CA2732131A1 - Compositions and methods for treating psychiatric disorders - Google Patents

Info

Publication number

CA2732131A1

CA2732131A1 CA2732131A CA2732131A CA2732131A1 CA 2732131 A1 CA2732131 A1 CA 2732131A1 CA 2732131 A CA2732131 A CA 2732131A CA 2732131 A CA2732131 A CA 2732131A CA 2732131 A1 CA2732131 A1 CA 2732131A1

Authority

CA

Canada

Prior art keywords

epileptic

disorder

disorders

dose

pharmaceutical composition

Prior art date

2008-08-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

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• 238000000034 method Methods 0.000 title claims abstract description 69
• 239000000203 mixture Substances 0.000 title claims description 46
• 239000001961 anticonvulsive agent Substances 0.000 claims abstract description 210
• 239000003368 psychostimulant agent Substances 0.000 claims abstract description 137
• 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 73
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 48
• 208000010877 cognitive disease Diseases 0.000 claims abstract description 36
• 208000030814 Eating disease Diseases 0.000 claims abstract description 27
• 208000019454 Feeding and Eating disease Diseases 0.000 claims abstract description 27
• 235000014632 disordered eating Nutrition 0.000 claims abstract description 27
• 208000027061 mild cognitive impairment Diseases 0.000 claims abstract description 20
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• 230000003412 degenerative effect Effects 0.000 claims abstract description 10
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• 238000011282 treatment Methods 0.000 claims description 122
• 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims description 115
• NIJJYAXOARWZEE-UHFFFAOYSA-N di-n-propyl-acetic acid Natural products CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 claims description 101
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• 239000000546 pharmaceutical excipient Substances 0.000 claims description 9
• 239000002775 capsule Substances 0.000 claims description 8
• ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims description 8
• 229960000632 dexamfetamine Drugs 0.000 claims description 8
• 229960002767 ethosuximide Drugs 0.000 claims description 8
• HAPOVYFOVVWLRS-UHFFFAOYSA-N ethosuximide Chemical compound CCC1(C)CC(=O)NC1=O HAPOVYFOVVWLRS-UHFFFAOYSA-N 0.000 claims description 8
• PCOBBVZJEWWZFR-UHFFFAOYSA-N ezogabine Chemical class C1=C(N)C(NC(=O)OCC)=CC=C1NCC1=CC=C(F)C=C1 PCOBBVZJEWWZFR-UHFFFAOYSA-N 0.000 claims description 8
• BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical class NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims description 8
• 229960003312 retigabine Drugs 0.000 claims description 8
• 206010012335 Dependence Diseases 0.000 claims description 7
• NRNCYVBFPDDJNE-UHFFFAOYSA-N pemoline Chemical compound O1C(N)=NC(=O)C1C1=CC=CC=C1 NRNCYVBFPDDJNE-UHFFFAOYSA-N 0.000 claims description 7
• 208000022821 personality disease Diseases 0.000 claims description 7
• DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 claims description 7
• 229960002695 phenobarbital Drugs 0.000 claims description 7
• 229960002393 primidone Drugs 0.000 claims description 7
• DQMZLTXERSFNPB-UHFFFAOYSA-N primidone Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NCNC1=O DQMZLTXERSFNPB-UHFFFAOYSA-N 0.000 claims description 7
• 239000000725 suspension Substances 0.000 claims description 7
• DBGIVFWFUFKIQN-UHFFFAOYSA-N (+-)-Fenfluramine Chemical compound CCNC(C)CC1=CC=CC(C(F)(F)F)=C1 DBGIVFWFUFKIQN-UHFFFAOYSA-N 0.000 claims description 6
• KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 claims description 6
• MVXGSLGVWBVZCA-UHFFFAOYSA-N 1,3-dimethyl-7-[2-(1-phenylpropan-2-ylamino)ethyl]purine-2,6-dione;hydrochloride Chemical compound Cl.C1=NC=2N(C)C(=O)N(C)C(=O)C=2N1CCNC(C)CC1=CC=CC=C1 MVXGSLGVWBVZCA-UHFFFAOYSA-N 0.000 claims description 6
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• 239000005557 antagonist Substances 0.000 claims description 6
• HJJPJSXJAXAIPN-UHFFFAOYSA-N arecoline Chemical compound COC(=O)C1=CCCN(C)C1 HJJPJSXJAXAIPN-UHFFFAOYSA-N 0.000 claims description 6
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• KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 claims description 6
• SANOUVWGPVYVAV-UHFFFAOYSA-N isovaleramide Chemical compound CC(C)CC(N)=O SANOUVWGPVYVAV-UHFFFAOYSA-N 0.000 claims description 6
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