CA2667487C - Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors - Google Patents
Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors Download PDFInfo
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- CA2667487C CA2667487C CA2667487A CA2667487A CA2667487C CA 2667487 C CA2667487 C CA 2667487C CA 2667487 A CA2667487 A CA 2667487A CA 2667487 A CA2667487 A CA 2667487A CA 2667487 C CA2667487 C CA 2667487C
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- LDIJKUBTLZTFRG-UHFFFAOYSA-N pyrazolo[1,5-a]pyrimidine Chemical class N1=CC=CN2N=CC=C21 LDIJKUBTLZTFRG-UHFFFAOYSA-N 0.000 title abstract description 7
- 239000003909 protein kinase inhibitor Substances 0.000 title abstract description 5
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- VTVRXITWWZGKHV-UHFFFAOYSA-N imidazo[1,2-b]pyridazine Chemical compound N1=CC=CC2=NC=CN21 VTVRXITWWZGKHV-UHFFFAOYSA-N 0.000 title abstract description 4
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- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 42
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- 125000001424 substituent group Chemical group 0.000 claims description 31
- 125000000217 alkyl group Chemical group 0.000 claims description 26
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 19
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- DCLWNTIANRACSB-UHFFFAOYSA-N imidazo[1,2-b]pyridazin-6-amine Chemical compound N1=C(N)C=CC2=NC=CN21 DCLWNTIANRACSB-UHFFFAOYSA-N 0.000 claims 1
- ZXNAXEZHUKKKTA-UHFFFAOYSA-N n-[(1-ethylpiperidin-4-yl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine Chemical compound C1CN(CC)CCC1CNC1=NN2C(C=3C=C(OC(F)(F)F)C=CC=3)=CN=C2C=C1 ZXNAXEZHUKKKTA-UHFFFAOYSA-N 0.000 claims 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86456606P | 2006-11-06 | 2006-11-06 | |
| US60/864,566 | 2006-11-06 | ||
| US89252307P | 2007-03-01 | 2007-03-01 | |
| US60/892,523 | 2007-03-01 | ||
| US95798807P | 2007-08-24 | 2007-08-24 | |
| US60/957,988 | 2007-08-24 | ||
| PCT/US2007/083773 WO2008058126A2 (en) | 2006-11-06 | 2007-11-06 | Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2667487A1 CA2667487A1 (en) | 2008-05-15 |
| CA2667487C true CA2667487C (en) | 2017-04-04 |
Family
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-
2007
- 2007-11-06 WO PCT/US2007/083773 patent/WO2008058126A2/en not_active Ceased
- 2007-11-06 NZ NZ576234A patent/NZ576234A/en unknown
- 2007-11-06 MY MYPI20091580A patent/MY146474A/en unknown
- 2007-11-06 JP JP2009535503A patent/JP5357763B2/ja active Active
- 2007-11-06 EP EP07863964.8A patent/EP2086979B1/en active Active
- 2007-11-06 MX MX2009004700A patent/MX2009004700A/es active IP Right Grant
- 2007-11-06 AU AU2007316417A patent/AU2007316417B2/en not_active Expired - Fee Related
- 2007-11-06 BR BRPI0718029-2A patent/BRPI0718029A2/pt not_active IP Right Cessation
- 2007-11-06 RU RU2009121577/04A patent/RU2487875C2/ru active
- 2007-11-06 CN CN2007800412832A patent/CN101600718B/zh active Active
- 2007-11-06 KR KR1020097010098A patent/KR101546493B1/ko active Active
- 2007-11-06 SG SG2011081619A patent/SG176461A1/en unknown
- 2007-11-06 CA CA2667487A patent/CA2667487C/en active Active
- 2007-11-06 US US11/935,959 patent/US7750007B2/en active Active
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2010
- 2010-05-21 US US12/785,322 patent/US20100227861A1/en not_active Abandoned
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2011
- 2011-07-21 US US13/188,195 patent/US8710057B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US7750007B2 (en) | 2010-07-06 |
| NZ576234A (en) | 2011-06-30 |
| KR20090086219A (ko) | 2009-08-11 |
| US20100227861A1 (en) | 2010-09-09 |
| BRPI0718029A2 (pt) | 2013-11-26 |
| US8710057B2 (en) | 2014-04-29 |
| RU2487875C2 (ru) | 2013-07-20 |
| JP2010509242A (ja) | 2010-03-25 |
| MY146474A (en) | 2012-08-15 |
| EP2086979A2 (en) | 2009-08-12 |
| CA2667487A1 (en) | 2008-05-15 |
| RU2009121577A (ru) | 2010-12-20 |
| AU2007316417B2 (en) | 2013-08-22 |
| EP2086979B1 (en) | 2015-06-03 |
| CN101600718A (zh) | 2009-12-09 |
| KR101546493B1 (ko) | 2015-08-21 |
| AU2007316417A1 (en) | 2008-05-15 |
| WO2008058126A2 (en) | 2008-05-15 |
| US20080261988A1 (en) | 2008-10-23 |
| US20110281863A1 (en) | 2011-11-17 |
| JP5357763B2 (ja) | 2013-12-04 |
| MX2009004700A (es) | 2009-05-15 |
| CN101600718B (zh) | 2013-07-03 |
| WO2008058126A3 (en) | 2008-06-26 |
| SG176461A1 (en) | 2011-12-29 |
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