CA2763135C - Systems and methods for delivering therapeutic agents - Google Patents

Systems and methods for delivering therapeutic agents Download PDF

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Publication number
CA2763135C
CA2763135C CA2763135A CA2763135A CA2763135C CA 2763135 C CA2763135 C CA 2763135C CA 2763135 A CA2763135 A CA 2763135A CA 2763135 A CA2763135 A CA 2763135A CA 2763135 C CA2763135 C CA 2763135C
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CA
Canada
Prior art keywords
container
region
fluid
therapeutic agent
tube
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2763135A
Other languages
English (en)
French (fr)
Other versions
CA2763135A1 (en
Inventor
Richard W. Ducharme
David E. Sugg
Eugene Skelton
Martin Bruggemann
Lyndsey Bryce
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cook Medical Technologies LLC
Original Assignee
Cook Medical Technologies LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cook Medical Technologies LLC filed Critical Cook Medical Technologies LLC
Publication of CA2763135A1 publication Critical patent/CA2763135A1/en
Application granted granted Critical
Publication of CA2763135C publication Critical patent/CA2763135C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/00491—Surgical glue applicators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/155—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by gas introduced into the reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/00491—Surgical glue applicators
    • A61B2017/00522—Sprayers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8218—Gas operated
    • A61M2205/8225—Gas operated using incorporated gas cartridges for the driving gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2053—Media being expelled from injector by pressurised fluid or vacuum

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Medical Informatics (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
CA2763135A 2009-05-29 2010-05-27 Systems and methods for delivering therapeutic agents Active CA2763135C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18246309P 2009-05-29 2009-05-29
US61/182,463 2009-05-29
PCT/US2010/036381 WO2010138703A1 (en) 2009-05-29 2010-05-27 Systems and methods for delivering therapeutic agents

Publications (2)

Publication Number Publication Date
CA2763135A1 CA2763135A1 (en) 2010-12-02
CA2763135C true CA2763135C (en) 2015-05-19

Family

ID=42342773

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2763135A Active CA2763135C (en) 2009-05-29 2010-05-27 Systems and methods for delivering therapeutic agents

Country Status (7)

Country Link
US (2) US8118777B2 (enExample)
EP (2) EP2435114B1 (enExample)
JP (2) JP5670439B2 (enExample)
AU (1) AU2010253997B2 (enExample)
CA (1) CA2763135C (enExample)
DK (2) DK3150240T3 (enExample)
WO (1) WO2010138703A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12496429B2 (en) 2022-10-18 2025-12-16 Cook Medical Technologies Llc Systems and methods for delivering pressurized fluid to a target site alone or in conjunction with therapeutic agents

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11167058B2 (en) 2005-02-15 2021-11-09 Virginia Commonwealth University Hemostasis of wound having high pressure blood flow
US7604819B2 (en) 2006-05-26 2009-10-20 Z-Medica Corporation Clay-based hemostatic agents and devices for the delivery thereof
US9101744B2 (en) 2009-05-29 2015-08-11 Cook Medical Technologies Llc Systems and methods for delivering therapeutic agents
US9205207B2 (en) * 2010-01-15 2015-12-08 Xin Ji Internal dry powder delivery system and method thereof
US8858969B2 (en) 2010-09-22 2014-10-14 Z-Medica, Llc Hemostatic compositions, devices, and methods
US8870756B2 (en) * 2010-10-08 2014-10-28 ERBE-USA, Inc. Hybrid apparatus for fluid supply for endoscopic irrigation and lens cleaning
US20120135526A1 (en) * 2010-11-23 2012-05-31 Kenneth Greenberg Low-pressure biolistic barrels
