CA2661012C - Method of treating stroke with thrombolytic agent - Google Patents
Method of treating stroke with thrombolytic agent Download PDFInfo
- Publication number
- CA2661012C CA2661012C CA2661012A CA2661012A CA2661012C CA 2661012 C CA2661012 C CA 2661012C CA 2661012 A CA2661012 A CA 2661012A CA 2661012 A CA2661012 A CA 2661012A CA 2661012 C CA2661012 C CA 2661012C
- Authority
- CA
- Canada
- Prior art keywords
- tenecteplase
- dose
- infusion
- ischemic stroke
- administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/49—Urokinase; Tissue plasminogen activator
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82386806P | 2006-08-29 | 2006-08-29 | |
| US60/823,868 | 2006-08-29 | ||
| PCT/US2007/074997 WO2008027687A2 (en) | 2006-08-29 | 2007-08-01 | Use of tenecteplase for treating acute ischemic stroke |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2661012A1 CA2661012A1 (en) | 2008-03-06 |
| CA2661012C true CA2661012C (en) | 2019-03-19 |
Family
ID=38835003
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2661012A Expired - Fee Related CA2661012C (en) | 2006-08-29 | 2007-08-01 | Method of treating stroke with thrombolytic agent |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US20080107641A1 (https=) |
| EP (1) | EP2056856B1 (https=) |
| JP (1) | JP5785687B2 (https=) |
| KR (1) | KR20090045405A (https=) |
| CN (1) | CN101505785A (https=) |
| AU (1) | AU2007290277B2 (https=) |
| BR (1) | BRPI0716143A2 (https=) |
| CA (1) | CA2661012C (https=) |
| CO (1) | CO6150188A2 (https=) |
| EA (1) | EA015573B1 (https=) |
| EC (1) | ECSP099178A (https=) |
| IL (2) | IL196987A (https=) |
| MX (1) | MX2009001918A (https=) |
| MY (1) | MY163119A (https=) |
| NO (1) | NO342302B1 (https=) |
| NZ (1) | NZ574767A (https=) |
| SG (3) | SG10201804944XA (https=) |
| TW (1) | TWI439282B (https=) |
| UA (1) | UA97486C2 (https=) |
| WO (1) | WO2008027687A2 (https=) |
| ZA (1) | ZA200900957B (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7759506B2 (en) | 2002-02-25 | 2010-07-20 | Diffusion Pharmaceuticals Llc | Bipolar trans carotenoid salts and their uses |
| UA95903C2 (ru) | 2005-02-24 | 2011-09-26 | Дифьюжен Фармасьютикалз Ллк | Транс-каротиноиды, их синтез, лекарственная форма и применение |
| UA97486C2 (ru) | 2006-08-29 | 2012-02-27 | Дженентек, Инк. | Применение тенектеплазы для лечения острого ишемического инсульта |
| CN101687757A (zh) | 2007-04-13 | 2010-03-31 | 扩散药品有限公司 | 双极性反式类胡萝卜素作为预治疗及其在周围血管疾病的治疗中的应用 |
| US9034007B2 (en) | 2007-09-21 | 2015-05-19 | Insera Therapeutics, Inc. | Distal embolic protection devices with a variable thickness microguidewire and methods for their use |
| EP2384141A1 (en) * | 2008-12-24 | 2011-11-09 | Koninklijke Philips Electronics N.V. | System, method and apparatus for cardiac intervention with mr stroke detection and treatment |
| KR101875843B1 (ko) | 2009-06-22 | 2018-07-06 | 디퓨젼 파마슈티컬즈 엘엘씨 | 확산 촉진 화합물 및 그 화합물 단독 또는 혈전 용해제와 합쳐진 화합물의 용도 |
| CA2772097C (en) | 2009-08-24 | 2019-04-30 | Hough Ear Institute | Methods for treating acute acoustic trauma |
| KR101891357B1 (ko) | 2010-06-02 | 2018-08-24 | 디퓨젼 파마슈티컬즈 엘엘씨 | 양극성 트랜스 카로티노이드의 경구용 제형 |
| ES2687850T3 (es) * | 2010-12-23 | 2018-10-29 | Gennova Biopharmaceuticals Ltd. | Composiciones farmacéuticas de tenecteplasa |
| US20150238502A1 (en) * | 2012-10-18 | 2015-08-27 | University Of South Florida | Compositions and Methods for Treating Stroke |
| US8690907B1 (en) | 2013-03-15 | 2014-04-08 | Insera Therapeutics, Inc. | Vascular treatment methods |
| US8679150B1 (en) | 2013-03-15 | 2014-03-25 | Insera Therapeutics, Inc. | Shape-set textile structure based mechanical thrombectomy methods |
| US8715314B1 (en) | 2013-03-15 | 2014-05-06 | Insera Therapeutics, Inc. | Vascular treatment measurement methods |
| CN116172656A (zh) | 2013-03-15 | 2023-05-30 | 伊瑟拉医疗公司 | 脉管治疗装置和方法 |
| US10220008B2 (en) | 2013-08-14 | 2019-03-05 | Stc.Unm | Treatment and prevention of stroke and other neurological disorders |
