CA2684644A1 - Quinoline-carboxamide derivatives as p2y12 antagonists - Google Patents
Quinoline-carboxamide derivatives as p2y12 antagonists Download PDFInfo
- Publication number
- CA2684644A1 CA2684644A1 CA002684644A CA2684644A CA2684644A1 CA 2684644 A1 CA2684644 A1 CA 2684644A1 CA 002684644 A CA002684644 A CA 002684644A CA 2684644 A CA2684644 A CA 2684644A CA 2684644 A1 CA2684644 A1 CA 2684644A1
- Authority
- CA
- Canada
- Prior art keywords
- oxo
- carbonyl
- quinoline
- piperazine
- ethoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000005557 antagonist Substances 0.000 title claims abstract description 18
- ZEXKKIXCRDTKBF-UHFFFAOYSA-N quinoline-2-carboxamide Chemical class C1=CC=CC2=NC(C(=O)N)=CC=C21 ZEXKKIXCRDTKBF-UHFFFAOYSA-N 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 166
- 238000000034 method Methods 0.000 claims abstract description 37
- 239000003814 drug Substances 0.000 claims abstract description 16
- 239000000825 pharmaceutical preparation Substances 0.000 claims abstract description 14
- 238000002360 preparation method Methods 0.000 claims abstract description 14
- 238000011321 prophylaxis Methods 0.000 claims abstract description 14
- 238000002560 therapeutic procedure Methods 0.000 claims abstract description 14
- 230000008569 process Effects 0.000 claims abstract description 8
- 208000001435 Thromboembolism Diseases 0.000 claims abstract description 7
- -1 aza-bicyclohexane Chemical compound 0.000 claims description 529
- 125000000217 alkyl group Chemical group 0.000 claims description 111
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 110
- 125000000623 heterocyclic group Chemical group 0.000 claims description 104
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims description 81
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 81
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 79
- 229910052736 halogen Inorganic materials 0.000 claims description 76
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 76
- 150000002367 halogens Chemical class 0.000 claims description 70
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 65
- 125000003118 aryl group Chemical group 0.000 claims description 61
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims description 54
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 54
- 150000003839 salts Chemical class 0.000 claims description 52
- 229910052757 nitrogen Inorganic materials 0.000 claims description 51
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims description 50
- 239000003112 inhibitor Substances 0.000 claims description 50
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 claims description 42
- 230000015572 biosynthetic process Effects 0.000 claims description 39
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims description 37
- 238000006243 chemical reaction Methods 0.000 claims description 35
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 35
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 33
- 125000001544 thienyl group Chemical group 0.000 claims description 33
- UWYZHKAOTLEWKK-UHFFFAOYSA-N 1,2,3,4-tetrahydroisoquinoline Chemical compound C1=CC=C2CNCCC2=C1 UWYZHKAOTLEWKK-UHFFFAOYSA-N 0.000 claims description 30
- 239000000203 mixture Substances 0.000 claims description 29
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims description 28
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 28
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 28
- LBUJPTNKIBCYBY-UHFFFAOYSA-N 1,2,3,4-tetrahydroquinoline Chemical compound C1=CC=C2CCCNC2=C1 LBUJPTNKIBCYBY-UHFFFAOYSA-N 0.000 claims description 27
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 claims description 27
- 125000004076 pyridyl group Chemical group 0.000 claims description 27
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims description 26
- 125000006375 C2-C10 alkynyl group Chemical group 0.000 claims description 26
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims description 26
- 125000000335 thiazolyl group Chemical group 0.000 claims description 26
- UZHVXJZEHGSWQV-UHFFFAOYSA-N 1,2,3,3a,4,5,6,6a-octahydrocyclopenta[c]pyrrole Chemical compound C1NCC2CCCC21 UZHVXJZEHGSWQV-UHFFFAOYSA-N 0.000 claims description 25
- FQUYSHZXSKYCSY-UHFFFAOYSA-N 1,4-diazepane Chemical compound C1CNCCNC1 FQUYSHZXSKYCSY-UHFFFAOYSA-N 0.000 claims description 25
- WRYCSMQKUKOKBP-UHFFFAOYSA-N Imidazolidine Chemical compound C1CNCN1 WRYCSMQKUKOKBP-UHFFFAOYSA-N 0.000 claims description 25
- 239000003795 chemical substances by application Substances 0.000 claims description 25
- USPWKWBDZOARPV-UHFFFAOYSA-N pyrazolidine Chemical compound C1CNNC1 USPWKWBDZOARPV-UHFFFAOYSA-N 0.000 claims description 25
- 125000004429 atom Chemical group 0.000 claims description 23
- 125000002393 azetidinyl group Chemical group 0.000 claims description 23
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims description 23
- 125000003386 piperidinyl group Chemical group 0.000 claims description 23
- 229910052717 sulfur Inorganic materials 0.000 claims description 23
- VGMJQHONPAXABH-UHFFFAOYSA-N 4,5,6,7-tetrahydro-1h-pyrazolo[4,3-c]pyridine Chemical compound C1NCCC2=C1C=NN2 VGMJQHONPAXABH-UHFFFAOYSA-N 0.000 claims description 22
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims description 22
- XYOVOXDWRFGKEX-UHFFFAOYSA-N azepine Chemical compound N1C=CC=CC=C1 XYOVOXDWRFGKEX-UHFFFAOYSA-N 0.000 claims description 22
- OPBSNAYKUYMJDO-UHFFFAOYSA-N 1,2,3,4,6,7-hexahydropyrrolo[1,2-a]pyrazine Chemical compound C1CNCC2=CCCN21 OPBSNAYKUYMJDO-UHFFFAOYSA-N 0.000 claims description 21
- LRANPJDWHYRCER-UHFFFAOYSA-N 1,2-diazepine Chemical compound N1C=CC=CC=N1 LRANPJDWHYRCER-UHFFFAOYSA-N 0.000 claims description 21
- CIISBYKBBMFLEZ-UHFFFAOYSA-N 1,2-oxazolidine Chemical compound C1CNOC1 CIISBYKBBMFLEZ-UHFFFAOYSA-N 0.000 claims description 21
- CZSRXHJVZUBEGW-UHFFFAOYSA-N 1,2-thiazolidine Chemical compound C1CNSC1 CZSRXHJVZUBEGW-UHFFFAOYSA-N 0.000 claims description 21
- OGYGFUAIIOPWQD-UHFFFAOYSA-N 1,3-thiazolidine Chemical compound C1CSCN1 OGYGFUAIIOPWQD-UHFFFAOYSA-N 0.000 claims description 21
- ZNGWEEUXTBNKFR-UHFFFAOYSA-N 1,4-oxazepane Chemical compound C1CNCCOC1 ZNGWEEUXTBNKFR-UHFFFAOYSA-N 0.000 claims description 21
- POXWDTQUDZUOGP-UHFFFAOYSA-N 1h-1,4-diazepine Chemical compound N1C=CC=NC=C1 POXWDTQUDZUOGP-UHFFFAOYSA-N 0.000 claims description 21
- VSWICNJIUPRZIK-UHFFFAOYSA-N 2-piperideine Chemical compound C1CNC=CC1 VSWICNJIUPRZIK-UHFFFAOYSA-N 0.000 claims description 21
- RSEBUVRVKCANEP-UHFFFAOYSA-N 2-pyrroline Chemical compound C1CC=CN1 RSEBUVRVKCANEP-UHFFFAOYSA-N 0.000 claims description 21
- MSRJJSCOWHWGGX-UHFFFAOYSA-N 2h-1,3-diazepine Chemical compound C1N=CC=CC=N1 MSRJJSCOWHWGGX-UHFFFAOYSA-N 0.000 claims description 21
- KGWNRZLPXLBMPS-UHFFFAOYSA-N 2h-1,3-oxazine Chemical compound C1OC=CC=N1 KGWNRZLPXLBMPS-UHFFFAOYSA-N 0.000 claims description 21
- NTYABNDBNKVWOO-UHFFFAOYSA-N 2h-1,3-thiazine Chemical compound C1SC=CC=N1 NTYABNDBNKVWOO-UHFFFAOYSA-N 0.000 claims description 21
- YHWMFDLNZGIJSD-UHFFFAOYSA-N 2h-1,4-oxazine Chemical compound C1OC=CN=C1 YHWMFDLNZGIJSD-UHFFFAOYSA-N 0.000 claims description 21
- ZAISDHPZTZIFQF-UHFFFAOYSA-N 2h-1,4-thiazine Chemical compound C1SC=CN=C1 ZAISDHPZTZIFQF-UHFFFAOYSA-N 0.000 claims description 21
- BCHZICNRHXRCHY-UHFFFAOYSA-N 2h-oxazine Chemical compound N1OC=CC=C1 BCHZICNRHXRCHY-UHFFFAOYSA-N 0.000 claims description 21
- AGIJRRREJXSQJR-UHFFFAOYSA-N 2h-thiazine Chemical compound N1SC=CC=C1 AGIJRRREJXSQJR-UHFFFAOYSA-N 0.000 claims description 21
- BWCDLEQTELFBAW-UHFFFAOYSA-N 3h-dioxazole Chemical compound N1OOC=C1 BWCDLEQTELFBAW-UHFFFAOYSA-N 0.000 claims description 21
- WEQPBCSPRXFQQS-UHFFFAOYSA-N 4,5-dihydro-1,2-oxazole Chemical compound C1CC=NO1 WEQPBCSPRXFQQS-UHFFFAOYSA-N 0.000 claims description 21
- GUUULVAMQJLDSY-UHFFFAOYSA-N 4,5-dihydro-1,2-thiazole Chemical compound C1CC=NS1 GUUULVAMQJLDSY-UHFFFAOYSA-N 0.000 claims description 21
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 21
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 claims description 21
- DPOPAJRDYZGTIR-UHFFFAOYSA-N Tetrazine Chemical compound C1=CN=NN=N1 DPOPAJRDYZGTIR-UHFFFAOYSA-N 0.000 claims description 21
- JZFICWYCTCCINF-UHFFFAOYSA-N Thiadiazin Chemical compound S=C1SC(C)NC(C)N1CCN1C(=S)SC(C)NC1C JZFICWYCTCCINF-UHFFFAOYSA-N 0.000 claims description 21
- 208000007536 Thrombosis Diseases 0.000 claims description 21
- 125000002947 alkylene group Chemical group 0.000 claims description 21
- HTFFABIIOAKIBH-UHFFFAOYSA-N diazinane Chemical compound C1CCNNC1 HTFFABIIOAKIBH-UHFFFAOYSA-N 0.000 claims description 21
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 21
- MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical compound C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 claims description 21
- OXUZCBDDXOMZAM-UHFFFAOYSA-N oxathiepane Chemical compound C1CCOSCC1 OXUZCBDDXOMZAM-UHFFFAOYSA-N 0.000 claims description 21
- DNXIASIHZYFFRO-UHFFFAOYSA-N pyrazoline Chemical compound C1CN=NC1 DNXIASIHZYFFRO-UHFFFAOYSA-N 0.000 claims description 21
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical compound C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 claims description 21
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims description 21
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 21
- ZVJHJDDKYZXRJI-UHFFFAOYSA-N pyrroline Natural products C1CC=NC1 ZVJHJDDKYZXRJI-UHFFFAOYSA-N 0.000 claims description 21
- 150000003536 tetrazoles Chemical class 0.000 claims description 21
- CBDKQYKMCICBOF-UHFFFAOYSA-N thiazoline Chemical compound C1CN=CS1 CBDKQYKMCICBOF-UHFFFAOYSA-N 0.000 claims description 21
- BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical compound C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 claims description 21
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 20
- 229910052794 bromium Inorganic materials 0.000 claims description 20
- 229910052760 oxygen Inorganic materials 0.000 claims description 20
- 239000001301 oxygen Substances 0.000 claims description 20
- 239000011593 sulfur Substances 0.000 claims description 20
- IGERFAHWSHDDHX-UHFFFAOYSA-N 1,3-dioxanyl Chemical group [CH]1OCCCO1 IGERFAHWSHDDHX-UHFFFAOYSA-N 0.000 claims description 19
- JPRPJUMQRZTTED-UHFFFAOYSA-N 1,3-dioxolanyl Chemical group [CH]1OCCO1 JPRPJUMQRZTTED-UHFFFAOYSA-N 0.000 claims description 19
- 125000004432 carbon atom Chemical group C* 0.000 claims description 19
- 125000002541 furyl group Chemical group 0.000 claims description 19
- 125000002757 morpholinyl group Chemical group 0.000 claims description 19
- 125000001715 oxadiazolyl group Chemical group 0.000 claims description 19
- 125000000160 oxazolidinyl group Chemical group 0.000 claims description 19
- 125000003566 oxetanyl group Chemical group 0.000 claims description 19
- 125000000714 pyrimidinyl group Chemical group 0.000 claims description 19
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims description 19
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims description 19
- 125000003831 tetrazolyl group Chemical group 0.000 claims description 19
- HXNOEHIMWZDRTK-UHFFFAOYSA-N 4,5,6,7-tetrahydrothieno[2,3-c]pyridine Chemical compound C1NCCC2=C1SC=C2 HXNOEHIMWZDRTK-UHFFFAOYSA-N 0.000 claims description 18
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 claims description 18
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 18
- YIGDNAMSWMGZNW-UHFFFAOYSA-N 4,5,6,7-tetrahydro-[1,2]oxazolo[4,5-c]pyridine Chemical compound C1NCCC2=C1C=NO2 YIGDNAMSWMGZNW-UHFFFAOYSA-N 0.000 claims description 17
- 239000000460 chlorine Substances 0.000 claims description 17
- 229910052801 chlorine Inorganic materials 0.000 claims description 17
- 239000001257 hydrogen Substances 0.000 claims description 17
- 229910052739 hydrogen Inorganic materials 0.000 claims description 17
- 239000002243 precursor Substances 0.000 claims description 17
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 16
- 125000005842 heteroatom Chemical group 0.000 claims description 16
- 125000005428 anthryl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C3C(*)=C([H])C([H])=C([H])C3=C([H])C2=C1[H] 0.000 claims description 15
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 15
- 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 claims description 15
- 229910052731 fluorine Inorganic materials 0.000 claims description 15
- 125000002950 monocyclic group Chemical group 0.000 claims description 15
- 125000001624 naphthyl group Chemical group 0.000 claims description 15
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims description 14
- OQJVXNHMUWQQEW-UHFFFAOYSA-N 1,2,3,4-tetrahydropyrazine Chemical compound C1CNC=CN1 OQJVXNHMUWQQEW-UHFFFAOYSA-N 0.000 claims description 14
- VWKKSBDTNICZRS-UHFFFAOYSA-N 1,2,4-triazinane Chemical compound C1CNNCN1 VWKKSBDTNICZRS-UHFFFAOYSA-N 0.000 claims description 14
- BKWQKVJYXODDAC-UHFFFAOYSA-N 1,2-dihydropyridazine Chemical compound N1NC=CC=C1 BKWQKVJYXODDAC-UHFFFAOYSA-N 0.000 claims description 14
- LKLLNYWECKEQIB-UHFFFAOYSA-N 1,3,5-triazinane Chemical compound C1NCNCN1 LKLLNYWECKEQIB-UHFFFAOYSA-N 0.000 claims description 14
- ZBOWKDHBOFMERX-UHFFFAOYSA-N 1,3-diazepane Chemical compound C1CCNCNC1 ZBOWKDHBOFMERX-UHFFFAOYSA-N 0.000 claims description 14
- ABADUMLIAZCWJD-UHFFFAOYSA-N 1,3-dioxole Chemical compound C1OC=CO1 ABADUMLIAZCWJD-UHFFFAOYSA-N 0.000 claims description 14
- QQUFDFQHIUKUFP-UHFFFAOYSA-N 1-azaspiro[2.2]pentane Chemical compound C1CC11NC1 QQUFDFQHIUKUFP-UHFFFAOYSA-N 0.000 claims description 14
- UUAVYXKRUSVCDJ-UHFFFAOYSA-N 1-cycloheptylazepane Chemical compound C1CCCCCC1N1CCCCCC1 UUAVYXKRUSVCDJ-UHFFFAOYSA-N 0.000 claims description 14
- LLSRLLPHUVVLQJ-UHFFFAOYSA-N 1-cycloheptyldiazepane Chemical compound C1CCCCCC1N1NCCCCC1 LLSRLLPHUVVLQJ-UHFFFAOYSA-N 0.000 claims description 14
- JWGMXWNVAYWSNI-UHFFFAOYSA-N 1-cyclohexyldiazinane Chemical compound C1CCCCC1N1NCCCC1 JWGMXWNVAYWSNI-UHFFFAOYSA-N 0.000 claims description 14
- BEWVAZNECYSPMT-UHFFFAOYSA-N 2,3-dihydro-1h-azepine Chemical compound C1CC=CC=CN1 BEWVAZNECYSPMT-UHFFFAOYSA-N 0.000 claims description 14
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 14
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims description 14
- ZSIQJIWKELUFRJ-UHFFFAOYSA-N azepane Chemical compound C1CCCNCC1 ZSIQJIWKELUFRJ-UHFFFAOYSA-N 0.000 claims description 14
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 claims description 14
- SFJGCXYXEFWEBK-UHFFFAOYSA-N oxazepine Chemical compound O1C=CC=CC=N1 SFJGCXYXEFWEBK-UHFFFAOYSA-N 0.000 claims description 14
- IWELDVXSEVIIGI-UHFFFAOYSA-N piperazin-2-one Chemical compound O=C1CNCCN1 IWELDVXSEVIIGI-UHFFFAOYSA-N 0.000 claims description 14
- 125000000168 pyrrolyl group Chemical group 0.000 claims description 14
- 125000002053 thietanyl group Chemical group 0.000 claims description 14
- UOBKULMUFKXXEA-UHFFFAOYSA-N triazepane Chemical compound C1CCNNNC1 UOBKULMUFKXXEA-UHFFFAOYSA-N 0.000 claims description 14
- 125000001399 1,2,3-triazolyl group Chemical group N1N=NC(=C1)* 0.000 claims description 13
- SCEIUGQQBYRBPP-UHFFFAOYSA-N 2,3,4,5-tetrahydro-1h-azepine Chemical compound C1CCC=CNC1 SCEIUGQQBYRBPP-UHFFFAOYSA-N 0.000 claims description 13
- 125000004122 cyclic group Chemical group 0.000 claims description 13
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 12
- VILAVOFMIJHSJA-UHFFFAOYSA-N dicarbon monoxide Chemical group [C]=C=O VILAVOFMIJHSJA-UHFFFAOYSA-N 0.000 claims description 12
- 238000001356 surgical procedure Methods 0.000 claims description 12
- FTUSZJTUFHXUPG-UHFFFAOYSA-N 1,2,3,3a,4,5-hexahydropyrrolo[2,3-c]pyrrole Chemical compound C1NC=C2NCCC21 FTUSZJTUFHXUPG-UHFFFAOYSA-N 0.000 claims description 11
- POTIYWUALSJREP-UHFFFAOYSA-N 1,2,3,4,4a,5,6,7,8,8a-decahydroquinoline Chemical compound N1CCCC2CCCCC21 POTIYWUALSJREP-UHFFFAOYSA-N 0.000 claims description 11
- QMWYDZLBWGJQOY-UHFFFAOYSA-N 1,3,8-triazaspiro[4.5]decane Chemical compound N1CNCC11CCNCC1 QMWYDZLBWGJQOY-UHFFFAOYSA-N 0.000 claims description 11
- QVFOROPZGGTFNG-UHFFFAOYSA-N 1,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidine Chemical compound C1NC=NC2=C1CNCC2 QVFOROPZGGTFNG-UHFFFAOYSA-N 0.000 claims description 11
- QUIJMHDIAFOPRK-UHFFFAOYSA-N 1-cyclooctylazocane Chemical compound C1CCCCCCC1N1CCCCCCC1 QUIJMHDIAFOPRK-UHFFFAOYSA-N 0.000 claims description 11
- JMWPSCUIQIMVQH-UHFFFAOYSA-N 2,3,3a,4,5,6,7,7a-octahydro-1h-pyrrolo[3,4-c]pyridine Chemical compound C1NCCC2CNCC21 JMWPSCUIQIMVQH-UHFFFAOYSA-N 0.000 claims description 11
- KSCPLKVBWDOSAI-UHFFFAOYSA-N 2,3,4,4a,5,6,7,7a-octahydro-1h-pyrrolo[3,4-b]pyridine Chemical compound N1CCCC2CNCC21 KSCPLKVBWDOSAI-UHFFFAOYSA-N 0.000 claims description 11
- UKHJNJFJCGBKSF-UHFFFAOYSA-N 2,5-diazabicyclo[2.2.1]heptane Chemical compound C1NC2CNC1C2 UKHJNJFJCGBKSF-UHFFFAOYSA-N 0.000 claims description 11
- WYZZNMWIWHRXRM-UHFFFAOYSA-N 2,8-diazaspiro[4.5]decane Chemical compound C1NCCC21CCNCC2 WYZZNMWIWHRXRM-UHFFFAOYSA-N 0.000 claims description 11
- KBKROXSTGCCVJV-UHFFFAOYSA-N 4,5,6,6a-tetrahydro-3ah-pyrrolo[3,4-d][1,2]oxazole Chemical compound C1=NOC2CNCC21 KBKROXSTGCCVJV-UHFFFAOYSA-N 0.000 claims description 11
- BFFIACPYUHJBDJ-UHFFFAOYSA-N 4,5,6,7-tetrahydro-[1,2]oxazolo[5,4-c]pyridine Chemical compound C1NCCC2=C1ON=C2 BFFIACPYUHJBDJ-UHFFFAOYSA-N 0.000 claims description 11
- QSLDIPUHQBHQGY-UHFFFAOYSA-N 4,5,6,7-tetrahydro-[1,3]thiazolo[5,4-c]pyridine Chemical compound C1NCCC2=C1SC=N2 QSLDIPUHQBHQGY-UHFFFAOYSA-N 0.000 claims description 11
- OGUWOLDNYOTRBO-UHFFFAOYSA-N 4,5,6,7-tetrahydrothieno[3,2-c]pyridine Chemical compound C1NCCC2=C1C=CS2 OGUWOLDNYOTRBO-UHFFFAOYSA-N 0.000 claims description 11
- WYNCHZVNFNFDNH-UHFFFAOYSA-N Oxazolidine Chemical compound C1COCN1 WYNCHZVNFNFDNH-UHFFFAOYSA-N 0.000 claims description 11
- 239000002253 acid Substances 0.000 claims description 11
- 230000009977 dual effect Effects 0.000 claims description 11
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 claims description 11
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 claims description 11
- LPAGFVYQRIESJQ-UHFFFAOYSA-N indoline Chemical compound C1=CC=C2NCCC2=C1 LPAGFVYQRIESJQ-UHFFFAOYSA-N 0.000 claims description 11
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- WQLCZPKSFDUTCN-UHFFFAOYSA-N butyl 4-[2-[[4-[2-(3-methoxypiperidin-1-yl)-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CC(CCC2)OC)=C(C=CC(C)=C2)C2=N1 WQLCZPKSFDUTCN-UHFFFAOYSA-N 0.000 claims 2
- ROOMEYQBXZFETI-UHFFFAOYSA-N butyl 4-[2-[[4-[2-(4-acetamidopiperidin-1-yl)-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CCC(CC2)NC(C)=O)=C(C=CC(C)=C2)C2=N1 ROOMEYQBXZFETI-UHFFFAOYSA-N 0.000 claims 2
- SORMDUFKWZAKCR-UHFFFAOYSA-N butyl 4-[2-[[4-[2-(4-cyclobutylpiperazin-1-yl)-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CCN(CC2)C2CCC2)=C(C=CC(C)=C2)C2=N1 SORMDUFKWZAKCR-UHFFFAOYSA-N 0.000 claims 2
- NGIBPQBVOPGMHV-UHFFFAOYSA-N butyl 4-[2-[[4-[2-(4-methoxypiperidin-1-yl)-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CCC(CC2)OC)=C(C=CC(C)=C2)C2=N1 NGIBPQBVOPGMHV-UHFFFAOYSA-N 0.000 claims 2
- JTZSDCFLQORECJ-UHFFFAOYSA-N butyl 4-[2-[[4-[2-(6,8-dihydro-5h-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CC3=NN=CN3CC2)=C(C=CC=C2)C2=N1 JTZSDCFLQORECJ-UHFFFAOYSA-N 0.000 claims 2
- XIUBCLJQBJITRH-DHIUTWEWSA-N butyl 4-[2-[[4-[2-[(1r,4r)-5-ethyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C([C@@]1(N(C[C@@]2([H])C1)CC)[H])N2C(=O)COC(C1=CC=C(C)C=C1N=1)=CC=1C(=O)NCC(=O)N1CCN(C(=O)OCCCC)CC1 XIUBCLJQBJITRH-DHIUTWEWSA-N 0.000 claims 2
- CBBLDWOHATULKR-HKBQPEDESA-N butyl 4-[2-[[4-[2-[(2s)-2-(2,3-dihydroindole-1-carbonyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)N2C3=CC=CC=C3CC2)=C(C=CC(C)=C2)C2=N1 CBBLDWOHATULKR-HKBQPEDESA-N 0.000 claims 2
- RTWHLRZPGYFVAR-YTTGMZPUSA-N butyl 4-[2-[[4-[2-[(2s)-2-(3,4-dihydro-2h-quinoline-1-carbonyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)N2C3=CC=CC=C3CCC2)=C(C=CC(C)=C2)C2=N1 RTWHLRZPGYFVAR-YTTGMZPUSA-N 0.000 claims 2
- MLYHCJLOXYXNGI-SANMLTNESA-N butyl 4-[2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-6,7-difluoroquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=C(F)C(F)=C2)C2=N1 MLYHCJLOXYXNGI-SANMLTNESA-N 0.000 claims 2
- OBELAOXLRYQBFP-NDEPHWFRSA-N butyl 4-[2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-6,7-dimethylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=C(C)C(C)=C2)C2=N1 OBELAOXLRYQBFP-NDEPHWFRSA-N 0.000 claims 2
- PTNQOIWQBVAXFP-SANMLTNESA-N butyl 4-[2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-6-fluoro-5-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C(C)=C(F)C=C2)C2=N1 PTNQOIWQBVAXFP-SANMLTNESA-N 0.000 claims 2
- OTIDEFVYWCBTLC-SANMLTNESA-N butyl 4-[2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC=C2)C2=N1 OTIDEFVYWCBTLC-SANMLTNESA-N 0.000 claims 2
- GBQVIHASLNIDIG-DEOSSOPVSA-N butyl 4-[2-[[4-[2-[(2s)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NCC)=C(C=CC=C2)C2=N1 GBQVIHASLNIDIG-DEOSSOPVSA-N 0.000 claims 2
- PVSUJRMOEMKGFV-QHCPKHFHSA-N butyl 4-[2-[[4-[2-[(2s)-2-(methylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC)=C(C=CC=C2)C2=N1 PVSUJRMOEMKGFV-QHCPKHFHSA-N 0.000 claims 2
- YYLIJTPNYLLXSN-VWLOTQADSA-N butyl 4-[2-[[4-[2-[(2s)-2-(tert-butylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC(C)(C)C)=C(C=CC=C2)C2=N1 YYLIJTPNYLLXSN-VWLOTQADSA-N 0.000 claims 2
- FYNXXWGKNVOKPP-FQEVSTJZSA-N butyl 4-[2-[[4-[2-[(2s)-2-cyanopyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C#N)=C(C=CC=C2)C2=N1 FYNXXWGKNVOKPP-FQEVSTJZSA-N 0.000 claims 2
- CYJGIONKDARNJJ-KCWPFWIISA-N butyl 4-[2-[[4-[2-[(2s,4r)-2-(cyclobutylcarbamoyl)-4-hydroxypyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](C[C@@H](O)C2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 CYJGIONKDARNJJ-KCWPFWIISA-N 0.000 claims 2
- DALRPCXVHZVTLO-OUTSHDOLSA-N butyl 4-[2-[[4-[2-[(2s,4r)-4-cyano-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-6,7-dimethylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](C[C@H](C2)C#N)C(=O)NC2CCC2)=C(C=C(C)C(C)=C2)C2=N1 DALRPCXVHZVTLO-OUTSHDOLSA-N 0.000 claims 2
