20130225659A1 (enExample)
EP (5) EP2595663A4 (enExample)
JP (5) JP5981428B2 (enExample)
KR (2) KR20180105730A (enExample)
CN (2) CN106434648A (enExample)
AU (6) AU2011282243B2 (enExample)
CA (2) CA2805791A1 (enExample)
DK (1) DK3031920T3 (enExample)
ES (1) ES2756326T3 (enExample)
HR (1) HRP20191753T1 (enExample)
IL (2) IL223962B (enExample)
PL (1) PL3031920T3 (enExample)
WO (2) WO2012012467A2 (enExample)

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