US9314568B2 (en) 2011-02-11 2016-04-19 Lifecell Corporation Devices and methods for tissue transfer
RU2013151160A (ru) * 2011-04-19 2015-05-27 ИНВИЗИДЕРМ ЭлЭлСи Способ создания веществ, перенасыщенных газом, устройство трансдермальной доставки и его использование
BR112013027010A2 (pt) * 2011-04-19 2016-12-27 Invisiderm Llc método de produzir substâncias com gás supersaturado, dispositivo para sua entrega trasdérmica, e seus usos
CN103619265B (zh) * 2011-04-27 2016-04-06 比奥马普公司 生物医学止血粉末分配器
US10130800B2 (en) * 2012-01-27 2018-11-20 Invisiderm, Llc Method of producing substances with supersaturated gas, transdermal delivery device thereof, and uses thereof
USD857882S1 (en) 2012-02-10 2019-08-27 Lifecell Corporation Tissue transfer apparatus
CA2865349C (en) * 2012-03-06 2021-07-06 Ferrosan Medical Devices A/S Pressurized container containing haemostatic paste
EP3412320A1 (en) 2012-06-22 2018-12-12 Z-Medica, LLC Hemostatic devices
US20140114248A1 (en) * 2012-10-24 2014-04-24 Nuance Designs, LLC Power pack for an autoinjector
US9358339B2 (en) * 2012-12-14 2016-06-07 Bay Genomics, LLC Particle based biologically active molecule delivery systems
WO2014099662A1 (en) * 2012-12-21 2014-06-26 Cook Medical Technologies Llc Systems and methods for delivering therapeutic agents
CN103041499A (zh) * 2013-01-18 2013-04-17 宁波市镇海怡福莱文化创意有限公司 一种气动喷粉器
US11931227B2 (en) 2013-03-15 2024-03-19 Cook Medical Technologies Llc Bimodal treatment methods and compositions for gastrointestinal lesions with active bleeding
US9867931B2 (en) 2013-10-02 2018-01-16 Cook Medical Technologies Llc Therapeutic agents for delivery using a catheter and pressure source
WO2015062420A1 (zh) * 2013-10-28 2015-05-07 浙江三创生物科技有限公司 粉末喷射方法及其装置
CA2965509C (en) 2014-10-24 2023-03-14 Avectas Limited Delivery across cell plasma membranes
CN107530502B (zh) 2015-02-20 2021-01-15 里珍纳龙药品有限公司 注射器系统、活塞密封系统、塞子系统
PL3295993T3 (pl) * 2015-05-15 2020-04-30 Beautygun S.L. Urządzenie do podawania produktu kosmetycznego, odpowiedni sposób i pojemnik
US11827899B2 (en) 2015-12-30 2023-11-28 Avectas Limited Vector-free delivery of gene editing proteins and compositions to cells and tissues
US10441761B2 (en) 2016-07-01 2019-10-15 Boston Scientific Scimed, Inc. Delivery devices and methods
WO2018059642A2 (en) 2016-09-28 2018-04-05 Ambu A/S An endoscope adapted for facilitating bal procedures
CN115591066A (zh) 2017-01-10 2023-01-13 波士顿科学国际有限公司（Us） 用于输送粉末药剂的装置和方法
WO2018202267A1 (en) 2017-05-02 2018-11-08 Ambu A/S An endoscope
US11602761B1 (en) * 2017-07-17 2023-03-14 Joseph D. Osborne Blower-attached product applicator, and method for dispensing a product into a moving airstream
US10786596B2 (en) 2018-01-12 2020-09-29 Boston Scientific Scimed, Inc. Powder for achieving hemostasis
US11766546B2 (en) 2018-01-31 2023-09-26 Boston Scientific Scimed, Inc. Apparatuses and methods for delivering powdered agents
CN117547720A (zh) * 2018-10-02 2024-02-13 波士顿科学国际有限公司 用于流体化和输送粉状剂的装置
AU2019352968B2 (en) 2018-10-02 2024-10-31 Boston Scientific Scimed, Inc. Devices for fluidization and delivering a powdered agent
CN110538365B (zh) * 2019-08-27 2021-05-18 佳木斯大学 一种儿科呼吸道内科雾化给药装置
US20210106717A1 (en) * 2019-10-10 2021-04-15 Cook Medical Technologies Llc Bonded powders for the treatment of bodily lesions
CN110538351A (zh) * 2019-10-21 2019-12-06 青州市中医院 一种用于去除上呼吸道中粘液的喷雾器
EP4017338B1 (en) 2019-12-03 2024-01-31 Boston Scientific Scimed, Inc. Medical devices for agent delivery
WO2021113324A1 (en) 2019-12-03 2021-06-10 Boston Scientific Scimed, Inc. Devices and methods for delivering powdered agents
EP4417233A3 (en) * 2019-12-03 2024-10-23 Boston Scientific Scimed, Inc. Medical devices for agent delivery
CN121102700A (zh) 2019-12-03 2025-12-12 波士顿科学国际有限公司 药剂施用医疗装置
CN114845644A (zh) 2019-12-20 2022-08-02 波士顿科学国际有限公司 药剂输送装置
CN119971275A (zh) 2020-01-06 2025-05-13 波士顿科学国际有限公司 用于输送粉末状药剂的装置
US12102749B2 (en) 2020-01-06 2024-10-01 Boston Scientific Scimed, Inc. Agent delivery systems and methods of using the same