- CQNYNPXYMYCTRE-FIPFOOKPSA-N butyl 4-[2-[[4-[2-[(2s,4r)-4-cyano-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](C[C@H](C2)C#N)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 CQNYNPXYMYCTRE-FIPFOOKPSA-N 0.000 claims 2
- OPQQMAKJHNYBGT-CUNXSJBXSA-N butyl 4-[2-[[4-[2-[(2s,4r)-4-cyano-2-(cyclopropylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](C[C@H](C2)C#N)C(=O)NC2CC2)=C(C=CC(C)=C2)C2=N1 OPQQMAKJHNYBGT-CUNXSJBXSA-N 0.000 claims 2
- LLSRYCDEEGDKMR-PMACEKPBSA-N butyl 4-[2-[[4-[2-[(2s,4s)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](C[C@H](F)C2)C#N)=C(C=CC=C2)C2=N1 LLSRYCDEEGDKMR-PMACEKPBSA-N 0.000 claims 2
- VMWFLZLMBIRPDK-QFIPXVFZSA-N butyl 4-[2-[[4-[2-[(3s)-3-acetamidopyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2C[C@H](CC2)NC(C)=O)=C(C=CC(C)=C2)C2=N1 VMWFLZLMBIRPDK-QFIPXVFZSA-N 0.000 claims 2
- PWYYVZPLBZMKPY-SANMLTNESA-N butyl 4-[2-[[4-[2-[(4s)-4-(cyclobutylcarbamoyl)-1,3-oxazolidin-3-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](COC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 PWYYVZPLBZMKPY-SANMLTNESA-N 0.000 claims 2
- SWQLQQAZZXNMKT-UHFFFAOYSA-N butyl 4-[2-[[4-[2-[3-(dimethylamino)piperidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CC(CCC2)N(C)C)=C(C=CC(C)=C2)C2=N1 SWQLQQAZZXNMKT-UHFFFAOYSA-N 0.000 claims 2
- KFEDYSLGEPJPQX-UHFFFAOYSA-N butyl 4-[2-[[4-[2-[3-(dimethylamino)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CC(CC2)N(C)C)=C(C=CC(C)=C2)C2=N1 KFEDYSLGEPJPQX-UHFFFAOYSA-N 0.000 claims 2
- KSKVBGOOGNGDHL-UHFFFAOYSA-N butyl 4-[2-[[4-[2-[3-[acetyl(methyl)amino]pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CC(CC2)N(C)C(C)=O)=C(C=CC(C)=C2)C2=N1 KSKVBGOOGNGDHL-UHFFFAOYSA-N 0.000 claims 2
- QBHKIMIPURTWSS-UHFFFAOYSA-N butyl 4-[2-[[4-[2-[4-(2-hydroxyethyl)piperazin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CCN(CCO)CC2)=C(C=CC=C2)C2=N1 QBHKIMIPURTWSS-UHFFFAOYSA-N 0.000 claims 2
- SBHBGZGEEQZTEW-UHFFFAOYSA-N butyl 4-[2-[[4-[2-[4-(cyanomethyl)piperazin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CCN(CC#N)CC2)=C(C=CC(C)=C2)C2=N1 SBHBGZGEEQZTEW-UHFFFAOYSA-N 0.000 claims 2
- HZSJDACMCMCCIT-UHFFFAOYSA-N butyl 4-[2-[[4-[2-oxo-2-(1-oxo-2,9-diazaspiro[4.5]decan-9-yl)ethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CC3(C(NCC3)=O)CCC2)=C(C=CC=C2)C2=N1 HZSJDACMCMCCIT-UHFFFAOYSA-N 0.000 claims 2
- JLMGXQWKZZZYSQ-UHFFFAOYSA-N butyl 4-[2-[[4-[2-oxo-2-(3-oxopiperazin-1-yl)ethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CC(=O)NCC2)=C(C=CC=C2)C2=N1 JLMGXQWKZZZYSQ-UHFFFAOYSA-N 0.000 claims 2
- QEFGNKZHTMCUTI-MHZLTWQESA-N butyl 4-[2-[[6-chloro-4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=C(Cl)C(C)=C2)C2=N1 QEFGNKZHTMCUTI-MHZLTWQESA-N 0.000 claims 2
- OELHVKYRDNYACX-SANMLTNESA-N butyl 4-[2-[[7-chloro-4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(Cl)=C2)C2=N1 OELHVKYRDNYACX-SANMLTNESA-N 0.000 claims 2
- CEPCNAUGBIBJQJ-IDISGSTGSA-N butyl 4-[2-[[7-chloro-4-[2-[(2s,4r)-4-cyano-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](C[C@H](C2)C#N)C(=O)NC2CCC2)=C(C=CC(Cl)=C2)C2=N1 CEPCNAUGBIBJQJ-IDISGSTGSA-N 0.000 claims 2
- ANGOSVWWJVHVBC-MHZLTWQESA-N butyl 4-[2-[[7-cyano-4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(=C2)C#N)C2=N1 ANGOSVWWJVHVBC-MHZLTWQESA-N 0.000 claims 2
- FCSRVRZNQVEZLM-CZUALIRWSA-N butyl 4-[2-[[7-methyl-4-[(2r)-1-(2-methyl-3,3a,4,6,7,7a-hexahydro-1h-pyrrolo[3,4-c]pyridin-5-yl)-1-oxopropan-2-yl]oxyquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(O[C@H](C)C(=O)N2CC3CN(C)CC3CC2)=C(C=CC(C)=C2)C2=N1 FCSRVRZNQVEZLM-CZUALIRWSA-N 0.000 claims 2
- ZUJZHJDMXOEGGO-UHFFFAOYSA-N butyl 4-[2-[[7-methyl-4-[2-(1-methyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CC=3N(C)N=CC=3C2)=C(C=CC(C)=C2)C2=N1 ZUJZHJDMXOEGGO-UHFFFAOYSA-N 0.000 claims 2
- CVCWNCHQYRVWPT-UHFFFAOYSA-N butyl 4-[2-[[7-methyl-4-[2-(2-methyl-3,3a,4,6,7,7a-hexahydro-1h-pyrrolo[3,4-c]pyridin-5-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CC3CN(C)CC3CC2)=C(C=CC(C)=C2)C2=N1 CVCWNCHQYRVWPT-UHFFFAOYSA-N 0.000 claims 2
- ZYEHWWLTZRVNEJ-UHFFFAOYSA-N butyl 4-[2-[[7-methyl-4-[2-(2-methyl-6,7-dihydro-4h-[1,3]oxazolo[5,4-c]pyridin-5-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CC=3OC(C)=NC=3CC2)=C(C=CC(C)=C2)C2=N1 ZYEHWWLTZRVNEJ-UHFFFAOYSA-N 0.000 claims 2
- SEMYVXLRCQVOMK-UHFFFAOYSA-N butyl 4-[2-[[7-methyl-4-[2-(3-methylsulfonylpyrrolidin-1-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CC(CC2)S(C)(=O)=O)=C(C=CC(C)=C2)C2=N1 SEMYVXLRCQVOMK-UHFFFAOYSA-N 0.000 claims 2
- LFIBUCNGCJWRGT-NDEPHWFRSA-N butyl 4-[2-[[7-methyl-4-[2-[(2s)-2-(4-methylpiperazine-1-carbonyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)N2CCN(C)CC2)=C(C=CC(C)=C2)C2=N1 LFIBUCNGCJWRGT-NDEPHWFRSA-N 0.000 claims 2
- MUZBZDAHAVTLJC-LJAQVGFWSA-N butyl 4-[2-[[7-methyl-4-[2-[(2s)-2-(4-methylpiperidine-1-carbonyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)N2CCC(C)CC2)=C(C=CC(C)=C2)C2=N1 MUZBZDAHAVTLJC-LJAQVGFWSA-N 0.000 claims 2
- SUDUEYJZLVVQRF-MHZLTWQESA-N butyl 4-[2-[[7-methyl-4-[2-[(2s)-2-[(1-methylazetidin-3-yl)carbamoyl]pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CN(C)C2)=C(C=CC(C)=C2)C2=N1 SUDUEYJZLVVQRF-MHZLTWQESA-N 0.000 claims 2
- TXMWEYZMAKKPLL-HSZRJFAPSA-N butyl 4-[2-[[7-methyl-4-[2-[(3r)-3-[(2-methylpropan-2-yl)oxycarbonylamino]pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2C[C@@H](CC2)NC(=O)OC(C)(C)C)=C(C=CC(C)=C2)C2=N1 TXMWEYZMAKKPLL-HSZRJFAPSA-N 0.000 claims 2
- RBALUQDFKLSXFB-UHFFFAOYSA-N butyl 4-[2-[[7-methyl-4-[2-[1-methyl-3-(trifluoromethyl)-6,7-dihydro-4h-pyrazolo[4,3-c]pyridin-5-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CC3=C(N(N=C3C(F)(F)F)C)CC2)=C(C=CC(C)=C2)C2=N1 RBALUQDFKLSXFB-UHFFFAOYSA-N 0.000 claims 2
- UIRDRTZIRDMVAZ-UHFFFAOYSA-N butyl 4-[2-[[7-methyl-4-[2-[2-(6-methylpyridin-2-yl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2N=C(C)C=CC=2)=C(C=CC(C)=C2)C2=N1 UIRDRTZIRDMVAZ-UHFFFAOYSA-N 0.000 claims 2
- DUUOHDLDVBLTEQ-UHFFFAOYSA-N butyl 4-[2-[[7-methyl-4-[2-oxo-2-(1-oxo-2,8-diazaspiro[4.5]decan-8-yl)ethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CCC3(C(NCC3)=O)CC2)=C(C=CC(C)=C2)C2=N1 DUUOHDLDVBLTEQ-UHFFFAOYSA-N 0.000 claims 2
- RPXMKICGILMLLS-UHFFFAOYSA-N butyl 4-[2-[[7-methyl-4-[2-oxo-2-(1-oxo-2,9-diazaspiro[4.5]decan-9-yl)ethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CC3(C(NCC3)=O)CCC2)=C(C=CC(C)=C2)C2=N1 RPXMKICGILMLLS-UHFFFAOYSA-N 0.000 claims 2
- GBVLTPIXQRZHEE-XMMPIXPASA-N butyl 4-[2-[[7-methyl-4-[2-oxo-2-[(2r)-2-(trifluoromethyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@H](CCC2)C(F)(F)F)=C(C=CC(C)=C2)C2=N1 GBVLTPIXQRZHEE-XMMPIXPASA-N 0.000 claims 2
- GRHADFNYADRMAU-DEOSSOPVSA-N butyl 4-[2-[[7-methyl-4-[2-oxo-2-[(2s)-2-(2,2,2-trifluoroethylcarbamoyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NCC(F)(F)F)=C(C=CC(C)=C2)C2=N1 GRHADFNYADRMAU-DEOSSOPVSA-N 0.000 claims 2
- JKQCJZCYDHDLJH-QHCPKHFHSA-N butyl 4-[2-[[7-methyl-4-[2-oxo-2-[(2s)-2-(2h-tetrazol-5-yl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C=2NN=NN=2)=C(C=CC(C)=C2)C2=N1 JKQCJZCYDHDLJH-QHCPKHFHSA-N 0.000 claims 2
- STFIGXPBNQDOIF-NRFANRHFSA-N butyl 4-[2-[[7-methyl-4-[2-oxo-2-[(2s)-2-(2h-tetrazol-5-ylmethyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)CC=2NN=NN=2)=C(C=CC(C)=C2)C2=N1 STFIGXPBNQDOIF-NRFANRHFSA-N 0.000 claims 2
- VXHPRORQLFGJAP-UHFFFAOYSA-N butyl 4-[2-[[7-methyl-4-[2-oxo-2-[4-(pyrrolidine-1-carbonyl)piperazin-1-yl]ethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CCN(CC2)C(=O)N2CCCC2)=C(C=CC(C)=C2)C2=N1 VXHPRORQLFGJAP-UHFFFAOYSA-N 0.000 claims 2
- LTZDGDDNQUKIJJ-UHFFFAOYSA-N butyl 4-[2-[[7-methyl-4-[2-oxo-2-[4-(pyrrolidine-1-carbonyl)piperidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CCC(CC2)C(=O)N2CCCC2)=C(C=CC(C)=C2)C2=N1 LTZDGDDNQUKIJJ-UHFFFAOYSA-N 0.000 claims 2
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- RZEKVGVHFLEQIL-UHFFFAOYSA-N celecoxib Chemical compound C1=CC(C)=CC=C1C1=CC(C(F)(F)F)=NN1C1=CC=C(S(N)(=O)=O)C=C1 RZEKVGVHFLEQIL-UHFFFAOYSA-N 0.000 claims 2
- 239000003354 cholesterol ester transfer protein inhibitor Substances 0.000 claims 2
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- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 2
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- KNHUKKLJHYUCFP-UHFFFAOYSA-N clofibrate Chemical compound CCOC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 KNHUKKLJHYUCFP-UHFFFAOYSA-N 0.000 claims 2
- FHLDYDYBMJAMHY-MGTSJQRLSA-N cyclobutyl 4-[(2s)-2-[[4-[(2r)-1-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-1-oxopropan-2-yl]oxy-7-methylquinoline-2-carbonyl]amino]-4-hydroxybutanoyl]piperazine-1-carboxylate Chemical compound O=C([C@H](CCO)NC(=O)C=1C=C(C2=CC=C(C)C=C2N=1)O[C@H](C)C(=O)N1[C@@H](CCC1)C(=O)NC1CCC1)N(CC1)CCN1C(=O)OC1CCC1 FHLDYDYBMJAMHY-MGTSJQRLSA-N 0.000 claims 2
- QNIBQSOEUVBIBP-MGTSJQRLSA-N cyclopropylmethyl 4-[(2s)-2-[[4-[(2r)-1-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-1-oxopropan-2-yl]oxy-7-methylquinoline-2-carbonyl]amino]-4-hydroxybutanoyl]piperazine-1-carboxylate Chemical compound O=C([C@H](CCO)NC(=O)C=1C=C(C2=CC=C(C)C=C2N=1)O[C@H](C)C(=O)N1[C@@H](CCC1)C(=O)NC1CCC1)N(CC1)CCN1C(=O)OCC1CC1 QNIBQSOEUVBIBP-MGTSJQRLSA-N 0.000 claims 2
- 229960003957 dexamethasone Drugs 0.000 claims 2
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 2
- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 claims 2
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- IQQBRKLVEALROM-UHFFFAOYSA-N drinabant Chemical compound C=1C(F)=CC(F)=CC=1N(S(=O)(=O)C)C(C1)CN1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 IQQBRKLVEALROM-UHFFFAOYSA-N 0.000 claims 2
- 229940073621 enbrel Drugs 0.000 claims 2
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- IQLINXQYDXIZES-ATILKMQGSA-N ethyl 4-[(2s)-2-[[4-[(2r)-1-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-1-oxopropan-2-yl]oxy-7-methylquinoline-2-carbonyl]amino]-4-hydroxybutanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCO)NC(=O)C1=CC(O[C@H](C)C(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 IQLINXQYDXIZES-ATILKMQGSA-N 0.000 claims 2
- UXVADFYIDIDVBR-IXLXJOPFSA-N ethyl 4-[(2s)-2-[[4-[(2r)-1-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-1-oxopropan-2-yl]oxy-7-methylquinoline-2-carbonyl]amino]-5-methoxy-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(=O)OC)NC(=O)C1=CC(O[C@H](C)C(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 UXVADFYIDIDVBR-IXLXJOPFSA-N 0.000 claims 2
- PMMDZQAGHNNAPR-LSYYVWMOSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-fluoroquinoline-2-carbonyl]amino]-5-ethoxy-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound O=C([C@@H]1CCCN1C(=O)COC=1C=C(N=C2C=C(F)C=CC2=1)C(=O)N[C@@H](CCC(=O)OCC)C(=O)N1CCN(CC1)C(=O)OCC)NC1CCC1 PMMDZQAGHNNAPR-LSYYVWMOSA-N 0.000 claims 2
- FVARMTYZMHIWLF-DITALETJSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(2-morpholin-4-ylethoxy)-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@@H](NC(=O)C=1N=C2C=C(C)C=CC2=C(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)C=1)CCC(=O)OCCN1CCOCC1 FVARMTYZMHIWLF-DITALETJSA-N 0.000 claims 2
- CBZLUFPHGAHYLC-IZEXYCQBSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-cyclobutyloxy-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@@H](NC(=O)C=1N=C2C=C(C)C=CC2=C(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)C=1)CCC(=O)OC1CCC1 CBZLUFPHGAHYLC-IZEXYCQBSA-N 0.000 claims 2
- OWBJSGUVJNCOLK-SANMLTNESA-N ethyl 4-[2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]-methylamino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)CN(C)C(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 OWBJSGUVJNCOLK-SANMLTNESA-N 0.000 claims 2
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- AFBYZJGKTHTBRP-QMHWCDLVSA-N (2r,4r)-1-[2-[2-[[(2s)-4-carboxy-1-(4-ethoxycarbonylpiperazin-1-yl)-1-oxobutan-2-yl]carbamoyl]-7-methylquinolin-4-yl]oxyacetyl]-4-hydroxypyrrolidine-2-carboxylic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@H](C[C@@H](O)C2)C(O)=O)=C(C=CC(C)=C2)C2=N1 AFBYZJGKTHTBRP-QMHWCDLVSA-N 0.000 claims 1
- BKLPDRDBAPJADY-IZIIKQMZSA-N (2s)-1-[(2r)-2-[2-[[(2s)-4-carboxy-1-(4-ethoxycarbonylpiperazin-1-yl)-1-oxobutan-2-yl]carbamoyl]-7-methylquinolin-4-yl]oxypropanoyl]pyrrolidine-2-carboxylic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(O[C@H](C)C(=O)N2[C@@H](CCC2)C(O)=O)=C(C=CC(C)=C2)C2=N1 BKLPDRDBAPJADY-IZIIKQMZSA-N 0.000 claims 1
- FNMXUQVWROVEHU-BGOLNKOXSA-N (2s)-1-[2-[2-[[(2s)-4-carboxy-1-(4-ethoxycarbonylpiperazin-1-yl)-1-oxobutan-2-yl]carbamoyl]-7-methylquinolin-4-yl]oxyacetyl]-2-methylpyrrolidine-2-carboxylic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@](CCC2)(C)C(O)=O)=C(C=CC(C)=C2)C2=N1 FNMXUQVWROVEHU-BGOLNKOXSA-N 0.000 claims 1
- KMFPLZZWUZASQL-UGKGYDQZSA-N (2s)-1-[2-[2-[[(2s)-4-carboxy-1-(4-ethoxycarbonylpiperazin-1-yl)-1-oxobutan-2-yl]carbamoyl]-7-methylquinolin-4-yl]oxyacetyl]azetidine-2-carboxylic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CC2)C(O)=O)=C(C=CC(C)=C2)C2=N1 KMFPLZZWUZASQL-UGKGYDQZSA-N 0.000 claims 1
- QAUVOYWAGNZPJD-URXFXBBRSA-N (2s)-1-[2-[2-[[(2s)-4-carboxy-1-(4-ethoxycarbonylpiperazin-1-yl)-1-oxobutan-2-yl]carbamoyl]-7-methylquinolin-4-yl]oxyacetyl]piperidine-2-carboxylic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCCC2)C(O)=O)=C(C=CC(C)=C2)C2=N1 QAUVOYWAGNZPJD-URXFXBBRSA-N 0.000 claims 1
- GKNFYWDNOMRVAK-REWPJTCUSA-N (2s)-1-[2-[2-[[(2s)-4-carboxy-1-(4-ethoxycarbonylpiperazin-1-yl)-1-oxobutan-2-yl]carbamoyl]-7-methylquinolin-4-yl]oxyacetyl]pyrrolidine-2-carboxylic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(O)=O)=C(C=CC(C)=C2)C2=N1 GKNFYWDNOMRVAK-REWPJTCUSA-N 0.000 claims 1
- PUNVVUBNSWNROR-OZXSUGGESA-N (2s)-1-[2-[2-[[(2s)-4-carboxy-1-(4-ethoxycarbonylpiperazin-1-yl)-1-oxobutan-2-yl]carbamoyl]quinolin-4-yl]oxyacetyl]-2,3-dihydroindole-2-carboxylic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C3=CC=CC=C3C[C@H]2C(O)=O)=C(C=CC=C2)C2=N1 PUNVVUBNSWNROR-OZXSUGGESA-N 0.000 claims 1
- COFOATSPKDPFSZ-JRPXNJEYSA-N (2s)-1-[2-[2-[[(2s)-4-carboxy-1-(4-ethoxycarbonylpiperazin-1-yl)-1-oxobutan-2-yl]carbamoyl]quinolin-4-yl]oxyacetyl]-2-methylpyrrolidine-2-carboxylic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@](CCC2)(C)C(O)=O)=C(C=CC=C2)C2=N1 COFOATSPKDPFSZ-JRPXNJEYSA-N 0.000 claims 1
- VFTXLBDPDGHZLW-FPOVZHCZSA-N (2s)-1-[2-[2-[[(2s)-4-carboxy-1-(4-ethoxycarbonylpiperazin-1-yl)-1-oxobutan-2-yl]carbamoyl]quinolin-4-yl]oxyacetyl]azetidine-2-carboxylic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CC2)C(O)=O)=C(C=CC=C2)C2=N1 VFTXLBDPDGHZLW-FPOVZHCZSA-N 0.000 claims 1
- FBMDQOKXVXDTEO-GMAHTHKFSA-N (2s)-1-[2-[2-[[(2s)-4-carboxy-1-(4-ethoxycarbonylpiperazin-1-yl)-1-oxobutan-2-yl]carbamoyl]quinolin-4-yl]oxyacetyl]piperidine-2-carboxylic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCCC2)C(O)=O)=C(C=CC=C2)C2=N1 FBMDQOKXVXDTEO-GMAHTHKFSA-N 0.000 claims 1
- ATJPMZKUKKLLQF-UNMCSNQZSA-N (2s)-1-[2-[2-[[(2s)-4-carboxy-1-(4-ethoxycarbonylpiperazin-1-yl)-1-oxobutan-2-yl]carbamoyl]quinolin-4-yl]oxyacetyl]pyrrolidine-2-carboxylic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(O)=O)=C(C=CC=C2)C2=N1 ATJPMZKUKKLLQF-UNMCSNQZSA-N 0.000 claims 1
- JBJLIQJQLZVOSH-QHCPKHFHSA-N (2s)-1-[2-[2-[[2-(4-butoxycarbonylpiperazin-1-yl)-2-oxoethyl]carbamoyl]-7-methylquinolin-4-yl]oxyacetyl]pyrrolidine-2-carboxylic acid Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(O)=O)=C(C=CC(C)=C2)C2=N1 JBJLIQJQLZVOSH-QHCPKHFHSA-N 0.000 claims 1
- JKOZGTOKFOQJHE-XCRWMPKNSA-N (2s,3ar,7ar)-1-[2-[2-[[2-(4-butoxycarbonylpiperazin-1-yl)-2-oxoethyl]carbamoyl]-7-methylquinolin-4-yl]oxyacetyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](C[C@H]3CCCC[C@H]32)C(O)=O)=C(C=CC(C)=C2)C2=N1 JKOZGTOKFOQJHE-XCRWMPKNSA-N 0.000 claims 1
- JVCGBUZCIPIKRY-NHZRIVAWSA-N (2s,3s)-1-[2-[2-[[(2s)-4-carboxy-1-(4-ethoxycarbonylpiperazin-1-yl)-1-oxobutan-2-yl]carbamoyl]-7-methylquinolin-4-yl]oxyacetyl]-3-hydroxypyrrolidine-2-carboxylic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H]([C@@H](O)CC2)C(O)=O)=C(C=CC(C)=C2)C2=N1 JVCGBUZCIPIKRY-NHZRIVAWSA-N 0.000 claims 1
- FEYOJVPQXMDIPR-OWHZGTRUSA-N (2s,3s)-1-[2-[2-[[(2s)-4-carboxy-1-(4-ethoxycarbonylpiperazin-1-yl)-1-oxobutan-2-yl]carbamoyl]quinolin-4-yl]oxyacetyl]-3-hydroxypyrrolidine-2-carboxylic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H]([C@@H](O)CC2)C(O)=O)=C(C=CC=C2)C2=N1 FEYOJVPQXMDIPR-OWHZGTRUSA-N 0.000 claims 1
- DNJPYTUSLPTACJ-AGHHOFFYSA-N (2s,4r)-1-[2-[2-[[(2s)-4-carboxy-1-(4-ethoxycarbonylpiperazin-1-yl)-1-oxobutan-2-yl]carbamoyl]quinolin-4-yl]oxyacetyl]-4-hydroxypyrrolidine-2-carboxylic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](C[C@@H](O)C2)C(O)=O)=C(C=CC=C2)C2=N1 DNJPYTUSLPTACJ-AGHHOFFYSA-N 0.000 claims 1
- HYRIMYCHNFUPGW-ITHJLQSDSA-N (2s,5r)-1-[2-[2-[[(2s)-4-carboxy-1-(4-ethoxycarbonylpiperazin-1-yl)-1-oxobutan-2-yl]carbamoyl]quinolin-4-yl]oxyacetyl]-5-phenylpyrrolidine-2-carboxylic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@H](CC[C@H]2C(O)=O)C=2C=CC=CC=2)=C(C=CC=C2)C2=N1 HYRIMYCHNFUPGW-ITHJLQSDSA-N 0.000 claims 1
- MHOOGDWOMUIDAP-BQQUOAEZSA-N (3s)-3-[[4-[(2r)-1-[(2s)-2-(cyclobutylcarbamoyl)azetidin-1-yl]-1-oxopropan-2-yl]oxy-7-methylquinoline-2-carbonyl]amino]-4-(4-ethoxycarbonylpiperazin-1-yl)-4-oxobutanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CC(O)=O)NC(=O)C1=CC(O[C@H](C)C(=O)N2[C@@H](CC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 MHOOGDWOMUIDAP-BQQUOAEZSA-N 0.000 claims 1
- PVLFYFSBPHSGCQ-BQQUOAEZSA-N (3s)-3-[[4-[(2r)-1-[(2s)-2-(cyclopropylcarbamoyl)pyrrolidin-1-yl]-1-oxopropan-2-yl]oxy-7-methylquinoline-2-carbonyl]amino]-4-(4-ethoxycarbonylpiperazin-1-yl)-4-oxobutanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CC(O)=O)NC(=O)C1=CC(O[C@H](C)C(=O)N2[C@@H](CCC2)C(=O)NC2CC2)=C(C=CC(C)=C2)C2=N1 PVLFYFSBPHSGCQ-BQQUOAEZSA-N 0.000 claims 1
- MHOOGDWOMUIDAP-XZZVZQAVSA-N (3s)-3-[[4-[(2s)-1-[(2s)-2-(cyclobutylcarbamoyl)azetidin-1-yl]-1-oxopropan-2-yl]oxy-7-methylquinoline-2-carbonyl]amino]-4-(4-ethoxycarbonylpiperazin-1-yl)-4-oxobutanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CC(O)=O)NC(=O)C1=CC(O[C@@H](C)C(=O)N2[C@@H](CC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 MHOOGDWOMUIDAP-XZZVZQAVSA-N 0.000 claims 1
- KKYXDVZTKJHXNM-PUUVEUEGSA-N (3s)-3-[[4-[(2s)-1-[(2s)-2-(cyclopentylcarbamoyl)azetidin-1-yl]-1-oxopropan-2-yl]oxy-7-methylquinoline-2-carbonyl]amino]-4-(4-ethoxycarbonylpiperazin-1-yl)-4-oxobutanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CC(O)=O)NC(=O)C1=CC(O[C@@H](C)C(=O)N2[C@@H](CC2)C(=O)NC2CCCC2)=C(C=CC(C)=C2)C2=N1 KKYXDVZTKJHXNM-PUUVEUEGSA-N 0.000 claims 1
- DJGXTUBSHKULRS-FAQZDJIUSA-N (3s)-3-[[4-[(2s)-1-[(2s)-2-(cyclopentylcarbamoyl)pyrrolidin-1-yl]-1-oxopropan-2-yl]oxy-7-methylquinoline-2-carbonyl]amino]-4-(4-ethoxycarbonylpiperazin-1-yl)-4-oxobutanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CC(O)=O)NC(=O)C1=CC(O[C@@H](C)C(=O)N2[C@@H](CCC2)C(=O)NC2CCCC2)=C(C=CC(C)=C2)C2=N1 DJGXTUBSHKULRS-FAQZDJIUSA-N 0.000 claims 1
- PVLFYFSBPHSGCQ-XZZVZQAVSA-N (3s)-3-[[4-[(2s)-1-[(2s)-2-(cyclopropylcarbamoyl)pyrrolidin-1-yl]-1-oxopropan-2-yl]oxy-7-methylquinoline-2-carbonyl]amino]-4-(4-ethoxycarbonylpiperazin-1-yl)-4-oxobutanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CC(O)=O)NC(=O)C1=CC(O[C@@H](C)C(=O)N2[C@@H](CCC2)C(=O)NC2CC2)=C(C=CC(C)=C2)C2=N1 PVLFYFSBPHSGCQ-XZZVZQAVSA-N 0.000 claims 1
- MBMRIVQZJQXSBS-DQEYMECFSA-N (3s)-3-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-5-fluoro-7-methylquinoline-2-carbonyl]amino]-4-(4-ethoxycarbonylpiperazin-1-yl)-4-oxobutanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C(F)=CC(C)=C2)C2=N1 MBMRIVQZJQXSBS-DQEYMECFSA-N 0.000 claims 1
- CONMIKDWMNRSOZ-ZEQRLZLVSA-N (3s)-3-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-5-fluoroquinoline-2-carbonyl]amino]-4-(4-ethoxycarbonylpiperazin-1-yl)-4-oxobutanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C(F)=CC=C2)C2=N1 CONMIKDWMNRSOZ-ZEQRLZLVSA-N 0.000 claims 1
- LDQOSHBJPCIPLH-UIOOFZCWSA-N (3s)-3-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-6-fluoro-7-methylquinoline-2-carbonyl]amino]-4-(4-ethoxycarbonylpiperazin-1-yl)-4-oxobutanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=C(F)C(C)=C2)C2=N1 LDQOSHBJPCIPLH-UIOOFZCWSA-N 0.000 claims 1
- JDLKULIEYANDDL-DQEYMECFSA-N (3s)-3-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-fluoroquinoline-2-carbonyl]amino]-4-(4-ethoxycarbonylpiperazin-1-yl)-4-oxobutanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(F)=C2)C2=N1 JDLKULIEYANDDL-DQEYMECFSA-N 0.000 claims 1
- WXXQPKYGFQMMDX-UIOOFZCWSA-N (3s)-3-[[4-[2-[(2s)-2-(cyclopentylcarbamoyl)azetidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-4-(4-ethoxycarbonylpiperazin-1-yl)-4-oxobutanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CC2)C(=O)NC2CCCC2)=C(C=CC(C)=C2)C2=N1 WXXQPKYGFQMMDX-UIOOFZCWSA-N 0.000 claims 1
- PVXRVLIQWNTJJN-DQEYMECFSA-N (3s)-3-[[4-[2-[(2s)-2-(cyclopentylcarbamoyl)azetidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-4-(4-ethoxycarbonylpiperazin-1-yl)-4-oxobutanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CC2)C(=O)NC2CCCC2)=C(C=CC=C2)C2=N1 PVXRVLIQWNTJJN-DQEYMECFSA-N 0.000 claims 1
- IBDOHNFYTPIZBQ-SVBPBHIXSA-N (3s)-3-[[4-[2-[(2s)-2-(cyclopentylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-4-(4-ethoxycarbonylpiperazin-1-yl)-4-oxobutanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCCC2)=C(C=CC(C)=C2)C2=N1 IBDOHNFYTPIZBQ-SVBPBHIXSA-N 0.000 claims 1
- JVFUGHOEIPXCIB-UIOOFZCWSA-N (3s)-3-[[4-[2-[(2s)-2-(cyclopentylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-4-(4-ethoxycarbonylpiperazin-1-yl)-4-oxobutanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCCC2)=C(C=CC=C2)C2=N1 JVFUGHOEIPXCIB-UIOOFZCWSA-N 0.000 claims 1
- HGKQEUBEIMDNFZ-ZEQRLZLVSA-N (3s)-3-[[4-[2-[(2s)-2-(cyclopropylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-fluoroquinoline-2-carbonyl]amino]-4-(4-ethoxycarbonylpiperazin-1-yl)-4-oxobutanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CC2)=C(C=CC(F)=C2)C2=N1 HGKQEUBEIMDNFZ-ZEQRLZLVSA-N 0.000 claims 1
- VGUGHCXOHVQLLJ-DQEYMECFSA-N (3s)-3-[[4-[2-[(2s)-2-(cyclopropylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-4-(4-ethoxycarbonylpiperazin-1-yl)-4-oxobutanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CC2)=C(C=CC(C)=C2)C2=N1 VGUGHCXOHVQLLJ-DQEYMECFSA-N 0.000 claims 1
