|
CA2725014C
(en)
|
2008-05-30 |
2014-06-17 |
Amgen Inc. |
Inhibitors of pi3 kinase
|
|
TWI378933B
(en)
|
2008-10-14 |
2012-12-11 |
Daiichi Sankyo Co Ltd |
Morpholinopurine derivatives
|
|
US20110053923A1
(en)
|
2008-12-22 |
2011-03-03 |
Astrazeneca |
Chemical compounds 610
|
|
ES2529205T3
(es)
|
2009-03-13 |
2015-02-17 |
Cellzome Limited |
Derivados de pirimidina como inhibidores de mTOR
|
|
UY32582A
(es)
|
2009-04-28 |
2010-11-30 |
Amgen Inc |
Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero
|
|
US8946204B2
(en)
|
2009-05-07 |
2015-02-03 |
Gruenenthal Gmbh |
Substituted phenylureas and phenylamides as vanilloid receptor ligands
|
|
CA2759951C
(en)
|
2009-05-07 |
2017-05-02 |
Gruenenthal Gmbh |
Substituted phenylureas and phenylamides as vanilloid receptor ligands
|
|
WO2011001115A1
(fr)
|
2009-07-02 |
2011-01-06 |
Sanofi-Aventis |
Nouveaux derives de 6-morpholin-4-yl-pyrimidin-4- ( 3h ) -one, leur preparation pharmaceutique comme inhibiteurs de phos phorylat i on d ' akt ( pkb )
|
|
SG10201402867TA
(en)
|
2009-07-02 |
2014-08-28 |
Sanofi Sa |
Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors
|
|
AR077468A1
(es)
|
2009-07-09 |
2011-08-31 |
Array Biopharma Inc |
Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
|
|
JP2013509444A
(ja)
|
2009-10-30 |
2013-03-14 |
アリアド・ファーマシューティカルズ・インコーポレイテッド |
がんの治療方法及び治療用組成物
|
|
CA2788678C
(en)
|
2010-02-03 |
2019-02-26 |
Signal Pharmaceuticals, Llc |
Identification of lkb1 mutation as a predictive biomarker for sensitivity to tor kinase inhibitors
|
|
EP2542536B1
(en)
|
2010-03-04 |
2015-01-21 |
Cellzome Limited |
Morpholino substituted urea derivatives as mtor inhibitors
|
|
BR112013005210A2
(pt)
*
|
2010-09-03 |
2019-09-24 |
Piramal Entpr Ltd |
compostos heterocíclicos como inibidores de dgat1
|
|
WO2012058671A1
(en)
|
2010-10-31 |
2012-05-03 |
Endo Pharmaceuticals Inc. |
Substituted quinazoline and pyrido-pyrimidine derivatives
|
|
US9133168B2
(en)
|
2010-12-28 |
2015-09-15 |
Sanofi |
Pyrimidine derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors
|
|
WO2012136622A1
(en)
|
2011-04-04 |
2012-10-11 |
Cellzome Limited |
Dihydropyrrolo pyrimidine derivatives as mtor inhibitors
|
|
HK1199068A1
(en)
|
2011-08-03 |
2015-06-19 |
西格诺药品有限公司 |
Identification of gene expression profile as a predictive biomarker for lkb1 status
|
|
WO2013041652A1
(en)
|
2011-09-21 |
2013-03-28 |
Cellzome Limited |
Morpholino substituted urea or carbamate derivatives as mtor inhibitors
|
|
BR112014007310A2
(pt)
|
2011-09-27 |
2017-04-04 |
Novartis Ag |
3-pirimidin-4-il-oxazolidin-2-onas como inibidores de idh mutante
|
|
KR20140084130A
(ko)
|
2011-10-07 |
2014-07-04 |
셀좀 리미티드 |
Mtor 억제제로서의 모르폴리노 치환된 바이사이클릭 피리미딘 우레아 또는 카르바메이트 유도체
|
|
UY34632A
(es)
|
2012-02-24 |
2013-05-31 |
Novartis Ag |
Compuestos de oxazolidin- 2- ona y usos de los mismos