US12083216B2 (en) 2020-02-18 2024-09-10 Boston Scientific Scimed, Inc. Hemostatic compositions and related methods
WO2021178239A1 (en) * 2020-03-06 2021-09-10 Cryoconcepts Lp Systems and methods for carbon dioxide enhanced delivery of topical substances
EP4623837A3 (en) 2020-03-06 2025-12-03 Boston Scientific Scimed, Inc. Devices for delivering powdered agents
JP7665646B2 (ja) 2020-03-24 2025-04-21 ボストン サイエンティフィック サイムド，インコーポレイテッド 薬剤送達システム及びその使用方法
KR20230007378A (ko) 2020-04-17 2023-01-12 보스톤 싸이엔티픽 싸이메드 인코포레이티드 지혈 조성물 및 관련 방법
WO2021247850A2 (en) 2020-06-05 2021-12-09 Cook Medical Technologies Llc Medical scopes for delivering therapeutic agents
US20220087688A1 (en) * 2020-09-22 2022-03-24 Boston Scientific Scimed, Inc. Pressure release for medical devices
KR20230128023A (ko) 2020-12-31 2023-09-01 리제너론 파아마슈티컬스, 인크. 자동 주사기 및 관련 사용 방법
US20230016512A1 (en) 2021-07-14 2023-01-19 Cook Medical Technologies Llc Systems and methods for preventing clogging of a delivery system
JP7762300B2 (ja) 2021-10-25 2025-10-29 クック・メディカル・テクノロジーズ・リミテッド・ライアビリティ・カンパニー 加圧流体を標的部位に単独で又は治療剤と併せて送達するためのシステム
US20230211074A1 (en) * 2022-01-03 2023-07-06 Carefusion 303, Inc. Intravenous pressure assembly
WO2024005555A1 (ko) 2022-07-01 2024-01-04 주식회사 리센스메디컬 냉각제 공급 장치에 이용되는 혼합 모듈
EP4368123A3 (en) 2022-10-18 2024-07-10 Cook Medical Technologies LLC Systems and methods for delivering pressurized fluid to a target site alone or in conjunction with therapeutic agents
US20240181177A1 (en) 2022-12-05 2024-06-06 Cook Medical Technologies Llc Therapeutic agent delivery systems having improved powder consistency

Family Cites Families (220)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US566411A (en) 1896-08-25 Josef schoene
US39678A (en) 1863-08-25 Improvement in powder-injectors
US460458A (en) 1891-09-29 Edward t
US576437A (en) 1897-02-02 Insufflator
US533489A (en) 1895-02-05 Thomas edwin ogram
US442785A (en) 1890-12-16 Atomizer
US471865A (en) 1892-03-29 Vaginal instrument
US1521396A (en) 1924-12-30 By mary v
US170182A (en) 1875-11-23 Improvement in syringes
CH15244A (de) 1897-09-24 1898-04-30 August Lauer Pulverbläser
US693587A (en) 1901-11-11 1902-02-18 Eugenia C Campbell Insufflator.
US881238A (en) 1902-12-08 1908-03-10 Sayer Hasbrouck Insufflator.
US775985A (en) 1904-03-18 1904-11-29 Harry L Mckain Machine for manufacturing artificial flowers, vines, &c.
US904149A (en) 1907-05-31 1908-11-17 Henry Rachmann Atomizer for scent and other sprays.
US938648A (en) 1909-05-21 1909-11-02 De Vilbiss Mfg Co Atomizer.
US1022601A (en) 1911-06-16 1912-04-09 Sven S Rumberg Vaginal syringe.
US1145520A (en) 1913-04-24 1915-07-06 John W Smith Vaginal powder-sprayer.
US1114114A (en) 1914-04-30 1914-10-20 William E Cochenour Powder-applicator.
US1261503A (en) 1917-05-02 1918-04-02 Whitall Tatum Co Atomizer.
US1357452A (en) 1919-05-03 1920-11-02 Burton P Hall Atomizer or sprayer
US1466119A (en) 1922-09-08 1923-08-28 Charles A Claflin Conduit member for conducting fluid under pressure
US1685280A (en) 1927-07-16 1928-09-25 Lester L Findley Powder-placing syringe
US1934793A (en) 1932-03-02 1933-11-14 Crain Insufflator
US2004402A (en) 1934-04-07 1935-06-11 Conklin John Edward Atomizer
US2151418A (en) 1937-05-12 1939-03-21 Scott & Bowne Powder applicator
US2223611A (en) 1939-05-22 1940-12-03 Richard E Gross Syringe
US2390313A (en) 1939-07-21 1945-12-04 Barr & Stroud Ltd Gas and liquid mixer
US2307986A (en) 1940-02-15 1943-01-12 Bolte Insufflator
US2519555A (en) 1945-08-31 1950-08-22 Abbott Lab Sterile medicament insufflator cartridge and insufflator
BE471028A (enExample) 1946-02-08
US2507702A (en) 1949-03-04 1950-05-16 Abbott Lab Insufflator
US2609155A (en) 1950-06-15 1952-09-02 Adolph Spreckles Fishing rod wrapping device
US2632444A (en) 1951-06-14 1953-03-24 Kas John Leo Pellet injector
US2805013A (en) 1955-04-19 1957-09-03 Comfort John Garment hanger
US2956579A (en) 1956-08-02 1960-10-18 Electro Way Corp Dishwashing apparatus