- QCLRNIOGFBSUHK-UIOOFZCWSA-N (3s)-3-[[4-[2-[(2s)-2-(cyclopropylmethylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-4-(4-ethoxycarbonylpiperazin-1-yl)-4-oxobutanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NCC2CC2)=C(C=CC(C)=C2)C2=N1 QCLRNIOGFBSUHK-UIOOFZCWSA-N 0.000 claims 1
- ZAIBESDLIXFDDE-NMMYMHLASA-N (3s)-4-(4-ethoxycarbonylpiperazin-1-yl)-3-[[4-[(2r)-1-[(3s)-3-(hydroxymethyl)pyrrolidin-1-yl]-1-oxopropan-2-yl]oxy-7-methylquinoline-2-carbonyl]amino]-4-oxobutanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CC(O)=O)NC(=O)C1=CC(O[C@H](C)C(=O)N2C[C@@H](CO)CC2)=C(C=CC(C)=C2)C2=N1 ZAIBESDLIXFDDE-NMMYMHLASA-N 0.000 claims 1
- GHGYQLLPFTXBIX-CYFREDJKSA-N (3s)-4-(4-ethoxycarbonylpiperazin-1-yl)-3-[[4-[(2s)-1-(4-hydroxypiperidin-1-yl)-1-oxopropan-2-yl]oxy-7-methylquinoline-2-carbonyl]amino]-4-oxobutanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CC(O)=O)NC(=O)C1=CC(O[C@@H](C)C(=O)N2CCC(O)CC2)=C(C=CC(C)=C2)C2=N1 GHGYQLLPFTXBIX-CYFREDJKSA-N 0.000 claims 1
- YQNXBKJARRLXRO-OPXMRZJTSA-N (3s)-4-(4-ethoxycarbonylpiperazin-1-yl)-3-[[4-[(2s)-1-[(2s)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopropan-2-yl]oxy-7-methylquinoline-2-carbonyl]amino]-4-oxobutanoic acid Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](C)OC1=CC(C(=O)N[C@@H](CC(O)=O)C(=O)N2CCN(CC2)C(=O)OCC)=NC2=CC(C)=CC=C12 YQNXBKJARRLXRO-OPXMRZJTSA-N 0.000 claims 1
- LSBAXBGBGHECQW-SKPFHBQLSA-N (3s)-4-(4-ethoxycarbonylpiperazin-1-yl)-3-[[4-[(2s)-1-[(2s)-2-(hydroxymethyl)pyrrolidin-1-yl]-1-oxopropan-2-yl]oxy-7-methylquinoline-2-carbonyl]amino]-4-oxobutanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CC(O)=O)NC(=O)C1=CC(O[C@@H](C)C(=O)N2[C@@H](CCC2)CO)=C(C=CC(C)=C2)C2=N1 LSBAXBGBGHECQW-SKPFHBQLSA-N 0.000 claims 1
- ZAIBESDLIXFDDE-SKPFHBQLSA-N (3s)-4-(4-ethoxycarbonylpiperazin-1-yl)-3-[[4-[(2s)-1-[(3s)-3-(hydroxymethyl)pyrrolidin-1-yl]-1-oxopropan-2-yl]oxy-7-methylquinoline-2-carbonyl]amino]-4-oxobutanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CC(O)=O)NC(=O)C1=CC(O[C@@H](C)C(=O)N2C[C@@H](CO)CC2)=C(C=CC(C)=C2)C2=N1 ZAIBESDLIXFDDE-SKPFHBQLSA-N 0.000 claims 1
- QPVHVXVDMNHLOF-GOTSBHOMSA-N (3s)-4-(4-ethoxycarbonylpiperazin-1-yl)-3-[[4-[2-[(2s)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-fluoroquinoline-2-carbonyl]amino]-4-oxobutanoic acid Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)COC1=CC(C(=O)N[C@@H](CC(O)=O)C(=O)N2CCN(CC2)C(=O)OCC)=NC2=CC(F)=CC=C12 QPVHVXVDMNHLOF-GOTSBHOMSA-N 0.000 claims 1
- ITRHJLAHEGKSJO-ZEQRLZLVSA-N (3s)-4-(4-ethoxycarbonylpiperazin-1-yl)-3-[[4-[2-[(2s)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-4-oxobutanoic acid Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)COC1=CC(C(=O)N[C@@H](CC(O)=O)C(=O)N2CCN(CC2)C(=O)OCC)=NC2=CC(C)=CC=C12 ITRHJLAHEGKSJO-ZEQRLZLVSA-N 0.000 claims 1
- KQQCBNRWHQMXPG-DQEYMECFSA-N (3s)-4-(4-ethoxycarbonylpiperazin-1-yl)-3-[[4-[2-[(2s)-2-[ethyl(methyl)carbamoyl]pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-4-oxobutanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)N(C)CC)=C(C=CC(C)=C2)C2=N1 KQQCBNRWHQMXPG-DQEYMECFSA-N 0.000 claims 1
- JDCXDLNMUBKLRA-GOTSBHOMSA-N (3s)-4-(4-ethoxycarbonylpiperazin-1-yl)-3-[[5-fluoro-4-[2-oxo-2-[(2s)-2-(propylcarbamoyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]-4-oxobutanoic acid Chemical compound CCCNC(=O)[C@@H]1CCCN1C(=O)COC1=CC(C(=O)N[C@@H](CC(O)=O)C(=O)N2CCN(CC2)C(=O)OCC)=NC2=CC=CC(F)=C12 JDCXDLNMUBKLRA-GOTSBHOMSA-N 0.000 claims 1
- WDUSYCXNXUWDSR-ZEQRLZLVSA-N (3s)-4-(4-ethoxycarbonylpiperazin-1-yl)-3-[[5-fluoro-4-[2-oxo-2-[(2s)-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]-4-oxobutanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)N2CCCC2)=C(C(F)=CC=C2)C2=N1 WDUSYCXNXUWDSR-ZEQRLZLVSA-N 0.000 claims 1
- HANVWTPVCLMAGI-ZEQRLZLVSA-N (3s)-4-(4-ethoxycarbonylpiperazin-1-yl)-3-[[5-fluoro-7-methyl-4-[2-oxo-2-[(2s)-2-(propylcarbamoyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]-4-oxobutanoic acid Chemical compound CCCNC(=O)[C@@H]1CCCN1C(=O)COC1=CC(C(=O)N[C@@H](CC(O)=O)C(=O)N2CCN(CC2)C(=O)OCC)=NC2=CC(C)=CC(F)=C12 HANVWTPVCLMAGI-ZEQRLZLVSA-N 0.000 claims 1
- MDQCLDSNDWJZRF-UIOOFZCWSA-N (3s)-4-(4-ethoxycarbonylpiperazin-1-yl)-3-[[6-fluoro-7-methyl-4-[2-oxo-2-[(2s)-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]-4-oxobutanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)N2CCCC2)=C(C=C(F)C(C)=C2)C2=N1 MDQCLDSNDWJZRF-UIOOFZCWSA-N 0.000 claims 1
- RDOHELGODHKOPY-ZEQRLZLVSA-N (3s)-4-(4-ethoxycarbonylpiperazin-1-yl)-3-[[7-fluoro-4-[2-oxo-2-[(2s)-2-(propylcarbamoyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]-4-oxobutanoic acid Chemical compound CCCNC(=O)[C@@H]1CCCN1C(=O)COC1=CC(C(=O)N[C@@H](CC(O)=O)C(=O)N2CCN(CC2)C(=O)OCC)=NC2=CC(F)=CC=C12 RDOHELGODHKOPY-ZEQRLZLVSA-N 0.000 claims 1
- LPLRYSVESVUPCR-NYMACZPPSA-N (3s)-4-(4-ethoxycarbonylpiperazin-1-yl)-3-[[7-methyl-4-[(2r)-1-oxo-1-[(2s)-2-(propylcarbamoyl)pyrrolidin-1-yl]propan-2-yl]oxyquinoline-2-carbonyl]amino]-4-oxobutanoic acid Chemical compound CCCNC(=O)[C@@H]1CCCN1C(=O)[C@@H](C)OC1=CC(C(=O)N[C@@H](CC(O)=O)C(=O)N2CCN(CC2)C(=O)OCC)=NC2=CC(C)=CC=C12 LPLRYSVESVUPCR-NYMACZPPSA-N 0.000 claims 1
- MRZSTHIEVRAQQN-ICTDUYRTSA-N (3s)-4-(4-ethoxycarbonylpiperazin-1-yl)-3-[[7-methyl-4-[(2r)-1-oxo-1-[(2s)-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]propan-2-yl]oxyquinoline-2-carbonyl]amino]-4-oxobutanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CC(O)=O)NC(=O)C1=CC(O[C@H](C)C(=O)N2[C@@H](CCC2)C(=O)N2CCCC2)=C(C=CC(C)=C2)C2=N1 MRZSTHIEVRAQQN-ICTDUYRTSA-N 0.000 claims 1
- HTGVCMSGEGDECC-MZBJOSPHSA-N (3s)-4-(4-ethoxycarbonylpiperazin-1-yl)-3-[[7-methyl-4-[(2s)-1-oxo-1-[(2s)-2-(propan-2-ylcarbamoyl)pyrrolidin-1-yl]propan-2-yl]oxyquinoline-2-carbonyl]amino]-4-oxobutanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CC(O)=O)NC(=O)C1=CC(O[C@@H](C)C(=O)N2[C@@H](CCC2)C(=O)NC(C)C)=C(C=CC(C)=C2)C2=N1 HTGVCMSGEGDECC-MZBJOSPHSA-N 0.000 claims 1
- SCALBYAKDRMOSQ-DQEYMECFSA-N (3s)-4-(4-ethoxycarbonylpiperazin-1-yl)-3-[[7-methyl-4-[2-oxo-2-[(2s)-2-(propan-2-ylcarbamoyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]-4-oxobutanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC(C)C)=C(C=CC(C)=C2)C2=N1 SCALBYAKDRMOSQ-DQEYMECFSA-N 0.000 claims 1
- ZKIBKFRABVECBP-DQEYMECFSA-N (3s)-4-(4-ethoxycarbonylpiperazin-1-yl)-3-[[7-methyl-4-[2-oxo-2-[(2s)-2-(propylcarbamoyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]-4-oxobutanoic acid Chemical compound CCCNC(=O)[C@@H]1CCCN1C(=O)COC1=CC(C(=O)N[C@@H](CC(O)=O)C(=O)N2CCN(CC2)C(=O)OCC)=NC2=CC(C)=CC=C12 ZKIBKFRABVECBP-DQEYMECFSA-N 0.000 claims 1
- CFBOGJQFEIVRIA-UIOOFZCWSA-N (3s)-4-(4-ethoxycarbonylpiperazin-1-yl)-3-[[7-methyl-4-[2-oxo-2-[(2s)-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]-4-oxobutanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)N2CCCC2)=C(C=CC(C)=C2)C2=N1 CFBOGJQFEIVRIA-UIOOFZCWSA-N 0.000 claims 1
- KHUVINUHOWDBSH-ATILKMQGSA-N (4s)-4-[[4-[(2r)-1-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-1-oxopropan-2-yl]oxy-7-methylquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(O[C@H](C)C(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 KHUVINUHOWDBSH-ATILKMQGSA-N 0.000 claims 1
- KKFQUZOXRSUJGQ-ATILKMQGSA-N (4s)-4-[[4-[(2r)-1-[(2s)-2-(cyclopropylmethylcarbamoyl)pyrrolidin-1-yl]-1-oxopropan-2-yl]oxy-7-methylquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(O[C@H](C)C(=O)N2[C@@H](CCC2)C(=O)NCC2CC2)=C(C=CC(C)=C2)C2=N1 KKFQUZOXRSUJGQ-ATILKMQGSA-N 0.000 claims 1
- KBSTZLXKJJRGNY-IGKIAQTJSA-N (4s)-4-[[4-[1-[(2s)-2-(cyclopropylcarbamoyl)pyrrolidin-1-yl]-2-methyl-1-oxopropan-2-yl]oxy-7-methylquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OC(C)(C)C(=O)N2[C@@H](CCC2)C(=O)NC2CC2)=C(C=CC(C)=C2)C2=N1 KBSTZLXKJJRGNY-IGKIAQTJSA-N 0.000 claims 1
- BAXMDRUAWNAPDT-NRFANRHFSA-N (4s)-4-[[4-[2-(2,2-dimethyl-3-oxopiperazin-1-yl)-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(C(=O)NCC2)(C)C)=C(C=CC(C)=C2)C2=N1 BAXMDRUAWNAPDT-NRFANRHFSA-N 0.000 claims 1
- FVXKZFXIDDQSFB-NRFANRHFSA-N (4s)-4-[[4-[2-(2,2-dimethyl-3-oxopiperazin-1-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(C(=O)NCC2)(C)C)=C(C=CC=C2)C2=N1 FVXKZFXIDDQSFB-NRFANRHFSA-N 0.000 claims 1
- NDVJFTDCXQWYOD-GJFCNDCISA-N (4s)-4-[[4-[2-(2,3,3a,4,6,6a-hexahydro-1h-pyrrolo[2,3-c]pyrrol-5-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC3NCCC3C2)=C(C=CC=C2)C2=N1 NDVJFTDCXQWYOD-GJFCNDCISA-N 0.000 claims 1
- MOKKLVHNPPWEEI-DEOSSOPVSA-N (4s)-4-[[4-[2-(2,3-dihydroindol-1-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C3=CC=CC=C3CC2)=C(C=CC=C2)C2=N1 MOKKLVHNPPWEEI-DEOSSOPVSA-N 0.000 claims 1
- XDIQAUUEADQJGW-NRFANRHFSA-N (4s)-4-[[4-[2-(2,4-dioxo-1,3,8-triazaspiro[4.5]decan-8-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CCC3(CC2)C(NC(=O)N3)=O)=C(C=CC=C2)C2=N1 XDIQAUUEADQJGW-NRFANRHFSA-N 0.000 claims 1
- BNXIBKGSEQJMMW-QSAPEBAKSA-N (4s)-4-[[4-[2-(2-butyl-4-methyl-3-oxopiperazin-1-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C)C(=O)C(CCCC)N1C(=O)COC1=CC(C(=O)N[C@@H](CCC(O)=O)C(=O)N2CCN(CC2)C(=O)OCC)=NC2=CC=CC=C12 BNXIBKGSEQJMMW-QSAPEBAKSA-N 0.000 claims 1
- KACWHEDAPZYBCN-TUXUZCGSSA-N (4s)-4-[[4-[2-(2-butylpyrrolidin-1-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound CCCCC1CCCN1C(=O)COC1=CC(C(=O)N[C@@H](CCC(O)=O)C(=O)N2CCN(CC2)C(=O)OCC)=NC2=CC=CC=C12 KACWHEDAPZYBCN-TUXUZCGSSA-N 0.000 claims 1
- HEIUKAACMDPOKC-PVCWFJFTSA-N (4s)-4-[[4-[2-(2-cyclopentylpyrrolidin-1-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)C2CCCC2)=C(C=CC=C2)C2=N1 HEIUKAACMDPOKC-PVCWFJFTSA-N 0.000 claims 1
- BZDDDNUQALMCHO-ZZHFZYNASA-N (4s)-4-[[4-[2-(2-tert-butylpyrrolidin-1-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)C(C)(C)C)=C(C=CC=C2)C2=N1 BZDDDNUQALMCHO-ZZHFZYNASA-N 0.000 claims 1
- HUKZEZJZIQILFF-FQEVSTJZSA-N (4s)-4-[[4-[2-(3,3-difluoropyrrolidin-1-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC(F)(F)CC2)=C(C=CC=C2)C2=N1 HUKZEZJZIQILFF-FQEVSTJZSA-N 0.000 claims 1
- IDAKBQHMRQBVDL-AKRCKQFNSA-N (4s)-4-[[4-[2-(3-acetamidopyrrolidin-1-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC(CC2)NC(C)=O)=C(C=CC=C2)C2=N1 IDAKBQHMRQBVDL-AKRCKQFNSA-N 0.000 claims 1
- MCHVZVPYMUJHFX-WKDCXCOVSA-N (4s)-4-[[4-[2-(3-anilinopyrrolidin-1-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC(CC2)NC=2C=CC=CC=2)=C(C=CC=C2)C2=N1 MCHVZVPYMUJHFX-WKDCXCOVSA-N 0.000 claims 1
- NDKWKNXODIKNRU-NRFANRHFSA-N (4s)-4-[[4-[2-(4,4-difluoropiperidin-1-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CCC(F)(F)CC2)=C(C=CC=C2)C2=N1 NDKWKNXODIKNRU-NRFANRHFSA-N 0.000 claims 1
- YTFWXAQFOGUHGB-NRFANRHFSA-N (4s)-4-[[4-[2-(4,4-dimethyl-1,3-oxazolidin-3-yl)-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(COC2)(C)C)=C(C=CC(C)=C2)C2=N1 YTFWXAQFOGUHGB-NRFANRHFSA-N 0.000 claims 1
- HVAOWDFEUJNSME-NRFANRHFSA-N (4s)-4-[[4-[2-(4,6-dihydro-1h-pyrrolo[3,4-c]pyrazol-5-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC=3NN=CC=3C2)=C(C=CC=C2)C2=N1 HVAOWDFEUJNSME-NRFANRHFSA-N 0.000 claims 1
- HAKPNJCYOHCZAS-SANMLTNESA-N (4s)-4-[[4-[2-(4-cyclohexyl-3-oxopiperazin-1-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC(=O)N(C3CCCCC3)CC2)=C(C=CC=C2)C2=N1 HAKPNJCYOHCZAS-SANMLTNESA-N 0.000 claims 1
- XUWBKXKTYHNLBB-SANMLTNESA-N (4s)-4-[[4-[2-(5-acetyl-2,3-dihydroindol-1-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C3=CC=C(C=C3CC2)C(C)=O)=C(C=CC=C2)C2=N1 XUWBKXKTYHNLBB-SANMLTNESA-N 0.000 claims 1
- FRWIVCYVPUGUBH-IPJJNNNSSA-N (4s)-4-[[4-[2-[(1s,4s)-2,5-diazabicyclo[2.2.1]heptan-2-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound O=C([C@H](CCC(O)=O)NC(=O)C=1C=C(C2=CC=CC=C2N=1)OCC(=O)N1C[C@]2(NC[C@]1([H])C2)[H])N1CCN(C(=O)OCC)CC1 FRWIVCYVPUGUBH-IPJJNNNSSA-N 0.000 claims 1
- HWUJVZXBYDTGFZ-WIOPSUGQSA-N (4s)-4-[[4-[2-[(2r)-2-(cyclopropylcarbamoyl)azetidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@H](CC2)C(=O)NC2CC2)=C(C=CC(C)=C2)C2=N1 HWUJVZXBYDTGFZ-WIOPSUGQSA-N 0.000 claims 1
- HSPPOVBKKSVMRY-RPLLCQBOSA-N (4s)-4-[[4-[2-[(2r)-2-(cyclopropylcarbamoyl)piperidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@H](CCCC2)C(=O)NC2CC2)=C(C=CC(C)=C2)C2=N1 HSPPOVBKKSVMRY-RPLLCQBOSA-N 0.000 claims 1
- QWJCYPMQQXRNIQ-AZGAKELHSA-N (4s)-4-[[4-[2-[(2r)-2-(cyclopropylcarbamoyl)piperidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@H](CCCC2)C(=O)NC2CC2)=C(C=CC=C2)C2=N1 QWJCYPMQQXRNIQ-AZGAKELHSA-N 0.000 claims 1
- USDUEZYEKAFIJK-JYFHCDHNSA-N (4s)-4-[[4-[2-[(2r)-2-(cyclopropylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@H](CCC2)C(=O)NC2CC2)=C(C=CC(C)=C2)C2=N1 USDUEZYEKAFIJK-JYFHCDHNSA-N 0.000 claims 1
- KXFAKGGQHMVWRN-NZQKXSOJSA-N (4s)-4-[[4-[2-[(2r)-2-carbamoylpyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@H](CCC2)C(N)=O)=C(C=CC(C)=C2)C2=N1 KXFAKGGQHMVWRN-NZQKXSOJSA-N 0.000 claims 1
- BUHZSFLIKHNJNH-RBBKRZOGSA-N (4s)-4-[[4-[2-[(2r)-2-carbamoylpyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@H](CCC2)C(N)=O)=C(C=CC=C2)C2=N1 BUHZSFLIKHNJNH-RBBKRZOGSA-N 0.000 claims 1
- PCZSPQLYXNTLJU-KNQAVFIVSA-N (4s)-4-[[4-[2-[(2r)-2-cyanopyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@H](CCC2)C#N)=C(C=CC=C2)C2=N1 PCZSPQLYXNTLJU-KNQAVFIVSA-N 0.000 claims 1
- NBRXXQVSHQQOJB-URXFXBBRSA-N (4s)-4-[[4-[2-[(2s)-2-(2,2-difluoroethylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NCC(F)F)=C(C=CC(C)=C2)C2=N1 NBRXXQVSHQQOJB-URXFXBBRSA-N 0.000 claims 1
- QFCZYPMPHQDNDL-GMAHTHKFSA-N (4s)-4-[[4-[2-[(2s)-2-(2,2-difluoroethylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NCC(F)F)=C(C=CC=C2)C2=N1 QFCZYPMPHQDNDL-GMAHTHKFSA-N 0.000 claims 1
- VTBRWDFFPRRHSQ-IGKIAQTJSA-N (4s)-4-[[4-[2-[(2s)-2-(4,4-difluoropiperidine-1-carbonyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)N2CCC(F)(F)CC2)=C(C=CC(C)=C2)C2=N1 VTBRWDFFPRRHSQ-IGKIAQTJSA-N 0.000 claims 1
- SATUVIMIPHJLJF-OZXSUGGESA-N (4s)-4-[[4-[2-[(2s)-2-(azetidine-1-carbonyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)N2CCC2)=C(C=CC(C)=C2)C2=N1 SATUVIMIPHJLJF-OZXSUGGESA-N 0.000 claims 1
- ISGBGWFYLKOGAR-UPVQGACJSA-N (4s)-4-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)azetidin-1-yl]-2-oxoethoxy]-5-fluoroquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CC2)C(=O)NC2CCC2)=C(C(F)=CC=C2)C2=N1 ISGBGWFYLKOGAR-UPVQGACJSA-N 0.000 claims 1
- UNVRSJGQTKYIEE-ZCYQVOJMSA-N (4s)-4-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)azetidin-1-yl]-2-oxoethoxy]-6-fluoroquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CC2)C(=O)NC2CCC2)=C(C=C(F)C=C2)C2=N1 UNVRSJGQTKYIEE-ZCYQVOJMSA-N 0.000 claims 1
- VNLSLYOMXJDNEB-DHLKQENFSA-N (4s)-4-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)azetidin-1-yl]-2-oxoethoxy]-7-fluoroquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CC2)C(=O)NC2CCC2)=C(C=CC(F)=C2)C2=N1 VNLSLYOMXJDNEB-DHLKQENFSA-N 0.000 claims 1
- PHQIJAPXDTWPPC-UPVQGACJSA-N (4s)-4-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)azetidin-1-yl]-2-oxoethoxy]-8-fluoroquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CC2)C(=O)NC2CCC2)=C(C=CC=C2F)C2=N1 PHQIJAPXDTWPPC-UPVQGACJSA-N 0.000 claims 1
- LRRIYCMIYCBBHV-OZXSUGGESA-N (4s)-4-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-5-fluoro-7-methylquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C(F)=CC(C)=C2)C2=N1 LRRIYCMIYCBBHV-OZXSUGGESA-N 0.000 claims 1
- NVBCSDHRQNNESS-ZCYQVOJMSA-N (4s)-4-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-5-fluoroquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C(F)=CC=C2)C2=N1 NVBCSDHRQNNESS-ZCYQVOJMSA-N 0.000 claims 1
- NGKQQHMHKYZOHJ-OZXSUGGESA-N (4s)-4-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-6,7-difluoroquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=C(F)C(F)=C2)C2=N1 NGKQQHMHKYZOHJ-OZXSUGGESA-N 0.000 claims 1
- GOLKNVMEHQAXJU-XCZPVHLTSA-N (4s)-4-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-6-ethoxyquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=C(OCC)C=C2)C2=N1 GOLKNVMEHQAXJU-XCZPVHLTSA-N 0.000 claims 1
- JIVIAIGXNWRNJD-AHWVRZQESA-N (4s)-4-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-6-fluoro-5-methylquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C(C)=C(F)C=C2)C2=N1 JIVIAIGXNWRNJD-AHWVRZQESA-N 0.000 claims 1
- FCDCKILAJDGKKD-IGKIAQTJSA-N (4s)-4-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-6-fluoro-7-methylquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=C(F)C(C)=C2)C2=N1 FCDCKILAJDGKKD-IGKIAQTJSA-N 0.000 claims 1
- GVNXSXHGRBCGSM-AHWVRZQESA-N (4s)-4-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-6-fluoroquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=C(F)C=C2)C2=N1 GVNXSXHGRBCGSM-AHWVRZQESA-N 0.000 claims 1
- MAYFQFMXCLCWHO-LSYYVWMOSA-N (4s)-4-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-ethylquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(CC)=C2)C2=N1 MAYFQFMXCLCWHO-LSYYVWMOSA-N 0.000 claims 1
- KVMUNAHYOZIYAO-OZXSUGGESA-N (4s)-4-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-fluoroquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(F)=C2)C2=N1 KVMUNAHYOZIYAO-OZXSUGGESA-N 0.000 claims 1
- DJHDSZCQRXUVML-IGKIAQTJSA-N (4s)-4-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methoxyquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(OC)=C2)C2=N1 DJHDSZCQRXUVML-IGKIAQTJSA-N 0.000 claims 1
- BIXVRCWHIQVYNI-WNJJXGMVSA-N (4s)-4-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(4-cyclobutyloxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound O=C([C@@H]1CCCN1C(=O)COC=1C2=CC=C(C=C2N=C(C=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N1CCN(CC1)C(=O)OC1CCC1)C)NC1CCC1 BIXVRCWHIQVYNI-WNJJXGMVSA-N 0.000 claims 1
- VWWBQDOWWQODMP-IGKIAQTJSA-N (4s)-4-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 VWWBQDOWWQODMP-IGKIAQTJSA-N 0.000 claims 1
- ANPHXDMJDQLIGJ-LSYYVWMOSA-N (4s)-4-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxo-5-(4-propoxycarbonylpiperazin-1-yl)pentanoic acid Chemical compound C1CN(C(=O)OCCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 ANPHXDMJDQLIGJ-LSYYVWMOSA-N 0.000 claims 1
- TUOKTRFZGQCHJM-ZCYQVOJMSA-N (4s)-4-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-8-fluoroquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC=C2F)C2=N1 TUOKTRFZGQCHJM-ZCYQVOJMSA-N 0.000 claims 1
- IBSNDHKVSUKNRI-AHWVRZQESA-N (4s)-4-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC=C2)C2=N1 IBSNDHKVSUKNRI-AHWVRZQESA-N 0.000 claims 1
- DCLWZGZSRSIMAV-SMCANUKXSA-N (4s)-4-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-[4-(3-methoxyphenyl)piperazin-1-yl]-5-oxopentanoic acid Chemical compound COC1=CC=CC(N2CCN(CC2)C(=O)[C@H](CCC(O)=O)NC(=O)C=2N=C3C=CC=CC3=C(OCC(=O)N3[C@@H](CCC3)C(=O)NC3CCC3)C=2)=C1 DCLWZGZSRSIMAV-SMCANUKXSA-N 0.000 claims 1
- QAIQKIWTNKOHRG-LSYYVWMOSA-N (4s)-4-[[4-[2-[(2s)-2-(cyclobutylmethylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NCC2CCC2)=C(C=CC(C)=C2)C2=N1 QAIQKIWTNKOHRG-LSYYVWMOSA-N 0.000 claims 1
- CVCSOIGWNGVPDG-IGKIAQTJSA-N (4s)-4-[[4-[2-[(2s)-2-(cyclopentylcarbamoyl)azetidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CC2)C(=O)NC2CCCC2)=C(C=CC(C)=C2)C2=N1 CVCSOIGWNGVPDG-IGKIAQTJSA-N 0.000 claims 1
- DJKFOXMNBDSOFN-LSYYVWMOSA-N (4s)-4-[[4-[2-[(2s)-2-(cyclopentylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCCC2)=C(C=CC(C)=C2)C2=N1 DJKFOXMNBDSOFN-LSYYVWMOSA-N 0.000 claims 1
- HSPPOVBKKSVMRY-IGKIAQTJSA-N (4s)-4-[[4-[2-[(2s)-2-(cyclopropylcarbamoyl)piperidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCCC2)C(=O)NC2CC2)=C(C=CC(C)=C2)C2=N1 HSPPOVBKKSVMRY-IGKIAQTJSA-N 0.000 claims 1
- QWJCYPMQQXRNIQ-AHWVRZQESA-N (4s)-4-[[4-[2-[(2s)-2-(cyclopropylcarbamoyl)piperidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCCC2)C(=O)NC2CC2)=C(C=CC=C2)C2=N1 QWJCYPMQQXRNIQ-AHWVRZQESA-N 0.000 claims 1
- USSXPCRZWHPACP-OZXSUGGESA-N (4s)-4-[[4-[2-[(2s)-2-(cyclopropylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-5,7-dimethylquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CC2)=C(C(C)=CC(C)=C2)C2=N1 USSXPCRZWHPACP-OZXSUGGESA-N 0.000 claims 1
- XJLZOFFMDVCWHS-UPVQGACJSA-N (4s)-4-[[4-[2-[(2s)-2-(cyclopropylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-5-fluoroquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CC2)=C(C(F)=CC=C2)C2=N1 XJLZOFFMDVCWHS-UPVQGACJSA-N 0.000 claims 1
- CFWNWQFMDZEICH-ZCYQVOJMSA-N (4s)-4-[[4-[2-[(2s)-2-(cyclopropylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-5-methylquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CC2)=C(C(C)=CC=C2)C2=N1 CFWNWQFMDZEICH-ZCYQVOJMSA-N 0.000 claims 1
- SLGIRMNDRINGOT-BDYUSTAISA-N (4s)-4-[[4-[2-[(2s)-2-(cyclopropylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-6-ethoxyquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CC2)=C(C=C(OCC)C=C2)C2=N1 SLGIRMNDRINGOT-BDYUSTAISA-N 0.000 claims 1
- WZZQPAPNOIESMX-OZXSUGGESA-N (4s)-4-[[4-[2-[(2s)-2-(cyclopropylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-6-fluoro-7-methylquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CC2)=C(C=C(F)C(C)=C2)C2=N1 WZZQPAPNOIESMX-OZXSUGGESA-N 0.000 claims 1
- PEVUZHQQADHQEF-ZCYQVOJMSA-N (4s)-4-[[4-[2-[(2s)-2-(cyclopropylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-6-fluoroquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CC2)=C(C=C(F)C=C2)C2=N1 PEVUZHQQADHQEF-ZCYQVOJMSA-N 0.000 claims 1
- UULPBIVEANDVLT-AHWVRZQESA-N (4s)-4-[[4-[2-[(2s)-2-(cyclopropylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-6-methylquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CC2)=C(C=C(C)C=C2)C2=N1 UULPBIVEANDVLT-AHWVRZQESA-N 0.000 claims 1
- TYWZBLKYQCILNX-XCZPVHLTSA-N (4s)-4-[[4-[2-[(2s)-2-(cyclopropylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7,8,9,10-tetrahydrobenzo[h]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CC2)=C(C=CC2=C3CCCC2)C3=N1 TYWZBLKYQCILNX-XCZPVHLTSA-N 0.000 claims 1
- MWJQWKLCGYJJGV-IGKIAQTJSA-N (4s)-4-[[4-[2-[(2s)-2-(cyclopropylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-ethylquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CC2)=C(C=CC(CC)=C2)C2=N1 MWJQWKLCGYJJGV-IGKIAQTJSA-N 0.000 claims 1
- NZHUXEXPBHMUMU-DHLKQENFSA-N (4s)-4-[[4-[2-[(2s)-2-(cyclopropylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-fluoroquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CC2)=C(C=CC(F)=C2)C2=N1 NZHUXEXPBHMUMU-DHLKQENFSA-N 0.000 claims 1
- USDUEZYEKAFIJK-OZXSUGGESA-N (4s)-4-[[4-[2-[(2s)-2-(cyclopropylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CC2)=C(C=CC(C)=C2)C2=N1 USDUEZYEKAFIJK-OZXSUGGESA-N 0.000 claims 1
