JP5785687B2 - 急性虚血性脳卒中を処置するためのテネクテプラーゼの使用 - Google Patents

急性虚血性脳卒中を処置するためのテネクテプラーゼの使用 Download PDF

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Publication number
JP5785687B2
JP5785687B2 JP2009526788A JP2009526788A JP5785687B2 JP 5785687 B2 JP5785687 B2 JP 5785687B2 JP 2009526788 A JP2009526788 A JP 2009526788A JP 2009526788 A JP2009526788 A JP 2009526788A JP 5785687 B2 JP5785687 B2 JP 5785687B2
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tenecteplase
dose
minutes
bolus
stroke
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JP2010502629A5 (https=
JP2010502629A (ja
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ピーター キューブラー，
ピーター キューブラー，
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Genentech Inc
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Genentech Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2009526788A 2006-08-29 2007-08-01 急性虚血性脳卒中を処置するためのテネクテプラーゼの使用 Active JP5785687B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US82386806P 2006-08-29 2006-08-29
US60/823,868 2006-08-29
PCT/US2007/074997 WO2008027687A2 (en) 2006-08-29 2007-08-01 Use of tenecteplase for treating acute ischemic stroke

Publications (3)

Publication Number Publication Date
JP2010502629A JP2010502629A (ja) 2010-01-28
JP2010502629A5 JP2010502629A5 (https=) 2011-08-18
JP5785687B2 true JP5785687B2 (ja) 2015-09-30

Family

ID=38835003

Family Applications (1)

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JP2009526788A Active JP5785687B2 (ja) 2006-08-29 2007-08-01 急性虚血性脳卒中を処置するためのテネクテプラーゼの使用

Country Status (21)

Country Link
US (2) US20080107641A1 (https=)
EP (1) EP2056856B1 (https=)
JP (1) JP5785687B2 (https=)
KR (1) KR20090045405A (https=)
CN (1) CN101505785A (https=)
AU (1) AU2007290277B2 (https=)
BR (1) BRPI0716143A2 (https=)
CA (1) CA2661012C (https=)
CO (1) CO6150188A2 (https=)
EA (1) EA015573B1 (https=)
EC (1) ECSP099178A (https=)
IL (2) IL196987A (https=)
MX (1) MX2009001918A (https=)
MY (1) MY163119A (https=)
NO (1) NO342302B1 (https=)
NZ (1) NZ574767A (https=)
SG (3) SG10201804944XA (https=)
TW (1) TWI439282B (https=)
UA (1) UA97486C2 (https=)
WO (1) WO2008027687A2 (https=)
ZA (1) ZA200900957B (https=)

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US7759506B2 (en) 2002-02-25 2010-07-20 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salts and their uses
UA95903C2 (ru) 2005-02-24 2011-09-26 Дифьюжен Фармасьютикалз Ллк Транс-каротиноиды, их синтез, лекарственная форма и применение
UA97486C2 (ru) 2006-08-29 2012-02-27 Дженентек, Инк. Применение тенектеплазы для лечения острого ишемического инсульта
CN101687757A (zh) 2007-04-13 2010-03-31 扩散药品有限公司 双极性反式类胡萝卜素作为预治疗及其在周围血管疾病的治疗中的应用
US9034007B2 (en) 2007-09-21 2015-05-19 Insera Therapeutics, Inc. Distal embolic protection devices with a variable thickness microguidewire and methods for their use
EP2384141A1 (en) * 2008-12-24 2011-11-09 Koninklijke Philips Electronics N.V. System, method and apparatus for cardiac intervention with mr stroke detection and treatment
KR101875843B1 (ko) 2009-06-22 2018-07-06 디퓨젼 파마슈티컬즈 엘엘씨 확산 촉진 화합물 및 그 화합물 단독 또는 혈전 용해제와 합쳐진 화합물의 용도
CA2772097C (en) 2009-08-24 2019-04-30 Hough Ear Institute Methods for treating acute acoustic trauma
KR101891357B1 (ko) 2010-06-02 2018-08-24 디퓨젼 파마슈티컬즈 엘엘씨 양극성 트랜스 카로티노이드의 경구용 제형
ES2687850T3 (es) * 2010-12-23 2018-10-29 Gennova Biopharmaceuticals Ltd. Composiciones farmacéuticas de tenecteplasa
US20150238502A1 (en) * 2012-10-18 2015-08-27 University Of South Florida Compositions and Methods for Treating Stroke
US8690907B1 (en) 2013-03-15 2014-04-08 Insera Therapeutics, Inc. Vascular treatment methods
US8679150B1 (en) 2013-03-15 2014-03-25 Insera Therapeutics, Inc. Shape-set textile structure based mechanical thrombectomy methods
US8715314B1 (en) 2013-03-15 2014-05-06 Insera Therapeutics, Inc. Vascular treatment measurement methods
CN116172656A (zh) 2013-03-15 2023-05-30 伊瑟拉医疗公司 脉管治疗装置和方法
US10220008B2 (en) 2013-08-14 2019-03-05 Stc.Unm Treatment and prevention of stroke and other neurological disorders
PT3209767T (pt) * 2014-10-21 2020-11-09 Gennova Biopharmaceuticals Ltd Um novo processo de purificação para isolamento e produção comercial de tnk-tpa recombinante (tenecteplase)
EP3416568A4 (en) 2016-02-16 2019-10-16 Insera Therapeutics, Inc. SUCTION DEVICES AND ANCHORED FLOW REVERSING DEVICES
US11185523B2 (en) 2016-03-24 2021-11-30 Diffusion Pharmaceuticals Llc Use of bipolar trans carotenoids with chemotherapy and radiotherapy for treatment of cancer
WO2018138634A1 (en) * 2017-01-24 2018-08-02 Ekos Corporation Method for the treatment of thromboembolism
WO2018210860A1 (en) * 2017-05-16 2018-11-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of acute ischemic stroke
US10426424B2 (en) 2017-11-21 2019-10-01 General Electric Company System and method for generating and performing imaging protocol simulations
US20230068460A1 (en) * 2020-02-04 2023-03-02 The Regents Of The University Of Colorado, A Body Corporate Prophylactic uses of annexin a2
WO2021165888A1 (en) * 2020-02-19 2021-08-26 Nono Inc. Combination treatment of stroke with plasmin-cleavable psd-95 inhibitor and reperfusion
CN114984197A (zh) * 2022-07-01 2022-09-02 江苏丰华生物制药有限公司 替奈普酶在制备用于治疗急性缺血性卒中的药物组合物中的应用
CN115487294A (zh) * 2022-07-12 2022-12-20 上海丰华天力通生物医药有限公司 替奈普酶在制备用于治疗轻型缺血性卒中的药物组合物中的应用