US2934314A (en) 1957-01-18 1960-04-26 Electro Way Corp Valve
US3016895A (en) 1958-08-01 1962-01-16 Pan American Lab Inc Injector for subcutaneous implantation of solids
US3050261A (en) 1961-04-24 1962-08-21 Robert Clayton Littlefield Spray pattern control mechanism for insecticide sprayer
NL145136C (enExample) 1967-07-25 1900-01-01
US3540444A (en) 1968-01-15 1970-11-17 Scherer Corp R P Plastic ampoule for use with hypodermic injector
GB1254534A (en) 1968-03-13 1971-11-24 Wallace Cameron & Company Ltd Improvements in or relating to treating means for wounds
US3506008A (en) 1968-03-25 1970-04-14 Ortho Pharma Corp Medical applicator
US3632046A (en) 1968-04-23 1972-01-04 Robert W Hengesbach Spray nozzle
US3599866A (en) 1968-08-21 1971-08-17 Soilserv Inc Atomizing spray process and apparatus
US3572335A (en) 1969-01-10 1971-03-23 Ralph R Robinson Cervical implant method and device
US3667465A (en) 1969-12-08 1972-06-06 Kimberly Clark Co Applicator tubes for suppositories and the like
US3649299A (en) 1970-03-17 1972-03-14 Jeffrey John Sholl Method of limiting the depth of penetration of tenderizing and/or flavoring liquids into meat
US3647143A (en) 1970-04-06 1972-03-07 Champion Spark Plug Co Atomizer
US3742955A (en) 1970-09-29 1973-07-03 Fmc Corp Fibrous collagen derived product having hemostatic and wound binding properties
US3788315A (en) 1971-04-20 1974-01-29 S Laurens Disposable cutaneous transjector
US3710400A (en) 1971-08-30 1973-01-16 C Sparks Graft member grown in a living body
DE2144861C2 (de) 1971-09-08 1973-06-20 Deutsche Nemectron GmbH, 7500 Karlsruhe Kosmetikgerät zur dermatologischen Behandlung mit einem Wasserdampf-Ozon-Gemisch
US3744493A (en) 1972-01-10 1973-07-10 Syntex Corp Implanter having an improved cartridge ejector
US3762410A (en) 1972-07-12 1973-10-02 P Bindel Undulating rectal flushing apparatus
US3900022A (en) 1973-12-10 1975-08-19 Jerrold Widran Endoscope with uninterrupted flow purging system
US4017007A (en) 1973-12-26 1977-04-12 Ciba-Geigy Corporation Single dose air pressure operated dispenser
US3916896A (en) 1974-08-05 1975-11-04 Alexander K S Ballard Portable douche and sitz bath
US4040420A (en) 1976-04-22 1977-08-09 General Dynamics Packaging and dispensing kit
GB1598081A (en) 1977-02-10 1981-09-16 Allen & Hanburys Ltd Inhaler device for dispensing medicaments
US4174811A (en) 1977-02-15 1979-11-20 Firma Airotechnik Siegfried Binder Gmbh Fluid substance sprayer having propellant gas and substance refill
US4184258A (en) 1978-01-30 1980-01-22 The United States Of America As Represented By The Department Of Health, Education And Welfare Powder blower device
US4900303A (en) 1978-03-10 1990-02-13 Lemelson Jerome H Dispensing catheter and method
US4204645A (en) 1978-05-17 1980-05-27 Column Corporation General purpose compression-type sprayer
US4204539A (en) 1979-04-23 1980-05-27 Mathews Van Brugge Pumps and syringes
AT366916B (de) 1980-04-02 1982-05-25 Immuno Ag Vorrichtung zur applikation eines gewebeklebstoffes auf basis von menschlichen oder tierischenproteinen
DE3024749A1 (de) 1980-06-30 1982-02-04 Elmont AG, Kreuzlingen Verfahren und vorrichtung zur erzeugung eines aus einer duese o.dgl. austretenden gas/fluessigkeits-sprays insbesondere fuer die mundhygiene
SU978999A2 (ru) 1981-03-04 1982-12-07 Филиал Ростовского-На-Дону Научно-Исследовательского Института Технологии Машиностроения В Г.Ровно Устройство дл смазки рабочих поверхностей штампов
DE3108918A1 (de) 1981-03-09 1982-09-16 Beiersdorf Ag, 2000 Hamburg "spuel-, kuehl- und spruehvorrichtung und deren verwendung"
US4539716A (en) 1981-03-19 1985-09-10 Massachusetts Institute Of Technology Fabrication of living blood vessels and glandular tissues
US4423727A (en) 1981-04-10 1984-01-03 Jerrold Widran Continuous flow urological endoscopic apparatus and method of using same
ATE20824T1 (de) 1981-06-25 1986-08-15 Serapharm Gmbh & Co Kg Angereichertes plasmaderivat zur unterstuetzung von wundverschluss und wundheilung.