|
|
KR20160027219A
(ko)
|
2012-05-23 |
2016-03-09 |
에프. 호프만-라 로슈 아게 |
내배엽 및 간세포를 수득하고 사용하는 조성물 및 방법
|
|
AU2013203714B2
(en)
|
2012-10-18 |
2015-12-03 |
Signal Pharmaceuticals, Llc |
Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity
|
|
US9296733B2
(en)
|
2012-11-12 |
2016-03-29 |
Novartis Ag |
Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases
|
|
JP6387360B2
(ja)
|
2013-03-14 |
2018-09-05 |
ノバルティス アーゲー |
変異ｉｄｈの阻害薬としての３−ピリミジン−４−イル−オキサゾリジン−２−オン
|
|
CA2909579A1
(en)
|
2013-04-17 |
2014-10-23 |
Signal Pharmaceuticals, Llc |
Combination therapy comprising a tor kinase inhibitor and n-(3-(5-fluoro-2-(4-(2-methoxyethoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide for treating cancer
|
|
CA2909629C
(en)
|
2013-04-17 |
2022-12-13 |
Signal Pharmaceuticals, Llc |
Pharmaceutical formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one
|
|
CA2908742C
(en)
|
2013-04-17 |
2021-06-01 |
Signal Pharmaceuticals, Llc |
Combination therapy comprising a tor kinase inhibitor and a cytidine analog for treating cancer
|
|
US9630966B2
(en)
|
2013-04-17 |
2017-04-25 |
Signal Pharmaceuticals, Llc |
Treatment of cancer with dihydropyrazino-pyrazines
|
|
WO2014172436A1
(en)
|
2013-04-17 |
2014-10-23 |
Signal Pharmaceuticals, Llc |
Combination therapy comprising a tor kinase inhibitor and a 5-substituted quinazolinone compound for treating cancer
|
|
CN105377299B
(zh)
|
2013-04-17 |
2018-06-12 |
西格诺药品有限公司 |
用于治疗前列腺癌的包含二氢吡嗪并-吡嗪化合物和雄激素受体拮抗剂的组合疗法
|
|
US9505764B2
(en)
|
2013-04-17 |
2016-11-29 |
Signal Pharmaceuticals, Llc |
Treatment of cancer with dihydropyrazino-pyrazines
|
|
NZ629486A
(en)
|
2013-05-29 |
2017-11-24 |
Signal Pharm Llc |
Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-b]pyrazin-2(1h)-one, a solid form thereof and methods of their use
|
|
US9512129B2
(en)
|
2014-04-16 |
2016-12-06 |
Signal Pharmaceuticals, Llc |
Solid forms comprising 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one and a coformer
|
|
NZ714742A
(en)
|
2014-04-16 |
2017-04-28 |
Signal Pharm Llc |
Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use
|
|
CA2948876A1
(en)
*
|
2014-05-21 |
2015-11-26 |
Allergan, Inc. |
Imidazole derivatives as formyl peptide receptor modulators
|
|
CR20170077A
(es)
|
2014-08-04 |
2017-06-26 |
Nuevolution As |
Derivados de heterociclilo opcionalmente condensados de pirimidina útiles para el tratamiento de enfermedades inflamatorias, metabólicas, oncológicas y autoinmunitarias
|
|
PT3524595T
(pt)
|
2014-08-28 |
2022-09-19 |
Eisai R&D Man Co Ltd |
Derivado de quinolina altamente puro e método para produção do mesmo
|
|
CN107001348B
(zh)
*
|
2014-12-17 |
2019-10-11 |
上海海雁医药科技有限公司 |
2-吗啉-4,6-二取代的嘧啶衍生物、其制法与医药上的用途
|
|
WO2016127074A1
(en)
|
2015-02-06 |
2016-08-11 |
Blueprint Medicines Corporation |