- JXCDZEGIKZWBAS-UPVQGACJSA-N (4s)-4-[[4-[2-[(2s)-2-(cyclopropylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-8-fluoroquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CC2)=C(C=CC=C2F)C2=N1 JXCDZEGIKZWBAS-UPVQGACJSA-N 0.000 claims 1
- AKGFUGJUVBBHIO-UIOOFZCWSA-N (4s)-4-[[4-[2-[(2s)-2-(cyclopropylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]naphthalene-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CC2)=C(C=CC=C2)C2=C1 AKGFUGJUVBBHIO-UIOOFZCWSA-N 0.000 claims 1
- QWTRIGZHEZSJTM-ZCYQVOJMSA-N (4s)-4-[[4-[2-[(2s)-2-(cyclopropylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CC2)=C(C=CC=C2)C2=N1 QWTRIGZHEZSJTM-ZCYQVOJMSA-N 0.000 claims 1
- VSGZZCVPOUFNHT-IGKIAQTJSA-N (4s)-4-[[4-[2-[(2s)-2-(cyclopropylmethylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NCC2CC2)=C(C=CC(C)=C2)C2=N1 VSGZZCVPOUFNHT-IGKIAQTJSA-N 0.000 claims 1
- OTHJQJFZKUCNCX-AHWVRZQESA-N (4s)-4-[[4-[2-[(2s)-2-(cyclopropylmethylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NCC2CC2)=C(C=CC=C2)C2=N1 OTHJQJFZKUCNCX-AHWVRZQESA-N 0.000 claims 1
- NCPQZNDVVAINBK-DHLKQENFSA-N (4s)-4-[[4-[2-[(2s)-2-(dimethylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)N(C)C)=C(C=CC(C)=C2)C2=N1 NCPQZNDVVAINBK-DHLKQENFSA-N 0.000 claims 1
- AASPONPONQMDEK-UPVQGACJSA-N (4s)-4-[[4-[2-[(2s)-2-(dimethylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)N(C)C)=C(C=CC=C2)C2=N1 AASPONPONQMDEK-UPVQGACJSA-N 0.000 claims 1
- KMYBEOHVHRTJAD-LSYYVWMOSA-N (4s)-4-[[4-[2-[(2s)-2-[cyclobutyl(methyl)carbamoyl]pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)N(C)C2CCC2)=C(C=CC(C)=C2)C2=N1 KMYBEOHVHRTJAD-LSYYVWMOSA-N 0.000 claims 1
- KXFAKGGQHMVWRN-REWPJTCUSA-N (4s)-4-[[4-[2-[(2s)-2-carbamoylpyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(N)=O)=C(C=CC(C)=C2)C2=N1 KXFAKGGQHMVWRN-REWPJTCUSA-N 0.000 claims 1
- BUHZSFLIKHNJNH-UNMCSNQZSA-N (4s)-4-[[4-[2-[(2s)-2-carbamoylpyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(N)=O)=C(C=CC=C2)C2=N1 BUHZSFLIKHNJNH-UNMCSNQZSA-N 0.000 claims 1
- PCZSPQLYXNTLJU-UGKGYDQZSA-N (4s)-4-[[4-[2-[(2s)-2-cyanopyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C#N)=C(C=CC=C2)C2=N1 PCZSPQLYXNTLJU-UGKGYDQZSA-N 0.000 claims 1
- UVCDGAJHHOUUDW-KJWPAHLWSA-N (4s)-4-[[4-[2-[(2s,4r)-2-ethoxycarbonyl-4-hydroxypyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound CCOC(=O)[C@@H]1C[C@@H](O)CN1C(=O)COC1=CC(C(=O)N[C@@H](CCC(O)=O)C(=O)N2CCN(CC2)C(=O)OCC)=NC2=CC(C)=CC=C12 UVCDGAJHHOUUDW-KJWPAHLWSA-N 0.000 claims 1
- CRKSPAUKYIMAMA-UCFCWBNQSA-N (4s)-4-[[4-[2-[(2s,4r)-2-ethoxycarbonyl-4-hydroxypyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound CCOC(=O)[C@@H]1C[C@@H](O)CN1C(=O)COC1=CC(C(=O)N[C@@H](CCC(O)=O)C(=O)N2CCN(CC2)C(=O)OCC)=NC2=CC=CC=C12 CRKSPAUKYIMAMA-UCFCWBNQSA-N 0.000 claims 1
- ORGOMJIJRSSPSU-QPPBQGQZSA-N (4s)-4-[[4-[2-[(3r)-3-(cyclopropylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C[C@@H](CC2)C(=O)NC2CC2)=C(C=CC(C)=C2)C2=N1 ORGOMJIJRSSPSU-QPPBQGQZSA-N 0.000 claims 1
- BBGZHTRDYCYIFN-YKSBVNFPSA-N (4s)-4-[[4-[2-[(3r)-3-(cyclopropylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C[C@@H](CC2)C(=O)NC2CC2)=C(C=CC=C2)C2=N1 BBGZHTRDYCYIFN-YKSBVNFPSA-N 0.000 claims 1
- ORGOMJIJRSSPSU-URXFXBBRSA-N (4s)-4-[[4-[2-[(3s)-3-(cyclopropylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C[C@H](CC2)C(=O)NC2CC2)=C(C=CC(C)=C2)C2=N1 ORGOMJIJRSSPSU-URXFXBBRSA-N 0.000 claims 1
- BBGZHTRDYCYIFN-RDPSFJRHSA-N (4s)-4-[[4-[2-[(3s)-3-(cyclopropylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C[C@H](CC2)C(=O)NC2CC2)=C(C=CC=C2)C2=N1 BBGZHTRDYCYIFN-RDPSFJRHSA-N 0.000 claims 1
- BQSVXJWESMKVEL-RXVVDRJESA-N (4s)-4-[[4-[2-[(3s)-3-aminopyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C[C@@H](N)CC2)=C(C=CC=C2)C2=N1 BQSVXJWESMKVEL-RXVVDRJESA-N 0.000 claims 1
- PEDZAFWAPUAMSC-VJBMBRPKSA-N (4s)-4-[[4-[2-[(3s,4s)-3,4-dihydroxypyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C[C@H](O)[C@@H](O)C2)=C(C=CC(C)=C2)C2=N1 PEDZAFWAPUAMSC-VJBMBRPKSA-N 0.000 claims 1
- SNOUTXDTTPNMOV-QODXOHEASA-N (4s)-4-[[4-[2-[2-(1h-benzimidazol-2-yl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2NC3=CC=CC=C3N=2)=C(C=CC=C2)C2=N1 SNOUTXDTTPNMOV-QODXOHEASA-N 0.000 claims 1
- GQTZKKUSWLDCBZ-QODXOHEASA-N (4s)-4-[[4-[2-[2-(2,4-difluorophenyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2C(=CC(F)=CC=2)F)=C(C=CC=C2)C2=N1 GQTZKKUSWLDCBZ-QODXOHEASA-N 0.000 claims 1
- QDDTUCLUZBSWGM-BVOOQYFDSA-N (4s)-4-[[4-[2-[2-(2,4-dimethoxyphenyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2C(=CC(OC)=CC=2)OC)=C(C=CC=C2)C2=N1 QDDTUCLUZBSWGM-BVOOQYFDSA-N 0.000 claims 1
- DELIPBYEGQOVIN-MBCWZBCWSA-N (4s)-4-[[4-[2-[2-(2,4-dimethylphenyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2C(=CC(C)=CC=2)C)=C(C=CC=C2)C2=N1 DELIPBYEGQOVIN-MBCWZBCWSA-N 0.000 claims 1
- RFRZNNMYPZSECH-MBCWZBCWSA-N (4s)-4-[[4-[2-[2-(2,5-dimethylphenyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2C(=CC=C(C)C=2)C)=C(C=CC=C2)C2=N1 RFRZNNMYPZSECH-MBCWZBCWSA-N 0.000 claims 1
- KXGUIQVYOSGVQC-QODXOHEASA-N (4s)-4-[[4-[2-[2-(3,4-difluorophenyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2C=C(F)C(F)=CC=2)=C(C=CC=C2)C2=N1 KXGUIQVYOSGVQC-QODXOHEASA-N 0.000 claims 1
- WFZWBFWKKOOMEK-QODXOHEASA-N (4s)-4-[[4-[2-[2-(3,4-dimethoxyphenyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2C=C(OC)C(OC)=CC=2)=C(C=CC=C2)C2=N1 WFZWBFWKKOOMEK-QODXOHEASA-N 0.000 claims 1
- GMFRNQBAVURUGE-MBCWZBCWSA-N (4s)-4-[[4-[2-[2-(3,4-dimethylphenyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2C=C(C)C(C)=CC=2)=C(C=CC=C2)C2=N1 GMFRNQBAVURUGE-MBCWZBCWSA-N 0.000 claims 1
- KKGQILLZVVFGGV-MBCWZBCWSA-N (4s)-4-[[4-[2-[2-(3,5-dimethylphenyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2C=C(C)C=C(C)C=2)=C(C=CC=C2)C2=N1 KKGQILLZVVFGGV-MBCWZBCWSA-N 0.000 claims 1
- LZFMYRVCOBTGKF-QODXOHEASA-N (4s)-4-[[4-[2-[2-(3-chlorophenyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2C=C(Cl)C=CC=2)=C(C=CC=C2)C2=N1 LZFMYRVCOBTGKF-QODXOHEASA-N 0.000 claims 1
- OGLIHWSOSRCEQN-PVCWFJFTSA-N (4s)-4-[[4-[2-[2-(5-bromopyridin-3-yl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2C=C(Br)C=NC=2)=C(C=CC=C2)C2=N1 OGLIHWSOSRCEQN-PVCWFJFTSA-N 0.000 claims 1
- DLBQUTLIDWHADS-QHCPKHFHSA-N (4s)-4-[[4-[2-[3-(cyclopropylcarbamoyl)azetidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC(C2)C(=O)NC2CC2)=C(C=CC=C2)C2=N1 DLBQUTLIDWHADS-QHCPKHFHSA-N 0.000 claims 1
- CLJCYTVQIWCHLE-TUXUZCGSSA-N (4s)-4-[[4-[2-[3-(cyclopropylcarbamoyl)piperidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC(CCC2)C(=O)NC2CC2)=C(C=CC(C)=C2)C2=N1 CLJCYTVQIWCHLE-TUXUZCGSSA-N 0.000 claims 1
- VKCGYRODFXRVQT-QBGQUKIHSA-N (4s)-4-[[4-[2-[3-(cyclopropylcarbamoyl)piperidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC(CCC2)C(=O)NC2CC2)=C(C=CC=C2)C2=N1 VKCGYRODFXRVQT-QBGQUKIHSA-N 0.000 claims 1
- BPPSIEAFPCIROQ-TUXUZCGSSA-N (4s)-4-[[4-[2-[3-(diethylamino)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC(CC2)N(CC)CC)=C(C=CC=C2)C2=N1 BPPSIEAFPCIROQ-TUXUZCGSSA-N 0.000 claims 1
- YZCJSZOPPGSKPX-DEOSSOPVSA-N (4s)-4-[[4-[2-[4-(cyclopropanecarbonyl)piperazin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CCN(CC2)C(=O)C2CC2)=C(C=CC=C2)C2=N1 YZCJSZOPPGSKPX-DEOSSOPVSA-N 0.000 claims 1
- VGFIWKGTJRPHAU-VWLOTQADSA-N (4s)-4-[[4-[2-[4-(cyclopropylcarbamoyl)piperidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CCC(CC2)C(=O)NC2CC2)=C(C=CC(C)=C2)C2=N1 VGFIWKGTJRPHAU-VWLOTQADSA-N 0.000 claims 1
- BXFSYUJHTGHISH-VWLOTQADSA-N (4s)-4-[[4-[2-[4-(cyclopropylcarbamoyl)piperidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CCC(CC2)C(=O)NC2CC2)=C(C=CC=C2)C2=N1 BXFSYUJHTGHISH-VWLOTQADSA-N 0.000 claims 1
- FFRYTOYBZWCRQU-LSYYVWMOSA-N (4s)-4-[[6,7-dimethyl-4-[2-oxo-2-[(2s)-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)N2CCCC2)=C(C=C(C)C(C)=C2)C2=N1 FFRYTOYBZWCRQU-LSYYVWMOSA-N 0.000 claims 1
- NGOPFUDJOXHSMN-ZCYQVOJMSA-N (4s)-4-[[6-chloro-4-[2-[(2s)-2-(cyclopropylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CC2)=C(C=C(Cl)C=C2)C2=N1 NGOPFUDJOXHSMN-ZCYQVOJMSA-N 0.000 claims 1
- XTSOQWGWCLRRSL-JDXGNMNLSA-N (4s)-5-(4-benzoylpiperazin-1-yl)-4-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound O=C([C@@H]1CCCN1C(=O)COC=1C=C(N=C2C=CC=CC2=1)C(=O)N[C@@H](CCC(=O)O)C(=O)N1CCN(CC1)C(=O)C=1C=CC=CC=1)NC1CCC1 XTSOQWGWCLRRSL-JDXGNMNLSA-N 0.000 claims 1
- SHZZLDXPERQEQA-SMCANUKXSA-N (4s)-5-(4-benzoylpiperidin-1-yl)-4-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound O=C([C@@H]1CCCN1C(=O)COC=1C=C(N=C2C=CC=CC2=1)C(=O)N[C@@H](CCC(=O)O)C(=O)N1CCC(CC1)C(=O)C=1C=CC=CC=1)NC1CCC1 SHZZLDXPERQEQA-SMCANUKXSA-N 0.000 claims 1
- YPUFPRPRFGUJOV-QFIPXVFZSA-N (4s)-5-(4-butoxycarbonylpiperazin-1-yl)-4-[[4-[2-(3,3-difluoropyrrolidin-1-yl)-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC(F)(F)CC2)=C(C=CC(C)=C2)C2=N1 YPUFPRPRFGUJOV-QFIPXVFZSA-N 0.000 claims 1
- ZJWDUTLHYQKDMF-QFIPXVFZSA-N (4s)-5-(4-butoxycarbonylpiperazin-1-yl)-4-[[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC(O)C2)=C(C=CC(C)=C2)C2=N1 ZJWDUTLHYQKDMF-QFIPXVFZSA-N 0.000 claims 1
- AVELZROOHRAXKU-GITCGBDTSA-N (4s)-5-(4-butoxycarbonylpiperazin-1-yl)-4-[[4-[2-(3-methoxypyrrolidin-1-yl)-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC(CC2)OC)=C(C=CC(C)=C2)C2=N1 AVELZROOHRAXKU-GITCGBDTSA-N 0.000 claims 1
- RITCOYINLOTLBE-QHCPKHFHSA-N (4s)-5-(4-butoxycarbonylpiperazin-1-yl)-4-[[4-[2-(4,6-dihydro-1h-pyrrolo[3,4-c]pyrazol-5-yl)-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC=3NN=CC=3C2)=C(C=CC(C)=C2)C2=N1 RITCOYINLOTLBE-QHCPKHFHSA-N 0.000 claims 1
- CNVUADWJASGDHG-DEOSSOPVSA-N (4s)-5-(4-butoxycarbonylpiperazin-1-yl)-4-[[4-[2-(4-hydroxypiperidin-1-yl)-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CCC(O)CC2)=C(C=CC(C)=C2)C2=N1 CNVUADWJASGDHG-DEOSSOPVSA-N 0.000 claims 1
- IOBIFNVZDVXHFQ-KYJUHHDHSA-N (4s)-5-(4-butoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylnaphthalene-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=C1 IOBIFNVZDVXHFQ-KYJUHHDHSA-N 0.000 claims 1
- WCWYTRSPJKLRAU-WNJJXGMVSA-N (4s)-5-(4-butoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 WCWYTRSPJKLRAU-WNJJXGMVSA-N 0.000 claims 1
- SOOKCFSHPWGFEI-UPVQGACJSA-N (4s)-5-(4-butoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(2s)-2-(hydroxymethyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)CO)=C(C=CC(C)=C2)C2=N1 SOOKCFSHPWGFEI-UPVQGACJSA-N 0.000 claims 1
- YFRGLIDJJZBBQY-ZCYQVOJMSA-N (4s)-5-(4-butoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(2s)-2-(methoxymethyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)COC)=C(C=CC(C)=C2)C2=N1 YFRGLIDJJZBBQY-ZCYQVOJMSA-N 0.000 claims 1
- XUMZXCKWTGAWKQ-KXGYFKBOSA-N (4s)-5-(4-butoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(2s)-2-[(2,2-difluorocyclopropyl)carbamoyl]pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2C(C2)(F)F)=C(C=CC(C)=C2)C2=N1 XUMZXCKWTGAWKQ-KXGYFKBOSA-N 0.000 claims 1
- WQTFRHSFNLQENI-UPVQGACJSA-N (4s)-5-(4-butoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(2s)-2-cyanopyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C#N)=C(C=CC(C)=C2)C2=N1 WQTFRHSFNLQENI-UPVQGACJSA-N 0.000 claims 1
- UXWJSNBPCXZREY-GGAORHGYSA-N (4s)-5-(4-butoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(3r)-3-hydroxypyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C[C@H](O)CC2)=C(C=CC(C)=C2)C2=N1 UXWJSNBPCXZREY-GGAORHGYSA-N 0.000 claims 1
- UXWJSNBPCXZREY-GMAHTHKFSA-N (4s)-5-(4-butoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(3s)-3-hydroxypyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C[C@@H](O)CC2)=C(C=CC(C)=C2)C2=N1 UXWJSNBPCXZREY-GMAHTHKFSA-N 0.000 claims 1
- QQGVXMZVCBOBCV-NPHAVVRNSA-N (4s)-5-(4-butoxycarbonylpiperazin-1-yl)-4-[[4-[2-[2-(2,4-difluorophenyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2C(=CC(F)=CC=2)F)=C(C=CC(C)=C2)C2=N1 QQGVXMZVCBOBCV-NPHAVVRNSA-N 0.000 claims 1
- IZHUODXODWEHRA-NPHAVVRNSA-N (4s)-5-(4-butoxycarbonylpiperazin-1-yl)-4-[[4-[2-[2-(3,4-difluorophenyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2C=C(F)C(F)=CC=2)=C(C=CC(C)=C2)C2=N1 IZHUODXODWEHRA-NPHAVVRNSA-N 0.000 claims 1
- AHWGEJWTWPCBPO-NPHAVVRNSA-N (4s)-5-(4-butoxycarbonylpiperazin-1-yl)-4-[[4-[2-[2-(4-fluorophenyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2C=CC(F)=CC=2)=C(C=CC(C)=C2)C2=N1 AHWGEJWTWPCBPO-NPHAVVRNSA-N 0.000 claims 1
- BLQIJVSGESUCSQ-ALLRNTDFSA-N (4s)-5-(4-butoxycarbonylpiperazin-1-yl)-4-[[4-[2-[2-(furan-2-yl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2OC=CC=2)=C(C=CC(C)=C2)C2=N1 BLQIJVSGESUCSQ-ALLRNTDFSA-N 0.000 claims 1
- RGOSHKZWUOZJMB-QHCPKHFHSA-N (4s)-5-(4-butoxycarbonylpiperazin-1-yl)-4-[[7-methyl-4-(2-oxo-2-piperazin-1-ylethoxy)quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CCNCC2)=C(C=CC(C)=C2)C2=N1 RGOSHKZWUOZJMB-QHCPKHFHSA-N 0.000 claims 1
- ZNBCEBUOPYZXKV-QHCPKHFHSA-N (4s)-5-(4-butoxycarbonylpiperazin-1-yl)-4-[[7-methyl-4-[2-(4-methyl-3-oxopiperazin-1-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC(=O)N(C)CC2)=C(C=CC(C)=C2)C2=N1 ZNBCEBUOPYZXKV-QHCPKHFHSA-N 0.000 claims 1
- AGJYSUZQWQLDRM-IAXKEJLGSA-N (4s)-5-(4-butoxycarbonylpiperazin-1-yl)-4-[[7-methyl-4-[2-(5-methyl-3-oxopyrazolidin-1-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CC(=O)N2)C)=C(C=CC(C)=C2)C2=N1 AGJYSUZQWQLDRM-IAXKEJLGSA-N 0.000 claims 1
- JGGJSLNIPPYVSR-IZEXYCQBSA-N (4s)-5-(4-butoxycarbonylpiperazin-1-yl)-4-[[7-methyl-4-[2-[(2s)-2-(5-methylpyridin-3-yl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C=2C=C(C)C=NC=2)=C(C=CC(C)=C2)C2=N1 JGGJSLNIPPYVSR-IZEXYCQBSA-N 0.000 claims 1
- OTPZQPLEPXSCLT-QGFKTNLFSA-N (4s)-5-(4-butoxycarbonylpiperazin-1-yl)-4-[[7-methyl-4-[2-[2-(2-methylphenyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2C(=CC=CC=2)C)=C(C=CC(C)=C2)C2=N1 OTPZQPLEPXSCLT-QGFKTNLFSA-N 0.000 claims 1
- NLIWAMHJOSZAIW-NRFANRHFSA-N (4s)-5-(4-butoxycarbonylpiperazin-1-yl)-4-[[7-methyl-4-[2-oxo-2-(2-oxo-1,3-oxazolidin-3-yl)ethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(OCC2)=O)=C(C=CC(C)=C2)C2=N1 NLIWAMHJOSZAIW-NRFANRHFSA-N 0.000 claims 1
- AKYPJOIDPBRAEP-QFIPXVFZSA-N (4s)-5-(4-butoxycarbonylpiperazin-1-yl)-4-[[7-methyl-4-[2-oxo-2-(3-oxopiperazin-1-yl)ethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC(=O)NCC2)=C(C=CC(C)=C2)C2=N1 AKYPJOIDPBRAEP-QFIPXVFZSA-N 0.000 claims 1
- ZMJAKOLRTWRHLU-NRFANRHFSA-N (4s)-5-(4-butoxycarbonylpiperazin-1-yl)-4-[[7-methyl-4-[2-oxo-2-(3-oxopyrazolidin-1-yl)ethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2NC(=O)CC2)=C(C=CC(C)=C2)C2=N1 ZMJAKOLRTWRHLU-NRFANRHFSA-N 0.000 claims 1
- ZNVFZYUUOHMTRE-VWLOTQADSA-N (4s)-5-(4-butoxycarbonylpiperazin-1-yl)-4-[[7-methyl-4-[2-oxo-2-(4-oxo-1,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6-yl)ethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC=3C(=O)NC=NC=3CC2)=C(C=CC(C)=C2)C2=N1 ZNVFZYUUOHMTRE-VWLOTQADSA-N 0.000 claims 1
- LDVOWMZRIFHOQV-IZEXYCQBSA-N (4s)-5-(4-butoxycarbonylpiperazin-1-yl)-4-[[7-methyl-4-[2-oxo-2-[(2s)-2-phenylpyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C=2C=CC=CC=2)=C(C=CC(C)=C2)C2=N1 LDVOWMZRIFHOQV-IZEXYCQBSA-N 0.000 claims 1
- RKBIXLJZZPAXEX-NRFANRHFSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-(2-morpholin-4-yl-2-oxoethoxy)quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CCOCC2)=C(C=CC=C2)C2=N1 RKBIXLJZZPAXEX-NRFANRHFSA-N 0.000 claims 1
- VOYXWHSVHWTPDR-QFIPXVFZSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-(1-methyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC=3N(C)N=CC=3C2)=C(C=CC=C2)C2=N1 VOYXWHSVHWTPDR-QFIPXVFZSA-N 0.000 claims 1
- NFYVXHZMNXTJGN-BBQAJUCSSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-(2-ethyl-3-oxopiperazin-1-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(C(=O)NCC2)CC)=C(C=CC=C2)C2=N1 NFYVXHZMNXTJGN-BBQAJUCSSA-N 0.000 claims 1
- COHZOWYXYVSGQW-AKRCKQFNSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-(2-ethylpyrrolidin-1-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)CC)=C(C=CC=C2)C2=N1 COHZOWYXYVSGQW-AKRCKQFNSA-N 0.000 claims 1
- PBEQIJHJYIOEHU-QBGQUKIHSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-(2-methyl-2,3-dihydroindol-1-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C3=CC=CC=C3CC2C)=C(C=CC=C2)C2=N1 PBEQIJHJYIOEHU-QBGQUKIHSA-N 0.000 claims 1
- JSCCGNBSGGRWLE-ZYZRXSCRSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-(2-methyl-3-oxopiperazin-1-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(C(=O)NCC2)C)=C(C=CC=C2)C2=N1 JSCCGNBSGGRWLE-ZYZRXSCRSA-N 0.000 claims 1
- GGUWWCDCRYTBAC-QHCPKHFHSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-(2-methyl-6,7-dihydro-4h-[1,3]oxazolo[5,4-c]pyridin-5-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC=3OC(C)=NC=3CC2)=C(C=CC=C2)C2=N1 GGUWWCDCRYTBAC-QHCPKHFHSA-N 0.000 claims 1
- RDZHHOKTNHWXBJ-QHCPKHFHSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-(2-methyl-6,7-dihydro-4h-[1,3]thiazolo[5,4-c]pyridin-5-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC=3SC(C)=NC=3CC2)=C(C=CC=C2)C2=N1 RDZHHOKTNHWXBJ-QHCPKHFHSA-N 0.000 claims 1
- DSLBHBCJGVRSSB-FQEVSTJZSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC(O)C2)=C(C=CC(C)=C2)C2=N1 DSLBHBCJGVRSSB-FQEVSTJZSA-N 0.000 claims 1
- ZMTAGYCPHPZQNX-IAXKEJLGSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-(3-hydroxypiperidin-1-yl)-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC(O)CCC2)=C(C=CC(C)=C2)C2=N1 ZMTAGYCPHPZQNX-IAXKEJLGSA-N 0.000 claims 1
- GXAPIEDXMPNVQU-BPARTEKVSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-(3-hydroxypiperidin-1-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC(O)CCC2)=C(C=CC=C2)C2=N1 GXAPIEDXMPNVQU-BPARTEKVSA-N 0.000 claims 1
- PQBFJMOVWNCKEN-MMPATGFWSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-(3-methoxy-3a,4,6,6a-tetrahydropyrrolo[3,4-d][1,2]oxazol-5-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC3C(OC)=NOC3C2)=C(C=CC=C2)C2=N1 PQBFJMOVWNCKEN-MMPATGFWSA-N 0.000 claims 1
- UTRMDGOVMOMJLK-BPARTEKVSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-(3-methoxypyrrolidin-1-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC(CC2)OC)=C(C=CC=C2)C2=N1 UTRMDGOVMOMJLK-BPARTEKVSA-N 0.000 claims 1
- UGTQQYUAURGXRY-QHCPKHFHSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-(4-ethoxycarbonylpiperazin-1-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)COC1=CC(C(=O)N[C@@H](CCC(O)=O)C(=O)N2CCN(CC2)C(=O)OCC)=NC2=CC=CC=C12 UGTQQYUAURGXRY-QHCPKHFHSA-N 0.000 claims 1
- WZAIAXFGYNHPLH-DEOSSOPVSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-(4-ethoxycarbonylpiperidin-1-yl)-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CC(C(=O)OCC)CCN1C(=O)COC1=CC(C(=O)N[C@@H](CCC(O)=O)C(=O)N2CCN(CC2)C(=O)OCC)=NC2=CC(C)=CC=C12 WZAIAXFGYNHPLH-DEOSSOPVSA-N 0.000 claims 1
- DXPPVHCOPNYOQS-DEOSSOPVSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-(4-ethoxycarbonylpiperidin-1-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CC(C(=O)OCC)CCN1C(=O)COC1=CC(C(=O)N[C@@H](CCC(O)=O)C(=O)N2CCN(CC2)C(=O)OCC)=NC2=CC=CC=C12 DXPPVHCOPNYOQS-DEOSSOPVSA-N 0.000 claims 1
- BSXOKNOIACPTBT-DEOSSOPVSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-(4-ethoxypiperidin-1-yl)-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CC(OCC)CCN1C(=O)COC1=CC(C(=O)N[C@@H](CCC(O)=O)C(=O)N2CCN(CC2)C(=O)OCC)=NC2=CC(C)=CC=C12 BSXOKNOIACPTBT-DEOSSOPVSA-N 0.000 claims 1
- BWUVPMMVVNBLDR-DEOSSOPVSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-(4-ethoxypiperidin-1-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CC(OCC)CCN1C(=O)COC1=CC(C(=O)N[C@@H](CCC(O)=O)C(=O)N2CCN(CC2)C(=O)OCC)=NC2=CC=CC=C12 BWUVPMMVVNBLDR-DEOSSOPVSA-N 0.000 claims 1
- VGUFGSKJDMSGSH-QHCPKHFHSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-(4-ethylsulfonylpiperazin-1-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CCN(CC2)S(=O)(=O)CC)=C(C=CC=C2)C2=N1 VGUFGSKJDMSGSH-QHCPKHFHSA-N 0.000 claims 1
- KJRAWXBSCDSMAK-MMPATGFWSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-(4-hydroxy-2-methoxycarbonylpyrrolidin-1-yl)-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CC(O)C2)C(=O)OC)=C(C=CC(C)=C2)C2=N1 KJRAWXBSCDSMAK-MMPATGFWSA-N 0.000 claims 1
- RAMPGIQQFUWTQW-STDCAVTESA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-(4-hydroxy-2-methoxycarbonylpyrrolidin-1-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CC(O)C2)C(=O)OC)=C(C=CC=C2)C2=N1 RAMPGIQQFUWTQW-STDCAVTESA-N 0.000 claims 1
- ZHPJRHIIEKFWAU-QFIPXVFZSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-(4-hydroxypiperidin-1-yl)-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CCC(O)CC2)=C(C=CC(C)=C2)C2=N1 ZHPJRHIIEKFWAU-QFIPXVFZSA-N 0.000 claims 1
- GQCFQOIHHDQSGN-QHCPKHFHSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-(4-methoxypiperidin-1-yl)-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CCC(CC2)OC)=C(C=CC(C)=C2)C2=N1 GQCFQOIHHDQSGN-QHCPKHFHSA-N 0.000 claims 1
- HXHKMYHEAIUEGP-QHCPKHFHSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-(4-methoxypiperidin-1-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CCC(CC2)OC)=C(C=CC=C2)C2=N1 HXHKMYHEAIUEGP-QHCPKHFHSA-N 0.000 claims 1
- RJHUEPDDEYMIAK-UHFKCPIBSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-(4-methyl-3-oxo-2-propan-2-ylpiperazin-1-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(C(=O)N(C)CC2)C(C)C)=C(C=CC=C2)C2=N1 RJHUEPDDEYMIAK-UHFKCPIBSA-N 0.000 claims 1
- KTIWBHYBCQUDSX-SANMLTNESA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-(4-morpholin-4-ylpiperidin-1-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CCC(CC2)N2CCOCC2)=C(C=CC=C2)C2=N1 KTIWBHYBCQUDSX-SANMLTNESA-N 0.000 claims 1
- BHYMXAYECQDJGD-DOXRDRLYSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-(6-methyl-3,4,4a,5,7,7a-hexahydro-2h-pyrrolo[3,4-b]pyridin-1-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C3CN(C)CC3CCC2)=C(C=CC=C2)C2=N1 BHYMXAYECQDJGD-DOXRDRLYSA-N 0.000 claims 1
- AMAUPAVBZBJGFI-OFNKIYASSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(2r)-2-(methoxymethyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@H](CCC2)COC)=C(C=CC=C2)C2=N1 AMAUPAVBZBJGFI-OFNKIYASSA-N 0.000 claims 1
- JZHZUBQEIOCXMB-WIOPSUGQSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(2r)-2-ethoxycarbonylpyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound CCOC(=O)[C@H]1CCCN1C(=O)COC1=CC(C(=O)N[C@@H](CCC(O)=O)C(=O)N2CCN(CC2)C(=O)OCC)=NC2=CC(C)=CC=C12 JZHZUBQEIOCXMB-WIOPSUGQSA-N 0.000 claims 1