SE438261B (sv) 1981-07-08 1985-04-15 Draco Ab Anvendning i dosinhalator av ett perforerat membran
US4516442A (en) 1982-01-06 1985-05-14 Davis Duane L Ratchet device
US4803977A (en) 1982-03-25 1989-02-14 Mallinckrodt, Inc. Method and apparatus for the diagnosis of respiratory diseases and allergies
US4578067A (en) 1982-04-12 1986-03-25 Alcon (Puerto Rico) Inc. Hemostatic-adhesive, collagen dressing for severed biological surfaces
GB8311345D0 (en) 1983-04-26 1983-06-02 Dobson Park Ind Oral administration of capsules to animals
GB8324265D0 (en) 1983-09-09 1983-10-12 Devilbiss Co Miniature spray guns
AT379311B (de) 1984-03-29 1985-12-27 Immuno Ag Vorrichtung zur applikation eines gewebeklebstoffes
US4620847A (en) 1984-06-01 1986-11-04 Vsesojuzny Nauchno-Issledovatelsky Institut Meditsinskikh Polimerov Device for administering powdered substances
JPS6144825A (ja) 1984-08-09 1986-03-04 Unitika Ltd 止血剤
US4872450A (en) 1984-08-17 1989-10-10 Austad Eric D Wound dressing and method of forming same
US4945050A (en) 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US4798606A (en) 1985-02-26 1989-01-17 Corvita Corporation Reinforcing structure for cardiovascular graft
AT382783B (de) 1985-06-20 1987-04-10 Immuno Ag Vorrichtung zur applikation eines gewebeklebstoffes
US5053000A (en) 1985-11-13 1991-10-01 Imperial Chemical Industries Plc Ocular treatment
US4738740A (en) 1985-11-21 1988-04-19 Corvita Corporation Method of forming implantable vascular grafts
DK38986A (da) * 1986-01-27 1987-10-10 Karl Holm Medicinsk inhalationsapparat
DE3613762A1 (de) 1986-04-23 1987-11-05 Simmet Ludwig Dr Med Vet Applikationsvorrichtung von injektionsgut, insbesondere zur instrumentellen besamung oder embryouebertragung
US4946870A (en) 1986-06-06 1990-08-07 Union Carbide Chemicals And Plastics Company Inc. Delivery systems for pharmaceutical or therapeutic actives
USH257H (en) 1986-08-01 1987-04-07 The United States Of America As Represented By The Secretary Of The Army Dry powder aerosolizer
USD303139S (en) 1986-08-25 1989-08-29 DeVilbiss Corporation Power washer gun
US4738658A (en) 1986-09-19 1988-04-19 Aries Medical Incorporated Tapered hemostatic device for use in conjunction with a catheter for alleviating blood leakage and method for using same
US5015580A (en) 1987-07-29 1991-05-14 Agracetus Particle-mediated transformation of soybean plants and lines
US5120657A (en) 1986-12-05 1992-06-09 Agracetus, Inc. Apparatus for genetic transformation
US4890612A (en) 1987-02-17 1990-01-02 Kensey Nash Corporation Device for sealing percutaneous puncture in a vessel
US4902278A (en) 1987-02-18 1990-02-20 Ivac Corporation Fluid delivery micropump
US4994028A (en) 1987-03-18 1991-02-19 Endocon, Inc. Injector for inplanting multiple pellet medicaments
EP0315656B1 (de) 1987-05-18 1993-07-07 Disetronic Ag Infusionsgerät
EP0292936B1 (en) 1987-05-26 1996-03-06 Sumitomo Pharmaceuticals Company, Limited Device for administering solid preparations
US4941880A (en) 1987-06-19 1990-07-17 Bioject, Inc. Pre-filled ampule and non-invasive hypodermic injection device assembly
DE3725552A1 (de) 1987-08-01 1989-02-09 Hoechst Ag Spruehkopf zum applizieren eines mehrkomponentenmaterials mittels gas
DE3802158A1 (de) 1987-08-11 1989-02-23 Hoechst Ag Vorrichtung zur applikation von implantaten
US4790819A (en) 1987-08-24 1988-12-13 American Cyanamid Company Fibrin clot delivery device and method
US4752466A (en) 1987-08-31 1988-06-21 Johnson & Johnson Products, Inc. Thrombin aerosol
US4978336A (en) 1987-09-29 1990-12-18 Hemaedics, Inc. Biological syringe system
US5009637A (en) 1987-11-16 1991-04-23 Sy-Quest International Limited Apparatus for hypodermic injection of liquids