2-(pyridin-3-yl)-pyrimidine derivatives as ret inhibitors
|
|
BR112018000808A2
(pt)
|
2015-07-16 |
2018-09-04 |
Array Biopharma Inc |
compostos de pirazolo[1,5-a]piridina substituída como inibidores de ret cinase
|
|
EP3368039A1
(en)
|
2015-10-26 |
2018-09-05 |
The Regents of The University of Colorado, A Body Corporate |
Point mutations in trk inhibitor-resistant cancer and methods relating to the same
|
|
SI3371171T1
(sl)
|
2015-11-02 |
2024-03-29 |
Blueprint Medicines Corporation |
Inhibitorji ret
|
|
US10183928B2
(en)
|
2016-03-17 |
2019-01-22 |
Blueprint Medicines Corporation |
Inhibitors of RET
|
|
AU2017246547B2
(en)
|
2016-04-04 |
2023-02-23 |
Loxo Oncology, Inc. |
Methods of treating pediatric cancers
|
|
FI3439662T3
(fi)
|
2016-04-04 |
2024-09-04 |
Loxo Oncology Inc |
(s)-n-(5-((r)-2-(2,5-difluorifenyyli)pyrrolidin-1-yyli)pyratsolo[1,5-a]pyrimidin-3-yyli)-3-hydroksipyrrolidiini-1-karboksamidin nesteformulaatioita
|
|
US10045991B2
(en)
|
2016-04-04 |
2018-08-14 |
Loxo Oncology, Inc. |
Methods of treating pediatric cancers
|
|
EP3458456B1
(en)
|
2016-05-18 |
2020-11-25 |
Loxo Oncology Inc. |
Preparation of (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
|
|
US10227329B2
(en)
|
2016-07-22 |
2019-03-12 |
Blueprint Medicines Corporation |
Compounds useful for treating disorders related to RET
|
|
TWI752098B
(zh)
|
2016-10-10 |
2022-01-11 |
美商亞雷生物製藥股份有限公司 |
作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物
|
|
TWI704148B
(zh)
|
2016-10-10 |
2020-09-11 |
美商亞雷生物製藥股份有限公司 |
作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物
|
|
JOP20190092A1
(ar)
|
2016-10-26 |
2019-04-25 |
Array Biopharma Inc |
عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
|
|
WO2018136661A1
(en)
|
2017-01-18 |
2018-07-26 |
Andrews Steven W |
SUBSTITUTED PYRAZOLO[1,5-a]PYRAZINE COMPOUNDS AS RET KINASE INHIBITORS
|
|
WO2018136663A1
(en)
|
2017-01-18 |
2018-07-26 |
Array Biopharma, Inc. |
Ret inhibitors
|
|
JOP20190213A1
(ar)
|
2017-03-16 |
2019-09-16 |
Array Biopharma Inc |
مركبات حلقية ضخمة كمثبطات لكيناز ros1
|
|
WO2018218197A2
(en)
|
2017-05-26 |
2018-11-29 |
Board Of Regents, The University Of Texas System |
Tetrahydropyrido[4,3-d]pyrimidine inhibitors of atr kinase
|
|
TWI787284B
(zh)
|
2017-06-22 |
2022-12-21 |
美商西建公司 |
以b型肝炎病毒感染表徵之肝細胞癌之治療
|
|
WO2019014618A1
(en)
|
2017-07-13 |
2019-01-17 |
Board Of Regents, University Of Texas System |
HETEROCYCLIC INHIBITORS OF KINASE ATR
|
|
JP7290627B2
(ja)
|
2017-08-17 |
2023-06-13 |
ボード オブ レジェンツ，ザ ユニバーシティ オブ テキサス システム |
Ａｔｒキナーゼの複素環式阻害剤
|
|
TWI791053B
(zh)
|
2017-10-10 |
2023-02-01 |
美商亞雷生物製藥股份有限公司 |
6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物
|
|
TWI876442B
(zh)
|
2017-10-10 |
2025-03-11 |
美商絡速藥業公司 |
6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物
|
|
US11472802B2
(en)
|
2018-01-18 |
2022-10-18 |