- XZCVFSPPVIKFTL-LADGPHEKSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(2r)-2-ethoxycarbonylpyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound CCOC(=O)[C@H]1CCCN1C(=O)COC1=CC(C(=O)N[C@@H](CCC(O)=O)C(=O)N2CCN(CC2)C(=O)OCC)=NC2=CC=CC=C12 XZCVFSPPVIKFTL-LADGPHEKSA-N 0.000 claims 1
- ZTWUPCXICXMCBN-DHLKQENFSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(2s)-2-(2-fluoroethylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NCCF)=C(C=CC(C)=C2)C2=N1 ZTWUPCXICXMCBN-DHLKQENFSA-N 0.000 claims 1
- BJGWGFRBMCBWIB-UPVQGACJSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(2s)-2-(2-fluoroethylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NCCF)=C(C=CC=C2)C2=N1 BJGWGFRBMCBWIB-UPVQGACJSA-N 0.000 claims 1
- KMCOVAYCTWUHMM-XCZPVHLTSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(2s)-2-(5-methylpyridin-3-yl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C=2C=C(C)C=NC=2)=C(C=CC=C2)C2=N1 KMCOVAYCTWUHMM-XCZPVHLTSA-N 0.000 claims 1
- JEIWAJKPJSIZFF-GMAHTHKFSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(2s)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-5-fluoroquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)COC1=CC(C(=O)N[C@@H](CCC(O)=O)C(=O)N2CCN(CC2)C(=O)OCC)=NC2=CC=CC(F)=C12 JEIWAJKPJSIZFF-GMAHTHKFSA-N 0.000 claims 1
- TZBNCOGOMLXVRI-URXFXBBRSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(2s)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-6,7-difluoroquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)COC1=CC(C(=O)N[C@@H](CCC(O)=O)C(=O)N2CCN(CC2)C(=O)OCC)=NC2=CC(F)=C(F)C=C12 TZBNCOGOMLXVRI-URXFXBBRSA-N 0.000 claims 1
- JTYZOWIYSNXUOU-UPVQGACJSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(2s)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-6-fluoro-5-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)COC1=CC(C(=O)N[C@@H](CCC(O)=O)C(=O)N2CCN(CC2)C(=O)OCC)=NC2=CC=C(F)C(C)=C12 JTYZOWIYSNXUOU-UPVQGACJSA-N 0.000 claims 1
- YMSIIQNABVTREE-DHLKQENFSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(2s)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-6-fluoro-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)COC1=CC(C(=O)N[C@@H](CCC(O)=O)C(=O)N2CCN(CC2)C(=O)OCC)=NC2=CC(C)=C(F)C=C12 YMSIIQNABVTREE-DHLKQENFSA-N 0.000 claims 1
- RIKXXEHCSXDIAW-UPVQGACJSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(2s)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-6-fluoroquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)COC1=CC(C(=O)N[C@@H](CCC(O)=O)C(=O)N2CCN(CC2)C(=O)OCC)=NC2=CC=C(F)C=C12 RIKXXEHCSXDIAW-UPVQGACJSA-N 0.000 claims 1
- MJGIEUFOQPNDFR-URXFXBBRSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(2s)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-fluoroquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)COC1=CC(C(=O)N[C@@H](CCC(O)=O)C(=O)N2CCN(CC2)C(=O)OCC)=NC2=CC(F)=CC=C12 MJGIEUFOQPNDFR-URXFXBBRSA-N 0.000 claims 1
- MCIDKNPHPHHUAG-DHLKQENFSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(2s)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)COC1=CC(C(=O)N[C@@H](CCC(O)=O)C(=O)N2CCN(CC2)C(=O)OCC)=NC2=CC(C)=CC=C12 MCIDKNPHPHHUAG-DHLKQENFSA-N 0.000 claims 1
- FFVZDDKFAQXNMN-GMAHTHKFSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(2s)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-8-fluoroquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)COC1=CC(C(=O)N[C@@H](CCC(O)=O)C(=O)N2CCN(CC2)C(=O)OCC)=NC2=C(F)C=CC=C12 FFVZDDKFAQXNMN-GMAHTHKFSA-N 0.000 claims 1
- OROHLTMFSFFWID-UPVQGACJSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(2s)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)COC1=CC(C(=O)N[C@@H](CCC(O)=O)C(=O)N2CCN(CC2)C(=O)OCC)=NC2=CC=CC=C12 OROHLTMFSFFWID-UPVQGACJSA-N 0.000 claims 1
- WYDMHLYKHQWZRX-UNMCSNQZSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(2s)-2-(hydroxymethyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)CO)=C(C=CC(C)=C2)C2=N1 WYDMHLYKHQWZRX-UNMCSNQZSA-N 0.000 claims 1
- HFWANRYEAWOFHX-UGKGYDQZSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(2s)-2-(hydroxymethyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)CO)=C(C=CC=C2)C2=N1 HFWANRYEAWOFHX-UGKGYDQZSA-N 0.000 claims 1
- SBDAGTYEQBSEQG-GMAHTHKFSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(2s)-2-(methoxymethyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)COC)=C(C=CC(C)=C2)C2=N1 SBDAGTYEQBSEQG-GMAHTHKFSA-N 0.000 claims 1
- AMAUPAVBZBJGFI-REWPJTCUSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(2s)-2-(methoxymethyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)COC)=C(C=CC=C2)C2=N1 AMAUPAVBZBJGFI-REWPJTCUSA-N 0.000 claims 1
- OWEPCRSIMYZSRK-OZXSUGGESA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(2s)-2-[ethyl(methyl)carbamoyl]pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)N(C)CC)=C(C=CC(C)=C2)C2=N1 OWEPCRSIMYZSRK-OZXSUGGESA-N 0.000 claims 1
- JZHZUBQEIOCXMB-DHLKQENFSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(2s)-2-ethoxycarbonylpyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound CCOC(=O)[C@@H]1CCCN1C(=O)COC1=CC(C(=O)N[C@@H](CCC(O)=O)C(=O)N2CCN(CC2)C(=O)OCC)=NC2=CC(C)=CC=C12 JZHZUBQEIOCXMB-DHLKQENFSA-N 0.000 claims 1
- PMFCAGRJISWYFN-URXFXBBRSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(2s)-2-methoxycarbonylpyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)OC)=C(C=CC(C)=C2)C2=N1 PMFCAGRJISWYFN-URXFXBBRSA-N 0.000 claims 1
- JSCCGNBSGGRWLE-RXVVDRJESA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(2s)-2-methyl-3-oxopiperazin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@H](C(=O)NCC2)C)=C(C=CC=C2)C2=N1 JSCCGNBSGGRWLE-RXVVDRJESA-N 0.000 claims 1
- KYKKKLHCXPCSFC-JZWVFAODSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(2s,4r)-4-fluoro-2-methoxycarbonylpyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](C[C@@H](F)C2)C(=O)OC)=C(C=CC=C2)C2=N1 KYKKKLHCXPCSFC-JZWVFAODSA-N 0.000 claims 1
- KYKKKLHCXPCSFC-HARLFGEKSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(2s,4s)-4-fluoro-2-methoxycarbonylpyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](C[C@H](F)C2)C(=O)OC)=C(C=CC=C2)C2=N1 KYKKKLHCXPCSFC-HARLFGEKSA-N 0.000 claims 1
- RAMPGIQQFUWTQW-HARLFGEKSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(2s,4s)-4-hydroxy-2-methoxycarbonylpyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](C[C@H](O)C2)C(=O)OC)=C(C=CC=C2)C2=N1 RAMPGIQQFUWTQW-HARLFGEKSA-N 0.000 claims 1
- CBFDBLMRBKGWCG-IRLDBZIGSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(3r)-3-(hydroxymethyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C[C@H](CO)CC2)=C(C=CC(C)=C2)C2=N1 CBFDBLMRBKGWCG-IRLDBZIGSA-N 0.000 claims 1
- AQWAJOOHEMIWLB-KNQAVFIVSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(3r)-3-(hydroxymethyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C[C@H](CO)CC2)=C(C=CC=C2)C2=N1 AQWAJOOHEMIWLB-KNQAVFIVSA-N 0.000 claims 1
- ZMTAGYCPHPZQNX-IRLDBZIGSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(3r)-3-hydroxypiperidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C[C@H](O)CCC2)=C(C=CC(C)=C2)C2=N1 ZMTAGYCPHPZQNX-IRLDBZIGSA-N 0.000 claims 1
- GXAPIEDXMPNVQU-KNQAVFIVSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(3r)-3-hydroxypiperidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C[C@H](O)CCC2)=C(C=CC=C2)C2=N1 GXAPIEDXMPNVQU-KNQAVFIVSA-N 0.000 claims 1
- LFDKFZRYHQQPNX-CTNGQTDRSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(3r)-3-hydroxypyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C[C@H](O)CC2)=C(C=CC(C)=C2)C2=N1 LFDKFZRYHQQPNX-CTNGQTDRSA-N 0.000 claims 1
- YDWFPMIWIBXWOV-NQIIRXRSSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(3r)-3-hydroxypyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C[C@H](O)CC2)=C(C=CC=C2)C2=N1 YDWFPMIWIBXWOV-NQIIRXRSSA-N 0.000 claims 1
- CBFDBLMRBKGWCG-UNMCSNQZSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(3s)-3-(hydroxymethyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C[C@@H](CO)CC2)=C(C=CC(C)=C2)C2=N1 CBFDBLMRBKGWCG-UNMCSNQZSA-N 0.000 claims 1
- AQWAJOOHEMIWLB-UGKGYDQZSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(3s)-3-(hydroxymethyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C[C@@H](CO)CC2)=C(C=CC=C2)C2=N1 AQWAJOOHEMIWLB-UGKGYDQZSA-N 0.000 claims 1
- LFDKFZRYHQQPNX-FPOVZHCZSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(3s)-3-hydroxypyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C[C@@H](O)CC2)=C(C=CC(C)=C2)C2=N1 LFDKFZRYHQQPNX-FPOVZHCZSA-N 0.000 claims 1
- YDWFPMIWIBXWOV-RXVVDRJESA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[(3s)-3-hydroxypyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C[C@@H](O)CC2)=C(C=CC=C2)C2=N1 YDWFPMIWIBXWOV-RXVVDRJESA-N 0.000 claims 1
- LMYIFGKHIDSHCE-KBHDRSMZSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[2-(1-methylpiperidin-2-yl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)C2N(CCCC2)C)=C(C=CC=C2)C2=N1 LMYIFGKHIDSHCE-KBHDRSMZSA-N 0.000 claims 1
- RTLWCRFOOBIDDS-QODXOHEASA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[2-(2-fluorophenyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2C(=CC=CC=2)F)=C(C=CC=C2)C2=N1 RTLWCRFOOBIDDS-QODXOHEASA-N 0.000 claims 1
- UKISVDRNSVRCRZ-QODXOHEASA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[2-(2-methoxyphenyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2C(=CC=CC=2)OC)=C(C=CC=C2)C2=N1 UKISVDRNSVRCRZ-QODXOHEASA-N 0.000 claims 1
- MJGOQTUMFLSYOA-BVOOQYFDSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[2-(2-methylphenyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2C(=CC=CC=2)C)=C(C=CC=C2)C2=N1 MJGOQTUMFLSYOA-BVOOQYFDSA-N 0.000 claims 1
- CDTPDTWNWSCXHO-QODXOHEASA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[2-(3-fluorophenyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2C=C(F)C=CC=2)=C(C=CC=C2)C2=N1 CDTPDTWNWSCXHO-QODXOHEASA-N 0.000 claims 1
- RSGDJGICBQHHRM-BVOOQYFDSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[2-(3-methoxyphenyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2C=C(OC)C=CC=2)=C(C=CC=C2)C2=N1 RSGDJGICBQHHRM-BVOOQYFDSA-N 0.000 claims 1
- IHAYQIRDOATKJB-BVOOQYFDSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[2-(3-methylphenyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2C=C(C)C=CC=2)=C(C=CC=C2)C2=N1 IHAYQIRDOATKJB-BVOOQYFDSA-N 0.000 claims 1
- PAAMDPNOPJODCA-BVOOQYFDSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[2-(4-methylphenyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2C=CC(C)=CC=2)=C(C=CC=C2)C2=N1 PAAMDPNOPJODCA-BVOOQYFDSA-N 0.000 claims 1
- JCOBCESXNIQBCL-QSAPEBAKSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[2-(5-methylfuran-2-yl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2OC(C)=CC=2)=C(C=CC=C2)C2=N1 JCOBCESXNIQBCL-QSAPEBAKSA-N 0.000 claims 1
- YHBWUJCMKNBDCZ-LFQPHHBNSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[2-(furan-2-yl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2OC=CC=2)=C(C=CC=C2)C2=N1 YHBWUJCMKNBDCZ-LFQPHHBNSA-N 0.000 claims 1
- XTQSDTAACVCOBU-TUXUZCGSSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[2-(hydroxymethyl)-2,3-dihydroindol-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C3=CC=CC=C3CC2CO)=C(C=CC=C2)C2=N1 XTQSDTAACVCOBU-TUXUZCGSSA-N 0.000 claims 1
- YCLSLGLUVAOAGF-IAXKEJLGSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[2-(hydroxymethyl)morpholin-4-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC(CO)OCC2)=C(C=CC(C)=C2)C2=N1 YCLSLGLUVAOAGF-IAXKEJLGSA-N 0.000 claims 1
- OHPFUAXWQSSFRB-BPARTEKVSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[2-(hydroxymethyl)morpholin-4-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC(CO)OCC2)=C(C=CC=C2)C2=N1 OHPFUAXWQSSFRB-BPARTEKVSA-N 0.000 claims 1
- QGTKMBZFJYYQKJ-FHZUCYEKSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[2-(methoxymethyl)piperidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCCC2)COC)=C(C=CC=C2)C2=N1 QGTKMBZFJYYQKJ-FHZUCYEKSA-N 0.000 claims 1
- ZOLSYRXFJRLWBF-AKRCKQFNSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[2-(methylsulfanylmethyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)CSC)=C(C=CC=C2)C2=N1 ZOLSYRXFJRLWBF-AKRCKQFNSA-N 0.000 claims 1
- WTAOGPTWPHBRLU-NASUQTAISA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[2-(morpholin-4-ylmethyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)CN2CCOCC2)=C(C=CC=C2)C2=N1 WTAOGPTWPHBRLU-NASUQTAISA-N 0.000 claims 1
- LSJUVQKIFWUBOG-ZUILJJEPSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[3-(2-fluorophenyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC(CC2)C=2C(=CC=CC=2)F)=C(C=CC=C2)C2=N1 LSJUVQKIFWUBOG-ZUILJJEPSA-N 0.000 claims 1
- PENLQDPUUBVVBS-SANMLTNESA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-[4-(2-morpholin-4-yl-2-oxoethyl)piperazin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CCN(CC(=O)N3CCOCC3)CC2)=C(C=CC=C2)C2=N1 PENLQDPUUBVVBS-SANMLTNESA-N 0.000 claims 1
- ASJWOLHLQJLZJZ-NRFANRHFSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[5-fluoro-4-[2-(4-hydroxypiperidin-1-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CCC(O)CC2)=C(C(F)=CC=C2)C2=N1 ASJWOLHLQJLZJZ-NRFANRHFSA-N 0.000 claims 1
- KQEOLJLICARANN-DHLKQENFSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[5-fluoro-7-methyl-4-[2-oxo-2-[(2s)-2-(propylcarbamoyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound CCCNC(=O)[C@@H]1CCCN1C(=O)COC1=CC(C(=O)N[C@@H](CCC(O)=O)C(=O)N2CCN(CC2)C(=O)OCC)=NC2=CC(C)=CC(F)=C12 KQEOLJLICARANN-DHLKQENFSA-N 0.000 claims 1
- OMQCZRXOHWFCJK-OZXSUGGESA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[5-fluoro-7-methyl-4-[2-oxo-2-[(2s)-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)N2CCCC2)=C(C(F)=CC(C)=C2)C2=N1 OMQCZRXOHWFCJK-OZXSUGGESA-N 0.000 claims 1
- UJSNJWAYMVNUII-AHWVRZQESA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[6-ethoxy-4-[2-[(2s)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)COC1=CC(C(=O)N[C@@H](CCC(O)=O)C(=O)N2CCN(CC2)C(=O)OCC)=NC2=CC=C(OCC)C=C12 UJSNJWAYMVNUII-AHWVRZQESA-N 0.000 claims 1
- SFYDWFACVKTMQJ-QFIPXVFZSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[6-fluoro-4-[2-(4-hydroxypiperidin-1-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CCC(O)CC2)=C(C=C(F)C=C2)C2=N1 SFYDWFACVKTMQJ-QFIPXVFZSA-N 0.000 claims 1
- YKMFGHFEROWDDI-IGKIAQTJSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[6-fluoro-7-methyl-4-[2-oxo-2-[(2s)-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)N2CCCC2)=C(C=C(F)C(C)=C2)C2=N1 YKMFGHFEROWDDI-IGKIAQTJSA-N 0.000 claims 1
- YYWWHLYIKLEEDQ-OZXSUGGESA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[7-ethyl-4-[2-[(2s)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)COC1=CC(C(=O)N[C@@H](CCC(O)=O)C(=O)N2CCN(CC2)C(=O)OCC)=NC2=CC(CC)=CC=C12 YYWWHLYIKLEEDQ-OZXSUGGESA-N 0.000 claims 1
- LMYXUFGVLMUATI-NRFANRHFSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[7-fluoro-4-[2-(4-hydroxypiperidin-1-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CCC(O)CC2)=C(C=CC(F)=C2)C2=N1 LMYXUFGVLMUATI-NRFANRHFSA-N 0.000 claims 1
- RKEMPOZEHLRMRV-DHLKQENFSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[7-fluoro-4-[2-oxo-2-[(2s)-2-(propylcarbamoyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound CCCNC(=O)[C@@H]1CCCN1C(=O)COC1=CC(C(=O)N[C@@H](CCC(O)=O)C(=O)N2CCN(CC2)C(=O)OCC)=NC2=CC(F)=CC=C12 RKEMPOZEHLRMRV-DHLKQENFSA-N 0.000 claims 1
- RARNELSXNMKMAB-OZXSUGGESA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[7-fluoro-4-[2-oxo-2-[(2s)-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)N2CCCC2)=C(C=CC(F)=C2)C2=N1 RARNELSXNMKMAB-OZXSUGGESA-N 0.000 claims 1
- UQAITOKJMPKOLW-NRFANRHFSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[7-methyl-4-(2-morpholin-4-yl-2-oxoethoxy)quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CCOCC2)=C(C=CC(C)=C2)C2=N1 UQAITOKJMPKOLW-NRFANRHFSA-N 0.000 claims 1
- BBMGDJREPSLORI-XOSZZMEKSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[7-methyl-4-[(2r)-1-oxo-1-(2-phenylpyrrolidin-1-yl)propan-2-yl]oxyquinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(O[C@H](C)C(=O)N2C(CCC2)C=2C=CC=CC=2)=C(C=CC(C)=C2)C2=N1 BBMGDJREPSLORI-XOSZZMEKSA-N 0.000 claims 1
- KEOMFMNNZPCAND-IAXKEJLGSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[7-methyl-4-[2-(3-methylsulfonylpyrrolidin-1-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC(CC2)S(C)(=O)=O)=C(C=CC(C)=C2)C2=N1 KEOMFMNNZPCAND-IAXKEJLGSA-N 0.000 claims 1
- TZIZSKJWOTZMAA-IBGZPJMESA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[7-methyl-4-[2-oxo-2-(2-oxo-1,3-oxazolidin-3-yl)ethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(OCC2)=O)=C(C=CC(C)=C2)C2=N1 TZIZSKJWOTZMAA-IBGZPJMESA-N 0.000 claims 1
- JAGSCRDJOVKZTL-FQEVSTJZSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[7-methyl-4-[2-oxo-2-(2-oxopyrrolidin-1-yl)ethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)=O)=C(C=CC(C)=C2)C2=N1 JAGSCRDJOVKZTL-FQEVSTJZSA-N 0.000 claims 1
- MFUXKILWVGAVRJ-FQEVSTJZSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[7-methyl-4-[2-oxo-2-(3-oxopiperazin-1-yl)ethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC(=O)NCC2)=C(C=CC(C)=C2)C2=N1 MFUXKILWVGAVRJ-FQEVSTJZSA-N 0.000 claims 1
- UDGVEEXJOWTXQU-IBGZPJMESA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[7-methyl-4-[2-oxo-2-(3-oxopyrazolidin-1-yl)ethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2NC(=O)CC2)=C(C=CC(C)=C2)C2=N1 UDGVEEXJOWTXQU-IBGZPJMESA-N 0.000 claims 1
- AFZUDKKIPDPWOV-NRFANRHFSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[7-methyl-4-[2-oxo-2-(3-oxopyrrolidin-1-yl)ethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC(=O)CC2)=C(C=CC(C)=C2)C2=N1 AFZUDKKIPDPWOV-NRFANRHFSA-N 0.000 claims 1
- FVPYRZPAICWIGK-NRFANRHFSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[7-methyl-4-[2-oxo-2-(5-oxo-1,4-diazepan-1-yl)ethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CCC(=O)NCC2)=C(C=CC(C)=C2)C2=N1 FVPYRZPAICWIGK-NRFANRHFSA-N 0.000 claims 1
- ZRWAWTRUFOLRJX-IMSXRSKXSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[7-methyl-4-[2-oxo-2-[(1r,5s)-3-oxo-8-azabicyclo[3.2.1]octan-8-yl]ethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound O=C([C@H](CCC(O)=O)NC(=O)C=1C=C(C2=CC=C(C)C=C2N=1)OCC(=O)N1[C@]2([H])CC[C@]1(CC(=O)C2)[H])N1CCN(C(=O)OCC)CC1 ZRWAWTRUFOLRJX-IMSXRSKXSA-N 0.000 claims 1
- DRMHCEBDDGLRLH-URXFXBBRSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[7-methyl-4-[2-oxo-2-[(2s)-2-(2,2,2-trifluoroethylcarbamoyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NCC(F)(F)F)=C(C=CC(C)=C2)C2=N1 DRMHCEBDDGLRLH-URXFXBBRSA-N 0.000 claims 1
- SHGPJCRQXUNPSA-LSYYVWMOSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[7-methyl-4-[2-oxo-2-[(2s)-2-(piperidine-1-carbonyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)N2CCCCC2)=C(C=CC(C)=C2)C2=N1 SHGPJCRQXUNPSA-LSYYVWMOSA-N 0.000 claims 1
- FMOVUBGQWGBZAX-OZXSUGGESA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[7-methyl-4-[2-oxo-2-[(2s)-2-(propan-2-ylcarbamoyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC(C)C)=C(C=CC(C)=C2)C2=N1 FMOVUBGQWGBZAX-OZXSUGGESA-N 0.000 claims 1
- ZYFAGCOHUBBMOH-OZXSUGGESA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[7-methyl-4-[2-oxo-2-[(2s)-2-(propylcarbamoyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound CCCNC(=O)[C@@H]1CCCN1C(=O)COC1=CC(C(=O)N[C@@H](CCC(O)=O)C(=O)N2CCN(CC2)C(=O)OCC)=NC2=CC(C)=CC=C12 ZYFAGCOHUBBMOH-OZXSUGGESA-N 0.000 claims 1
- WBORKYOPOZSQQB-IGKIAQTJSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[7-methyl-4-[2-oxo-2-[(2s)-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)N2CCCC2)=C(C=CC(C)=C2)C2=N1 WBORKYOPOZSQQB-IGKIAQTJSA-N 0.000 claims 1
- YJYMCQCOIMVVBC-NRFANRHFSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[8-fluoro-4-[2-(4-hydroxypiperidin-1-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CCC(O)CC2)=C(C=CC=C2F)C2=N1 YJYMCQCOIMVVBC-NRFANRHFSA-N 0.000 claims 1
- VYOVSXWOCBSRKF-NRFANRHFSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-(2-oxo-2-piperazin-1-ylethoxy)quinoline-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CCNCC2)=C(C=CC=C2)C2=N1 VYOVSXWOCBSRKF-NRFANRHFSA-N 0.000 claims 1
- IHWKSLTWLGQOCV-FQEVSTJZSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-[2-oxo-2-(2-oxopyrrolidin-1-yl)ethoxy]quinoline-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)=O)=C(C=CC=C2)C2=N1 IHWKSLTWLGQOCV-FQEVSTJZSA-N 0.000 claims 1
- FAJICISULDPTIS-QODXOHEASA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-[2-oxo-2-(2-phenylpyrrolidin-1-yl)ethoxy]quinoline-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2C=CC=CC=2)=C(C=CC=C2)C2=N1 FAJICISULDPTIS-QODXOHEASA-N 0.000 claims 1
- DOZPMXHIABVNFN-LFQPHHBNSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-[2-oxo-2-(2-propan-2-ylpyrrolidin-1-yl)ethoxy]quinoline-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)C(C)C)=C(C=CC=C2)C2=N1 DOZPMXHIABVNFN-LFQPHHBNSA-N 0.000 claims 1
- IYFHXTJZSFZFIJ-PVCWFJFTSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-[2-oxo-2-(2-pyridin-2-ylpyrrolidin-1-yl)ethoxy]quinoline-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2N=CC=CC=2)=C(C=CC=C2)C2=N1 IYFHXTJZSFZFIJ-PVCWFJFTSA-N 0.000 claims 1
- WFUXYBBSNLKEKN-PVCWFJFTSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-[2-oxo-2-(2-pyridin-3-ylpyrrolidin-1-yl)ethoxy]quinoline-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2C=NC=CC=2)=C(C=CC=C2)C2=N1 WFUXYBBSNLKEKN-PVCWFJFTSA-N 0.000 claims 1
- JTQIMCBYBRDNKT-QSAPEBAKSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-[2-oxo-2-(2-pyrimidin-4-ylpyrrolidin-1-yl)ethoxy]quinoline-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2N=CN=CC=2)=C(C=CC=C2)C2=N1 JTQIMCBYBRDNKT-QSAPEBAKSA-N 0.000 claims 1
- ICXLSBJDBYMFIU-LFQPHHBNSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-[2-oxo-2-(2-thiophen-2-ylpyrrolidin-1-yl)ethoxy]quinoline-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2SC=CC=2)=C(C=CC=C2)C2=N1 ICXLSBJDBYMFIU-LFQPHHBNSA-N 0.000 claims 1
- KAQZCXSVMDQYSI-SANMLTNESA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-[2-oxo-2-(3-oxo-4-phenylpiperazin-1-yl)ethoxy]quinoline-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC(=O)N(CC2)C=2C=CC=CC=2)=C(C=CC=C2)C2=N1 KAQZCXSVMDQYSI-SANMLTNESA-N 0.000 claims 1