US5129825A (en) 1987-12-21 1992-07-14 Discko John Jr Dental syringe and capsule for use therewith
US5179022A (en) 1988-02-29 1993-01-12 E. I. Du Pont De Nemours & Co. Biolistic apparatus for delivering substances into cells and tissues in a non-lethal manner
US4874368A (en) 1988-07-25 1989-10-17 Micromedics, Inc. Fibrin glue delivery system
US4902281A (en) 1988-08-16 1990-02-20 Corus Medical Corporation Fibrinogen dispensing kit
US4929246A (en) 1988-10-27 1990-05-29 C. R. Bard, Inc. Method for closing and sealing an artery after removing a catheter
US4927410A (en) 1988-11-18 1990-05-22 University Of South Florida Method for fabricating prosthesis material
US5059187A (en) 1988-11-30 1991-10-22 Dey Laboratories, Inc. Method for the cleansing of wounds using an aerosol container having liquid wound cleansing solution
CA2013636A1 (en) 1989-04-06 1990-10-06 Sang I. Han Disposable pressure wound irrigation device
US5061180A (en) 1989-05-01 1991-10-29 Wiele Gary B Dental instrument
US5226877A (en) 1989-06-23 1993-07-13 Epstein Gordon H Method and apparatus for preparing fibrinogen adhesive from whole blood
US5116315A (en) 1989-10-03 1992-05-26 Hemaedics, Inc. Biological syringe system
US5064413A (en) 1989-11-09 1991-11-12 Bioject, Inc. Needleless hypodermic injection device
US5219328A (en) 1990-01-03 1993-06-15 Cryolife, Inc. Fibrin sealant delivery method
EP0443227A1 (en) 1990-02-19 1991-08-28 Ito Corporation Analytical microsyringe
WO1991013595A1 (en) 1990-03-15 1991-09-19 The United States Of America, As Represented By The Secretary Of The Army Chemotherapeutic treatment of bacterial infections with an antibiotic encapsulated within a biodegradable polymeric matrix
US5021059A (en) 1990-05-07 1991-06-04 Kensey Nash Corporation Plug device with pulley for sealing punctures in tissue and methods of use
US5204253A (en) 1990-05-29 1993-04-20 E. I. Du Pont De Nemours And Company Method and apparatus for introducing biological substances into living cells
US5149655A (en) 1990-06-21 1992-09-22 Agracetus, Inc. Apparatus for genetic transformation
US5391183A (en) 1990-09-21 1995-02-21 Datascope Investment Corp Device and method sealing puncture wounds
US5141515A (en) 1990-10-11 1992-08-25 Eberbach Mark A Apparatus and methods for repairing hernias
USD333000S (en) 1990-11-06 1993-02-02 Devilbiss Health Care, Inc. Disposable medical atomizer for wound irrigation
US5129882A (en) 1990-12-27 1992-07-14 Novoste Corporation Wound clotting device and method of using same
US5147295A (en) 1991-01-23 1992-09-15 Ideal Instruments, Inc. Retractable implanter
US5147292A (en) 1991-02-05 1992-09-15 C. R. Bard, Inc. Control handle with locking means for surgical irrigation
US5176642A (en) 1991-03-11 1993-01-05 Mectra Labs, Inc. Vacuum powdered syringe
US5310407A (en) 1991-06-17 1994-05-10 Datascope Investment Corp. Laparoscopic hemostat delivery system and method for using said system
US5538162A (en) 1991-09-09 1996-07-23 Buhler Ag Apparatus and method for dosing
EP0531758B1 (de) 1991-09-09 1995-10-25 Buehler Ag Vorrichtung und Verfahren zum Dosieren von in einem Gas/Fest-Stoff-Strom vorliegenden Feststoff aus einem Wirbelbett
IL103238A (en) 1991-09-25 1995-07-31 Fisons Plc Pressurised aerosol compositions
DK166691D0 (da) 1991-09-30 1991-09-30 Unes As Flerkomponentsproejte
US5226567A (en) 1991-10-03 1993-07-13 Dominic A. Sansalone Garden powder duster
US5165604A (en) 1991-10-03 1992-11-24 Copp Jr William H Air supply and control assembly for an automatic spray gun
US5312333A (en) 1992-04-03 1994-05-17 United States Surgical Corporation Endoscopic material delivery device
FR2693924B1 (fr) 1992-07-21 1994-09-23 Sicmo Pistolet à peinture, basse pression dont la tête de pulvérisation est perfectionnée.