| PT3209767T (pt) * | 2014-10-21 | 2020-11-09 | Gennova Biopharmaceuticals Ltd | Um novo processo de purificação para isolamento e produção comercial de tnk-tpa recombinante (tenecteplase) |
| EP3416568A4 (en) | 2016-02-16 | 2019-10-16 | Insera Therapeutics, Inc. | SUCTION DEVICES AND ANCHORED FLOW REVERSING DEVICES |
| US11185523B2 (en) | 2016-03-24 | 2021-11-30 | Diffusion Pharmaceuticals Llc | Use of bipolar trans carotenoids with chemotherapy and radiotherapy for treatment of cancer |
| WO2018138634A1 (en) * | 2017-01-24 | 2018-08-02 | Ekos Corporation | Method for the treatment of thromboembolism |
| WO2018210860A1 (en) * | 2017-05-16 | 2018-11-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of acute ischemic stroke |
| US10426424B2 (en) | 2017-11-21 | 2019-10-01 | General Electric Company | System and method for generating and performing imaging protocol simulations |
| US20230068460A1 (en) * | 2020-02-04 | 2023-03-02 | The Regents Of The University Of Colorado, A Body Corporate | Prophylactic uses of annexin a2 |
| WO2021165888A1 (en) * | 2020-02-19 | 2021-08-26 | Nono Inc. | Combination treatment of stroke with plasmin-cleavable psd-95 inhibitor and reperfusion |
| CN114984197A (zh) * | 2022-07-01 | 2022-09-02 | 江苏丰华生物制药有限公司 | 替奈普酶在制备用于治疗急性缺血性卒中的药物组合物中的应用 |
| CN115487294A (zh) * | 2022-07-12 | 2022-12-20 | 上海丰华天力通生物医药有限公司 | 替奈普酶在制备用于治疗轻型缺血性卒中的药物组合物中的应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| DK0643772T3 (da) | 1992-06-03 | 1998-02-02 | Genentech Inc | Glycosyleringsvarianter af vævsplasminogenaktivator med forbedrede terapeutiske egenskaber |
| JP2002173447A (ja) * | 2000-09-29 | 2002-06-21 | Yamanouchi Pharmaceut Co Ltd | 脳塞栓症治療用医薬組成物 |
| US7084118B2 (en) * | 2002-02-22 | 2006-08-01 | Genentech, Inc. | Combination treatment with t-PA variant and low molecular weight heparin |
| US20030180282A1 (en) * | 2002-03-25 | 2003-09-25 | Victor Serebruany | Method of treatment of thrombotic events |
| US20070014779A1 (en) * | 2002-11-14 | 2007-01-18 | Genentech, Inc. | Plasminogen activator variant formulations |
| WO2006094120A2 (en) * | 2005-03-02 | 2006-09-08 | The Regents Of The University Of California | Treatment for embolic stroke |
| UA97486C2 (ru) | 2006-08-29 | 2012-02-27 | Дженентек, Инк. | Применение тенектеплазы для лечения острого ишемического инсульта |
-
2007
- 2007-08-01 UA UAA200902855A patent/UA97486C2/ru unknown
- 2007-08-01 US US11/832,291 patent/US20080107641A1/en not_active Abandoned
- 2007-08-01 TW TW096128284A patent/TWI439282B/zh active
- 2007-08-01 MY MYPI20090793A patent/MY163119A/en unknown
- 2007-08-01 CN CNA2007800318116A patent/CN101505785A/zh active Pending
- 2007-08-01 EP EP07840638.6A patent/EP2056856B1/en active Active
- 2007-08-01 NZ NZ574767A patent/NZ574767A/en unknown
- 2007-08-01 EA EA200970237A patent/EA015573B1/ru unknown
- 2007-08-01 AU AU2007290277A patent/AU2007290277B2/en active Active
- 2007-08-01 CA CA2661012A patent/CA2661012C/en not_active Expired - Fee Related
- 2007-08-01 BR BRPI0716143-3A patent/BRPI0716143A2/pt not_active Application Discontinuation
- 2007-08-01 SG SG10201804944XA patent/SG10201804944XA/en unknown
- 2007-08-01 MX MX2009001918A patent/MX2009001918A/es active IP Right Grant
- 2007-08-01 WO PCT/US2007/074997 patent/WO2008027687A2/en not_active Ceased
- 2007-08-01 ZA ZA200900957A patent/ZA200900957B/xx unknown
- 2007-08-01 JP JP2009526788A patent/JP5785687B2/ja active Active
- 2007-08-01 SG SG2011062213A patent/SG174753A1/en unknown
- 2007-08-01 SG SG10201501498VA patent/SG10201501498VA/en unknown
- 2007-08-01 KR KR1020097006363A patent/KR20090045405A/ko not_active Ceased
-
2009
- 2009-02-09 IL IL196987A patent/IL196987A/en active IP Right Grant
- 2009-02-27 CO CO09020350A patent/CO6150188A2/es unknown
- 2009-03-12 EC EC2009009178A patent/ECSP099178A/es unknown
- 2009-03-27 NO NO20091296A patent/NO342302B1/no unknown
-
2011
- 2011-07-22 US US13/189,413 patent/US9023346B2/en active Active
-
2016
- 2016-10-05 IL IL248176A patent/IL248176A0/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20210803 |