- SSGABMNXWLTJFR-NRFANRHFSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-[2-oxo-2-(3-oxo-5,7-dihydro-4h-[1,2]oxazolo[5,4-c]pyridin-6-yl)ethoxy]quinoline-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC=3ON=C(O)C=3CC2)=C(C=CC=C2)C2=N1 SSGABMNXWLTJFR-NRFANRHFSA-N 0.000 claims 1
- IKMUCSMEEIIXPV-IBGZPJMESA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-[2-oxo-2-(3-oxopyrazolidin-1-yl)ethoxy]quinoline-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2NC(=O)CC2)=C(C=CC=C2)C2=N1 IKMUCSMEEIIXPV-IBGZPJMESA-N 0.000 claims 1
- NBWBLSJRISBSTH-NRFANRHFSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-[2-oxo-2-(3-oxopyrrolidin-1-yl)ethoxy]quinoline-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC(=O)CC2)=C(C=CC=C2)C2=N1 NBWBLSJRISBSTH-NRFANRHFSA-N 0.000 claims 1
- BGEQYJSKMKYDBB-NMXAJACMSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-[2-oxo-2-(3-phenylmethoxypyrrolidin-1-yl)ethoxy]quinoline-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC(CC2)OCC=2C=CC=CC=2)=C(C=CC=C2)C2=N1 BGEQYJSKMKYDBB-NMXAJACMSA-N 0.000 claims 1
- DFIHHJYMWXWJSG-WKDCXCOVSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-[2-oxo-2-(3-phenylpyrrolidin-1-yl)ethoxy]quinoline-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC(CC2)C=2C=CC=CC=2)=C(C=CC=C2)C2=N1 DFIHHJYMWXWJSG-WKDCXCOVSA-N 0.000 claims 1
- WSUACCPHWPFBEL-NASUQTAISA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-[2-oxo-2-(3-pyridin-4-ylpyrrolidin-1-yl)ethoxy]quinoline-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC(CC2)C=2C=CN=CC=2)=C(C=CC=C2)C2=N1 WSUACCPHWPFBEL-NASUQTAISA-N 0.000 claims 1
- NWLGJZAMMBEDIG-TUXUZCGSSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-[2-oxo-2-(3-pyrrolidin-1-ylpyrrolidin-1-yl)ethoxy]quinoline-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC(CC2)N2CCCC2)=C(C=CC=C2)C2=N1 NWLGJZAMMBEDIG-TUXUZCGSSA-N 0.000 claims 1
- OKHFIGZEPFVOOT-IRSIHTCSSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-[2-oxo-2-(4-oxo-1,3,3a,5,6,6a-hexahydrocyclopenta[c]pyrrol-2-yl)ethoxy]quinoline-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC3C(=O)CCC3C2)=C(C=CC=C2)C2=N1 OKHFIGZEPFVOOT-IRSIHTCSSA-N 0.000 claims 1
- WDCJJKPGZOTLKA-QHCPKHFHSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-[2-oxo-2-(4-oxo-1,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6-yl)ethoxy]quinoline-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC=3C(=O)NC=NC=3CC2)=C(C=CC=C2)C2=N1 WDCJJKPGZOTLKA-QHCPKHFHSA-N 0.000 claims 1
- KXJWISGSRLCUQL-IBGZPJMESA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-[2-oxo-2-(4-oxoimidazolidin-1-yl)ethoxy]quinoline-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC(=O)NC2)=C(C=CC=C2)C2=N1 KXJWISGSRLCUQL-IBGZPJMESA-N 0.000 claims 1
- CBCVKKKQXQLQBX-VWLOTQADSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-[2-oxo-2-(4-propan-2-yloxypiperidin-1-yl)ethoxy]quinoline-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CCC(CC2)OC(C)C)=C(C=CC=C2)C2=N1 CBCVKKKQXQLQBX-VWLOTQADSA-N 0.000 claims 1
- CEUBQPMLTUASJV-DEOSSOPVSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-[2-oxo-2-(4-propan-2-ylpiperazin-1-yl)ethoxy]quinoline-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CCN(CC2)C(C)C)=C(C=CC=C2)C2=N1 CEUBQPMLTUASJV-DEOSSOPVSA-N 0.000 claims 1
- BVDOYLUEARFVOZ-NRFANRHFSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-[2-oxo-2-(5-oxo-1,4-diazepan-1-yl)ethoxy]quinoline-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CCC(=O)NCC2)=C(C=CC=C2)C2=N1 BVDOYLUEARFVOZ-NRFANRHFSA-N 0.000 claims 1
- LSAMBJNGLCXUJV-ROKPMTFOSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-[2-oxo-2-[(1r,5s)-3-oxo-8-azabicyclo[3.2.1]octan-8-yl]ethoxy]quinoline-2-carbonyl]amino]pentanoic acid Chemical compound O=C([C@H](CCC(O)=O)NC(=O)C=1C=C(C2=CC=CC=C2N=1)OCC(=O)N1[C@]2([H])CC[C@]1(CC(=O)C2)[H])N1CCN(C(=O)OCC)CC1 LSAMBJNGLCXUJV-ROKPMTFOSA-N 0.000 claims 1
- FAJICISULDPTIS-XTEPFMGCSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-[2-oxo-2-[(2r)-2-phenylpyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@H](CCC2)C=2C=CC=CC=2)=C(C=CC=C2)C2=N1 FAJICISULDPTIS-XTEPFMGCSA-N 0.000 claims 1
- VJXSMCCYWUYSBG-GMAHTHKFSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-[2-oxo-2-[(2s)-2-(2,2,2-trifluoroethylcarbamoyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NCC(F)(F)F)=C(C=CC=C2)C2=N1 VJXSMCCYWUYSBG-GMAHTHKFSA-N 0.000 claims 1
- BXTDKQOSDQBEQS-UGKGYDQZSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-[2-oxo-2-[(2s)-2-(2h-tetrazol-5-ylmethyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)CC=2NN=NN=2)=C(C=CC=C2)C2=N1 BXTDKQOSDQBEQS-UGKGYDQZSA-N 0.000 claims 1
- RTKHIMVDXDWUAI-XCZPVHLTSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-[2-oxo-2-[(2s)-2-(phenylcarbamoyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC=2C=CC=CC=2)=C(C=CC=C2)C2=N1 RTKHIMVDXDWUAI-XCZPVHLTSA-N 0.000 claims 1
- QFEFOMNIZBINGP-REWPJTCUSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-[2-oxo-2-[(2s)-2-(trifluoromethyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(F)(F)F)=C(C=CC=C2)C2=N1 QFEFOMNIZBINGP-REWPJTCUSA-N 0.000 claims 1
- FAJICISULDPTIS-XCZPVHLTSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-[2-oxo-2-[(2s)-2-phenylpyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C=2C=CC=CC=2)=C(C=CC=C2)C2=N1 FAJICISULDPTIS-XCZPVHLTSA-N 0.000 claims 1
- DFIHHJYMWXWJSG-IGKIAQTJSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-[2-oxo-2-[(3r)-3-phenylpyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C[C@H](CC2)C=2C=CC=CC=2)=C(C=CC=C2)C2=N1 DFIHHJYMWXWJSG-IGKIAQTJSA-N 0.000 claims 1
- DFQSOQNEESKKRB-OWJIYDKWSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-[2-oxo-2-[2-(1,3-thiazol-2-yl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2SC=CN=2)=C(C=CC=C2)C2=N1 DFQSOQNEESKKRB-OWJIYDKWSA-N 0.000 claims 1
- OEHBIYSNBJRBCS-NNTRXQOJSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-[2-oxo-2-[2-(oxolan-2-yl)piperidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCCC2)C2OCCC2)=C(C=CC=C2)C2=N1 OEHBIYSNBJRBCS-NNTRXQOJSA-N 0.000 claims 1
- BIFMSTZRZNRKRS-BPARTEKVSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-[2-oxo-2-[2-(trifluoromethoxymethyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CCC2)COC(F)(F)F)=C(C=CC=C2)C2=N1 BIFMSTZRZNRKRS-BPARTEKVSA-N 0.000 claims 1
- BAWVRGMOPFVMHH-QFIPXVFZSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-[2-oxo-2-[3-(trifluoromethyl)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl]ethoxy]quinoline-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC=3C(=NNC=3CC2)C(F)(F)F)=C(C=CC=C2)C2=N1 BAWVRGMOPFVMHH-QFIPXVFZSA-N 0.000 claims 1
- TZVBTWDCSRKUOI-ZYZRXSCRSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-[2-oxo-2-[3-(trifluoromethyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC(CC2)C(F)(F)F)=C(C=CC=C2)C2=N1 TZVBTWDCSRKUOI-ZYZRXSCRSA-N 0.000 claims 1
- DOMGZCPKCLEKAI-NASUQTAISA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-[2-oxo-2-[3-[(2-oxopyrrolidin-1-yl)methyl]piperidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC(CN3C(CCC3)=O)CCC2)=C(C=CC=C2)C2=N1 DOMGZCPKCLEKAI-NASUQTAISA-N 0.000 claims 1
- WRHPOWKSTBEXQY-SANMLTNESA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-[2-oxo-2-[4-(2-oxopiperidin-1-yl)piperidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CCC(CC2)N2C(CCCC2)=O)=C(C=CC=C2)C2=N1 WRHPOWKSTBEXQY-SANMLTNESA-N 0.000 claims 1
- VPADRCCDVMFMCO-VWLOTQADSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-[2-oxo-2-[4-(2-oxopyrrolidin-1-yl)piperidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CCC(CC2)N2C(CCC2)=O)=C(C=CC=C2)C2=N1 VPADRCCDVMFMCO-VWLOTQADSA-N 0.000 claims 1
- MCEBFWZEBZZUJQ-BDYUSTAISA-N (4s)-5-[(1-butoxycarbonylazetidin-3-yl)amino]-4-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1N(C(=O)OCCCC)CC1NC(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC=C2)C2=N1 MCEBFWZEBZZUJQ-BDYUSTAISA-N 0.000 claims 1
- IEPYGJZAWXVYBW-BDYUSTAISA-N (4s)-5-[3-(butoxycarbonylamino)azetidin-1-yl]-4-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1C(NC(=O)OCCCC)CN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC=C2)C2=N1 IEPYGJZAWXVYBW-BDYUSTAISA-N 0.000 claims 1
- FTKHPONDZFEAMK-SMCANUKXSA-N (4s)-5-[4-(3-chlorobenzoyl)piperidin-1-yl]-4-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound O=C([C@@H]1CCCN1C(=O)COC=1C=C(N=C2C=CC=CC2=1)C(=O)N[C@@H](CCC(=O)O)C(=O)N1CCC(CC1)C(=O)C=1C=C(Cl)C=CC=1)NC1CCC1 FTKHPONDZFEAMK-SMCANUKXSA-N 0.000 claims 1
- KTTMHMBSHJMNMQ-BDYUSTAISA-N (5s)-5-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-6-(4-ethoxycarbonylpiperazin-1-yl)-6-oxohexanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCCC(O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC=C2)C2=N1 KTTMHMBSHJMNMQ-BDYUSTAISA-N 0.000 claims 1
- IENYRYSYHARJTQ-YDNXMHBPSA-N 1-[2-[2-[[(2s)-4-carboxy-1-(4-ethoxycarbonylpiperazin-1-yl)-1-oxobutan-2-yl]carbamoyl]-7-methylquinolin-4-yl]oxyacetyl]-4,4-difluoropyrrolidine-2-carboxylic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CC(F)(F)C2)C(O)=O)=C(C=CC(C)=C2)C2=N1 IENYRYSYHARJTQ-YDNXMHBPSA-N 0.000 claims 1
- DTAPCGSLPWLZKS-FQEVSTJZSA-N 1-[2-[2-[[(2s)-4-carboxy-1-(4-ethoxycarbonylpiperazin-1-yl)-1-oxobutan-2-yl]carbamoyl]-7-methylquinolin-4-yl]oxyacetyl]azetidine-3-carboxylic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC(C2)C(O)=O)=C(C=CC(C)=C2)C2=N1 DTAPCGSLPWLZKS-FQEVSTJZSA-N 0.000 claims 1
- VASZIBLMRWWJEC-QFIPXVFZSA-N 1-[2-[2-[[(2s)-4-carboxy-1-(4-ethoxycarbonylpiperazin-1-yl)-1-oxobutan-2-yl]carbamoyl]-7-methylquinolin-4-yl]oxyacetyl]piperidine-4-carboxylic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CCC(CC2)C(O)=O)=C(C=CC(C)=C2)C2=N1 VASZIBLMRWWJEC-QFIPXVFZSA-N 0.000 claims 1
- BFDQZNNQQGGXOY-QWAKEFERSA-N 1-[2-[2-[[(2s)-4-carboxy-1-(4-ethoxycarbonylpiperazin-1-yl)-1-oxobutan-2-yl]carbamoyl]-7-methylquinolin-4-yl]oxyacetyl]pyrrolidine-3-carboxylic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC(CC2)C(O)=O)=C(C=CC(C)=C2)C2=N1 BFDQZNNQQGGXOY-QWAKEFERSA-N 0.000 claims 1
- SRPVQFIMLLXYME-ZQRQZVKFSA-N 1-[2-[2-[[(2s)-4-carboxy-1-(4-ethoxycarbonylpiperazin-1-yl)-1-oxobutan-2-yl]carbamoyl]quinolin-4-yl]oxyacetyl]-4,4-difluoropyrrolidine-2-carboxylic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2C(CC(F)(F)C2)C(O)=O)=C(C=CC=C2)C2=N1 SRPVQFIMLLXYME-ZQRQZVKFSA-N 0.000 claims 1
- QLPLTCSXGWKJNS-QFIPXVFZSA-N 1-[2-[2-[[(2s)-4-carboxy-1-(4-ethoxycarbonylpiperazin-1-yl)-1-oxobutan-2-yl]carbamoyl]quinolin-4-yl]oxyacetyl]piperidine-4-carboxylic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CCC(CC2)C(O)=O)=C(C=CC=C2)C2=N1 QLPLTCSXGWKJNS-QFIPXVFZSA-N 0.000 claims 1
- JMXRBYVEUHQKNA-ZYZRXSCRSA-N 1-[2-[2-[[(2s)-4-carboxy-1-(4-ethoxycarbonylpiperazin-1-yl)-1-oxobutan-2-yl]carbamoyl]quinolin-4-yl]oxyacetyl]pyrrolidine-3-carboxylic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OCC(=O)N2CC(CC2)C(O)=O)=C(C=CC=C2)C2=N1 JMXRBYVEUHQKNA-ZYZRXSCRSA-N 0.000 claims 1
- AJECNUWXLXUGAM-LSYYVWMOSA-N 4-[(2S)-2-[[4-[2-[(2S)-2-(cyclobutylcarbamoyl)-4,4-difluoropyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(2-ethoxyethoxy)-5-oxopentanoyl]piperazine-1-carboxylic acid Chemical compound C1(CCC1)NC(=O)[C@H]1N(CC(C1)(F)F)C(COC1=CC(=NC2=CC(=CC=C12)C)C(=O)N[C@H](C(=O)N1CCN(CC1)C(=O)O)CCC(=O)OCCOCC)=O AJECNUWXLXUGAM-LSYYVWMOSA-N 0.000 claims 1
- ZRCJXAZSTFEFLZ-DHLKQENFSA-N 4-[(2S)-2-[[4-[2-[(2S)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-4-(2-oxo-3H-1,3,4-oxadiazol-5-yl)butanoyl]piperazine-1-carboxylic acid Chemical compound C1(CCC1)NC(=O)[C@H]1N(CCC1)C(COC1=CC(=NC2=CC(=CC=C12)C)C(=O)N[C@H](C(=O)N1CCN(CC1)C(=O)O)CCC=1OC(NN=1)=O)=O ZRCJXAZSTFEFLZ-DHLKQENFSA-N 0.000 claims 1
- BYALJIWKNMRFJO-XWUYKKJTSA-N 4-[(2S)-2-[[4-[2-[(2S)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(1-morpholin-4-ylbutan-2-yloxy)-5-oxopentanoyl]piperazine-1-carboxylic acid Chemical compound C1(CCC1)NC(=O)[C@H]1N(CCC1)C(COC1=CC(=NC2=CC(=CC=C12)C)C(=O)N[C@H](C(=O)N1CCN(CC1)C(=O)O)CCC(=O)OC(CC)CN1CCOCC1)=O BYALJIWKNMRFJO-XWUYKKJTSA-N 0.000 claims 1
- FBCDIABICYBCIB-KKEGNHTRSA-N 4-[(2S)-2-[[4-[2-[(2S)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(1-morpholin-4-ylpropan-2-yloxy)-5-oxopentanoyl]piperazine-1-carboxylic acid Chemical compound C1(CCC1)NC(=O)[C@H]1N(CCC1)C(COC1=CC(=NC2=CC(=CC=C12)C)C(=O)N[C@H](C(=O)N1CCN(CC1)C(=O)O)CCC(=O)OC(CN1CCOCC1)C)=O FBCDIABICYBCIB-KKEGNHTRSA-N 0.000 claims 1
- YAQPSMLMEZXHBH-KVPHSSHNSA-N 4-[(2S)-2-[[4-[2-[(2S)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(oxan-3-ylmethoxy)-5-oxopentanoyl]piperazine-1-carboxylic acid Chemical compound C1(CCC1)NC(=O)[C@H]1N(CCC1)C(COC1=CC(=NC2=CC(=CC=C12)C)C(=O)N[C@H](C(=O)N1CCN(CC1)C(=O)O)CCC(=O)OCC1COCCC1)=O YAQPSMLMEZXHBH-KVPHSSHNSA-N 0.000 claims 1
- MNRBDVYVSZCXOI-IZEXYCQBSA-N 4-[(2S)-2-[[4-[2-[(2S)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(oxan-4-ylmethoxy)-5-oxopentanoyl]piperazine-1-carboxylic acid Chemical compound C1(CCC1)NC(=O)[C@H]1N(CCC1)C(COC1=CC(=NC2=CC(=CC=C12)C)C(=O)N[C@H](C(=O)N1CCN(CC1)C(=O)O)CCC(=O)OCC1CCOCC1)=O MNRBDVYVSZCXOI-IZEXYCQBSA-N 0.000 claims 1
- QJAXLXGBCHTSCG-WNJJXGMVSA-N 4-[(2S)-2-[[4-[2-[(2S)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-[(3-methyloxetan-3-yl)methoxy]-5-oxopentanoyl]piperazine-1-carboxylic acid Chemical compound C1(CCC1)NC(=O)[C@H]1N(CCC1)C(COC1=CC(=NC2=CC(=CC=C12)C)C(=O)N[C@H](C(=O)N1CCN(CC1)C(=O)O)CCC(=O)OCC1(COC1)C)=O QJAXLXGBCHTSCG-WNJJXGMVSA-N 0.000 claims 1
- JLZOXYQEKWRJCK-FIBWVYCGSA-N 4-[(2S)-2-[[4-[2-[(2S)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-[2-(dimethylamino)-2-methylpropoxy]-5-oxopentanoyl]piperazine-1-carboxylic acid Chemical compound C1(CCC1)NC(=O)[C@H]1N(CCC1)C(COC1=CC(=NC2=CC(=CC=C12)C)C(=O)N[C@H](C(=O)N1CCN(CC1)C(=O)O)CCC(=O)OCC(C)(C)N(C)C)=O JLZOXYQEKWRJCK-FIBWVYCGSA-N 0.000 claims 1
- ZOTOBSOXLICBBW-ODONTMFISA-N 4-[(2S)-5-[[(1R,4S)-2-bicyclo[2.2.1]heptanyl]methoxy]-2-[[4-[2-[(2S)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoyl]piperazine-1-carboxylic acid Chemical compound O=C([C@@H]1CCCN1C(=O)COC=1C=C(N=C2C=C(C)C=CC2=1)C(=O)N[C@@H](CCC(=O)OCC1[C@]2([H])CC[C@@](C2)(C1)[H])C(=O)N1CCN(CC1)C(O)=O)NC1CCC1 ZOTOBSOXLICBBW-ODONTMFISA-N 0.000 claims 1
- KCNKJCHARANTIP-SNAWJCMRSA-N allyl-{4-[3-(4-bromo-phenyl)-benzofuran-6-yloxy]-but-2-enyl}-methyl-amine Chemical group C=1OC2=CC(OC/C=C/CN(CC=C)C)=CC=C2C=1C1=CC=C(Br)C=C1 KCNKJCHARANTIP-SNAWJCMRSA-N 0.000 claims 1
- UEBQAOCKPLMOBT-NSOVKSMOSA-N butyl 4-[(2r)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-3-fluoropropanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CF)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 UEBQAOCKPLMOBT-NSOVKSMOSA-N 0.000 claims 1
- REIYICAQKXSXKQ-XWJWOQKWSA-N butyl 4-[(2s)-2-[[4-[(2r)-1-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-1-oxopropan-2-yl]oxy-7-methylquinoline-2-carbonyl]amino]-4-hydroxybutanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCO)NC(=O)C1=CC(O[C@H](C)C(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 REIYICAQKXSXKQ-XWJWOQKWSA-N 0.000 claims 1
- LYRHGGNGZNFCPF-SANMLTNESA-N butyl 4-[(2s)-2-[[4-[2-(3,3-difluoropyrrolidin-1-yl)-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(2-ethoxyethoxy)-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(=O)OCCOCC)NC(=O)C1=CC(OCC(=O)N2CC(F)(F)CC2)=C(C=CC(C)=C2)C2=N1 LYRHGGNGZNFCPF-SANMLTNESA-N 0.000 claims 1
- JFQVZYWVVZFZMY-ZPGRZCPFSA-N butyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylnaphthalene-2-carbonyl]amino]-5-(cyclopentylmethoxy)-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@@H](NC(=O)C=1C=C2C=C(C)C=CC2=C(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)C=1)CCC(=O)OCC1CCCC1 JFQVZYWVVZFZMY-ZPGRZCPFSA-N 0.000 claims 1
- DOEGZLDXTLDWAQ-ACHIHNKUSA-N butyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylnaphthalene-2-carbonyl]amino]-5-ethoxy-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(=O)OCC)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=C1 DOEGZLDXTLDWAQ-ACHIHNKUSA-N 0.000 claims 1
- UNOXJNXIZDTYHO-CONSDPRKSA-N butyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylnaphthalene-2-carbonyl]amino]-5-methoxy-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(=O)OC)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=C1 UNOXJNXIZDTYHO-CONSDPRKSA-N 0.000 claims 1
- BEYWPAPEHVRCQR-CONSDPRKSA-N butyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-3-cyclopropylpropanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@@H](NC(=O)C=1N=C2C=C(C)C=CC2=C(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)C=1)CC1CC1 BEYWPAPEHVRCQR-CONSDPRKSA-N 0.000 claims 1
- AJZCRSIXTBZEPZ-KYJUHHDHSA-N butyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-3-ethoxypropanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](COCC)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 AJZCRSIXTBZEPZ-KYJUHHDHSA-N 0.000 claims 1
- APYOVRGGRCRMQL-QCENPCRXSA-N butyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-3-hydroxy-3-methylbutanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](C(C)(C)O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 APYOVRGGRCRMQL-QCENPCRXSA-N 0.000 claims 1
- IEPRSILLVXTIIZ-NSOVKSMOSA-N butyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-3-hydroxypropanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CO)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 IEPRSILLVXTIIZ-NSOVKSMOSA-N 0.000 claims 1
- XWPHCBFDHPNDHY-VMPREFPWSA-N butyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-3-methoxypropanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](COC)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 XWPHCBFDHPNDHY-VMPREFPWSA-N 0.000 claims 1
- IHWNKTBIHOEVSE-NSOVKSMOSA-N butyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-4,4-difluorobutanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CC(F)F)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 IHWNKTBIHOEVSE-NSOVKSMOSA-N 0.000 claims 1
- KXBOXRFDFHPCAB-WNJJXGMVSA-N butyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-4-(2h-tetrazol-5-yl)butanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@@H](NC(=O)C=1N=C2C=C(C)C=CC2=C(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)C=1)CCC1=NNN=N1 KXBOXRFDFHPCAB-WNJJXGMVSA-N 0.000 claims 1
- IFCOISJMMCWJME-WNJJXGMVSA-N butyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-4-hydroxybutanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCO)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 IFCOISJMMCWJME-WNJJXGMVSA-N 0.000 claims 1
- KYBRXHAFUFBFOD-DITALETJSA-N butyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(2-ethoxyethoxy)-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(=O)OCCOCC)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 KYBRXHAFUFBFOD-DITALETJSA-N 0.000 claims 1
- CUWAGLCKLUIULY-SHUZPENHSA-N butyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(cyclopentylmethoxy)-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@@H](NC(=O)C=1N=C2C=C(C)C=CC2=C(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)C=1)CCC(=O)OCC1CCCC1 CUWAGLCKLUIULY-SHUZPENHSA-N 0.000 claims 1
- ISEGEXXTBTYKGY-VBTAUBHQSA-N butyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-[(3-ethyloxetan-3-yl)methoxy]-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@@H](NC(=O)C=1N=C2C=C(C)C=CC2=C(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)C=1)CCC(=O)OCC1(CC)COC1 ISEGEXXTBTYKGY-VBTAUBHQSA-N 0.000 claims 1
- MXSGIMGOBDLYQY-IZEXYCQBSA-N butyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-ethoxy-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(=O)OCC)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 MXSGIMGOBDLYQY-IZEXYCQBSA-N 0.000 claims 1
- DAHAQZUCFZTWRO-FIBWVYCGSA-N butyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-hydroxypentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCCO)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 DAHAQZUCFZTWRO-FIBWVYCGSA-N 0.000 claims 1
- LXKRHZWWEBZBNT-FIBWVYCGSA-N butyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-methoxy-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(=O)OC)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 LXKRHZWWEBZBNT-FIBWVYCGSA-N 0.000 claims 1
- ANUJWMLMSBBCNS-WNJJXGMVSA-N butyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]butanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CC)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 ANUJWMLMSBBCNS-WNJJXGMVSA-N 0.000 claims 1
- PHTPLCXBZORIHH-FIPFOOKPSA-N butyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]propanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](C)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 PHTPLCXBZORIHH-FIPFOOKPSA-N 0.000 claims 1
- RHZFEEYYWWEJGN-XCZPVHLTSA-N butyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-4-hydroxybutanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCO)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC=C2)C2=N1 RHZFEEYYWWEJGN-XCZPVHLTSA-N 0.000 claims 1
- DQFLQJLRUMDLRS-TWJUONSBSA-N butyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-(cyclopentylmethoxy)-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@@H](NC(=O)C=1N=C2C=CC=CC2=C(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)C=1)CCC(=O)OCC1CCCC1 DQFLQJLRUMDLRS-TWJUONSBSA-N 0.000 claims 1
- VRXZEWYLJBOBEI-VBTAUBHQSA-N butyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylmethylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(2-ethoxyethoxy)-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(=O)OCCOCC)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NCC2CCC2)=C(C=CC(C)=C2)C2=N1 VRXZEWYLJBOBEI-VBTAUBHQSA-N 0.000 claims 1
- YLMCJIHZIOEXMB-JUKUECOXSA-N butyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylmethylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(cyclopentylmethoxy)-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@@H](NC(=O)C=1N=C2C=C(C)C=CC2=C(OCC(=O)N2[C@@H](CCC2)C(=O)NCC2CCC2)C=1)CCC(=O)OCC1CCCC1 YLMCJIHZIOEXMB-JUKUECOXSA-N 0.000 claims 1
- HNLKIKZNQWTIDB-NYDCQLBNSA-N butyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclopropylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(2-ethoxyethoxy)-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(=O)OCCOCC)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CC2)=C(C=CC(C)=C2)C2=N1 HNLKIKZNQWTIDB-NYDCQLBNSA-N 0.000 claims 1