US5273531A (en) 1992-09-21 1993-12-28 Knoepfler Dennis J Method of applying thrombic powder in laparoscopic procedures
WO1994007420A1 (fr) 1992-09-26 1994-04-14 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Applicateur d'adhesif destine a des tissus
NZ250214A (en) 1992-12-23 1995-10-26 Ndm Acquisition Corp Deep wound dressing and syringe therefor
US5292309A (en) 1993-01-22 1994-03-08 Schneider (Usa) Inc. Surgical depth measuring instrument and method
US5749968A (en) 1993-03-01 1998-05-12 Focal, Inc. Device for priming for improved adherence of gels to substrates
DE69414558T2 (de) 1993-03-23 1999-07-15 Focal, Inc., Lexington, Mass. Gerät und methode für den lokalen auftrag von polymermaterial auf gewebe
US5584815A (en) 1993-04-02 1996-12-17 Eli Lilly And Company Multi-cartridge medication injection device
AU6705894A (en) 1993-04-20 1994-11-08 Medchem Products, Inc. Apparatus and method for applying a particulate hemostatic agent to living tissue
US5328459A (en) 1993-05-06 1994-07-12 Laghi Aldo A Apparatus and method for dispensing and aspirating high viscosity materials
DE59400518D1 (de) 1993-06-16 1996-09-26 White Spot Ag Vorrichtung zum einbringen von fibrinkleber in einen stichkanal
US5398851A (en) 1993-08-06 1995-03-21 River Medical, Inc. Liquid delivery device
WO1995007053A1 (en) 1993-09-07 1995-03-16 Invamed, Inc. Safety shielded, reusable trocar
JP2809976B2 (ja) 1993-10-04 1998-10-15 株式会社カイゲン 散粉器及び散粉器に接続する散粉用ノズル
US5395326A (en) 1993-10-20 1995-03-07 Habley Medical Technology Corporation Pharmaceutical storage and mixing syringe having high pressure assisted discharge
WO1995019799A1 (en) 1994-01-21 1995-07-27 Agracetus, Inc. Gas driven gene delivery instrument
AT400304B (de) 1994-02-28 1995-12-27 Immuno Ag Vorrichtung zur applikation eines mehrkomponenten-gewebeklebstoffes
US5484403A (en) 1994-04-05 1996-01-16 Avid Marketing, Inc. Hypodermic syringe for implanting solid objects
US5429278A (en) 1994-05-09 1995-07-04 Sansalone; Dominic A. Portable garden powder duster
US5520667A (en) 1994-06-29 1996-05-28 Innovative Surgical Devices Corporation Methods for bone and other tissue preparation
US5605541A (en) 1994-12-07 1997-02-25 E. R. Squibb And Sons, Inc. Fibrin sealant applicatoor
JPH10512470A (ja) 1995-01-18 1998-12-02 メドケム プロダクツ，インコーポレーテッド 組織に止血剤を適用する装置および方法
JPH08206229A (ja) * 1995-02-02 1996-08-13 Teruo Hoshino 薬剤投与装置
GB9502879D0 (en) * 1995-02-14 1995-04-05 Oxford Biosciences Ltd Particle delivery
US5503623A (en) 1995-03-17 1996-04-02 Tilton, Jr.; Eugene B. Instrumentation for laparoscopic insertion and application of sheet like surgical material
US5919184A (en) 1995-03-17 1999-07-06 Tilton, Jr.; Eugene B. Instrumentation for laparoscopic insertion and application of surgical sheet material
EP0738498A1 (en) 1995-04-18 1996-10-23 Machida Endoscope Co., Ltd Surgical adhesive sprayer
US5554172A (en) 1995-05-09 1996-09-10 The Larren Corporation Directed energy surgical method and assembly
US6013050A (en) 1995-10-20 2000-01-11 Powderject Research Limited Particle delivery
US5759169A (en) 1996-03-13 1998-06-02 New York Blood Center Inc. Fibrin sealant glue-gun
US5788625A (en) 1996-04-05 1998-08-04 Depuy Orthopaedics, Inc. Method of making reconstructive SIS structure for cartilaginous elements in situ
AR013829A1 (es) 1996-07-12 2001-01-31 Baxter Int Un dispositivo medico para suministrar cantidades volumetricas de un primer y un segundo fluido, bioquimicamente reactivos, y metodo para suministrarfibrina a una superficie con dicho dispositivo
US5759171A (en) 1996-09-27 1998-06-02 Thermogenesis Corp. Sprayer for fibrin glue
US5902228A (en) 1996-10-11 1999-05-11 Cornell Research Foundation, Inc. Method and apparatus for support and tubularization of surgical grafts
PT951311E (pt) 1996-11-15 2007-06-05 Vivolution As Dispositivo para aplicar numa mistura de dois ou mais componentes líquidos para formar um biomaterial
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US6331172B1 (en) 1997-04-14 2001-12-18 Baxter International Inc. Applicator for dispensing measured quantities with use of controlled suction
DE19723648C1 (de) 1997-06-05 1998-08-27 Disetronic Licensing Ag Vorrichtung zur dosierten Verabreichung einer Medikamentflüssigkeit
US6077217A (en) 1997-06-25 2000-06-20 Ramus Medical Technologies, Inc. System and method for assembling graft structures
JP2001509411A (ja) 1997-07-14 2001-07-24 クック ウロロジカル インク． 空気式組織除去器
US6021776A (en) 1997-09-09 2000-02-08 Intertex Research, Inc. Disposable atomizer device with trigger valve system
US5873530A (en) 1997-09-26 1999-02-23 Chizinsky; George Liquid atomizing spray gun
US20030170250A1 (en) 1998-03-23 2003-09-11 Ezrin Alan M. Local delivery of long lasting therapeutic agents