Array Biopharma Inc. |
Substituted pyrazolyl[4,3-c]pyridine compounds as RET kinase inhibitors
|
|
JP7060694B2
(ja)
|
2018-01-18 |
2022-04-26 |
アレイ バイオファーマ インコーポレイテッド |
Ｒｅｔキナーゼ阻害剤としての置換ピロロ［２，３－ｄ］ピリミジン化合物
|
|
EP3740490A1
(en)
|
2018-01-18 |
2020-11-25 |
Array Biopharma, Inc. |
Substituted pyrazolo[3,4-d]pyrimidine compounds as ret kinase inhibitors
|
|
JP7341156B2
(ja)
|
2018-03-16 |
2023-09-08 |
ボード オブ レジェンツ，ザ ユニバーシティ オブ テキサス システム |
Ａｔｒキナーゼの複素環式阻害剤
|
|
PE20210096A1
(es)
|
2018-04-03 |
2021-01-12 |
Blueprint Medicines Corp |
Inhibidor de ret para uso en tratar cancer que tiene una alteracion de ret
|
|
CN117285467A
(zh)
|
2018-07-31 |
2023-12-26 |
罗索肿瘤学公司 |
喷雾干燥的分散体和制剂
|
|
CN112996794A
(zh)
|
2018-09-10 |
2021-06-18 |
阿雷生物药品公司 |
作为ret激酶抑制剂的稠合杂环化合物
|
|
EP3898626A1
(en)
|
2018-12-19 |
2021-10-27 |
Array Biopharma, Inc. |
Substituted pyrazolo[1,5-a]pyridine compounds as inhibitors of fgfr tyrosine kinases
|
|
US12351571B2
(en)
|
2018-12-19 |
2025-07-08 |
Array Biopharma Inc. |
Substituted quinoxaline compounds as inhibitors of FGFR tyrosine kinases
|
|
CN118619944A
(zh)
|
2019-06-06 |
2024-09-10 |
北京泰德制药股份有限公司 |
作为atr激酶抑制剂的2,4,6-三取代的嘧啶化合物
|
|
US20230101747A1
(en)
|
2019-12-06 |
2023-03-30 |
Schrödinger, Inc. |
Cyclic compounds and methods of using same
|
|
MX2022007265A
(es)
|
2019-12-20 |
2022-09-09 |
Nuevolution As |
Compuestos activos frente a receptores nucleares.
|
|
UY38994A
(es)
|
2019-12-20 |
2021-07-30 |
Nuevolution As |
Compuestos activos frente a receptores nucleares
|
|
IL294214B2
(en)
|
2019-12-27 |
2026-04-01 |
Schrodinger Inc |
Cyclic compounds and methods for using them
|
|
WO2021198956A1
(en)
|
2020-03-31 |
2021-10-07 |
Nuevolution A/S |
Compounds active towards nuclear receptors
|
|
AU2021245397A1
(en)
|
2020-03-31 |
2022-10-20 |
Nuevolution A/S |
Compounds active towards nuclear receptors
|
|
EP4157829A1
(en)
|
2020-05-29 |
2023-04-05 |
Blueprint Medicines Corporation |
Solid forms of pralsetinib
|
|
CN111646985A
(zh)
*
|
2020-06-01 |
2020-09-11 |
江苏集萃分子工程研究院有限公司 |
一种含嘧啶杂环抗肿瘤药物分子azd6738的合成方法
|
|
TWI894285B
(zh)
|
2020-06-04 |
2025-08-21 |
英屬開曼群島商百濟神州有限公司 |
作為IAP拮抗劑的吡啶並[2,3-b][1,4]噁嗪或四氫吡啶並[2,3-b][1,4]氧氮呯
|
|
CN116490507A
(zh)
|
2020-09-10 |
2023-07-25 |
薛定谔公司 |
用于治疗癌症的杂环包缩合cdc7激酶抑制剂
|
|
EP4284804A1
(en)
|
2021-01-26 |
2023-12-06 |
Schrödinger, Inc. |
Tricyclic compounds useful in the treatment of cancer, autoimmune and inflammatory disorders
|
|
TW202300150A
(zh)
|
2021-03-18 |
2023-01-01 |
美商薛定諤公司 |
環狀化合物及其使用方法
|
|
CA3241096A1
(en)
*
|
2021-12-02 |
2023-06-08 |
Beigene Switzerland Gmbh |
Methods of synthesis of chiral 3,5-disubstituted morpholine compounds a nd intermediates useful therein
|
|
WO2025059027A1
(en)
|
2023-09-11 |
2025-03-20 |
Schrödinger, Inc. |
Cyclopenta[e]pyrazolo[1,5-a]pyrimidine derivatives as malt1 inhibitors
|