- HSHAXUMKJDYFAF-VBTAUBHQSA-N butyl 4-[(2s)-2-[[4-[2-[(2s)-2-[cyclobutyl(methyl)carbamoyl]pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(2-ethoxyethoxy)-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(=O)OCCOCC)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)N(C)C2CCC2)=C(C=CC(C)=C2)C2=N1 HSHAXUMKJDYFAF-VBTAUBHQSA-N 0.000 claims 1
- OYACYMDHIVGLIM-JUKUECOXSA-N butyl 4-[(2s)-2-[[4-[2-[(2s)-2-[cyclobutyl(methyl)carbamoyl]pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(cyclopentylmethoxy)-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@@H](NC(=O)C=1N=C2C=C(C)C=CC2=C(OCC(=O)N2[C@@H](CCC2)C(=O)N(C)C2CCC2)C=1)CCC(=O)OCC1CCCC1 OYACYMDHIVGLIM-JUKUECOXSA-N 0.000 claims 1
- HBRRMGRVQRMPDF-UPVQGACJSA-N butyl 4-[(2s)-2-[[4-[2-[(2s)-2-cyanopyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-4-(2h-tetrazol-5-yl)butanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@@H](NC(=O)C=1N=C2C=C(C)C=CC2=C(OCC(=O)N2[C@@H](CCC2)C#N)C=1)CCC1=NNN=N1 HBRRMGRVQRMPDF-UPVQGACJSA-N 0.000 claims 1
- UJISYUKNEVSREP-ACHIHNKUSA-N butyl 4-[(2s)-3-cyclobutyl-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]propanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@@H](NC(=O)C=1N=C2C=C(C)C=CC2=C(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)C=1)CC1CCC1 UJISYUKNEVSREP-ACHIHNKUSA-N 0.000 claims 1
- WNIAQVDTTIYRGQ-YTMVLYRLSA-N butyl 4-[(2s)-5-(2-ethoxyethoxy)-2-[[4-[2-[(2s)-2-(methoxymethyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(=O)OCCOCC)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)COC)=C(C=CC(C)=C2)C2=N1 WNIAQVDTTIYRGQ-YTMVLYRLSA-N 0.000 claims 1
- NTODJZUIAJVHER-VPUSJEBWSA-N butyl 4-[(2s)-5-(2-ethoxyethoxy)-2-[[4-[2-[(3r)-3-hydroxypyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(=O)OCCOCC)NC(=O)C1=CC(OCC(=O)N2C[C@H](O)CC2)=C(C=CC(C)=C2)C2=N1 NTODJZUIAJVHER-VPUSJEBWSA-N 0.000 claims 1
- QCKOFUWDRAEMQF-SHUZPENHSA-N butyl 4-[(2s)-5-(2-ethoxyethoxy)-2-[[7-methyl-4-[2-oxo-2-[(2s)-2-phenylpyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(=O)OCCOCC)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C=2C=CC=CC=2)=C(C=CC(C)=C2)C2=N1 QCKOFUWDRAEMQF-SHUZPENHSA-N 0.000 claims 1
- PNLFGPJKQCPYKH-NDEPHWFRSA-N butyl 4-[(2s)-5-(cyclopentylmethoxy)-2-[[4-[2-(3,3-difluoropyrrolidin-1-yl)-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@@H](NC(=O)C=1N=C2C=C(C)C=CC2=C(OCC(=O)N2CC(F)(F)CC2)C=1)CCC(=O)OCC1CCCC1 PNLFGPJKQCPYKH-NDEPHWFRSA-N 0.000 claims 1
- ZSPIMQDBBJPNGS-VBTAUBHQSA-N butyl 4-[(2s)-5-(cyclopentylmethoxy)-2-[[4-[2-[(2s)-2-(cyclopropylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@@H](NC(=O)C=1N=C2C=C(C)C=CC2=C(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CC2)C=1)CCC(=O)OCC1CCCC1 ZSPIMQDBBJPNGS-VBTAUBHQSA-N 0.000 claims 1
- OGPGTLDHCZPTNM-SMCANUKXSA-N butyl 4-[(2s)-5-(cyclopentylmethoxy)-2-[[4-[2-[(2s)-2-(methoxymethyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@@H](NC(=O)C=1N=C2C=C(C)C=CC2=C(OCC(=O)N2[C@@H](CCC2)COC)C=1)CCC(=O)OCC1CCCC1 OGPGTLDHCZPTNM-SMCANUKXSA-N 0.000 claims 1
- VHNNUSCAGUEGKN-PXJZQJOASA-N butyl 4-[(2s)-5-(cyclopentylmethoxy)-2-[[4-[2-[(3r)-3-hydroxypyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@@H](NC(=O)C=1N=C2C=C(C)C=CC2=C(OCC(=O)N2C[C@H](O)CC2)C=1)CCC(=O)OCC1CCCC1 VHNNUSCAGUEGKN-PXJZQJOASA-N 0.000 claims 1
- UAMKIXYYPDLDSF-UNVMMQEESA-N butyl 4-[(2s)-5-(cyclopentylmethoxy)-2-[[7-methyl-4-[2-oxo-2-[(2s)-2-phenylpyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@@H](NC(=O)C=1N=C2C=C(C)C=CC2=C(OCC(=O)N2[C@@H](CCC2)C=2C=CC=CC=2)C=1)CCC(=O)OCC1CCCC1 UAMKIXYYPDLDSF-UNVMMQEESA-N 0.000 claims 1
- DHAIVSINFKJYSO-YEOMKBMOSA-N butyl 4-[(2s,3r)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-3-methoxybutanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H]([C@@H](C)OC)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 DHAIVSINFKJYSO-YEOMKBMOSA-N 0.000 claims 1
- WPFDXUHQIDAOHW-DYMXRVJRSA-N butyl 4-[(2s,3s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-3-methylpentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H]([C@@H](C)CC)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 WPFDXUHQIDAOHW-DYMXRVJRSA-N 0.000 claims 1
- BZGIAWMXMFAFAG-LXFBAYGMSA-N butyl 4-[2-[[4-[(2r)-1-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-1-oxopropan-2-yl]oxy-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(O[C@H](C)C(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 BZGIAWMXMFAFAG-LXFBAYGMSA-N 0.000 claims 1
- WIRGEISUMYKRRH-UHFFFAOYSA-N butyl 4-[2-[[4-[2-(2,4-dioxo-1,3,8-triazaspiro[4.5]decan-8-yl)-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CCC3(CC2)C(NC(=O)N3)=O)=C(C=CC(C)=C2)C2=N1 WIRGEISUMYKRRH-UHFFFAOYSA-N 0.000 claims 1
- BAUARULBZWXDPT-UHFFFAOYSA-N butyl 4-[2-[[4-[2-(2,4-dioxo-1,3,9-triazaspiro[4.5]decan-9-yl)-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CC3(CCC2)C(NC(=O)N3)=O)=C(C=CC(C)=C2)C2=N1 BAUARULBZWXDPT-UHFFFAOYSA-N 0.000 claims 1
- PLOQFTPDZDMLCC-UHFFFAOYSA-N butyl 4-[2-[[4-[2-(3,3-difluoropiperidin-1-yl)-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CC(F)(F)CCC2)=C(C=CC(C)=C2)C2=N1 PLOQFTPDZDMLCC-UHFFFAOYSA-N 0.000 claims 1
- IGXNOJJMMVTWKF-UHFFFAOYSA-N butyl 4-[2-[[4-[2-(3,3-difluoropyrrolidin-1-yl)-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CC(F)(F)CC2)=C(C=CC(C)=C2)C2=N1 IGXNOJJMMVTWKF-UHFFFAOYSA-N 0.000 claims 1
- IUHQTVWOTYSQAD-UHFFFAOYSA-N butyl 4-[2-[[4-[2-(3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl)-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CC3CCCN3CC2)=C(C=CC(C)=C2)C2=N1 IUHQTVWOTYSQAD-UHFFFAOYSA-N 0.000 claims 1
- OUCSCFRYMAOYDR-UHFFFAOYSA-N butyl 4-[2-[[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CC(O)C2)=C(C=CC(C)=C2)C2=N1 OUCSCFRYMAOYDR-UHFFFAOYSA-N 0.000 claims 1
- SIHSPNLMQBREDJ-UHFFFAOYSA-N butyl 4-[2-[[4-[2-(3-methoxypyrrolidin-1-yl)-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CC(CC2)OC)=C(C=CC(C)=C2)C2=N1 SIHSPNLMQBREDJ-UHFFFAOYSA-N 0.000 claims 1
- WBYKYRNKVZMLOS-UHFFFAOYSA-N butyl 4-[2-[[4-[2-(4,4-difluoropiperidin-1-yl)-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CCC(F)(F)CC2)=C(C=CC(C)=C2)C2=N1 WBYKYRNKVZMLOS-UHFFFAOYSA-N 0.000 claims 1
- FHYLQYXNVGLWNT-UHFFFAOYSA-N butyl 4-[2-[[4-[2-(4,6-dihydro-1h-pyrrolo[3,4-c]pyrazol-5-yl)-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CC=3NN=CC=3C2)=C(C=CC(C)=C2)C2=N1 FHYLQYXNVGLWNT-UHFFFAOYSA-N 0.000 claims 1
- REVXDAADLXCGMG-UHFFFAOYSA-N butyl 4-[2-[[4-[2-(4-cyclopropylpiperazin-1-yl)-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CCN(CC2)C2CC2)=C(C=CC(C)=C2)C2=N1 REVXDAADLXCGMG-UHFFFAOYSA-N 0.000 claims 1
- FSOSSNOVZQUVOY-UHFFFAOYSA-N butyl 4-[2-[[4-[2-(4-ethoxycarbonylpiperazin-1-yl)-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CCN(CC2)C(=O)OCC)=C(C=CC(C)=C2)C2=N1 FSOSSNOVZQUVOY-UHFFFAOYSA-N 0.000 claims 1
- DQXFEZKTSWYLNK-UHFFFAOYSA-N butyl 4-[2-[[4-[2-(4-ethylpiperazin-1-yl)-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CCN(CC)CC2)=C(C=CC(C)=C2)C2=N1 DQXFEZKTSWYLNK-UHFFFAOYSA-N 0.000 claims 1
- ZWNWGGUXAFLUFG-UHFFFAOYSA-N butyl 4-[2-[[4-[2-(4-hydroxypiperidin-1-yl)-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CCC(O)CC2)=C(C=CC(C)=C2)C2=N1 ZWNWGGUXAFLUFG-UHFFFAOYSA-N 0.000 claims 1
- GWZKHCMWPLJCEU-UHFFFAOYSA-N butyl 4-[2-[[4-[2-(4-methoxycarbonylpiperazin-1-yl)-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CCN(CC2)C(=O)OC)=C(C=CC(C)=C2)C2=N1 GWZKHCMWPLJCEU-UHFFFAOYSA-N 0.000 claims 1
- UYFXGNDHHVFSGF-OAQYLSRUSA-N butyl 4-[2-[[4-[2-[(2r)-2-(hydroxymethyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@H](CCC2)CO)=C(C=CC(C)=C2)C2=N1 UYFXGNDHHVFSGF-OAQYLSRUSA-N 0.000 claims 1
- AQSBEFWMVGGCRX-MHZLTWQESA-N butyl 4-[2-[[4-[2-[(2s)-2-(4,4-difluoropiperidine-1-carbonyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)N2CCC(F)(F)CC2)=C(C=CC(C)=C2)C2=N1 AQSBEFWMVGGCRX-MHZLTWQESA-N 0.000 claims 1
- MGKDBAGSNRRZCP-MHZLTWQESA-N butyl 4-[2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methoxyquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(OC)=C2)C2=N1 MGKDBAGSNRRZCP-MHZLTWQESA-N 0.000 claims 1
- DBBVOLMRCCJLES-NDEPHWFRSA-N butyl 4-[2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]-methylamino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CN(C)C(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 DBBVOLMRCCJLES-NDEPHWFRSA-N 0.000 claims 1
- SIKUDYLDBXAECB-PTYUOYDSSA-N butyl 4-[2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-2-(oxan-4-yl)acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)C(C1CCOCC1)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 SIKUDYLDBXAECB-PTYUOYDSSA-N 0.000 claims 1
- VZIYSDXSRKWMAH-HLJRPHAASA-N butyl 4-[2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-2-(oxolan-3-yl)acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)C(C1COCC1)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 VZIYSDXSRKWMAH-HLJRPHAASA-N 0.000 claims 1
- WAVGDYBUJGTNJH-MHZLTWQESA-N butyl 4-[2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 WAVGDYBUJGTNJH-MHZLTWQESA-N 0.000 claims 1
- MDLVIUPOMNITBW-NDEPHWFRSA-N butyl 4-[2-[[4-[2-[(2s)-2-(cyclopentylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCCC2)=C(C=CC(C)=C2)C2=N1 MDLVIUPOMNITBW-NDEPHWFRSA-N 0.000 claims 1
- IVPNHVPGLUWOPE-SANMLTNESA-N butyl 4-[2-[[4-[2-[(2s)-2-(cyclopropylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CC2)=C(C=CC(C)=C2)C2=N1 IVPNHVPGLUWOPE-SANMLTNESA-N 0.000 claims 1
- BEKZIOIPPSQIBH-MHZLTWQESA-N butyl 4-[2-[[4-[2-[(2s)-2-(cyclopropylmethylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NCC2CC2)=C(C=CC(C)=C2)C2=N1 BEKZIOIPPSQIBH-MHZLTWQESA-N 0.000 claims 1
- GFKDEHLHVGZKSQ-QFIPXVFZSA-N butyl 4-[2-[[4-[2-[(2s)-2-(methoxymethyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)COC)=C(C=CC(C)=C2)C2=N1 GFKDEHLHVGZKSQ-QFIPXVFZSA-N 0.000 claims 1
- SINZFBYIWYVAQB-QSAPEBAKSA-N butyl 4-[2-[[4-[2-[(2s)-2-[(2,2-difluorocyclopropyl)carbamoyl]pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2C(C2)(F)F)=C(C=CC(C)=C2)C2=N1 SINZFBYIWYVAQB-QSAPEBAKSA-N 0.000 claims 1
- JUVMQYBDFCGFBU-NRFANRHFSA-N butyl 4-[2-[[4-[2-[(2s)-2-cyanopyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C#N)=C(C=CC(C)=C2)C2=N1 JUVMQYBDFCGFBU-NRFANRHFSA-N 0.000 claims 1
- FGYLZAPSORGPEK-VWLOTQADSA-N butyl 4-[2-[[4-[2-[(2s)-2-ethoxycarbonylpyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)OCC)=C(C=CC(C)=C2)C2=N1 FGYLZAPSORGPEK-VWLOTQADSA-N 0.000 claims 1
- CKOPCJWUPXIUGP-SFTDATJTSA-N butyl 4-[2-[[4-[2-[(2s,4s)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](C[C@H](F)C2)C#N)=C(C=CC(C)=C2)C2=N1 CKOPCJWUPXIUGP-SFTDATJTSA-N 0.000 claims 1
- JFUCZERPRXHDAG-CONSDPRKSA-N butyl 4-[2-[[4-[2-[(2s,5s)-2,5-bis(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CC[C@H]2C(=O)NC2CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 JFUCZERPRXHDAG-CONSDPRKSA-N 0.000 claims 1
- KFEDYSLGEPJPQX-JOCHJYFZSA-N butyl 4-[2-[[4-[2-[(3r)-3-(dimethylamino)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2C[C@@H](CC2)N(C)C)=C(C=CC(C)=C2)C2=N1 KFEDYSLGEPJPQX-JOCHJYFZSA-N 0.000 claims 1
- VMWFLZLMBIRPDK-JOCHJYFZSA-N butyl 4-[2-[[4-[2-[(3r)-3-acetamidopyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2C[C@@H](CC2)NC(C)=O)=C(C=CC(C)=C2)C2=N1 VMWFLZLMBIRPDK-JOCHJYFZSA-N 0.000 claims 1
- MOOKTVPGDYDHLI-HXUWFJFHSA-N butyl 4-[2-[[4-[2-[(3r)-3-hydroxypyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2C[C@H](O)CC2)=C(C=CC(C)=C2)C2=N1 MOOKTVPGDYDHLI-HXUWFJFHSA-N 0.000 claims 1
- KFEDYSLGEPJPQX-QFIPXVFZSA-N butyl 4-[2-[[4-[2-[(3s)-3-(dimethylamino)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2C[C@H](CC2)N(C)C)=C(C=CC(C)=C2)C2=N1 KFEDYSLGEPJPQX-QFIPXVFZSA-N 0.000 claims 1
- MOOKTVPGDYDHLI-FQEVSTJZSA-N butyl 4-[2-[[4-[2-[(3s)-3-hydroxypyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2C[C@@H](O)CC2)=C(C=CC(C)=C2)C2=N1 MOOKTVPGDYDHLI-FQEVSTJZSA-N 0.000 claims 1
- APEURLPFSYYPFZ-UHFFFAOYSA-N butyl 4-[2-[[4-[2-[2-(1h-benzimidazol-2-yl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2NC3=CC=CC=C3N=2)=C(C=CC(C)=C2)C2=N1 APEURLPFSYYPFZ-UHFFFAOYSA-N 0.000 claims 1
- XVFIBZMWDHINQJ-UHFFFAOYSA-N butyl 4-[2-[[4-[2-[2-(1h-indol-2-yl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2NC3=CC=CC=C3C=2)=C(C=CC(C)=C2)C2=N1 XVFIBZMWDHINQJ-UHFFFAOYSA-N 0.000 claims 1
- JHRWXHFXWLVSAA-UHFFFAOYSA-N butyl 4-[2-[[4-[2-[2-(2,4-difluorophenyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2C(=CC(F)=CC=2)F)=C(C=CC(C)=C2)C2=N1 JHRWXHFXWLVSAA-UHFFFAOYSA-N 0.000 claims 1
- JMEFTHBWKSXJPM-UHFFFAOYSA-N butyl 4-[2-[[4-[2-[2-(3,4-difluorophenyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2C=C(F)C(F)=CC=2)=C(C=CC(C)=C2)C2=N1 JMEFTHBWKSXJPM-UHFFFAOYSA-N 0.000 claims 1
- OLPOMPBWMDPUKO-UHFFFAOYSA-N butyl 4-[2-[[4-[2-[2-(4-fluorophenyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2C=CC(F)=CC=2)=C(C=CC(C)=C2)C2=N1 OLPOMPBWMDPUKO-UHFFFAOYSA-N 0.000 claims 1
- JLVIRAPKCXUCAD-UHFFFAOYSA-N butyl 4-[2-[[4-[2-[2-(furan-2-yl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2OC=CC=2)=C(C=CC(C)=C2)C2=N1 JLVIRAPKCXUCAD-UHFFFAOYSA-N 0.000 claims 1
- VQADWKYXOYILGI-UHFFFAOYSA-N butyl 4-[2-[[4-[2-[4-(2-hydroxyethyl)piperazin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CCN(CCO)CC2)=C(C=CC(C)=C2)C2=N1 VQADWKYXOYILGI-UHFFFAOYSA-N 0.000 claims 1
- XJRKRHORGWJFJY-UHFFFAOYSA-N butyl 4-[2-[[4-[2-[4-(2-methoxyethyl)piperazin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CCN(CCOC)CC2)=C(C=CC(C)=C2)C2=N1 XJRKRHORGWJFJY-UHFFFAOYSA-N 0.000 claims 1
- WBZXGCBSNAHLOJ-UHFFFAOYSA-N butyl 4-[2-[[4-[2-[4-(cyclopropylmethyl)piperazin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CCN(CC3CC3)CC2)=C(C=CC(C)=C2)C2=N1 WBZXGCBSNAHLOJ-UHFFFAOYSA-N 0.000 claims 1
- WKWAOKKDLIGYNZ-UHFFFAOYSA-N butyl 4-[2-[[7-methyl-4-(2-oxo-2-piperazin-1-ylethoxy)quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CCNCC2)=C(C=CC(C)=C2)C2=N1 WKWAOKKDLIGYNZ-UHFFFAOYSA-N 0.000 claims 1
- ROUPQJMTCUOWJZ-UHFFFAOYSA-N butyl 4-[2-[[7-methyl-4-[2-(4-methyl-3-oxopiperazin-1-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CC(=O)N(C)CC2)=C(C=CC(C)=C2)C2=N1 ROUPQJMTCUOWJZ-UHFFFAOYSA-N 0.000 claims 1
- BLPZSFSJYAWTQD-UHFFFAOYSA-N butyl 4-[2-[[7-methyl-4-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CCN(C)CC2)=C(C=CC(C)=C2)C2=N1 BLPZSFSJYAWTQD-UHFFFAOYSA-N 0.000 claims 1
- IRXISIFWONQCPK-LJAQVGFWSA-N butyl 4-[2-[[7-methyl-4-[2-[(2s)-2-(5-methylpyridin-3-yl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C=2C=C(C)C=NC=2)=C(C=CC(C)=C2)C2=N1 IRXISIFWONQCPK-LJAQVGFWSA-N 0.000 claims 1
- HUIZPUNBZHVWRE-MHZLTWQESA-N butyl 4-[2-[[7-methyl-4-[2-[(2s)-2-(morpholine-4-carbonyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)N2CCOCC2)=C(C=CC(C)=C2)C2=N1 HUIZPUNBZHVWRE-MHZLTWQESA-N 0.000 claims 1
- TXMWEYZMAKKPLL-QHCPKHFHSA-N butyl 4-[2-[[7-methyl-4-[2-[(3s)-3-[(2-methylpropan-2-yl)oxycarbonylamino]pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2C[C@H](CC2)NC(=O)OC(C)(C)C)=C(C=CC(C)=C2)C2=N1 TXMWEYZMAKKPLL-QHCPKHFHSA-N 0.000 claims 1
- DSJUSCBMWJYQAV-UHFFFAOYSA-N butyl 4-[2-[[7-methyl-4-[2-[2-(3-methyl-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2C(CCC2)C=2ON=C(C)N=2)=C(C=CC(C)=C2)C2=N1 DSJUSCBMWJYQAV-UHFFFAOYSA-N 0.000 claims 1
- BLLUTMFQVZICSU-UHFFFAOYSA-N butyl 4-[2-[[7-methyl-4-[2-[4-(2-methylpropyl)piperazin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CCN(CC(C)C)CC2)=C(C=CC(C)=C2)C2=N1 BLLUTMFQVZICSU-UHFFFAOYSA-N 0.000 claims 1
- DHKVLKWLKKMLHY-UHFFFAOYSA-N butyl 4-[2-[[7-methyl-4-[2-oxo-2-(3-oxo-5,7-dihydro-4h-[1,2]oxazolo[5,4-c]pyridin-6-yl)ethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CC=3ON=C(O)C=3CC2)=C(C=CC(C)=C2)C2=N1 DHKVLKWLKKMLHY-UHFFFAOYSA-N 0.000 claims 1
- OATDRARCMQJXRV-UHFFFAOYSA-N butyl 4-[2-[[7-methyl-4-[2-oxo-2-(3-oxopiperazin-1-yl)ethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CC(=O)NCC2)=C(C=CC(C)=C2)C2=N1 OATDRARCMQJXRV-UHFFFAOYSA-N 0.000 claims 1
- NJBWGJICASICKC-UHFFFAOYSA-N butyl 4-[2-[[7-methyl-4-[2-oxo-2-(3-oxopyrazolidin-1-yl)ethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2NC(=O)CC2)=C(C=CC(C)=C2)C2=N1 NJBWGJICASICKC-UHFFFAOYSA-N 0.000 claims 1
- ISCCKMNDMMGKHU-UHFFFAOYSA-N butyl 4-[2-[[7-methyl-4-[2-oxo-2-(3-oxopyrrolidin-1-yl)ethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CC(=O)CC2)=C(C=CC(C)=C2)C2=N1 ISCCKMNDMMGKHU-UHFFFAOYSA-N 0.000 claims 1
- KWWRUSQUOJIYCU-UHFFFAOYSA-N butyl 4-[2-[[7-methyl-4-[2-oxo-2-(4-oxo-1,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6-yl)ethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CC=3C(=O)NC=NC=3CC2)=C(C=CC(C)=C2)C2=N1 KWWRUSQUOJIYCU-UHFFFAOYSA-N 0.000 claims 1
- DUFXGRSSDVYXHB-UHFFFAOYSA-N butyl 4-[2-[[7-methyl-4-[2-oxo-2-(6-oxo-1,3,4,7,8,8a-hexahydropyrrolo[1,2-a]pyrazin-2-yl)ethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CC3N(C(CC3)=O)CC2)=C(C=CC(C)=C2)C2=N1 DUFXGRSSDVYXHB-UHFFFAOYSA-N 0.000 claims 1
- QKPJEJBEUFIUBQ-LJAQVGFWSA-N butyl 4-[2-[[7-methyl-4-[2-oxo-2-[(2s)-2-(phenylcarbamoyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC=2C=CC=CC=2)=C(C=CC(C)=C2)C2=N1 QKPJEJBEUFIUBQ-LJAQVGFWSA-N 0.000 claims 1
- JPCVEAXQUFJOKO-NDEPHWFRSA-N butyl 4-[2-[[7-methyl-4-[2-oxo-2-[(2s)-2-(piperidine-1-carbonyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)N2CCCCC2)=C(C=CC(C)=C2)C2=N1 JPCVEAXQUFJOKO-NDEPHWFRSA-N 0.000 claims 1
- CCGNMKYFERLNDN-SANMLTNESA-N butyl 4-[2-[[7-methyl-4-[2-oxo-2-[(2s)-2-(propylcarbamoyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NCCC)=C(C=CC(C)=C2)C2=N1 CCGNMKYFERLNDN-SANMLTNESA-N 0.000 claims 1
- XJFUNYNMSJVUAG-MHZLTWQESA-N butyl 4-[2-[[7-methyl-4-[2-oxo-2-[(2s)-2-(pyridin-2-ylcarbamoyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC=2N=CC=CC=2)=C(C=CC(C)=C2)C2=N1 XJFUNYNMSJVUAG-MHZLTWQESA-N 0.000 claims 1
- OARKOUAVBWQUBM-MHZLTWQESA-N butyl 4-[2-[[7-methyl-4-[2-oxo-2-[(2s)-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)N2CCCC2)=C(C=CC(C)=C2)C2=N1 OARKOUAVBWQUBM-MHZLTWQESA-N 0.000 claims 1
- GBVLTPIXQRZHEE-DEOSSOPVSA-N butyl 4-[2-[[7-methyl-4-[2-oxo-2-[(2s)-2-(trifluoromethyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(F)(F)F)=C(C=CC(C)=C2)C2=N1 GBVLTPIXQRZHEE-DEOSSOPVSA-N 0.000 claims 1
- CEJADVCQOZRBEN-LJAQVGFWSA-N butyl 4-[2-[[7-methyl-4-[2-oxo-2-[(2s)-2-phenylpyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C=2C=CC=CC=2)=C(C=CC(C)=C2)C2=N1 CEJADVCQOZRBEN-LJAQVGFWSA-N 0.000 claims 1
- BSYHQCIVKZRUAM-UHFFFAOYSA-N butyl 4-[2-[[7-methyl-4-[2-oxo-2-[2-(trifluoromethoxymethyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2C(CCC2)COC(F)(F)F)=C(C=CC(C)=C2)C2=N1 BSYHQCIVKZRUAM-UHFFFAOYSA-N 0.000 claims 1
- GBVLTPIXQRZHEE-UHFFFAOYSA-N butyl 4-[2-[[7-methyl-4-[2-oxo-2-[2-(trifluoromethyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2C(CCC2)C(F)(F)F)=C(C=CC(C)=C2)C2=N1 GBVLTPIXQRZHEE-UHFFFAOYSA-N 0.000 claims 1
- DKAQYGFIXQYLRP-UHFFFAOYSA-N butyl 4-[2-[[7-methyl-4-[2-oxo-2-[3-(trifluoromethyl)-4,6-dihydro-1h-pyrrolo[3,4-c]pyrazol-5-yl]ethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CC=3C(=NNC=3C2)C(F)(F)F)=C(C=CC(C)=C2)C2=N1 DKAQYGFIXQYLRP-UHFFFAOYSA-N 0.000 claims 1
- KDBDRKXSUIMSCD-UHFFFAOYSA-N butyl 4-[2-[[7-methyl-4-[2-oxo-2-[3-(trifluoromethyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CC(CC2)C(F)(F)F)=C(C=CC(C)=C2)C2=N1 KDBDRKXSUIMSCD-UHFFFAOYSA-N 0.000 claims 1
- JWKZJCRNJGTSII-UHFFFAOYSA-N butyl 4-[2-[[7-methyl-4-[2-oxo-2-[4-(2,2,2-trifluoroethyl)piperazin-1-yl]ethoxy]quinoline-2-carbonyl]amino]acetyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CCN(CC(F)(F)F)CC2)=C(C=CC(C)=C2)C2=N1 JWKZJCRNJGTSII-UHFFFAOYSA-N 0.000 claims 1
- PAFDHOUPJPOODQ-WNJJXGMVSA-N cyclobutyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-4-hydroxybutanoyl]piperazine-1-carboxylate Chemical compound O=C([C@@H]1CCCN1C(=O)COC=1C2=CC=C(C=C2N=C(C=1)C(=O)N[C@@H](CCO)C(=O)N1CCN(CC1)C(=O)OC1CCC1)C)NC1CCC1 PAFDHOUPJPOODQ-WNJJXGMVSA-N 0.000 claims 1
- KZEPNKUBNXMJKM-SHUZPENHSA-N cyclobutyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(cyclopentylmethoxy)-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound O=C([C@@H]1CCCN1C(=O)COC=1C2=CC=C(C=C2N=C(C=1)C(=O)N[C@@H](CCC(=O)OCC1CCCC1)C(=O)N1CCN(CC1)C(=O)OC1CCC1)C)NC1CCC1 KZEPNKUBNXMJKM-SHUZPENHSA-N 0.000 claims 1
- YAAXSMRVTPHODD-FIBWVYCGSA-N cyclobutyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-methoxy-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound O=C([C@@H]1CCCN1C(=O)COC=1C=C(N=C2C=C(C)C=CC2=1)C(=O)N[C@@H](CCC(=O)OC)C(=O)N1CCN(CC1)C(=O)OC1CCC1)NC1CCC1 YAAXSMRVTPHODD-FIBWVYCGSA-N 0.000 claims 1
- PHUSUSHDMVJPFL-WNJJXGMVSA-N cyclopropylmethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-4-hydroxybutanoyl]piperazine-1-carboxylate Chemical compound O=C([C@@H]1CCCN1C(=O)COC=1C2=CC=C(C=C2N=C(C=1)C(=O)N[C@@H](CCO)C(=O)N1CCN(CC1)C(=O)OCC1CC1)C)NC1CCC1 PHUSUSHDMVJPFL-WNJJXGMVSA-N 0.000 claims 1
- FIMOUPMPUAQRNL-UHFFFAOYSA-N ethyl 3-[2-[2-[[2-(4-butoxycarbonylpiperazin-1-yl)-2-oxoethyl]carbamoyl]-7-methylquinolin-4-yl]oxyacetyl]-3-azabicyclo[3.1.0]hexane-6-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)CNC(=O)C1=CC(OCC(=O)N2CC3C(C3C(=O)OCC)C2)=C(C=CC(C)=C2)C2=N1 FIMOUPMPUAQRNL-UHFFFAOYSA-N 0.000 claims 1
- QMTWSHRTRUHJPU-LSYYVWMOSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-5-fluoro-7-methylquinoline-2-carbonyl]amino]-5-ethoxy-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound O=C([C@@H]1CCCN1C(=O)COC=1C=C(N=C2C=C(C)C=C(F)C2=1)C(=O)N[C@@H](CCC(=O)OCC)C(=O)N1CCN(CC1)C(=O)OCC)NC1CCC1 QMTWSHRTRUHJPU-LSYYVWMOSA-N 0.000 claims 1
- NHBDIBFRBOMPGE-WNJJXGMVSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-6-fluoro-7-methylquinoline-2-carbonyl]amino]-5-ethoxy-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound O=C([C@@H]1CCCN1C(=O)COC=1C=C(N=C2C=C(C)C(F)=CC2=1)C(=O)N[C@@H](CCC(=O)OCC)C(=O)N1CCN(CC1)C(=O)OCC)NC1CCC1 NHBDIBFRBOMPGE-WNJJXGMVSA-N 0.000 claims 1
- OIEODKZENBSMST-UIOOFZCWSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-4,4-difluorobutanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CC(F)F)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 OIEODKZENBSMST-UIOOFZCWSA-N 0.000 claims 1
- MTNFYONFLUHMCK-IGKIAQTJSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-4-hydroxybutanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCO)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 MTNFYONFLUHMCK-IGKIAQTJSA-N 0.000 claims 1