US6610026B2 (en) 1998-05-01 2003-08-26 Sub-Q, Inc. Method of hydrating a sponge material for delivery to a body
US6461361B1 (en) 1998-05-01 2002-10-08 Baxter International Inc. Gas-driven spraying of mixed sealant agents
AU5560899A (en) 1998-08-14 2000-03-06 Incept Llc Methods and apparatus for in situ formation of hydrogels
US7347850B2 (en) 1998-08-14 2008-03-25 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
US6689108B2 (en) * 1998-11-13 2004-02-10 Elan Pharma International Limited Device for measuring a volume of drug
US6432102B2 (en) 1999-03-15 2002-08-13 Cryovascular Systems, Inc. Cryosurgical fluid supply
US20040214783A1 (en) 2002-05-08 2004-10-28 Terman David S. Compositions and methods for treatment of neoplastic disease
US6503273B1 (en) 1999-11-22 2003-01-07 Cyograft Tissue Engineering, Inc. Tissue engineered blood vessels and methods and apparatus for their manufacture
WO2001072354A2 (en) * 2000-03-28 2001-10-04 Elan Pharma International Limited Device for measuring a volume of drug
US6716190B1 (en) 2000-04-19 2004-04-06 Scimed Life Systems, Inc. Device and methods for the delivery and injection of therapeutic and diagnostic agents to a target site within a body
ES2705729T3 (es) 2000-11-30 2019-03-26 Valeritas Inc Sistemas de suministro y medición de fluidos
US6478754B1 (en) 2001-04-23 2002-11-12 Advanced Medical Applications, Inc. Ultrasonic method and device for wound treatment
EG24184A (en) * 2001-06-15 2008-10-08 Otsuka Pharma Co Ltd Dry powder inhalation system for transpulmonary
US6723067B2 (en) 2001-07-26 2004-04-20 David H. Nielson Apparatus for delivering aerosolized fibrin endoscopically to a wound
US7691244B2 (en) 2001-12-18 2010-04-06 Massachusetts Institute Of Technology Microfluidic pumps and mixers driven by induced-charge electro-osmosis
WO2003057072A2 (en) 2001-12-31 2003-07-17 Ares Laboratories, Llc Hemostatic compositions and methods for controlling bleeding
US7544177B2 (en) 2002-01-24 2009-06-09 The Regents Of The University Of California Aerosol device to deliver bioactive agent
US6863660B2 (en) 2002-03-27 2005-03-08 Hapio Biotech, Inc. Fibrin applicator pistol
US20030216695A1 (en) 2002-05-17 2003-11-20 Chang-Ming Yang Needle syringe
US7166133B2 (en) 2002-06-13 2007-01-23 Kensey Nash Corporation Devices and methods for treating defects in the tissue of a living being
US6843388B1 (en) 2002-07-22 2005-01-18 Anthony Scott Hollars Compressed gas cartridge dispensing system allowing interchangeable use of different capacity compressed gas cartridges and novel storage feature
US7641668B2 (en) 2003-05-16 2010-01-05 Scimed Life Systems, Inc. Fluid delivery system and related methods of use
US7824373B2 (en) 2003-05-28 2010-11-02 Ducksoo Kim Self-contained power-assisted syringe
US6863550B2 (en) * 2003-05-29 2005-03-08 Gateway, Inc. Self ejecting cover
GB0313604D0 (en) * 2003-06-12 2003-07-16 Britannia Pharmaceuticals Ltd Delivery device for powdered medicament
US7632245B1 (en) 2003-08-18 2009-12-15 Medrad, Inc. Devices, systems and methods for delivery of a fluid into a patient during a magnetic resonance procedure
EP1742692A4 (en) * 2004-03-17 2012-06-27 Genzyme Corp ANTI-ADHERENCE SPRAY
JP2005270372A (ja) * 2004-03-25 2005-10-06 Fumio Saito パウダー点鼻薬用噴霧容器
US7334598B1 (en) 2004-06-16 2008-02-26 Anthony Scott Hollars Pressure regulator adaptable to compressed gas cartridge
EP1768692B8 (en) 2004-07-01 2015-06-17 Yale University Targeted and high density drug loaded polymeric materials
US7857167B1 (en) 2005-08-29 2010-12-28 Anthony Scott Hollars Compressed gas cartridge permeation dispenser having a predictable permeation rate
US7673783B2 (en) 2005-11-04 2010-03-09 Ethicon Endo-Surgery, Inc. Surgical stapling instruments structured for delivery of medical agents
WO2007116386A1 (en) 2006-04-07 2007-10-18 Avonmed Healthcare Limited A device for connection to a tubular element
US20080027272A1 (en) 2006-07-26 2008-01-31 Terumo Cardiovascular Systems Corporation Device for processing blood vessel harvested for bypass graft surgery
JP2008049883A (ja) 2006-08-25 2008-03-06 Calsonic Kansei Corp エアバッグリッド部の製造方法
US20090023474A1 (en) * 2007-07-18 2009-01-22 Motorola, Inc. Token-based dynamic authorization management of rfid systems
US8361100B2 (en) 2008-03-17 2013-01-29 Ethicon, Inc. Applicator instruments for the delivery, deployment, and tamponade of hemostats and methods therefor
US8366733B2 (en) 2008-03-28 2013-02-05 Ethicon, Inc. Applicator instruments for controlling bleeding at surgical sites and methods therefor

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12496429B2 (en) 2022-10-18 2025-12-16 Cook Medical Technologies Llc Systems and methods for delivering pressurized fluid to a target site alone or in conjunction with therapeutic agents

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