Family Cites Families (10)

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Publication number Priority date Publication date Assignee Title
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
DK0643772T3 (da) 1992-06-03 1998-02-02 Genentech Inc Glycosyleringsvarianter af vævsplasminogenaktivator med forbedrede terapeutiske egenskaber
JP2002173447A (ja) * 2000-09-29 2002-06-21 Yamanouchi Pharmaceut Co Ltd 脳塞栓症治療用医薬組成物
US7084118B2 (en) * 2002-02-22 2006-08-01 Genentech, Inc. Combination treatment with t-PA variant and low molecular weight heparin
US20030180282A1 (en) * 2002-03-25 2003-09-25 Victor Serebruany Method of treatment of thrombotic events
US20070014779A1 (en) * 2002-11-14 2007-01-18 Genentech, Inc. Plasminogen activator variant formulations
WO2006094120A2 (en) * 2005-03-02 2006-09-08 The Regents Of The University Of California Treatment for embolic stroke
UA97486C2 (ru) 2006-08-29 2012-02-27 Дженентек, Инк. Применение тенектеплазы для лечения острого ишемического инсульта

Also Published As

Publication number Publication date
SG10201501498VA (en) 2015-04-29
HK1131054A1 (en) 2010-01-15
CO6150188A2 (es) 2010-04-20
NZ574767A (en) 2012-02-24
CA2661012C (en) 2019-03-19
UA97486C2 (ru) 2012-02-27
NO342302B1 (no) 2018-04-30
US20080107641A1 (en) 2008-05-08
TW200817033A (en) 2008-04-16
AU2007290277A1 (en) 2008-03-06
CA2661012A1 (en) 2008-03-06
WO2008027687A2 (en) 2008-03-06
BRPI0716143A2 (pt) 2013-11-26
MY163119A (en) 2017-08-15
WO2008027687A3 (en) 2008-05-22
MX2009001918A (es) 2009-03-06
EA015573B1 (ru) 2011-10-31
IL248176A0 (en) 2016-11-30
US9023346B2 (en) 2015-05-05
AU2007290277B2 (en) 2013-04-11
SG174753A1 (en) 2011-10-28
NO20091296L (no) 2009-05-28
TWI439282B (zh) 2014-06-01
EP2056856A2 (en) 2009-05-13
ZA200900957B (en) 2010-05-26
KR20090045405A (ko) 2009-05-07
EP2056856B1 (en) 2015-01-14
SG10201804944XA (en) 2018-07-30
EA200970237A1 (ru) 2009-08-28
IL196987A0 (en) 2011-08-01
JP2010502629A (ja) 2010-01-28
US20120164157A1 (en) 2012-06-28
CN101505785A (zh) 2009-08-12
ECSP099178A (es) 2009-06-30
IL196987A (en) 2016-10-31

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