- YGVCIXZJOXKYMF-JUKUECOXSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(2,3-dihydro-1h-inden-5-yloxy)-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@@H](NC(=O)C=1N=C2C=C(C)C=CC2=C(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)C=1)CCC(=O)OC1=CC=C(CCC2)C2=C1 YGVCIXZJOXKYMF-JUKUECOXSA-N 0.000 claims 1
- FBSYCXVLZGVWHW-VBTAUBHQSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(2-cyclopentylethoxy)-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@@H](NC(=O)C=1N=C2C=C(C)C=CC2=C(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)C=1)CCC(=O)OCCC1CCCC1 FBSYCXVLZGVWHW-VBTAUBHQSA-N 0.000 claims 1
- GDEKYNASPQQRKI-IZEXYCQBSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(2-ethoxyethoxy)-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound O=C([C@@H]1CCCN1C(=O)COC=1C=C(N=C2C=C(C)C=CC2=1)C(=O)N[C@@H](CCC(=O)OCCOCC)C(=O)N1CCN(CC1)C(=O)OCC)NC1CCC1 GDEKYNASPQQRKI-IZEXYCQBSA-N 0.000 claims 1
- VQHWANZCPRHKHR-GSICNFHRSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(2-hydroxy-2-methylbutoxy)-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(=O)OCC(C)(O)CC)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 VQHWANZCPRHKHR-GSICNFHRSA-N 0.000 claims 1
- GXMLVJFGVGKPLH-IZEXYCQBSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(2-methylpropoxy)-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(=O)OCC(C)C)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 GXMLVJFGVGKPLH-IZEXYCQBSA-N 0.000 claims 1
- AOSHIVINRLAGHN-IZEXYCQBSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(3-hydroxy-3-methylbutoxy)-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(=O)OCCC(C)(C)O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 AOSHIVINRLAGHN-IZEXYCQBSA-N 0.000 claims 1
- CAIPPYZUPVHGQC-KKEGNHTRSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(3-methoxybutoxy)-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(=O)OCCC(C)OC)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 CAIPPYZUPVHGQC-KKEGNHTRSA-N 0.000 claims 1
- JOPAMJGJPDWILJ-IZEXYCQBSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(3-methoxypropoxy)-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(=O)OCCCOC)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 JOPAMJGJPDWILJ-IZEXYCQBSA-N 0.000 claims 1
- UDLMDZWPJIHDPL-NYDCQLBNSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(cyclobutylmethoxy)-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@@H](NC(=O)C=1N=C2C=C(C)C=CC2=C(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)C=1)CCC(=O)OCC1CCC1 UDLMDZWPJIHDPL-NYDCQLBNSA-N 0.000 claims 1
- OHVOCNDAVJFBRD-VBTAUBHQSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(cyclohexylmethoxy)-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@@H](NC(=O)C=1N=C2C=C(C)C=CC2=C(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)C=1)CCC(=O)OCC1CCCCC1 OHVOCNDAVJFBRD-VBTAUBHQSA-N 0.000 claims 1
- YMAJDVNUMNUNJO-DITALETJSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(cyclopentylmethoxy)-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@@H](NC(=O)C=1N=C2C=C(C)C=CC2=C(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)C=1)CCC(=O)OCC1CCCC1 YMAJDVNUMNUNJO-DITALETJSA-N 0.000 claims 1
- CSZGDIYRCSFVPB-FIBWVYCGSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(cyclopropylamino)-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@@H](NC(=O)C=1N=C2C=C(C)C=CC2=C(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)C=1)CCC(=O)NC1CC1 CSZGDIYRCSFVPB-FIBWVYCGSA-N 0.000 claims 1
- LAXOQDWXNYRUNM-IZEXYCQBSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(cyclopropylmethoxy)-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@@H](NC(=O)C=1N=C2C=C(C)C=CC2=C(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)C=1)CCC(=O)OCC1CC1 LAXOQDWXNYRUNM-IZEXYCQBSA-N 0.000 claims 1
- SRFXDILTUCGAKF-WNJJXGMVSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(dimethylamino)-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(=O)N(C)C)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 SRFXDILTUCGAKF-WNJJXGMVSA-N 0.000 claims 1
- VYLQLPSFMXZYBE-WNJJXGMVSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(ethylamino)-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound O=C([C@@H]1CCCN1C(=O)COC=1C=C(N=C2C=C(C)C=CC2=1)C(=O)N[C@@H](CCC(=O)NCC)C(=O)N1CCN(CC1)C(=O)OCC)NC1CCC1 VYLQLPSFMXZYBE-WNJJXGMVSA-N 0.000 claims 1
- ZIQKJJBKVHZYFB-LSYYVWMOSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-(methylamino)-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(=O)NC)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 ZIQKJJBKVHZYFB-LSYYVWMOSA-N 0.000 claims 1
- FAYBHYDOTDMVCG-NYDCQLBNSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-[(3-ethyloxetan-3-yl)methoxy]-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@@H](NC(=O)C=1N=C2C=C(C)C=CC2=C(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)C=1)CCC(=O)OCC1(CC)COC1 FAYBHYDOTDMVCG-NYDCQLBNSA-N 0.000 claims 1
- KTLWNWSRCMOYSJ-IZEXYCQBSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-[2-(dimethylamino)ethoxy]-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(=O)OCCN(C)C)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 KTLWNWSRCMOYSJ-IZEXYCQBSA-N 0.000 claims 1
- SNOHWVHYOBKJFZ-DITALETJSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-cyclohexyloxy-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@@H](NC(=O)C=1N=C2C=C(C)C=CC2=C(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)C=1)CCC(=O)OC1CCCCC1 SNOHWVHYOBKJFZ-DITALETJSA-N 0.000 claims 1
- ZRIUVFZQIMKPGO-NYDCQLBNSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-cyclopentyloxy-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@@H](NC(=O)C=1N=C2C=C(C)C=CC2=C(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)C=1)CCC(=O)OC1CCCC1 ZRIUVFZQIMKPGO-NYDCQLBNSA-N 0.000 claims 1
- NQEXVPKCNVISFR-WNJJXGMVSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-ethoxy-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound O=C([C@@H]1CCCN1C(=O)COC=1C=C(N=C2C=C(C)C=CC2=1)C(=O)N[C@@H](CCC(=O)OCC)C(=O)N1CCN(CC1)C(=O)OCC)NC1CCC1 NQEXVPKCNVISFR-WNJJXGMVSA-N 0.000 claims 1
- WQQWCAAJZWQBIA-LSYYVWMOSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-methoxy-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(=O)OC)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 WQQWCAAJZWQBIA-LSYYVWMOSA-N 0.000 claims 1
- RSDIPORMBRLGIM-NYDCQLBNSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxo-5-(2-propan-2-yloxyethoxy)pentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(=O)OCCOC(C)C)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 RSDIPORMBRLGIM-NYDCQLBNSA-N 0.000 claims 1
- AYGLTFVIURRVRG-NYDCQLBNSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxo-5-pentan-3-yloxypentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(=O)OC(CC)CC)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 AYGLTFVIURRVRG-NYDCQLBNSA-N 0.000 claims 1
- MLALLKSAKAXYPW-NYDCQLBNSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxo-5-pentoxypentanoyl]piperazine-1-carboxylate Chemical compound O=C([C@@H]1CCCN1C(=O)COC=1C=C(N=C2C=C(C)C=CC2=1)C(=O)N[C@@H](CCC(=O)OCCCCC)C(=O)N1CCN(CC1)C(=O)OCC)NC1CCC1 MLALLKSAKAXYPW-NYDCQLBNSA-N 0.000 claims 1
- PTWGIFAKGOAZLZ-VBTAUBHQSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxo-5-phenylmethoxypentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@@H](NC(=O)C=1N=C2C=C(C)C=CC2=C(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)C=1)CCC(=O)OCC1=CC=CC=C1 PTWGIFAKGOAZLZ-VBTAUBHQSA-N 0.000 claims 1
- WRDXFMIMEXVRNW-FIBWVYCGSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxo-5-propan-2-yloxypentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(=O)OC(C)C)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 WRDXFMIMEXVRNW-FIBWVYCGSA-N 0.000 claims 1
- MYVQIUOYWZBSSD-FIBWVYCGSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxo-5-propoxypentanoyl]piperazine-1-carboxylate Chemical compound O=C([C@@H]1CCCN1C(=O)COC=1C=C(N=C2C=C(C)C=CC2=1)C(=O)N[C@@H](CCC(=O)OCCC)C(=O)N1CCN(CC1)C(=O)OCC)NC1CCC1 MYVQIUOYWZBSSD-FIBWVYCGSA-N 0.000 claims 1
- OKMZNHLYLXCCTG-VBTAUBHQSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-6-(cyclopentylmethoxy)-6-oxohexanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@@H](NC(=O)C=1N=C2C=C(C)C=CC2=C(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)C=1)CCCC(=O)OCC1CCCC1 OKMZNHLYLXCCTG-VBTAUBHQSA-N 0.000 claims 1
- QNOBNCMBDHXVRV-AHWVRZQESA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-4-hydroxybutanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCO)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC=C2)C2=N1 QNOBNCMBDHXVRV-AHWVRZQESA-N 0.000 claims 1
- XREMEHHOBBRHBP-BDYUSTAISA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-4-methylsulfonylbutanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCS(C)(=O)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC=C2)C2=N1 XREMEHHOBBRHBP-BDYUSTAISA-N 0.000 claims 1
- OPMDDKNGPSPKCW-FIBWVYCGSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclopentylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-ethoxy-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound O=C([C@@H]1CCCN1C(=O)COC=1C=C(N=C2C=C(C)C=CC2=1)C(=O)N[C@@H](CCC(=O)OCC)C(=O)N1CCN(CC1)C(=O)OCC)NC1CCCC1 OPMDDKNGPSPKCW-FIBWVYCGSA-N 0.000 claims 1
- GOQIZPRCEYKGOV-LSYYVWMOSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclopropylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-6-fluoro-7-methylquinoline-2-carbonyl]amino]-5-ethoxy-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound O=C([C@@H]1CCCN1C(=O)COC=1C=C(N=C2C=C(C)C(F)=CC2=1)C(=O)N[C@@H](CCC(=O)OCC)C(=O)N1CCN(CC1)C(=O)OCC)NC1CC1 GOQIZPRCEYKGOV-LSYYVWMOSA-N 0.000 claims 1
- SFYILRQXMCMLJA-LSYYVWMOSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclopropylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-ethoxy-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound O=C([C@@H]1CCCN1C(=O)COC=1C=C(N=C2C=C(C)C=CC2=1)C(=O)N[C@@H](CCC(=O)OCC)C(=O)N1CCN(CC1)C(=O)OCC)NC1CC1 SFYILRQXMCMLJA-LSYYVWMOSA-N 0.000 claims 1
- SVHBBOXKLMBZOX-BDYUSTAISA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-(cyclopropylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]quinoline-2-carbonyl]amino]-5-ethoxy-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound O=C([C@@H]1CCCN1C(=O)COC=1C=C(N=C2C=CC=CC2=1)C(=O)N[C@@H](CCC(=O)OCC)C(=O)N1CCN(CC1)C(=O)OCC)NC1CC1 SVHBBOXKLMBZOX-BDYUSTAISA-N 0.000 claims 1
- XDBQGHOXYVFDOU-FIBWVYCGSA-N ethyl 4-[(2s)-2-[[4-[2-[(2s)-2-[cyclobutyl(methyl)carbamoyl]pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-ethoxy-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound O=C([C@@H]1CCCN1C(=O)COC=1C=C(N=C2C=C(C)C=CC2=1)C(=O)N[C@@H](CCC(=O)OCC)C(=O)N1CCN(CC1)C(=O)OCC)N(C)C1CCC1 XDBQGHOXYVFDOU-FIBWVYCGSA-N 0.000 claims 1
- SCZDYTFZZWZXSZ-IGKIAQTJSA-N ethyl 4-[(2s)-5-amino-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(N)=O)NC(=O)C1=CC(OCC(=O)N2[C@@H](CCC2)C(=O)NC2CCC2)=C(C=CC(C)=C2)C2=N1 SCZDYTFZZWZXSZ-IGKIAQTJSA-N 0.000 claims 1
- XIDZOEZJFVQVBR-IZEXYCQBSA-N ethyl 4-[(2s)-5-butoxy-2-[[4-[2-[(2s)-2-(cyclobutylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound O=C([C@@H]1CCCN1C(=O)COC=1C=C(N=C2C=C(C)C=CC2=1)C(=O)N[C@@H](CCC(=O)OCCCC)C(=O)N1CCN(CC1)C(=O)OCC)NC1CCC1 XIDZOEZJFVQVBR-IZEXYCQBSA-N 0.000 claims 1
- DEZPDGICUIPEPB-DEOSSOPVSA-N ethyl 4-[(2s)-5-ethoxy-2-[[4-[2-(4-hydroxypiperidin-1-yl)-2-oxoethoxy]-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound N([C@@H](CCC(=O)OCC)C(=O)N1CCN(CC1)C(=O)OCC)C(=O)C(N=C1C=C(C)C=CC1=1)=CC=1OCC(=O)N1CCC(O)CC1 DEZPDGICUIPEPB-DEOSSOPVSA-N 0.000 claims 1
- QUCIMQNWSJXDGQ-IGKIAQTJSA-N ethyl 4-[(2s)-5-ethoxy-2-[[4-[2-[(2s)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-6-fluoro-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)COC1=CC(C(=O)N[C@@H](CCC(=O)OCC)C(=O)N2CCN(CC2)C(=O)OCC)=NC2=CC(C)=C(F)C=C12 QUCIMQNWSJXDGQ-IGKIAQTJSA-N 0.000 claims 1
- FWMPWFYSJWPFFM-OZXSUGGESA-N ethyl 4-[(2s)-5-ethoxy-2-[[4-[2-[(2s)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-2-oxoethoxy]-7-fluoroquinoline-2-carbonyl]amino]-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)COC1=CC(C(=O)N[C@@H](CCC(=O)OCC)C(=O)N2CCN(CC2)C(=O)OCC)=NC2=CC(F)=CC=C12 FWMPWFYSJWPFFM-OZXSUGGESA-N 0.000 claims 1
- JWNRACFIJMUCAQ-IGKIAQTJSA-N ethyl 4-[(2s)-5-ethoxy-2-[[5-fluoro-7-methyl-4-[2-oxo-2-[(2s)-2-(propylcarbamoyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound CCCNC(=O)[C@@H]1CCCN1C(=O)COC1=CC(C(=O)N[C@@H](CCC(=O)OCC)C(=O)N2CCN(CC2)C(=O)OCC)=NC2=CC(C)=CC(F)=C12 JWNRACFIJMUCAQ-IGKIAQTJSA-N 0.000 claims 1
- JXDIJCAPYXCGCM-LSYYVWMOSA-N ethyl 4-[(2s)-5-ethoxy-2-[[5-fluoro-7-methyl-4-[2-oxo-2-[(2s)-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]ethoxy]quinoline-2-carbonyl]amino]-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound O=C([C@@H]1CCCN1C(=O)COC=1C=C(N=C2C=C(C)C=C(F)C2=1)C(=O)N[C@@H](CCC(=O)OCC)C(=O)N1CCN(CC1)C(=O)OCC)N1CCCC1 JXDIJCAPYXCGCM-LSYYVWMOSA-N 0.000 claims 1
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A61P31/12—Antivirals
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Engineering & Computer Science (AREA)
- Cardiology (AREA)
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- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
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- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Virology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Quinoline Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07008209.4 | 2007-04-23 | ||
| EP07008209 | 2007-04-23 | ||
| PCT/EP2008/002790 WO2008128647A1 (en) | 2007-04-23 | 2008-04-09 | Quinoline-carboxamide derivatives as p2y12 antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2684644A1 true CA2684644A1 (en) | 2008-10-30 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002684644A Abandoned CA2684644A1 (en) | 2007-04-23 | 2008-04-09 | Quinoline-carboxamide derivatives as p2y12 antagonists |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8669266B2 (enExample) |
| EP (1) | EP2148871A1 (enExample) |
| JP (1) | JP5309131B2 (enExample) |
| KR (1) | KR20100015886A (enExample) |
| CN (1) | CN101663293B (enExample) |
| AR (1) | AR066225A1 (enExample) |
| AU (1) | AU2008241091B2 (enExample) |
| BR (1) | BRPI0810462A2 (enExample) |
| CA (1) | CA2684644A1 (enExample) |
| CL (1) | CL2008001157A1 (enExample) |
| IL (1) | IL201620A (enExample) |
| MX (1) | MX2009011089A (enExample) |
| MY (1) | MY153427A (enExample) |
| PA (1) | PA8777901A1 (enExample) |
| PE (1) | PE20090241A1 (enExample) |
| TW (1) | TW200848042A (enExample) |
| UY (1) | UY31039A1 (enExample) |
| WO (1) | WO2008128647A1 (enExample) |
Families Citing this family (28)
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| AR071653A1 (es) | 2008-04-11 | 2010-07-07 | Actelion Pharmaceuticals Ltd | Derivados 2-fenil-4-ciclopropil-pirimidina |
| RU2401831C2 (ru) * | 2008-12-15 | 2010-10-20 | Алла Хем, Ллс | Средство, снижающее влечение к алкоголю, фармацевтическая композиция и способы ее получения, лекарственное средство и способ лечения |
| WO2010116328A2 (en) * | 2009-04-08 | 2010-10-14 | Actelion Pharmaceuticals Ltd | 6-(3-aza-bicyclo[3.1.0]hex-3-yl)-2-phenyl-pyrimidines |
| EP2421859B1 (en) | 2009-04-22 | 2014-04-09 | Actelion Pharmaceuticals Ltd. | Thiazole derivatives and their use as p2y12 receptor antagonists |
| JP5597202B2 (ja) | 2009-08-28 | 2014-10-01 | 第一三共株式会社 | ３−（ビアリールオキシ）プロピオン酸誘導体 |
| AR079451A1 (es) * | 2009-12-18 | 2012-01-25 | Nycomed Gmbh | Compuestos 3,4,4a,10b-tetrahidro-1h-tiopirano[4,3-c]isoquinolina |
| CN103857288B (zh) | 2011-03-04 | 2016-09-21 | 葛兰素史密斯克莱知识产权发展有限公司 | 作为激酶抑制剂的氨基-喹啉 |
| TWI547494B (zh) | 2011-08-18 | 2016-09-01 | 葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之胺基喹唑啉類 |
| WO2013033178A1 (en) | 2011-08-30 | 2013-03-07 | University Of Utah Research Foundation | Methods and compositions for treating nephrogenic diabetes insipidus |
| CN102584852B (zh) * | 2011-12-30 | 2014-08-13 | 厦门大学 | 真菌代谢产物桥南霉素及其制备方法和应用 |
| AR092529A1 (es) | 2012-09-13 | 2015-04-22 | Glaxosmithkline Llc | Compuesto de aminoquinazolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento |
| AR092530A1 (es) | 2012-09-13 | 2015-04-22 | Glaxosmithkline Llc | Compuesto de amino-quinolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento |
| EP2725025A1 (fr) * | 2012-10-26 | 2014-04-30 | Sanofi | Dérives de 1H-indole-3-carboxamide et leurs utilisation comme antagonistes du P2Y12 |
| EP2958911B1 (en) | 2013-02-21 | 2017-10-18 | GlaxoSmithKline Intellectual Property Development Limited | Quinazolines as kinase inhibitors |
| CN104109158A (zh) * | 2013-04-16 | 2014-10-22 | 上海医药工业研究院 | 一种纯化利伐沙班的方法 |
| DE102014108210A1 (de) | 2014-06-11 | 2015-12-17 | Dietrich Gulba | Rodentizid |
| DE102015217396B4 (de) | 2014-09-11 | 2018-07-26 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | System, insbesondere System zur Eingabesteuerung für eine Arbeitshilfe |
| CN106496249B (zh) * | 2015-09-07 | 2019-12-13 | 江苏恒瑞医药股份有限公司 | 噁唑并吲哚类衍生物、其制备方法及其在医药上的应用 |
| US10730868B2 (en) * | 2016-07-14 | 2020-08-04 | Bristol-Myers Squibb Company | Bicyclic heteroaryl substituted compounds |
| HUE057772T2 (hu) | 2016-09-22 | 2022-06-28 | Idorsia Pharmaceuticals Ltd | Kristályos formák |
| KR102510832B1 (ko) | 2017-03-15 | 2023-03-15 | 이도르시아 파마슈티컬스 리미티드 | P2y12 수용체 안타고니스트의 피하 투여 |
| CN107648607A (zh) * | 2017-09-11 | 2018-02-02 | 南昌大学 | 嘌呤2y12受体拮抗剂在制备糖尿病神经病理损伤疾病药物中的应用 |
| EP4070658A1 (de) | 2021-04-06 | 2022-10-12 | BIORoxx GmbH | Verwendung von blutgerinnungshemmenden verbindungen als rodentizide |
| WO2023108363A1 (en) * | 2021-12-13 | 2023-06-22 | Beijing Honghui Meditech Co., Ltd | Pyrimidine-annulated triazole derivatives and their use in platelet aggregation inhibition |
| CN115429874A (zh) * | 2022-09-20 | 2022-12-06 | 暨南大学 | 水蛭素靶向并抑制dpp4治疗糖尿病 |
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| US5612359A (en) * | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
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| PE121699A1 (es) | 1997-02-18 | 1999-12-08 | Boehringer Ingelheim Pharma | Heterociclos biciclicos disustituidos como inhibidores de la trombina |
| ZA985247B (en) | 1997-06-19 | 1999-12-17 | Du Pont Merck Pharma | Guanidine mimics as factor Xa inhibitors. |
| IL140622A0 (en) | 1998-07-06 | 2002-02-10 | Bristol Myers Squibb Co | Biphenyl sufonamide derivatives, pharmaceutical compositions containing the same and methods for the preparation thereof |
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| MY125533A (en) | 1999-12-06 | 2006-08-30 | Bristol Myers Squibb Co | Heterocyclic dihydropyrimidine compounds |
| DE19962924A1 (de) | 1999-12-24 | 2001-07-05 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
| AR035216A1 (es) | 2000-12-01 | 2004-05-05 | Astrazeneca Ab | Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios |
| US6861424B2 (en) * | 2001-06-06 | 2005-03-01 | Schering Aktiengesellschaft | Platelet adenosine diphosphate receptor antagonists |
| SI1427415T1 (sl) | 2001-09-21 | 2009-12-31 | Bristol Myers Squibb Co | Sestavine, ki vsebujejo laktame in njihovi derivati kot inhibitorji faktorja xa |
| KR20050085580A (ko) * | 2002-12-11 | 2005-08-29 | 쉐링 악티엔게젤샤프트 | 혈소판 아데노신 디포스페이트 수용체 길항제로서의2-아미노카르보닐-퀴놀린 화합물 |
| MXPA06000675A (es) | 2003-07-24 | 2006-04-19 | Astellas Pharma Inc | Derivado de quinolona o sal del mismo. |
| US7157445B2 (en) * | 2004-02-26 | 2007-01-02 | Aventis Pharma S.A. | Administration of enoxaparin sodium to patients with severe renal impairment |
| JP2008094720A (ja) | 2005-01-20 | 2008-04-24 | Astellas Pharma Inc | キノロン誘導体のプロドラッグ又はその塩 |
| TW200640877A (en) * | 2005-04-28 | 2006-12-01 | Actelion Pharmaceuticals Ltd | Pyrimidine derivatives |
| MX2008002363A (es) * | 2005-08-17 | 2008-03-18 | Schering Corp | Ligandos novedosos de cinasa basados en quinolina de alta afinidad. |
-
2008
- 2008-04-09 KR KR1020097022288A patent/KR20100015886A/ko not_active Ceased
- 2008-04-09 CA CA002684644A patent/CA2684644A1/en not_active Abandoned
- 2008-04-09 EP EP08735104A patent/EP2148871A1/en not_active Withdrawn
- 2008-04-09 MX MX2009011089A patent/MX2009011089A/es active IP Right Grant
- 2008-04-09 AU AU2008241091A patent/AU2008241091B2/en not_active Ceased
- 2008-04-09 JP JP2010504490A patent/JP5309131B2/ja not_active Expired - Fee Related
- 2008-04-09 CN CN200880013208XA patent/CN101663293B/zh not_active Expired - Fee Related
- 2008-04-09 WO PCT/EP2008/002790 patent/WO2008128647A1/en not_active Ceased
- 2008-04-09 MY MYPI20094191A patent/MY153427A/en unknown
- 2008-04-09 BR BRPI0810462-0A2A patent/BRPI0810462A2/pt not_active IP Right Cessation
- 2008-04-21 AR ARP080101660A patent/AR066225A1/es not_active Application Discontinuation
- 2008-04-21 PE PE2008000685A patent/PE20090241A1/es not_active Application Discontinuation
- 2008-04-21 TW TW097114392A patent/TW200848042A/zh unknown
- 2008-04-21 UY UY31039A patent/UY31039A1/es not_active Application Discontinuation
- 2008-04-22 CL CL2008001157A patent/CL2008001157A1/es unknown
- 2008-04-23 PA PA20088777901A patent/PA8777901A1/es unknown
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2009
- 2009-10-05 US US12/573,551 patent/US8669266B2/en not_active Expired - Fee Related
- 2009-10-19 IL IL201620A patent/IL201620A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008128647A1 (en) | 2008-10-30 |
| AU2008241091B2 (en) | 2013-05-09 |
| JP5309131B2 (ja) | 2013-10-09 |
| CN101663293B (zh) | 2013-07-31 |
| US8669266B2 (en) | 2014-03-11 |
| KR20100015886A (ko) | 2010-02-12 |
| HK1141803A1 (en) | 2010-11-19 |
| PE20090241A1 (es) | 2009-04-03 |
| PA8777901A1 (es) | 2008-11-19 |
| CN101663293A (zh) | 2010-03-03 |
| MY153427A (en) | 2015-02-13 |
| IL201620A (en) | 2013-11-28 |
| CL2008001157A1 (es) | 2008-11-03 |
| JP2010524984A (ja) | 2010-07-22 |
| BRPI0810462A2 (pt) | 2014-10-14 |
| MX2009011089A (es) | 2009-10-30 |
| AU2008241091A1 (en) | 2008-10-30 |
| EP2148871A1 (en) | 2010-02-03 |
| UY31039A1 (es) | 2008-11-28 |
| TW200848042A (en) | 2008-12-16 |
| AR066225A1 (es) | 2009-08-05 |
| US20100135999A1 (en) | 2010-06-03 |
| IL201620A0 (en) | 2010-05-31 |
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